Haruna Isiyaku Umar
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View article: Contextual adaptation and validation of the international Pro-VC-Be tool for measuring healthcare worker vaccine confidence in Nigeria
Contextual adaptation and validation of the international Pro-VC-Be tool for measuring healthcare worker vaccine confidence in Nigeria Open
The adapted iPro-VC-Be was valid, however, we recommend using a shorter 6-item version for Nigeria that does not include items linked to immunization resources.
View article: In Silico Exploration of Anti‐Cancer Phytochemicals as Novel Inhibitors of LRRK2 via the WDR Domain
In Silico Exploration of Anti‐Cancer Phytochemicals as Novel Inhibitors of LRRK2 via the WDR Domain Open
LRRK2 serves as a significant oncogenic driver in multiple malignancies, including glioblastoma, lung, breast, and ovarian cancers. It enhances cancer cell growth, metastasis, and survival by modulating critical signaling pathways, includi…
View article: Computer-aided identification of Neisseria gonorrhoeae’s Bacteriophage-Q-beta inhibitors from selected anti-gonorrheal plants
Computer-aided identification of Neisseria gonorrhoeae’s Bacteriophage-Q-beta inhibitors from selected anti-gonorrheal plants Open
The emergence of multidrug-resistant Neisseria gonorrhoeae has intensified the need for innovative therapeutic strategies. One promising but underexplored target is the Hfq protein, a key regulator in bacterial stress response and pathogen…
View article: Identification of novel DYRK1A inhibitors as treatment options for alzheimer’s disease through comprehensive in silico approaches
Identification of novel DYRK1A inhibitors as treatment options for alzheimer’s disease through comprehensive in silico approaches Open
This study aims to identify potential DYRK1A inhibitors from a curated database and utilize a QSAR model to predict the bioactivity of drug compounds in inhibiting the enzyme involved in tau protein oligomerization, a key process in AD pat…
View article: Computer-aided identification of Neisseria gonorrhea’s Bacteriophage-Q-beta inhibitors from selected Anti-gonorrheal plants
Computer-aided identification of Neisseria gonorrhea’s Bacteriophage-Q-beta inhibitors from selected Anti-gonorrheal plants Open
The emergence of multidrug-resistant Neisseria gonorrhoeae has intensified the need for innovative therapeutic strategies. One promising but underexplored target is the Hfq protein, a key regulator in bacteriophage Qβ replication and bacte…
View article: Economic Inequality and Healthcare Access in ECOWAS: The Impact of Government Health Spending
Economic Inequality and Healthcare Access in ECOWAS: The Impact of Government Health Spending Open
Economic inequality remains a significant barrier to healthcare accessibility in the Economic Community of West African States (ECOWAS), where inadequate government health spending and inequality hinder healthcare access across the region.…
View article: <i>In silico</i> study of selected alkaloids as dual inhibitors of β- and γ-secretases for Alzheimer's disease
<i>In silico</i> study of selected alkaloids as dual inhibitors of β- and γ-secretases for Alzheimer's disease Open
Background Alzheimer's disease (AD) has become common as the number of aged people increases making it as a socioeconomic problem lately. To date, no success is recorded for disease-modifying therapies for AD but only drugs for symptomatic…
View article: Pharmacological assessment of <i>Coffea arabica</i> compounds as potential therapeutics for cervical cancer
Pharmacological assessment of <i>Coffea arabica</i> compounds as potential therapeutics for cervical cancer Open
Motivation Cervical cancer remains a leading cause of gynecological mortality, with existing treatments often limited by resistance and suboptimal efficacy. While Coffea arabica is rich in phytochemicals with reported anticancer properties…
View article: Computational Evaluation of Bioactive Compounds in <i>Vernonia Amygdalina</i> as a Novel Therapeutics for Acute Myeloid Leukemia: Targeting the Hedgehog Pathway
Computational Evaluation of Bioactive Compounds in <i>Vernonia Amygdalina</i> as a Novel Therapeutics for Acute Myeloid Leukemia: Targeting the Hedgehog Pathway Open
The drug resistance challenges in acute myeloid leukemia have been linked the hedgehog (HH) signaling pathway activation by many studies. Furthermore, studies have shown that the components of the HH pathway, including 12‐pass transmembran…
View article: <i>In silico</i>study of selected alkaloids as dual inhibitors of β and γ-Secretases for Alzheimer’s disease
<i>In silico</i>study of selected alkaloids as dual inhibitors of β and γ-Secretases for Alzheimer’s disease Open
Alzheimer’s disease (AD) has become ubiquitous as the number of elderly individuals increases and has been conceived as a socioeconomic problem lately. To date, no success is recorded for disease-modifying therapies for AD but only drugs f…
View article: Predictive identification and design of potent inhibitors targeting resistance-inducing candidate genes from E. coli whole-genome sequences
Predictive identification and design of potent inhibitors targeting resistance-inducing candidate genes from E. coli whole-genome sequences Open
Introduction: This work utilizes predictive modeling in drug discovery to unravel potential candidate genes from Escherichia coli that are implicated in antimicrobial resistance; we subsequently target the gidB, MacB, and KatG genes with s…
View article: Taxifolin alleviate metabolic and neurochemical alterations in the hippocampus and cortex of rats with rotenone-induced toxicity: In vivo and in silico insight
Taxifolin alleviate metabolic and neurochemical alterations in the hippocampus and cortex of rats with rotenone-induced toxicity: In vivo and in silico insight Open
Introduction: Exposure to rotenone could directly affects the function of mitochondrial which leads to neurodegeneration. This study evaluated the therapeutic potential of taxifolin (Huāqí sōng dài; 花旗松甙) to alleviate metabolic and neuroch…
View article: Glycosylated Antibiotics: New Promising Bacterial Efflux Pumps Inhibitors
Glycosylated Antibiotics: New Promising Bacterial Efflux Pumps Inhibitors Open
Antimicrobial resistance is considered a major concern problem; bacteria have evolved mechanisms to overcome antibiotics’ action through evolutionary process. One main resistance mechanism that bacteria developed is the pumping of the anti…
View article: Chemical Composition Antioxidant and Anti-Inflammatory Activities of Myrtus communis L. Leaf Extract: Forecasting ADMET Profiling and Anti-Inflammatory Targets Using Molecular Docking Tools
Chemical Composition Antioxidant and Anti-Inflammatory Activities of Myrtus communis L. Leaf Extract: Forecasting ADMET Profiling and Anti-Inflammatory Targets Using Molecular Docking Tools Open
Compounds derived from natural sources continue to serve as chemical scaffolds for designing prophylactic/therapeutic options for human healthcare. In this study, we aimed to systematically unravel the chemical profile and antioxidant and …
View article: FMS-like tyrosine kinase 3 inhibitory potentials of some phytochemicals from anti-leukemic plants using computational chemical methodologies
FMS-like tyrosine kinase 3 inhibitory potentials of some phytochemicals from anti-leukemic plants using computational chemical methodologies Open
Acute myeloid leukemia (AML) takes center stage as a highly prevalent and aggressive clonal disorder affecting hematological stem cells. FMS-like tyrosine kinase 3 (FLT3) mutations were prevalent in nearly 30% of the AML cases. However, ef…
View article: Computer-aided analysis of quercetin mechanism of overcoming docetaxel resistance in docetaxel-resistant prostate cancer
Computer-aided analysis of quercetin mechanism of overcoming docetaxel resistance in docetaxel-resistant prostate cancer Open
Further analysis revealed epidermal growth factor receptor (EGFR) as the most pertinent target of quercetin in reversing DR in DRPC, while molecular docking simulation revealed an effective interaction between quercetin and EGFR. Ultimatel…
View article: In silico molecular modeling and simulations of black tea theaflavins revealed theaflavin-3’-gallate as putative liver X receptor-beta agonist
In silico molecular modeling and simulations of black tea theaflavins revealed theaflavin-3’-gallate as putative liver X receptor-beta agonist Open
The low constitutive activation of Liver X receptor, an endogenous nuclear receptor with two subtypes (α and β), is a condition lying at the crossroad of cancer and cardiovascular disease. Both natural and synthetic Liver X receptor agonis…
View article: Computational Investigation of 1, 3, 4 Oxadiazole Derivatives as Lead Inhibitors of VEGFR 2 in Comparison with EGFR: Density Functional Theory, Molecular Docking and Molecular Dynamics Simulation Studies
Computational Investigation of 1, 3, 4 Oxadiazole Derivatives as Lead Inhibitors of VEGFR 2 in Comparison with EGFR: Density Functional Theory, Molecular Docking and Molecular Dynamics Simulation Studies Open
Vascular endothelial growth factor (VEGF) is an angiogenic factor involved in tumor growth and metastasis. Gremlin has been proposed as a novel therapeutic pathway for the treatment of renal inflammatory diseases, acting via VEGFR 2 recept…
View article: Discovery of Novel HSP27 Inhibitors as Prospective Anti-Cancer Agents Utilizing Computer-Assisted Therapeutic Discovery Approaches
Discovery of Novel HSP27 Inhibitors as Prospective Anti-Cancer Agents Utilizing Computer-Assisted Therapeutic Discovery Approaches Open
Heat shock protein 27 (HSP27) is a protein that works as a chaperone and an antioxidant and is activated by heat shock, environmental stress, and pathophysiological stress. However, HSP27 dysregulation is a characteristic of many human can…
View article: Mistletoe infested Moringa oleifera and Terminalia catappa leaves supplemented diet enhances antioxidant and insulin-like peptide mRNA levels in Drosophila melanogaster
Mistletoe infested Moringa oleifera and Terminalia catappa leaves supplemented diet enhances antioxidant and insulin-like peptide mRNA levels in Drosophila melanogaster Open
Moringa and Almond are common plants of medicinal and economic value which are often infested with mistletoe. Host plants' infestation could result in major differences in their phytoconstituents and biological activities. Thus, effects of…
View article: Inhibitory potentials of ivermectin, nafamostat, and camostat on spike protein and some nonstructural proteins of SARS-CoV-2: Virtual screening approach
Inhibitory potentials of ivermectin, nafamostat, and camostat on spike protein and some nonstructural proteins of SARS-CoV-2: Virtual screening approach Open
The search for potent oral drugs either through synthetic routes or by drug repurposing for combating the dreaded covid-19 virus is still ongoing. The coronavirus spike glycoprotein and several other non-structural proteins play crucial ro…
View article: Computer-aided Degradation Susceptibility Study of Crude Oil Compounds at Bacillus subtilis Protein Target
Computer-aided Degradation Susceptibility Study of Crude Oil Compounds at Bacillus subtilis Protein Target Open
Certain bacteria and fungi have been associated with the oxidative degradation of hydrocarbons and hydrocarbon derivatives in soil and water contaminated by crude oil spilling in these ecosystems. The binding affinity of hydrocarbons and h…
View article: Will Africans take COVID-19 vaccination?
Will Africans take COVID-19 vaccination? Open
The economic and humanistic impact of COVID-19 pandemic is enormous globally. No definitive treatment exists, hence accelerated development and approval of COVID-19 vaccines, offers a unique opportunity for COVID-19 prevention and control.…
View article: Taxifolin Alleviates Metabolic and Neurochemical Alterations in Hippocampus and Cortex of Brain of Rotenone-Toxified Rats in Vivo and Effectively Interacts with Enzymes Involve in Neurotransmission in Silico
Taxifolin Alleviates Metabolic and Neurochemical Alterations in Hippocampus and Cortex of Brain of Rotenone-Toxified Rats in Vivo and Effectively Interacts with Enzymes Involve in Neurotransmission in Silico Open
Rotenone is a naturally occurring compound and inhibitor of mitochondrial complex I. Its exposure is toxic and directly affects the function of mitochondrial which leads to neurodegeneration. Taxifolin is a flavonoid that exhibits therapeu…