H. Winter
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View article: Plasma proteomic profiling and molecular clustering reveal immune‐defined prognostic subtypes in lung adenocarcinoma
Plasma proteomic profiling and molecular clustering reveal immune‐defined prognostic subtypes in lung adenocarcinoma Open
Lung adenocarcinoma (LUAD) is a biologically and clinically heterogeneous disease that poses a major challenge for prognosis and treatment. In this study, we performed proteomic profiling in a cohort of 88 LUAD patients to identify molecul…
View article: msBayesImpute: A Versatile Framework for Addressing Missing Values in Biomedical Mass Spectrometry Proteomics Data
msBayesImpute: A Versatile Framework for Addressing Missing Values in Biomedical Mass Spectrometry Proteomics Data Open
Advancements in mass spectrometry (MS) technologies have significantly improved the ability to quantify proteins and analyse their modifications. However, MS-based proteomics datasets frequently encounter missing values due to a complex in…
Contralateral Robotic-Assisted Anatomical Resection for Synchronous or Metachronous Lung Cancer: A Retrospective Case Series Open
Background: Advances in screening programs have led to increased detection of early-stage non-small cell lung cancer (NSCLC), including synchronous or metachronous nodules amenable to surgical resection. Patients requiring contralateral an…
View article: Living human lung slices for ex vivo modelling of lung cancer
Living human lung slices for ex vivo modelling of lung cancer Open
The tumor microenvironment (TME) markedly affects cancer progression, yet traditional animal models do not fully recapitulate the situation in humans. To address this, we developed tumor-derived precision lung slices (TD-PCLS), an ex vivo …
Prognostic impact of lepidic growth in intermediate and high-grade lung adenocarcinoma Open
Lepidic growth did not demonstrate prognostic significance in intermediate and high-grade non-mucinous lung adenocarcinoma in this study.
Macrophage fatty acid metabolism under chronic hypoxia shapes γδ T cell recruitment via CCL22 Open
Hypoxia in solid tumors is associated with poor outcomes because of metabolic adaptations that support tumor cell survival and alter immune cell function. However, the metabolic and phenotypic adaptations of macrophages (MФs) to chronic hy…
Image analysis: 68Ga-FAPI-46 PET derived texture parameters improve the differentiation of malignant and benign pulmonary lesions Open
Background Pulmonary lesions inconclusive in 18 F-FDG PET/CT are a known clinical problem. Both texture analysis and 68 Ga-FAPI-46 have shown potential in thoracic oncological problems but their combination has not been assessed yet. This …
Robot‐Assisted Versus Open Surgery for the Resection of Large Thymomas: A Retrospective Cohort Study Open
Background Robot‐assisted thoracic surgery (RATS) is increasingly becoming the preferred surgical method for the resection of thymomas. We initiated the current study to evaluate perioperative outcomes and early recurrence associated with …
View article: NeoTRACK trial: Neoadjuvant TiRagolumab, Atezolizumab and Chemotherapy – dissection of IO- efficacy in NSCLC by longitudinal tracKing – protocol of a non-randomised, open-label, single-arm, phase II study
NeoTRACK trial: Neoadjuvant TiRagolumab, Atezolizumab and Chemotherapy – dissection of IO- efficacy in NSCLC by longitudinal tracKing – protocol of a non-randomised, open-label, single-arm, phase II study Open
Background Immunotherapies targeting the programmed death receptor-1/programmed death ligand-1(PD-1/PD-L1) checkpoint have a major impact on the treatment of both resectable and advanced non-small cell lung cancer (NSCLC). Additional block…
Pulmonary arteriovenous malformation causing lung sequestration and media infarction: a case report Open
Pulmonary arteriovenous malformations (PAVMs) are rare vascular malformations of the lungs. Direct communication of pulmonary arteries to pulmonary veins is the defining characteristic allowing venous blood to bypass the pulmonary capillar…
Intratumor Heterogeneity Predicts Prognosis in Lepidic Predominant Lung Adenocarcinoma Open
Objective Among the different subtypes of invasive lung adenocarcinoma, lepidic predominant adenocarcinoma (LPA) has been recognized as the lowest‐risk subtype with good prognosis. The aim of this study is to provide insight into the heter…
Dextromethorphan inhibits collagen and collagen-like cargo secretion to ameliorate lung fibrosis Open
Excessive deposition of fibrillar collagen in the interstitial extracellular matrix (ECM) of human lung tissue causes fibrosis, which can ultimately lead to organ failure. Despite our understanding of the molecular mechanisms underlying th…
Thoracic surgery - An underestimated dream job? Open
The development of an objective and structured training plan could define the roles and responsibilities of the senior surgeon and the trainee, leading to improved training and, at the very least, ensuring good recruitment of junior thorac…
View article: Data from The HDAC2-SP1 axis orchestrates pro-tumor macrophage polarization
Data from The HDAC2-SP1 axis orchestrates pro-tumor macrophage polarization Open
Tumor-associated macrophages (TAMs), including anti-tumor M1-like TAMs and pro-tumor M2-like TAMs, are transcriptionally dynamic innate immune cells with diverse roles in lung cancer development. Epigenetic regulators are key in controllin…
View article: Supplementary Data from The HDAC2-SP1 axis orchestrates pro-tumor macrophage polarization
Supplementary Data from The HDAC2-SP1 axis orchestrates pro-tumor macrophage polarization Open
Supplementary Data with figires_tables
View article: Supplementary Data from The HDAC2-SP1 axis orchestrates pro-tumor macrophage polarization
Supplementary Data from The HDAC2-SP1 axis orchestrates pro-tumor macrophage polarization Open
Supplementary Data with figires_tables
View article: Cine-MRI and T1TSE Sequence for Mediastinal Mass
Cine-MRI and T1TSE Sequence for Mediastinal Mass Open
Background/Objectives: Contrast-enhanced computed tomography (CT) is the standard radiologic examination for evaluating the extent of mediastinal tumors. If tumor infiltration into the large central thoracic vessels, the pericardium, or th…
Germline Polymorphisms Associated with Overall Survival in Lung Adenocarcinoma: Genome-Wide Analysis Open
Background/Objectives: Lung cancer remains a global health concern, with substantial variation in patient survival. Despite advances in detection and treatment, the genetic basis for the divergent outcomes is not understood. We investigate…
View article: Carbon Ion Beam Radiation Therapy as Part of a Trimodal Therapy for Non-small Cell Superior Sulcus Tumors: The INKA Study
Carbon Ion Beam Radiation Therapy as Part of a Trimodal Therapy for Non-small Cell Superior Sulcus Tumors: The INKA Study Open
The INKA trial is the first study to evaluate nCRT with C12-RT and showed excellent response, low toxicity, and rapid pain relief.
View article: CT-guided needle biopsy is not associated with increased ipsilateral pleural metastasis
CT-guided needle biopsy is not associated with increased ipsilateral pleural metastasis Open
CTGNB is safe and not associated with an increased incidence of IPR in our cohort of patients. This observation remains to be validated in a larger multicenter patient cohort.
View article: Surgical therapy of a Fetal Lung Interstitial Tumor (FLIT) in an infant – A case report and review of surgical considerations
Surgical therapy of a Fetal Lung Interstitial Tumor (FLIT) in an infant – A case report and review of surgical considerations Open
Congenital lung masses are rare and their clinical presentation is highly variable. If newborns present with respiratory distress immediately after birth, early surgical therapy can be necessary. Here, we present the case of a newborn with…