Hadas Lewinsky
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View article: CD84 is a regulator of the immunosuppressive microenvironment in multiple myeloma
CD84 is a regulator of the immunosuppressive microenvironment in multiple myeloma Open
sentative flow plots provided for CD14 -HD-PD and CD14 + HD-PD were incorrect.The correct figure part is shown below.
View article: CD74 as a regulator of transcription in normal B cells
CD74 as a regulator of transcription in normal B cells Open
CD74 is receptor for the cytokine macrophage migration inhibitory factor (MIF). MIF binding to CD74 induces a signaling cascade resulting in the release of its cytosolic intracellular domain (CD74-ICD) that serves as a transcriptional regu…
View article: CD74 is a regulator of hematopoietic stem cell maintenance
CD74 is a regulator of hematopoietic stem cell maintenance Open
Hematopoietic stem and progenitor cells (HSPCs) are a small population of undifferentiated cells that have the capacity for self-renewal and differentiate into all blood cell lineages. These cells are the most useful cells for clinical tra…
View article: CD84 is a regulator of the immunosuppressive microenvironment in Multiple Myeloma
CD84 is a regulator of the immunosuppressive microenvironment in Multiple Myeloma Open
Multiple myeloma (MM) is characterized by an accumulation of malignant plasma cells (PCs) within the BM. The BM microenvironment supports survival of the malignant cells and is composed of cellular fractions that foster myeloma development…
View article: SLAMF9 regulates pDC homeostasis and function in health and disease
SLAMF9 regulates pDC homeostasis and function in health and disease Open
SLAMF9 belongs to the conserved lymphocytic activation molecule family (SLAMF). Unlike other SLAMs, which have been extensively studied, the role of SLAMF9 in the immune system remained mostly unexplored. By generating CRISPR/Cas9 SLAMF9 k…
View article: CD84 regulates PD-1/PD-L1 expression and function in chronic lymphocytic leukemia
CD84 regulates PD-1/PD-L1 expression and function in chronic lymphocytic leukemia Open
Chronic lymphocytic leukemia (CLL) is characterized by clonal proliferation and progressive accumulation of mature B lymphocytes in the peripheral blood, lymphoid tissues, and bone marrow. CLL is characterized by profound immune defects le…
View article: T Cells Regulate Peripheral Naive Mature B Cell Survival by Cell–Cell Contact Mediated through SLAMF6 and SAP
T Cells Regulate Peripheral Naive Mature B Cell Survival by Cell–Cell Contact Mediated through SLAMF6 and SAP Open
The control of lymphoid homeostasis is the result of a very fine balance between lymphocyte production, proliferation, and apoptosis. In this study, we focused on the role of T cells in the maintenance/survival of the mature naive peripher…
View article: CD74 is a novel transcription regulator
CD74 is a novel transcription regulator Open
Significance CD74 has been associated with tumor progression and metastasis. Its expression has been suggested to serve as a prognostic factor in many cancers, with higher relative expression behaving as a marker of tumor progression. Our …