Haian Fu
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View article: Integrated phenotypic and proteomic screening identifies top‐tier Alzheimer's disease therapeutic targets
Integrated phenotypic and proteomic screening identifies top‐tier Alzheimer's disease therapeutic targets Open
INTRODUCTION Alzheimer's disease (AD) is a complex neurodegenerative disorder. Hundreds of therapeutic targets have been nominated through genetic and multi‐omic studies, but effective prioritization remains a major bottleneck. METHODS We …
View article: MiR-24-3p delivered by adipose derived stem cells exosomes alleviate macrophage pyroptosis via NLRP3/Caspase1/GSDMD in sepsis ALI
MiR-24-3p delivered by adipose derived stem cells exosomes alleviate macrophage pyroptosis via NLRP3/Caspase1/GSDMD in sepsis ALI Open
Our findings indicate that ADSCs-exo attenuates ALI by modulating macrophage pyroptosis through the miR-24-3p/NLRP3/Caspase1/GSDMD axis, thereby presenting a promising therapeutic approach for sepsis-associated ALI.
View article: Monkeypox Virus Is Inhibited by Nucleoside Analogues Including the Acyclic Phosphonates Adefovir and Tenofovir In Vitro
Monkeypox Virus Is Inhibited by Nucleoside Analogues Including the Acyclic Phosphonates Adefovir and Tenofovir In Vitro Open
Mpox, caused by the orthopoxvirus monkeypox virus (MPXV), has garnered worldwide attention during a global outbreak in 2022 and in an ongoing outbreak in Central Africa. Because of drug resistance and toxicity risks with current antiviral …
View article: Integrated phenotypic and proteomic screening identifies top-tier Alzheimer’s disease therapeutic targets
Integrated phenotypic and proteomic screening identifies top-tier Alzheimer’s disease therapeutic targets Open
Introduction Alzheimer’s disease (AD) is a complex neurodegenerative disorder. Hundreds of therapeutic targets have been nominated through genetic and multi-omic studies, but effective prioritization remains a major bottleneck. Methods We …
View article: Non-canonical dihydrolipoyl transacetylase promotes chemotherapy resistance via mitochondrial tetrahydrofolate signaling
Non-canonical dihydrolipoyl transacetylase promotes chemotherapy resistance via mitochondrial tetrahydrofolate signaling Open
Chemotherapy is often a primary treatment for cancer. However, resistance leads to therapeutic failure. Acetylation dynamics play important regulatory roles in cancer cells, but the mechanisms by which acetylation mediates therapy resistan…
View article: Comprehensive investigation of a new signature integrating lipid metabolism and immune-related genes for clear cell renal cell carcinoma prognosis and immunometabolism landscapes
Comprehensive investigation of a new signature integrating lipid metabolism and immune-related genes for clear cell renal cell carcinoma prognosis and immunometabolism landscapes Open
Multi-omics studies have significantly advanced our understanding of ccRCC. These studies have revealed that aggressive ccRCC is closely associated with metabolic reprogramming, particularly involving lipid metabolism. Recent studies have …
View article: High PER1 expression is associated with STK11 mutation and clinical biomarkers of immunotherapy resistance in lung adenocarcinoma
High PER1 expression is associated with STK11 mutation and clinical biomarkers of immunotherapy resistance in lung adenocarcinoma Open
AIM: This study characterizes the functional effects and clinical characteristics of high PER1 mRNA and high PER1 protein expression in treatment resistant lung adenocarcinoma. METHODS: HBEC3-KT cells were modified by STK11 CRISPR knockout…
View article: Suppression of LKB1-mutant lung adenocarcinoma by natural killer cells from females
Suppression of LKB1-mutant lung adenocarcinoma by natural killer cells from females Open
Background This study addressed the enigma of sex differences in smoking-related lung cancer, particularly focusing on the low LKB1 mutation frequency in female patients with lung adenocarcinoma. Methods Sex bias was studied with a genetic…
View article: Development and Evaluation of a Droplet Digital PCR Assay for the Accurately Detecting the CircHIPK3 in Plasma Samples from Patients with Hepatocellular Carcinoma
Development and Evaluation of a Droplet Digital PCR Assay for the Accurately Detecting the CircHIPK3 in Plasma Samples from Patients with Hepatocellular Carcinoma Open
Hepatocellular carcinoma (HCC) is an increasingly prevalent malignant neoplasm on a global scale. Circrna HIPK3 (circHIPK3) has been identified as playing a key role in HCC tumorigenesis and as a novel biomarker. In this study, we aimed at…
View article: CAPN2: A Target Enabling Package
CAPN2: A Target Enabling Package Open
CAPN2 mediates neurodegenerative effect through cleavage of a range of proteins linked to tau hyperphosphorylation (GSK-3β), higher levels of Aβ (NCX3), or poor memory (CPEB3). Inhibiting calpain-2 might reduce cleavage of these proteins a…
View article: Uncovering the rewired IAP-JAK regulatory axis as an immune-dependent vulnerability of LKB1-mutant lung cancer
Uncovering the rewired IAP-JAK regulatory axis as an immune-dependent vulnerability of LKB1-mutant lung cancer Open
Harnessing the power of immune system to treat cancer has become a core clinical approach. However, rewiring of intrinsic circuitry by genomic alterations enables tumor cells to escape immune surveillance, leading to therapeutic failure. U…
View article: Correction: A novel platinum(<scp>ii</scp>) complex with a berberine derivative as a potential antitumor agent targeting G-quadruplex DNA
Correction: A novel platinum(<span>ii</span>) complex with a berberine derivative as a potential antitumor agent targeting G-quadruplex DNA Open
Correction for ‘A novel platinum( ii ) complex with a berberine derivative as a potential antitumor agent targeting G-quadruplex DNA’ by Shu-Lin Zhang et al. , Org. Biomol. Chem. , 2025, https://doi.org/10.1039/d4ob01705f.
View article: The Emory‐Sage‐SGC‐JAX TREAT‐AD Center: Target Enabling Packages for Alzheimer’s Disease Emerging Targets
The Emory‐Sage‐SGC‐JAX TREAT‐AD Center: Target Enabling Packages for Alzheimer’s Disease Emerging Targets Open
Background There is an urgent need for new therapeutic and diagnostic targets for Alzheimer’s disease (AD). Dementia afflicts roughly 55 million individuals worldwide, and the prevalence is increasing with longer lifespans and the absence …
View article: Table S1 from Live-Cell Invasive Phenotyping Uncovers ALK2 as a Therapeutic Target in <i>LKB1</i>-Mutant Lung Cancer
Table S1 from Live-Cell Invasive Phenotyping Uncovers ALK2 as a Therapeutic Target in <i>LKB1</i>-Mutant Lung Cancer Open
List of upregulated transcripts in KL vs. KP invasive spheroids with respect to K>C.
View article: Figure S5 from Live-Cell Invasive Phenotyping Uncovers ALK2 as a Therapeutic Target in <i>LKB1</i>-Mutant Lung Cancer
Figure S5 from Live-Cell Invasive Phenotyping Uncovers ALK2 as a Therapeutic Target in <i>LKB1</i>-Mutant Lung Cancer Open
Figure S5
View article: Figure S4 from Live-Cell Invasive Phenotyping Uncovers ALK2 as a Therapeutic Target in <i>LKB1</i>-Mutant Lung Cancer
Figure S4 from Live-Cell Invasive Phenotyping Uncovers ALK2 as a Therapeutic Target in <i>LKB1</i>-Mutant Lung Cancer Open
Dose response in 2D and 3D
View article: Figure S2 from Live-Cell Invasive Phenotyping Uncovers ALK2 as a Therapeutic Target in <i>LKB1</i>-Mutant Lung Cancer
Figure S2 from Live-Cell Invasive Phenotyping Uncovers ALK2 as a Therapeutic Target in <i>LKB1</i>-Mutant Lung Cancer Open
Figure S2
View article: Supplementary Figure Legends from Live-Cell Invasive Phenotyping Uncovers ALK2 as a Therapeutic Target in <i>LKB1</i>-Mutant Lung Cancer
Supplementary Figure Legends from Live-Cell Invasive Phenotyping Uncovers ALK2 as a Therapeutic Target in <i>LKB1</i>-Mutant Lung Cancer Open
Legends for Supplementary Figures
View article: Supplementary Video 1 from Live-Cell Invasive Phenotyping Uncovers ALK2 as a Therapeutic Target in <i>LKB1</i>-Mutant Lung Cancer
Supplementary Video 1 from Live-Cell Invasive Phenotyping Uncovers ALK2 as a Therapeutic Target in <i>LKB1</i>-Mutant Lung Cancer Open
Invasive phenotyping of K, KL, and KP HBECs
View article: Figure S1 from Live-Cell Invasive Phenotyping Uncovers ALK2 as a Therapeutic Target in <i>LKB1</i>-Mutant Lung Cancer
Figure S1 from Live-Cell Invasive Phenotyping Uncovers ALK2 as a Therapeutic Target in <i>LKB1</i>-Mutant Lung Cancer Open
Figure S1
View article: Figure S3 from Live-Cell Invasive Phenotyping Uncovers ALK2 as a Therapeutic Target in <i>LKB1</i>-Mutant Lung Cancer
Figure S3 from Live-Cell Invasive Phenotyping Uncovers ALK2 as a Therapeutic Target in <i>LKB1</i>-Mutant Lung Cancer Open
Figure S3
View article: Figure S5 from Live-Cell Invasive Phenotyping Uncovers ALK2 as a Therapeutic Target in <i>LKB1</i>-Mutant Lung Cancer
Figure S5 from Live-Cell Invasive Phenotyping Uncovers ALK2 as a Therapeutic Target in <i>LKB1</i>-Mutant Lung Cancer Open
Figure S5
View article: Figure S2 from Live-Cell Invasive Phenotyping Uncovers ALK2 as a Therapeutic Target in <i>LKB1</i>-Mutant Lung Cancer
Figure S2 from Live-Cell Invasive Phenotyping Uncovers ALK2 as a Therapeutic Target in <i>LKB1</i>-Mutant Lung Cancer Open
Figure S2
View article: Table S1 from Live-Cell Invasive Phenotyping Uncovers ALK2 as a Therapeutic Target in <i>LKB1</i>-Mutant Lung Cancer
Table S1 from Live-Cell Invasive Phenotyping Uncovers ALK2 as a Therapeutic Target in <i>LKB1</i>-Mutant Lung Cancer Open
List of upregulated transcripts in KL vs. KP invasive spheroids with respect to K>C.
View article: Supplementary Video 1 from Live-Cell Invasive Phenotyping Uncovers ALK2 as a Therapeutic Target in <i>LKB1</i>-Mutant Lung Cancer
Supplementary Video 1 from Live-Cell Invasive Phenotyping Uncovers ALK2 as a Therapeutic Target in <i>LKB1</i>-Mutant Lung Cancer Open
Invasive phenotyping of K, KL, and KP HBECs