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View article: Family dermatology life quality index (F-DLQI): German validation and applicability to parents of infants and toddlers with dermatological conditions
Family dermatology life quality index (F-DLQI): German validation and applicability to parents of infants and toddlers with dermatological conditions Open
Parents of children with skin conditions face an additional caregiving burden and significant health-related quality of life (HRQoL) impairments. This study aimed to (1) test the psychometric properties of the German version of the Family …
View article: A Growing Concern for Cashew and an Unexpected Risk From Almonds: Data From the Anaphylaxis Registry
A Growing Concern for Cashew and an Unexpected Risk From Almonds: Data From the Anaphylaxis Registry Open
Background Food allergies are a major health concern with rising prevalence. Dietary habits are changing, and information about cashew‐induced anaphylaxis is limited. Methods Cases of tree nut‐induced anaphylaxis (TIA) registered from 2007…
View article: Safety and tolerability of losartan to treat recessive dystrophic epidermolysis bullosa in children (REFLECT): an open-label, single-arm, phase 1/2 trial
Safety and tolerability of losartan to treat recessive dystrophic epidermolysis bullosa in children (REFLECT): an open-label, single-arm, phase 1/2 trial Open
Debra International, the Department of Dermatology, Medical Center-University of Freiburg (Berta-Ottenstein Advanced Clinician Scientist Program of the Medical Faculty), and the German Research Foundation.
View article: ERRATUM: Pediatric obesity and skin disease: cutaneous findings and associated quality-of-life impairments in 103 children and adolescents with obesity
ERRATUM: Pediatric obesity and skin disease: cutaneous findings and associated quality-of-life impairments in 103 children and adolescents with obesity Open
View article: Towards a roadmap for COSEB: the next steps in harmonization of outcomes for epidermolysis bullosa
Towards a roadmap for COSEB: the next steps in harmonization of outcomes for epidermolysis bullosa Open
The COSEB initiative aims for standardized and uniform measurement by developing core outcome sets for epidermolysis bullosa. This report describes the COSEB workshop organized in December 2023, which led to a broad stakeholder consensus-b…
View article: Epidermolytic ichthyosis: Clinical spectrum and burden of disease in a large German cohort
Epidermolytic ichthyosis: Clinical spectrum and burden of disease in a large German cohort Open
Background Keratinopathic ichthyoses are a group of hereditary skin disorders caused by pathogenic variants in keratin genes such as KRT1 , KRT2 and KRT10 , resulting in conditions such as epidermolytic ichthyosis (EI), autosomal‐recessive…
View article: Expansion of the complex genotypic and phenotypic spectrum of FGFR2-associated neurocutaneous syndromes
Expansion of the complex genotypic and phenotypic spectrum of FGFR2-associated neurocutaneous syndromes Open
The fibroblast growth factor receptors comprise a family of related but individually distinct tyrosine kinase receptors. Within this family, FGFR2 is a key regulator in many biological processes, e.g., cell proliferation, tumorigenesis, me…
View article: Neonatal epidermolysis bullosa: a clinical practice guideline
Neonatal epidermolysis bullosa: a clinical practice guideline Open
DEBRA International is undertaking a long-term initiative to develop clinical practice guidelines (CPGs) for epidermolysis bullosa (EB), to improve the clinical care of people living with EB. Current neonatal care is based on evidence, cl…
View article: Pediatric obesity and skin disease: cutaneous findings and associated quality-of-life impairments in 103 children and adolescents with obesity
Pediatric obesity and skin disease: cutaneous findings and associated quality-of-life impairments in 103 children and adolescents with obesity Open
Objective Little is known about specific cutaneous findings in children and adolescents with overweight and obesity. This study assessed the association of skin signs with pivotal auxological and endocrinological parameters and their influ…
View article: S1‐Leitlinie Onychomykose
S1‐Leitlinie Onychomykose Open
Zusammenfassung Die Onychomykose ist eine Pilzinfektion des Nagelorgans und betrifft sowohl Finger‐ als auch Zehennägel. Sie wird in Europa vor allem durch Dermatophyten verursacht. Die Diagnostik erfolgt mittels direktmikroskopischer, kul…
View article: S1 Guideline onychomycosis
S1 Guideline onychomycosis Open
Summary Onychomycosis is a fungal infection of the fingernails and toenails. In Europe, tinea unguium is mainly caused by dermatophytes. The diagnostic workup comprises microscopic examination, culture and/or molecular testing (nail scrapi…
View article: Skin manifestations in rare types of diabetes and other endocrine conditions
Skin manifestations in rare types of diabetes and other endocrine conditions Open
As the most visible and vulnerable organ of the human organism, the skin can provide an impression of its state of health. Rare forms of diabetes and endocrinopathies are often diagnosed late or primarily misinterpreted due to their rarity…
View article: S3‐Leitlinie Urtikaria. Teil 2: Therapie der Urtikaria – deutschsprachige Adaption der internationalen S3‐Leitlinie
S3‐Leitlinie Urtikaria. Teil 2: Therapie der Urtikaria – deutschsprachige Adaption der internationalen S3‐Leitlinie Open
Zusammenfassung Die vorliegende Publikation ist der zweite Abschnitt der deutschsprachigen S3‐Leitlinie Urtikaria. Sie umfasst das Management der Urtikaria und sollte gemeinsam mit Teil 1 der Leitlinie zur Klassifikation und Diagnostik gen…
View article: S3 Guideline Urticaria. Part 2: Treatment of urticaria – German‐language adaptation of the international S3 guideline
S3 Guideline Urticaria. Part 2: Treatment of urticaria – German‐language adaptation of the international S3 guideline Open
Summary This publication is the second part of the German‐language S3 guideline on urticaria. It covers the management of urticaria and should be used together with Part 1 of the guideline on classification and diagnosis. This publication …
View article: Systematic genetic analysis of pediatric patients with autoinflammatory diseases
Systematic genetic analysis of pediatric patients with autoinflammatory diseases Open
Monogenic autoinflammatory diseases (AID) encompass a growing group of inborn errors of the innate immune system causing unprovoked or exaggerated systemic inflammation. Diagnosis of monogenic AID requires an accurate description of the pa…
View article: S3 Guideline Urticaria. Part 1: Classification and diagnosis of urticaria – German‐language adaptation of the international S3 Guideline
S3 Guideline Urticaria. Part 1: Classification and diagnosis of urticaria – German‐language adaptation of the international S3 Guideline Open
Summary The lifetime prevalence of urticaria, a severe allergic disease, is almost 20%. It not only limits the quality of life of those affected, but also their general performance at work and in their daily activities. This publication is…
View article: S3‐Leitlinie Urtikaria. Teil 1: Klassifikation und Diagnostik der Urtikaria – deutschsprachige Adaptation der internationalen S3‐Leitlinie
S3‐Leitlinie Urtikaria. Teil 1: Klassifikation und Diagnostik der Urtikaria – deutschsprachige Adaptation der internationalen S3‐Leitlinie Open
Zusammenfassung Die Lebenszeitprävalenz für Urtikaria, die zu den schweren allergischen Erkrankungen zählt, liegt bei nahezu 20%. Sie schränkt nicht nur die Lebensqualität der Betroffenen ein, sondern die generelle Leistungsfähigkeit in Be…
View article: Case Report: Rubella Virus-Induced Cutaneous Granulomas in Two Pediatric Patients With DNA Double Strand Breakage Repair Disorders – Outcome After Hematopoietic Stem Cell Transplantation
Case Report: Rubella Virus-Induced Cutaneous Granulomas in Two Pediatric Patients With DNA Double Strand Breakage Repair Disorders – Outcome After Hematopoietic Stem Cell Transplantation Open
We report two patients with DNA repair disorders (Artemis deficiency, Ataxia telangiectasia) with destructive skin granulomas, presumably triggered by live-attenuated rubella vaccinations. Both patients showed reduced naïve T cells. Rapid …
View article: Organ‐specific symptom patterns during oral food challenge in children with peanut and tree nut allergy
Organ‐specific symptom patterns during oral food challenge in children with peanut and tree nut allergy Open
Background Peanut and tree nut allergies are common in childhood and often severe in nature. The clinical picture shows a wide variety of symptoms. Objective To analyze the distribution of clinical symptoms and severity during oral food ch…
View article: Author response for "Organ‐specific symptom patterns during oral food challenge in children with peanut and tree nut allergy"
Author response for "Organ‐specific symptom patterns during oral food challenge in children with peanut and tree nut allergy" Open
View article: Genetics in inborn errors of immunity: pediatric autoinflammatory phenotypes and the underlying genetic causes in 125 families
Genetics in inborn errors of immunity: pediatric autoinflammatory phenotypes and the underlying genetic causes in 125 families Open
Monogenic autoinflammatory diseases (AID) encompass a growing group of inborn errors in the innate immune system causing unprovoked or exaggerated systemic inflammation. Diagnosis of monogenic AID requires an accurate description of the pa…
View article: Paradigm Shift in Treatment Strategies for Second-Degree Burns Using a Caprolactone Dressing (Suprathel®)? A 15-Year Pediatric Burn Center Experience in 2084 Patients
Paradigm Shift in Treatment Strategies for Second-Degree Burns Using a Caprolactone Dressing (Suprathel®)? A 15-Year Pediatric Burn Center Experience in 2084 Patients Open
Background: Thermal injuries represent a highly relevant epidemiologic problem with 11 million individuals affected globally each year, of which around 2.75 million are children. Different approaches to the conservative treatment of second…
View article: Identification of compound heterozygous mutations in <i>AP1B1</i> leading to the newly described recessive keratitis–ichthyosis–deafness (KIDAR) syndrome
Identification of compound heterozygous mutations in <i>AP1B1</i> leading to the newly described recessive keratitis–ichthyosis–deafness (KIDAR) syndrome Open
Dear Editor, Recently, mutations in adaptor-related protein complex 1 subunit beta 1 (AP1B1) have been identified as the cause of a new form of syndromic ichthyosis, which is characterized by neonatal onset of ichthyosis, erythroderma and …
View article: Induction of penicillin tolerance during pregnancy: Allergological opinion on the recommendation of the current AWMF Guidelines on Diagnosis and Treatment of Syphilis (AWMF Registry No. 059-002)
Induction of penicillin tolerance during pregnancy: Allergological opinion on the recommendation of the current AWMF Guidelines on Diagnosis and Treatment of Syphilis (AWMF Registry No. 059-002) Open
Not available.
View article: Rund um Arzneimittelüberempfindlichkeiten
Rund um Arzneimittelüberempfindlichkeiten Open
View article: Author response for "Lipoatrophy in children, adolescents and adults with insulin pump treatment: is there a beneficial effect of insulin glulisine?"
Author response for "Lipoatrophy in children, adolescents and adults with insulin pump treatment: is there a beneficial effect of insulin glulisine?" Open
View article: Pityriasis lichenoides acuta (PLEVA) pemphigoides: A rare bullous variant of PLEVA
Pityriasis lichenoides acuta (PLEVA) pemphigoides: A rare bullous variant of PLEVA Open
Although the clinical presentations of patients with pityriasis lichenoides et varioliformis acuta (PLEVA) may vary, bullae are not usually part of the clinical spectrum. To date, only two other cases of a bullous variant of PLEVA with evi…
View article: Guideline on diagnostic procedures for suspected hypersensitivity to beta-lactam antibiotics
Guideline on diagnostic procedures for suspected hypersensitivity to beta-lactam antibiotics Open
This guideline on diagnostic procedures for suspected beta-lactam antibiotic (BLA) hypersensitivity was written by the German and Austrian professional associations for allergology, and the Paul-Ehrlich Society for Chemotherapy in a consen…
View article: Guideline on diagnostic procedures for suspected hypersensitivity to beta-lactam antibiotics
Guideline on diagnostic procedures for suspected hypersensitivity to beta-lactam antibiotics Open
This guideline on diagnostic procedures for suspected beta-lactam antibiotic (BLA) hypersensitivity was written by the German and Austrian professional associations for allergology, and the Paul-Ehrlich Society for Chemotherapy in a consen…
View article: Mechanism of Oleogel‐S10: A triterpene preparation for the treatment of epidermolysis bullosa
Mechanism of Oleogel‐S10: A triterpene preparation for the treatment of epidermolysis bullosa Open
Epidermolysis bullosa (EB) is a group of rare heterogeneous, genetic disorders. Currently, there is no effective pharmacological or genetic therapy for all EB subtypes. Dry extract from birch bark and betulin upregulate some pro-inflammato…