Kevin Lin
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View article: A novel ZIKV-targeted scRNA-seq method for precise quantification of ZIKV RNA
A novel ZIKV-targeted scRNA-seq method for precise quantification of ZIKV RNA Open
Zika virus (ZIKV), transmitted by mosquitoes, poses a serious public health threat. Currently, precise quantitative diagnostic methods are lacking. Existing single-cell RNA-sequencing (scRNA-seq) techniques are challenged to detect ZIKV RN…
View article: Deciphering Cell Fate and Clonal Dynamics via Integrative Single-Cell Lineage Modeling
Deciphering Cell Fate and Clonal Dynamics via Integrative Single-Cell Lineage Modeling Open
Through natural or synthetic lineage barcodes, single-cell technologies now enable the joint measurement of molecular states and clonal identities, providing an unprecedented opportunity to study cell fate and dynamics. Yet, most computati…
View article: Impact of Amelogenesis Imperfecta on Junctional Epithelium Structure and Function
Impact of Amelogenesis Imperfecta on Junctional Epithelium Structure and Function Open
The junctional epithelium, which lines the inner gingival surface, seals the gingival sulcus to block the infiltration of food debris and pathogens. The junctional epithelium is derived from the reduced enamel epithelium, consisting of lat…
View article: Consumer Attitude Towards Intention to Invest Private Retirement Scheme (PRS) in Structure Equation Modelling
Consumer Attitude Towards Intention to Invest Private Retirement Scheme (PRS) in Structure Equation Modelling Open
Manuscript type: Research paper Research aims: The study examines the factors influencing the intention to invest in Private Retirement Schemes (PRS), with attitudes as moderating variables. Design/Methodology/Approach: A quantitative appr…
View article: Intraoperative Radiation Therapy (IORT) for Breast Cancer: The Final Analysis of a Prospective Cohort of 1828 Cases
Intraoperative Radiation Therapy (IORT) for Breast Cancer: The Final Analysis of a Prospective Cohort of 1828 Cases Open
Background Intraoperative radiation therapy (IORT) delivers the full course of radiation therapy during the initial surgical excision. In the early 2000s, IORT was a promising method of breast cancer treatment de-escalation, offering many …
View article: Point-RFT: Improving Multimodal Reasoning with Visually Grounded Reinforcement Finetuning
Point-RFT: Improving Multimodal Reasoning with Visually Grounded Reinforcement Finetuning Open
Recent advances in large language models have significantly improved textual reasoning through the effective use of Chain-of-Thought (CoT) and reinforcement learning. However, extending these successes to vision-language tasks remains chal…
View article: Development of a four autophagy-related gene signature for active tuberculosis diagnosis
Development of a four autophagy-related gene signature for active tuberculosis diagnosis Open
Background Tuberculosis (TB) diagnostics urgently require non-sputum biomarkers to address the limitations of conventional methods in distinguishing active TB (ATB) from latent infection (LTBI), healthy controls (HCs), and TB-mimicking dis…
View article: Cannabis April 20th Celebration and Related Emergency Department Visits
Cannabis April 20th Celebration and Related Emergency Department Visits Open
This cross-sectional study examines the association between April 20th cannabis celebrations and rates of cannabis-related emergency department visits in the US.
View article: Histone methyltransferase ASH1L primes metastases and metabolic reprogramming of macrophages in the bone niche
Histone methyltransferase ASH1L primes metastases and metabolic reprogramming of macrophages in the bone niche Open
Bone metastasis is a major cause of cancer death; however, the epigenetic determinants driving this process remain elusive. Here, we report that histone methyltransferase ASH1L is genetically amplified and is required for bone metastasis i…
View article: Ultrasmall platinum single-atom enzyme alleviates oxidative stress and macrophage polarization induced by acute kidney ischemia–reperfusion injury through inhibition of cell death storm
Ultrasmall platinum single-atom enzyme alleviates oxidative stress and macrophage polarization induced by acute kidney ischemia–reperfusion injury through inhibition of cell death storm Open
Acute kidney injury (AKI), characterized by a rapid decline in renal function, is associated with impaired mitochondrial function and excessive reactive oxygen species (ROS). Therefore, the exploration of ROS scavengers provides promising …
View article: Sleep-time Compute: Beyond Inference Scaling at Test-time
Sleep-time Compute: Beyond Inference Scaling at Test-time Open
Scaling test-time compute has emerged as a key ingredient for enabling large language models (LLMs) to solve difficult problems, but comes with high latency and inference cost. We introduce sleep-time compute, which allows models to "think…
View article: BizGen: Advancing Article-level Visual Text Rendering for Infographics Generation
BizGen: Advancing Article-level Visual Text Rendering for Infographics Generation Open
Recently, state-of-the-art text-to-image generation models, such as Flux and Ideogram 2.0, have made significant progress in sentence-level visual text rendering. In this paper, we focus on the more challenging scenarios of article-level v…
View article: Absorption, metabolism, and bioconversion of trans-palmitoleic acid in C57BL/6J mice: Implications for lipid metabolism
Absorption, metabolism, and bioconversion of trans-palmitoleic acid in C57BL/6J mice: Implications for lipid metabolism Open
TRANS: palmitoleic acid (TPA), a naturally occurring trans fatty acid found in ruminant-derived products such as dairy products, has been associated with various potential health benefits. However, its digestion, absorption, tissue distrib…
View article: GR00T N1: An Open Foundation Model for Generalist Humanoid Robots
GR00T N1: An Open Foundation Model for Generalist Humanoid Robots Open
General-purpose robots need a versatile body and an intelligent mind. Recent advancements in humanoid robots have shown great promise as a hardware platform for building generalist autonomy in the human world. A robot foundation model, tra…
View article: Genetic risk implicating endolysosomal network genes correlates with endolysosomal dysfunction across neural cell types in Alzheimer’s disease
Genetic risk implicating endolysosomal network genes correlates with endolysosomal dysfunction across neural cell types in Alzheimer’s disease Open
Late-onset Alzheimer’s disease (LOAD) has a complex genomic architecture. LOAD risk variants suggest multiple pathways, including the endolysosomal network (ELN), contribute to the pathobiology of Alzheimer’s disease (AD). Whether genetic …
View article: Cancer cells avoid ferroptosis induced by immune cells via fatty acid binding proteins
Cancer cells avoid ferroptosis induced by immune cells via fatty acid binding proteins Open
Our study uncovers a novel mechanism by which cancer cells evade immune-mediated ferroptosis through Fabp7 upregulation. This protein reprograms lipid metabolism and disrupts circadian regulation in immune cells, promoting tumor survival a…
View article: Constitutional Classifiers: Defending against Universal Jailbreaks across Thousands of Hours of Red Teaming
Constitutional Classifiers: Defending against Universal Jailbreaks across Thousands of Hours of Red Teaming Open
Large language models (LLMs) are vulnerable to universal jailbreaks-prompting strategies that systematically bypass model safeguards and enable users to carry out harmful processes that require many model interactions, like manufacturing i…
View article: A dendritic hexamer acceptor enables 19.4% efficiency with exceptional stability in organic solar cells
A dendritic hexamer acceptor enables 19.4% efficiency with exceptional stability in organic solar cells Open
To achieve the commercialization of organic solar cells (OSCs), it is crucial not only to enhance power conversion efficiency (PCE) but also to improve device stability through rational molecular design. Recently emerging giant molecular a…
View article: Canonical androgen response element motifs are tumor suppressive regulatory elements in the prostate
Canonical androgen response element motifs are tumor suppressive regulatory elements in the prostate Open
The androgen receptor (AR) is central in prostate tissue identity and differentiation, and controls normal growth-suppressive, prostate-specific gene expression. It also drives prostate tumorigenesis when hijacked for oncogenic transcripti…