Hadar Golan-Berman
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View article: A Novel Cisplatin-Based Prodrug Inhibits Lysine Deacetylases, Suppresses Nucleotide Excision Repair, and Overcomes Resistance
A Novel Cisplatin-Based Prodrug Inhibits Lysine Deacetylases, Suppresses Nucleotide Excision Repair, and Overcomes Resistance Open
Cisplatin [cis-diamminedichloroplatinum(II)] is a widely used chemotherapeutic agent that induces cytotoxicity primarily through DNA damage, but drug resistance severely limits its efficacy and use. Cisplatin resistance is complex and mult…
View article: Gene architecture is a determinant of the transcriptional response to bulky DNA damages
Gene architecture is a determinant of the transcriptional response to bulky DNA damages Open
Bulky DNA damages block transcription and compromise genome integrity and function. The cellular response to these damages includes global transcription shutdown. Still, active transcription is necessary for transcription-coupled repair an…
View article: SARS-CoV-2 Omicron Induces Enhanced Mucosal Interferon Response Compared to other Variants of Concern, Associated with Restricted Replication in Human Lung Tissues
SARS-CoV-2 Omicron Induces Enhanced Mucosal Interferon Response Compared to other Variants of Concern, Associated with Restricted Replication in Human Lung Tissues Open
SARS-CoV-2 Omicron variant has been characterized by decreased clinical severity, raising the question of whether early variant-specific interactions within the mucosal surfaces of the respiratory tract could mediate its attenuated pathoge…
View article: Identification of SARS-CoV-2 Variants of Concern Using Amplicon Next-Generation Sequencing
Identification of SARS-CoV-2 Variants of Concern Using Amplicon Next-Generation Sequencing Open
The manuscript described SARS-Cov-2 genotyping by VOC-NGS, which presents an ideal balance of accuracy, rapidity, and cost for detecting and globally tracking VOCs and some VOI of SARS-CoV-2. A large number of clinical samples can be teste…
View article: SARS-CoV-2 Omicron is specifically restricted in its replication in human lung tissue, compared to other variants of concern
SARS-CoV-2 Omicron is specifically restricted in its replication in human lung tissue, compared to other variants of concern Open
SARS-CoV-2 Omicron variant has been characterized by decreased clinical severity, raising the question of whether early variant-specific interactions within the mucosal surfaces of the respiratory tract could mediate its attenuated pathoge…
View article: External Quality Assessment of SARS-CoV-2 Sequencing: an ESGMD-SSM Pilot Trial across 15 European Laboratories
External Quality Assessment of SARS-CoV-2 Sequencing: an ESGMD-SSM Pilot Trial across 15 European Laboratories Open
This first pilot trial on external quality assessment (EQA) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) whole-genome sequencing, initiated by the European Society of Clinical Microbiology and Infectious Diseases (ESCMID…
View article: Genomic Characterization of Cisplatin Response Uncovers Priming of Cisplatin-Induced Genes in a Resistant Cell Line
Genomic Characterization of Cisplatin Response Uncovers Priming of Cisplatin-Induced Genes in a Resistant Cell Line Open
Cisplatin is a chemotherapy drug that kills cancer cells by damaging their DNA. In human cells, this damage is repaired primarily by nucleotide excision repair. While cisplatin is generally effective, many cancers exhibit initial or acquir…
View article: Lessons from applied large-scale pooling of 133,816 SARS-CoV-2 RT-PCR tests
Lessons from applied large-scale pooling of 133,816 SARS-CoV-2 RT-PCR tests Open
Adaptive sample pooling for SARS-CoV-2 testing based on positivity rates spares 76% of test reactions without compromising specificity or sensitivity.
View article: The sequential and cooperative action of CSB, CSA and UVSSA targets the TFIIH complex to DNA damage-stalled RNA polymerase II
The sequential and cooperative action of CSB, CSA and UVSSA targets the TFIIH complex to DNA damage-stalled RNA polymerase II Open
Summary The response to DNA damage-stalled RNA polymerase II (RNAPIIo) involves the assembly of the transcription-coupled repair (TCR) complex on actively transcribed strands. The function of the TCR proteins CSB, CSA and UVSSA and the man…
View article: Quantifying thermohaline circulations: seawater isotopic compositions and salinity as proxies of the ratio between advection time and evaporation time
Quantifying thermohaline circulations: seawater isotopic compositions and salinity as proxies of the ratio between advection time and evaporation time Open
Uncertainties in quantitative estimates of the thermohaline circulation in any particular basin are large, partly due to large uncertainties in quantifying excess evaporation over precipitation and surface velocities. A single nondimensi…