Hadeel Alkofide
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View article: Correction: Aljahili et al. Safety of Switching from a Reference Biologic to Its Biosimilar: A Systematic Review and Meta-Analysis. Biologics 2025, 5, 6
Correction: Aljahili et al. Safety of Switching from a Reference Biologic to Its Biosimilar: A Systematic Review and Meta-Analysis. Biologics 2025, 5, 6 Open
In the original publication [...]
View article: Prevalence of uncommon side effects of 5-fluorouracil and capecitabine in Saudi patients with cancer: A cross-sectional observational study
Prevalence of uncommon side effects of 5-fluorouracil and capecitabine in Saudi patients with cancer: A cross-sectional observational study Open
5-Fluorouracil (5-FU) and its prodrug, capecitabine, are widely used in chemotherapy for various cancers, including colorectal, breast, and gastrointestinal malignancies. While their common toxicities are well documented, uncommon, and sev…
View article: The influence of workplace stressors on the risk of cardiovascular diseases among healthcare providers: a systematic review
The influence of workplace stressors on the risk of cardiovascular diseases among healthcare providers: a systematic review Open
Background Cardiovascular diseases (CVDs) are a leading cause of death worldwide. Healthcare workers are at increased risk due to workplace stressors such as long hours, shift work, and high job demands, which may worsen both modifiable an…
View article: Patient-reported outcome measurements in clinical trials in Saudi Arabia
Patient-reported outcome measurements in clinical trials in Saudi Arabia Open
Forty percent of the registered clinical trials in Saudi Arabia used at least one PRO. This highlights the need to address barriers to PRO use to facilitate generation of local evidence.
View article: Prevalence and characteristics of long COVID among COVID-19 survivors in Saudi Arabia: A cross-sectional study
Prevalence and characteristics of long COVID among COVID-19 survivors in Saudi Arabia: A cross-sectional study Open
This study underscores the significance of understanding long COVID's impact on individuals' health and quality of life. It highlights the necessity for further research to guide health care strategies and support COVID-19 survivors in Sau…
View article: Safety of Switching from a Reference Biologic to Its Biosimilar: A Systematic Review and Meta-Analysis
Safety of Switching from a Reference Biologic to Its Biosimilar: A Systematic Review and Meta-Analysis Open
Background: Biosimilars are designed to closely resemble their reference biologics in terms of quality, safety, and efficacy, with only minor variations in clinically inactive components and manufacturing methods. Evaluating the safety of …
View article: Opioid and benzodiazepine requirements in critically ill post-surgical children with down syndrome: a systematic review and meta-analysis
Opioid and benzodiazepine requirements in critically ill post-surgical children with down syndrome: a systematic review and meta-analysis Open
Patients with Down syndrome did not require more sedation or analgesia in the first three days after surgery than patients without Down syndrome. Additionally, the two groups showed no significant difference in the duration of mechanical v…
View article: Evaluating the effectiveness of nicotine replacement therapy in critically ill smokers: A meta-analysis of randomized controlled trials
Evaluating the effectiveness of nicotine replacement therapy in critically ill smokers: A meta-analysis of randomized controlled trials Open
Critically ill smoker patients who received NRT experienced a significantly shorter ICU LOS but no significant differences in the durations of MV, vasopressor use, or delirium.
View article: Pharmacovigilance Practices by Healthcare Providers in Oncology: A Cross-Sectional Study
Pharmacovigilance Practices by Healthcare Providers in Oncology: A Cross-Sectional Study Open
Investigating pharmacovigilance (PV) practices among oncology healthcare providers (HCPs) is crucial for patient safety in oncology settings. This study aimed to assess the awareness, attitudes, and practices towards PV and identify barrie…
View article: Evaluation of Apixaban standard dosing in underweight patients with non-valvular atrial fibrillation: a retrospective cohort study
Evaluation of Apixaban standard dosing in underweight patients with non-valvular atrial fibrillation: a retrospective cohort study Open
View article: The concomitant use of ultra short beta-blockers with vasopressors and inotropes in critically ill patients with septic shock: A systematic review and meta-analysis of randomized controlled trials
The concomitant use of ultra short beta-blockers with vasopressors and inotropes in critically ill patients with septic shock: A systematic review and meta-analysis of randomized controlled trials Open
The use of ultra short beta-blockers concomitantly with either epinephrine or norepinephrine in critically ill patients with septic shock was associated with better heart rate control and survival benefits without increment in the inotrope…
View article: Evaluation of factors affecting pharmacists and pharmacy technicians' satisfaction towards practicing CE activities in Saudi Arabia
Evaluation of factors affecting pharmacists and pharmacy technicians' satisfaction towards practicing CE activities in Saudi Arabia Open
View article: Hospitalization Endpoint in Clinical Trials of Outpatient Settings: using Anti-SARS-COV-2 Therapy as an Example
Hospitalization Endpoint in Clinical Trials of Outpatient Settings: using Anti-SARS-COV-2 Therapy as an Example Open
Choosing hospitalization as an endpoint may provide meaningful data such as the cost-effectiveness ratio of a drug. However, different hospital utilisation patterns and investigator decisions could bias clinical outcomes if no specific cri…
View article: Ketamine-based Sedation Use in Mechanically Ventilated Critically Ill Patients with COVID-19: A Multicenter Cohort Study
Ketamine-based Sedation Use in Mechanically Ventilated Critically Ill Patients with COVID-19: A Multicenter Cohort Study Open
Ketamine-based sedation was associated with lower hospital LOS and faster lactic acid normalization but no mortality benefits in critically ill patients with COVID-19. Thus, larger prospective studies are recommended to assess the safety a…
View article: Team-based learning versus traditional teaching effect on pharmacy Students’ Performance: A systematic review and Meta-Analysis
Team-based learning versus traditional teaching effect on pharmacy Students’ Performance: A systematic review and Meta-Analysis Open
View article: The Impact of the COVID-19 Pandemic on Diabetes Self-Management in Saudi Arabia
The Impact of the COVID-19 Pandemic on Diabetes Self-Management in Saudi Arabia Open
The COVID-19 pandemic disrupted healthcare worldwide, potentially impacting disease management. The objective of this study was to assess the self-management behaviors of Saudi patients with diabetes during and after the COVID pandemic per…
View article: Are drug safety measures harmonized? A real-world evidence from three regulatory authorities
Are drug safety measures harmonized? A real-world evidence from three regulatory authorities Open
View article: The Impact of the COVID-19 Pandemic on Diabetes Self-Management in Saudi Arabia
The Impact of the COVID-19 Pandemic on Diabetes Self-Management in Saudi Arabia Open
The COVID-19 pandemic has disrupted healthcare worldwide, potentially impacting disease management. This cross-sectional study assessed the influence of COVID-19 on diabetes self-management in 341 Saudis with type 2 diabetes using the Diab…
View article: The impact of a restricted pregabalin prescription policy on drug utilization: An observational multicenter study
The impact of a restricted pregabalin prescription policy on drug utilization: An observational multicenter study Open
View article: Potentially Inappropriate Medications Use among Older Adults with Dyslipidaemia
Potentially Inappropriate Medications Use among Older Adults with Dyslipidaemia Open
Background: Since older patients with dyslipidemia frequently receive many prescriptions, medication errors are typical and expected in this population. This risk has increased by using potentially inappropriate medications. The 2019 Beers…
View article: Thromboprophylaxis in Hospitalized Non-Critically Ill Patients With Mild-to-Moderate COVID-19 Infection: A Systematic Review and Meta-Analysis
Thromboprophylaxis in Hospitalized Non-Critically Ill Patients With Mild-to-Moderate COVID-19 Infection: A Systematic Review and Meta-Analysis Open
The prevalence of venous thromboembolism is high in patients with COVID-19, despite prophylactic anticoagulation. The evidence that supports the preferred thromboprophylaxis regimen in non-critically ill patients with mild to moderate COVI…
View article: Incidence and Clinical Outcomes of New-Onset Atrial Fibrillation in Critically Ill Patients with COVID-19: A Multicenter Cohort Study
Incidence and Clinical Outcomes of New-Onset Atrial Fibrillation in Critically Ill Patients with COVID-19: A Multicenter Cohort Study Open
Atrial fibrillation (Afib) can contribute to a significant increase in mortality and morbidity in critically ill patients. Thus, our study aims to investigate the incidence and clinical outcomes associated with the new-onset Afib in critic…
View article: Evaluation of the Safety and Effectiveness of Topical Intrapleural Application of Tranexamic Acid in Thoracic Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Evaluation of the Safety and Effectiveness of Topical Intrapleural Application of Tranexamic Acid in Thoracic Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Open
Objectives Bleeding remains a common complication post-thoracic surgery. Although intravenous tranexamic acid (TXA) has been shown to decrease blood loss, its use has been associated with adverse effects. Accordingly, topical TXA has been …
View article: The impact of HMG-CoA reductase inhibitors use on the clinical outcomes in critically ill patients with COVID-19: A multicenter, cohort study
The impact of HMG-CoA reductase inhibitors use on the clinical outcomes in critically ill patients with COVID-19: A multicenter, cohort study Open
Background The cardiovascular complications of Coronavirus Disease 2019 (COVID-19) may be attributed to the hyperinflammatory state leading to increased mortality in patients with COVID-19. HMG-CoA Reductase Inhibitors (statins) are known …
View article: The use of enoxaparin as venous thromboembolism prophylaxis in bariatric surgery: A retrospective cohort study
The use of enoxaparin as venous thromboembolism prophylaxis in bariatric surgery: A retrospective cohort study Open
View article: Adherence to Prescribing Guideline-Directed Medical Therapy at Hospital Discharge in Subjects With Acute Coronary Syndrome, and the Relationship With Mortality
Adherence to Prescribing Guideline-Directed Medical Therapy at Hospital Discharge in Subjects With Acute Coronary Syndrome, and the Relationship With Mortality Open
Introduction The use of guideline-directed medical therapy (GDMT) after acute coronary syndrome (ACS) is associated with a significant reduction in mortality; however, suboptimal prescribing of these therapies has been reported. This study…
View article: Interrupted versus uninterrupted anticoagulation therapy for catheter ablation in adults with arrhythmias
Interrupted versus uninterrupted anticoagulation therapy for catheter ablation in adults with arrhythmias Open
This meta-analysis showed that the evidence is uncertain to inform the decision to either interrupt or continue anticoagulation therapy around CA procedure in adults with arrhythmia on outcomes of thromboembolic events, major and minor ble…
View article: Secondary Hyperparathyroidism in Obese Patients Post Sleeve Gastrectomy
Secondary Hyperparathyroidism in Obese Patients Post Sleeve Gastrectomy Open
Our study showed that the higher levels of PTH post LSG can be related to vitamin D deficiency and lower calcium levels, despite patients following the provided recommendations for supplementation. This study also emphasizes the importance…
View article: Student-Led discharge counseling program for High-Risk medications in a teaching hospital in Saudi Arabia: A pilot study
Student-Led discharge counseling program for High-Risk medications in a teaching hospital in Saudi Arabia: A pilot study Open
View article: Patients, Prescribers, and Institutional Factors Associated with Inappropriate Use of Acid Suppressive Therapy in Medical Wards: An Experience of a Single-Center in Saudi Arabia
Patients, Prescribers, and Institutional Factors Associated with Inappropriate Use of Acid Suppressive Therapy in Medical Wards: An Experience of a Single-Center in Saudi Arabia Open
This study demonstrated the overuse of AST in the medical ward. Therefore, improving providers' awareness about AST and implementing an AST stewardship program in institutions is necessary to limit this long-lasting issue.