Hagen Klett
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View article: Integrative ensemble modelling of cetuximab sensitivity in colorectal cancer patient-derived xenografts
Integrative ensemble modelling of cetuximab sensitivity in colorectal cancer patient-derived xenografts Open
View article: Discrimination of pancreato-biliary cancer and pancreatitis patients by non-invasive liquid biopsy
Discrimination of pancreato-biliary cancer and pancreatitis patients by non-invasive liquid biopsy Open
View article: Integrative ensemble modelling of cetuximab sensitivity in colorectal cancer PDXs
Integrative ensemble modelling of cetuximab sensitivity in colorectal cancer PDXs Open
A bstract Patient-derived xenografts (PDXs) are tumour fragments engrafted into mice for preclinical studies. PDXs offer clear advantages over simpler in vitro cancer models - such as cancer cell lines (CCLs) and organoids - in terms of st…
View article: The impact of pre‐pregnancy folic acid intake on placental <scp>DNA</scp> methylation in a fortified cohort
The impact of pre‐pregnancy folic acid intake on placental <span>DNA</span> methylation in a fortified cohort Open
Folate plays an important role in the modulation of one‐carbon metabolism and DNA methylation through a complex biosynthesis pathway. Folate deficiency during pregnancy has been associated with an increased risk for birth defects. This stu…
View article: Drug screening and genome editing in human pancreatic cancer organoids identifies drug-gene interactions and candidates for off-label therapy
Drug screening and genome editing in human pancreatic cancer organoids identifies drug-gene interactions and candidates for off-label therapy Open
View article: Stromal fibroblasts shape the myeloid phenotype in normal colon and colorectal cancer and induce CD163 and CCL2 expression in macrophages
Stromal fibroblasts shape the myeloid phenotype in normal colon and colorectal cancer and induce CD163 and CCL2 expression in macrophages Open
Colorectal cancer (CRC) accounts for about 10% of cancer deaths worldwide. Colon carcinogenesis is critically influenced by the tumor microenvironment. Cancer associated fibroblasts (CAFs) and tumor associated macrophages (TAMs) represent …
View article: Induction of Acquired Resistance towards EGFR Inhibitor Gefitinib in a Patient-Derived Xenograft Model of Non-Small Cell Lung Cancer and Subsequent Molecular Characterization
Induction of Acquired Resistance towards EGFR Inhibitor Gefitinib in a Patient-Derived Xenograft Model of Non-Small Cell Lung Cancer and Subsequent Molecular Characterization Open
In up to 30% of non-small cell lung cancer (NSCLC) patients, the oncogenic driver of tumor growth is a constitutively activated epidermal growth factor receptor (EGFR). Although these patients gain great benefit from treatment with EGFR ty…
View article: Delineating the Dynamic Transcriptome Response of mRNA and microRNA during Zebrafish Heart Regeneration
Delineating the Dynamic Transcriptome Response of mRNA and microRNA during Zebrafish Heart Regeneration Open
Heart diseases are the leading cause of death for the vast majority of people around the world, which is often due to the limited capability of human cardiac regeneration. In contrast, zebrafish have the capacity to fully regenerate their …
View article: Identification and Validation of a Diagnostic and Prognostic Multi-Gene Biomarker Panel for Pancreatic Ductal Adenocarcinoma
Identification and Validation of a Diagnostic and Prognostic Multi-Gene Biomarker Panel for Pancreatic Ductal Adenocarcinoma Open
Late diagnosis and systemic dissemination essentially contribute to the invariably poor prognosis of pancreatic ductal adenocarcinoma (PDAC). Therefore, the development of diagnostic biomarkers for PDAC are urgently needed to improve patie…
View article: Robust prediction of gene regulation in colorectal cancer tissues from DNA methylation profiles
Robust prediction of gene regulation in colorectal cancer tissues from DNA methylation profiles Open
DNA methylation is recognized as one of several epigenetic regulators of gene expression and as potential driver of carcinogenesis through gene-silencing of tumor suppressors and activation of oncogenes. However, abnormal methylation, even…
View article: Differences in DNA Methylation and Functional Expression in Lactase Persistent and Non-persistent Individuals
Differences in DNA Methylation and Functional Expression in Lactase Persistent and Non-persistent Individuals Open
View article: Robust prediction of gene regulation in colorectal cancer tissues from DNA methylation profiles
Robust prediction of gene regulation in colorectal cancer tissues from DNA methylation profiles Open
DNA methylation is recognized as one of several epigenetic regulators of gene expression and as potential driver of carcinogenesis through gene-silencing of tumor suppressors and activation of oncogenes. However, abnormal methylation, even…
View article: Smoking is associated with hypermethylation of the <i>APC</i> 1A promoter in colorectal cancer: the ColoCare Study
Smoking is associated with hypermethylation of the <i>APC</i> 1A promoter in colorectal cancer: the ColoCare Study Open
Smoking tobacco is a known risk factor for the development of colorectal cancer and for mortality associated with the disease. Smoking has been reported to be associated with changes in DNA methylation in blood and in lung tumour tissues, …