Hae Woong Choi
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View article: Identification of Tie2 as a sensor for reactive oxygen species and its therapeutic implication
Identification of Tie2 as a sensor for reactive oxygen species and its therapeutic implication Open
View article: Mechanistic Insights Into Persistent Bacterial Cystitis as a Basis for Vaccine Development: A Narrative Review
Mechanistic Insights Into Persistent Bacterial Cystitis as a Basis for Vaccine Development: A Narrative Review Open
Urinary tract infections (UTIs) are primarily caused by uropathogenic Escherichia coli (UPEC), which frequently lead to recurrent infections. These bacteria utilize several strategies to establish infection in the host; in particula…
View article: A shared mechanism of multidrug resistance in laboratory-evolved uropathogenic <i>Escherichia coli</i>
A shared mechanism of multidrug resistance in laboratory-evolved uropathogenic <i>Escherichia coli</i> Open
The emergence of multidrug-resistant bacteria poses a significant threat to human health, necessitating a comprehensive understanding of their underlying mechanisms. Uropathogenic Escherichia coli (UPEC), the primary causative agent…
View article: Recurrent infections drive persistent bladder dysfunction and pain via sensory nerve sprouting and mast cell activity
Recurrent infections drive persistent bladder dysfunction and pain via sensory nerve sprouting and mast cell activity Open
Urinary tract infections (UTIs) account for almost 25% of infections in women. Many are recurrent (rUTI), with patients frequently experiencing chronic pelvic pain and urinary frequency despite clearance of bacteriuria after antibiotics. T…
View article: A Dynamic Interplay of Innate Immune Responses During Urinary Tract Infection
A Dynamic Interplay of Innate Immune Responses During Urinary Tract Infection Open
Urinary tract infections (UTIs) represent one of the most prevalent bacterial infections globally, manifesting in diverse clinical phenotypes with varying degrees of severity and complications. The mechanisms underlying UTIs are gradually …
View article: Stabilization of activated mast cells by ORAI1 inhibitor suppresses peanut-induced anaphylaxis and acute diarrhea
Stabilization of activated mast cells by ORAI1 inhibitor suppresses peanut-induced anaphylaxis and acute diarrhea Open
Mast cell (MC) activation triggered by immunoglobulin E (IgE)-antigen crosslinking involves intracellular Ca2+ influx through the ORAI1 channel, which precedes granule exteriorization and de novo synthesis of mediators. Pharmaco…
View article: α-Hemolysin promotes uropathogenic E. coli persistence in bladder epithelial cells via abrogating bacteria-harboring lysosome acidification
α-Hemolysin promotes uropathogenic E. coli persistence in bladder epithelial cells via abrogating bacteria-harboring lysosome acidification Open
There is a growing consensus that a significant proportion of recurrent urinary tract infections are linked to the persistence of uropathogens within the urinary tract and their re-emergence upon the conclusion of antibiotic treatment. Stu…
View article: Mobilization of Inflammasome Components forAnaphylactic Degranulation by Mast Cells
Mobilization of Inflammasome Components forAnaphylactic Degranulation by Mast Cells Open
Inflammasome components, NLRP3 and ASC are cytosolic proteins which upon sensing endotoxins/danger cues, form multimeric complexes to process IL-1β for secretion. Here, we reveal that the iconic IgE/antigen (Ag) mediated mast cell (MC) deg…
View article: Microbiome in urological diseases: Axis crosstalk and bladder disorders
Microbiome in urological diseases: Axis crosstalk and bladder disorders Open
Since the identification of the human urinary microbiome, numerous studies have characterized this microbial community and improved our knowledge of its association with urinary diseases. This association between urinary diseases and micro…
View article: The Urinary Microbiome: Role in Bladder Cancer and Treatment
The Urinary Microbiome: Role in Bladder Cancer and Treatment Open
Commensal microbes have increasingly been found to be involved in the development and progression of cancer. The recent discovery of the urinary microbiome bolstered the notion that microbes might play a role in bladder cancer. Although mi…
View article: <i>Lactobacillus crispatus</i> Limits Bladder Uropathogenic <i>E. coli</i> Infection by Triggering a Host Type I Interferon Response
<i>Lactobacillus crispatus</i> Limits Bladder Uropathogenic <i>E. coli</i> Infection by Triggering a Host Type I Interferon Response Open
Many urinary tract infections (UTIs) are recurrent because uropathogens persist within the bladder epithelial cells (BECs) for extended periods between bouts of infection. Because persistent uropathogens are intracellular, they are often r…
View article: Enhancing adoptive T‐cell therapy with fucoidan‐based <scp>IL</scp> ‐2 delivery microcapsules
Enhancing adoptive T‐cell therapy with fucoidan‐based <span>IL</span> ‐2 delivery microcapsules Open
Adoptive cell therapy (ACT) with antigen‐specific T cells is a promising treatment approach for solid cancers. Interleukin‐2 (IL‐2) has been utilized in boosting the efficacy of ACT. However, the clinical applications of IL‐2 in combinatio…
View article: FK506-binding protein-like and FK506-binding protein 8 regulate dual leucine zipper kinase degradation and neuronal responses to axon injury
FK506-binding protein-like and FK506-binding protein 8 regulate dual leucine zipper kinase degradation and neuronal responses to axon injury Open
View article: β-Defensin 2, an Antimicrobial Peptide, as a Novel Biomarker for Ulcerative Interstitial Cystitis; Can β-Defensin 2 Suspect the Dysbiosis of Urine Microbiota?
β-Defensin 2, an Antimicrobial Peptide, as a Novel Biomarker for Ulcerative Interstitial Cystitis; Can β-Defensin 2 Suspect the Dysbiosis of Urine Microbiota? Open
As urine is not sterile, inflammatory reactions caused by dysbiosis of the urinary microbiota may induce interstitial cystitis. A study was conducted to determine whether β-defensin 2 (BD-2), a specific antimicrobial peptide in the bladder…
View article: Tumor-Associated Mast Cells in Urothelial Bladder Cancer: Optimizing Immuno-Oncology
Tumor-Associated Mast Cells in Urothelial Bladder Cancer: Optimizing Immuno-Oncology Open
Urothelial bladder cancer (UBC) is one of the most prevalent and aggressive malignancies. Recent evidence indicates that the tumor microenvironment (TME), including a variety of immune cells, is a critical modulator of tumor initiation, pr…
View article: The Microbiome’s Function in Disorders of the Urinary Bladder
The Microbiome’s Function in Disorders of the Urinary Bladder Open
The introduction of next generation sequencing techniques has enabled the characterization of the urinary tract microbiome, which resulted in the rejection of the long-held notion of urinary bladder sterility. Since the discovery and confi…
View article: Nasal Immunization With Small Molecule Mast Cell Activators Enhance Immunity to Co-Administered Subunit Immunogens
Nasal Immunization With Small Molecule Mast Cell Activators Enhance Immunity to Co-Administered Subunit Immunogens Open
Mast cell activators are a novel class of mucosal vaccine adjuvants. The polymeric compound, Compound 48/80 (C48/80), and cationic peptide, Mastoparan 7 (M7) are mast cell activators that provide adjuvant activity when administered by the …
View article: Data from: Nasal immunization with small molecule mast cell activators enhance immunity to co-administered subunit immunogens
Data from: Nasal immunization with small molecule mast cell activators enhance immunity to co-administered subunit immunogens Open
Mast cell activators are a novel class of mucosal vaccine adjuvants. The polymeric compound, Compound 48/80 (C48/80), and cationic peptide, Mastoparan 7 (M7) are mast cell activators that provide adjuvant activity when administered by the …
View article: A highly polarized TH2 bladder response to infection promotes epithelial repair at the expense of preventing new infections
A highly polarized TH2 bladder response to infection promotes epithelial repair at the expense of preventing new infections Open
View article: Platelets trigger perivascular mast cell degranulation to cause inflammatory responses and tissue injury
Platelets trigger perivascular mast cell degranulation to cause inflammatory responses and tissue injury Open
Activated platelets cause microvascular inflammation via direct activation of perivascular mast cells.
View article: Novel mucosal adjuvant, mastoparan-7, improves cocaine vaccine efficacy
Novel mucosal adjuvant, mastoparan-7, improves cocaine vaccine efficacy Open
Cocaine is one of the most potent and addictive psychostimulants known and there are no available pharmacotherapies to treat cocaine addiction. Here we describe a novel cocaine vaccine employing the mucosal adjuvant and mast cell-activatin…
View article: A humanized mouse model to study mast cells mediated cutaneous adverse drug reactions
A humanized mouse model to study mast cells mediated cutaneous adverse drug reactions Open
Recently a G-protein-coupled receptor, MAS Related GPR Family Member X2 (MRGPRX2), was identified as a specific receptor on human mast cells responsible for IgE independent adverse drug reactions (ADR). Although a murine homologue, Mrgprb2…
View article: Identification of Novel Mast Cell Activators Using Cell-Based High-Throughput Screening
Identification of Novel Mast Cell Activators Using Cell-Based High-Throughput Screening Open
Mast cells (MCs) are known to regulate innate and adaptive immunity. MC activators have recently been described as safe and effective vaccine adjuvants. Many currently known MC activators are inadequate for in vivo applications, however, a…
View article: MRGPR-mediated activation of local mast cells clears cutaneous bacterial infection and protects against reinfection
MRGPR-mediated activation of local mast cells clears cutaneous bacterial infection and protects against reinfection Open
Selective activation of local mast cells promotes healing of bacterial skin infections and protects against reinfection.
View article: Perivascular dendritic cells elicit anaphylaxis by relaying allergens to mast cells via microvesicles
Perivascular dendritic cells elicit anaphylaxis by relaying allergens to mast cells via microvesicles Open
Dendritic cells give mast cells a nudge Anaphylaxis is a life-threatening allergic reaction triggered after antigen-specific immunoglobulin E (IgE) antibodies bind to target allergens. These antibodies then cross-link IgE-specific Fc recep…
View article: Necroptosis of infiltrated macrophages drives Yersinia pestis dispersal within buboes
Necroptosis of infiltrated macrophages drives Yersinia pestis dispersal within buboes Open
When draining lymph nodes become infected by Yersinia pestis (Y. pestis), a massive influx of phagocytic cells occurs, resulting in distended and necrotic structures known as buboes. The bubonic stage of the Y. pestis life cycle precedes s…
View article: IL-27 Facilitates Skin Wound Healing through Induction of Epidermal Proliferation and Host Defense
IL-27 Facilitates Skin Wound Healing through Induction of Epidermal Proliferation and Host Defense Open
Skin wound repair requires a coordinated program of epithelial cell proliferation and differentiation as well as resistance to invading microbes. However, the factors that trigger epithelial cell proliferation in this inflammatory process …
View article: Loss of Bladder Epithelium Induced by Cytolytic Mast Cell Granules
Loss of Bladder Epithelium Induced by Cytolytic Mast Cell Granules Open
View article: Mast cell desensitization inhibits calcium flux and aberrantly remodels actin
Mast cell desensitization inhibits calcium flux and aberrantly remodels actin Open
Rush desensitization (DS) is a widely used and effective clinical strategy for the rapid inhibition of IgE-mediated anaphylactic responses. However, the cellular targets and underlying mechanisms behind this process remain unclear. Recent …
View article: Why Serological Responses during Cystitis are Limited
Why Serological Responses during Cystitis are Limited Open
The high frequency of urinary tract infections (UTIs), some of which appear to be endogenous relapses rather than reinfections by new isolates, point to defects in the host’s memory immune response. It has been known for many decades that,…