Ziad Nahas
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View article: Durability of the Benefit of Vagus Nerve Stimulation in Markedly Treatment-Resistant Major Depression: A RECOVER Trial Report
Durability of the Benefit of Vagus Nerve Stimulation in Markedly Treatment-Resistant Major Depression: A RECOVER Trial Report Open
Importance Greater levels of treatment resistance in major depressive disorder (MDD) are associated with lower rates of initial benefit and higher rates of relapse (lower durability). Objective Characterize depressive symptoms, function, a…
View article: Personalized Adaptive Cortical Electro-stimulation (PACE) in Treatment-Resistant Depression
Personalized Adaptive Cortical Electro-stimulation (PACE) in Treatment-Resistant Depression Open
Treatment-resistant depression (TRD) is a leading cause of premature death. For decades investigators have assessed the clinical efficacy of direct brain stimulation for TRD. Outcomes have been inconsistent due to imprecise brain targeting…
View article: Prefrontal Cortical Stimulation for Treatment-Resistant Depression
Prefrontal Cortical Stimulation for Treatment-Resistant Depression Open
View article: An action networks model for pain reveals cortical neuromodulation targets
An action networks model for pain reveals cortical neuromodulation targets Open
Chronic neuropathic pain is a debilitating condition, difficult to treat, and associated with poor outcomes, including addiction and suicide. Neuromodulation of primary motor cortex and dorsolateral prefrontal cortex (dlPFC) alleviates neu…
View article: Towards accredited clinical training in brain stimulation: Proceedings from the brain stimulation subspecialty summits
Towards accredited clinical training in brain stimulation: Proceedings from the brain stimulation subspecialty summits Open
The rapid development and clinical use of brain stimulation has renewed debates about whether to define and accredit a pathway for clinical subspecialty training. To address this, the Brain Stimulation Subspecialty Summits (BraSSS) were co…
View article: The effects of pulse amplitude in electroconvulsive therapy on seizure threshold, seizure duration, and time to reorientation
The effects of pulse amplitude in electroconvulsive therapy on seizure threshold, seizure duration, and time to reorientation Open
View article: Convergence of individualized functional neural networks and structural connectivity in subdural prefrontal cortical stimulation
Convergence of individualized functional neural networks and structural connectivity in subdural prefrontal cortical stimulation Open
View article: Predicting antidepressant response to repetitive transcranial magnetic stimulation (rTMS) based on prior treatment history
Predicting antidepressant response to repetitive transcranial magnetic stimulation (rTMS) based on prior treatment history Open
View article: Towards Accredited Clinical Training in Brain Stimulation: Proceedings from the Brain Stimulation Subspecialty Summits
Towards Accredited Clinical Training in Brain Stimulation: Proceedings from the Brain Stimulation Subspecialty Summits Open
View article: Vagus nerve stimulation in treatment-resistant depression: A one-year, randomized, sham-controlled trial
Vagus nerve stimulation in treatment-resistant depression: A one-year, randomized, sham-controlled trial Open
Percent time in MADRS response did not distinguish the treatment groups, but on multiple instruments time in response and PR showed a positive treatment effect. VNS was found safe and effective in participants with marked TRD.
View article: Effects of vagus nerve stimulation on daily function and quality of life in markedly treatment-resistant major depression: Findings from a one-year, randomized, sham-controlled trial
Effects of vagus nerve stimulation on daily function and quality of life in markedly treatment-resistant major depression: Findings from a one-year, randomized, sham-controlled trial Open
Active VNS was superior to sham VNS in improving QoL and psychosocial function in patients with TRD. VNS has a broader therapeutic impact than symptom improvement alone in patients with marked psychosocial impairment.
View article: Real-time TMS-EEG for brain state-controlled research and precision treatment: a narrative review and guide
Real-time TMS-EEG for brain state-controlled research and precision treatment: a narrative review and guide Open
Transcranial magnetic stimulation (TMS) modulates neuronal activity, but the efficacy of an open-loop approach is limited due to the brain state’s dynamic nature. Real-time integration with electroencephalography (EEG) increases experiment…
View article: Trajectory Modeling and Response Prediction in Transcranial Magnetic Stimulation for Depression
Trajectory Modeling and Response Prediction in Transcranial Magnetic Stimulation for Depression Open
Repetitive transcranial magnetic stimulation (rTMS) therapy could be improved by better and earlier prediction of response. Latent class mixture (LCMM) and non-linear mixed effects (NLME) modelling have been applied to model the trajectori…
View article: Effects of TMS on anhedonia and suicidal ideation in treatment-resistant depression: Outcomes from the University of Minnesota Interventional Psychiatry Program
Effects of TMS on anhedonia and suicidal ideation in treatment-resistant depression: Outcomes from the University of Minnesota Interventional Psychiatry Program Open
Our results reinforce the effectiveness of TMS in TRD and provide new evidence that anhedonia and SI may belong to a broader symptom cluster potentially undergirded by a shared circuitry accessible to dlPFC TMS.
View article: Causally Probing the Role of the Hippocampus in Fear Discrimination: A Precision Functional Mapping–Guided, Transcranial Magnetic Stimulation Study in Participants With Posttraumatic Stress Symptoms
Causally Probing the Role of the Hippocampus in Fear Discrimination: A Precision Functional Mapping–Guided, Transcranial Magnetic Stimulation Study in Participants With Posttraumatic Stress Symptoms Open
Overgeneralization is an associative process that reflects deficient discrimination of the fear cue from similar cues. In contrast, sensitization reflects nonassociative responding unrelated to fear cue similarity. Our results suggest that…
View article: Deep transcranial magnetic stimulation for adolescents with treatment-resistant depression: A preliminary dose-finding study exploring safety and clinical effectiveness
Deep transcranial magnetic stimulation for adolescents with treatment-resistant depression: A preliminary dose-finding study exploring safety and clinical effectiveness Open
View article: Clinical characteristics and treatment exposure of patients with marked treatment-resistant unipolar major depressive disorder: A RECOVER trial report
Clinical characteristics and treatment exposure of patients with marked treatment-resistant unipolar major depressive disorder: A RECOVER trial report Open
ClinicalTrials.gov Identifier NCT03887715.
View article: Rewriting the Script: the Need for Effective Education to Address Racial Disparities in Transcranial Magnetic Stimulation Uptake in BIPOC Communities
Rewriting the Script: the Need for Effective Education to Address Racial Disparities in Transcranial Magnetic Stimulation Uptake in BIPOC Communities Open
Depression is a widespread concern in the United States. Neuromodulation treatments are becoming more common but there is emerging concern for racial disparities in neuromodulation treatment utilization. This study focuses on Transcranial …
View article: Causally probing the role of the human hippocampus in fear discrimination: A precision functional mapping guided TMS study in individuals with post-traumatic stress symptoms
Causally probing the role of the human hippocampus in fear discrimination: A precision functional mapping guided TMS study in individuals with post-traumatic stress symptoms Open
Fear overgeneralization is a potential pathogenic mechanism of anxiety-related disorders. A dominant model posits that overgeneralization occurs when the hippocampus fails to distinctly encode benign stimuli with insufficient similarity to…
View article: Effects of vagus nerve on central nervous system (epilepsy, depression and neuroimaging)
Effects of vagus nerve on central nervous system (epilepsy, depression and neuroimaging) Open
View article: Causally mapping human threat extinction relevant circuits with depolarizing brain stimulation methods
Causally mapping human threat extinction relevant circuits with depolarizing brain stimulation methods Open
View article: Sustained Activation of the Anterior Thalamic Neurons with Low Doses of Kainic Acid Boosts Hippocampal Neurogenesis
Sustained Activation of the Anterior Thalamic Neurons with Low Doses of Kainic Acid Boosts Hippocampal Neurogenesis Open
Adult hippocampal neurogenesis is prone to modulation by several intrinsic and extrinsic factors. The anterior nucleus (AN) of the thalamus has extensive connections with the hippocampus, and stimulation of this region may play a role in a…
View article: DLPFC stimulation alters working memory related activations and performance: An interleaved TMS-fMRI study
DLPFC stimulation alters working memory related activations and performance: An interleaved TMS-fMRI study Open
View article: Personalizing Dual-Target Cortical Stimulation with Bayesian Parameter Optimization Successfully Treats Central Post-Stroke Pain: A Case Report
Personalizing Dual-Target Cortical Stimulation with Bayesian Parameter Optimization Successfully Treats Central Post-Stroke Pain: A Case Report Open
Central pain disorders, such as central post-stroke pain, remain clinically challenging to treat, despite many decades of pharmacological advances and the evolution of neuromodulation. For treatment refractory cases, previous studies have …
View article: Outcomes from University of Minnesota Clinical rTMS Clinic for resistant depression: naturalistic data on suicidal ideation
Outcomes from University of Minnesota Clinical rTMS Clinic for resistant depression: naturalistic data on suicidal ideation Open
View article: Covid effects on clinical outcomes of TMS treatment: a naturalistic study
Covid effects on clinical outcomes of TMS treatment: a naturalistic study Open
View article: A narrative review on invasive brain stimulation for treatment-resistant depression
A narrative review on invasive brain stimulation for treatment-resistant depression Open
While most patients with depression respond to pharmacotherapy and psychotherapy, about one-third will present treatment resistance to these interventions. For patients with treatment-resistant depression (TRD), invasive neurostimulation t…
View article: Changes in sleep with transcranial magnetic stimulation in adults with treatment resistant depression: Preliminary results from a naturalistic study
Changes in sleep with transcranial magnetic stimulation in adults with treatment resistant depression: Preliminary results from a naturalistic study Open
Introduction Sleep disturbance specifically insomnia, non-restorative sleep, and hypersomnia are common symptoms of major depressive disorder (MDD). As it alleviates major depressive disorder, transcranial magnetic stimulation (TMS) may im…
View article: Long-term stimulation of the anteromedial thalamus increases hippocampal neurogenesis and spatial reference memory in adult rats
Long-term stimulation of the anteromedial thalamus increases hippocampal neurogenesis and spatial reference memory in adult rats Open
View article: Decreased interhemispheric connectivity and increased cortical excitability in unmedicated schizophrenia: A prefrontal interleaved TMS fMRI study
Decreased interhemispheric connectivity and increased cortical excitability in unmedicated schizophrenia: A prefrontal interleaved TMS fMRI study Open