Hadil Najjar
YOU?
Author Swipe
View article: Distances and charges along the Orai1 nexus-TM3 interface control STIM1-binding and pore opening
Distances and charges along the Orai1 nexus-TM3 interface control STIM1-binding and pore opening Open
Calcium (Ca 2+ ) influx through the Ca 2+ release-activated Ca 2+ (CRAC) channel is triggered by binding of the Ca 2+ sensor Stromal Interaction Molecule 1 (STIM1) to the pore-forming Orai1 complex, primarily to its cytosolic C-termini. Th…
View article: STIM1-induced widening of non-pore-lining TM interfaces is crucial for Orai1 pore opening
STIM1-induced widening of non-pore-lining TM interfaces is crucial for Orai1 pore opening Open
View article: Water in peripheral TM-interfaces of Orai1-channels triggers pore opening
Water in peripheral TM-interfaces of Orai1-channels triggers pore opening Open
The activation of the Ca 2+ -channel Orai1 via the physiological activator stromal interaction molecule 1 (STIM1) requires structural rearrangements within the entire channel complex involving a series of gating checkpoints. Focusing on th…
View article: Photocrosslinking-induced CRAC channel-like Orai1 activation independent of STIM1
Photocrosslinking-induced CRAC channel-like Orai1 activation independent of STIM1 Open
View article: Photocrosslinking-induced CRAC channel-like Orai1 activation independent of STIM1
Photocrosslinking-induced CRAC channel-like Orai1 activation independent of STIM1 Open
Ca2+ release-activated Ca2+ (CRAC) channels, indispensable for the immune system and various other human body functions, consist of two transmembrane (TM) proteins, the Ca2+-sensor STIM1 in the ER membrane …
View article: Deciphering Molecular Mechanisms and Intervening in Physiological and Pathophysiological Processes of Ca2+ Signaling Mechanisms Using Optogenetic Tools
Deciphering Molecular Mechanisms and Intervening in Physiological and Pathophysiological Processes of Ca2+ Signaling Mechanisms Using Optogenetic Tools Open
Calcium ion channels are involved in numerous biological functions such as lymphocyte activation, muscle contraction, neurotransmission, excitation, hormone secretion, gene expression, cell migration, memory, and aging. Therefore, their dy…