Hai‐Bin Luo
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View article: #2303 PDE5 inhibitor LW1646 improves kidney fibrosis by alleviating ER stress and mitochondrial calcium overload
#2303 PDE5 inhibitor LW1646 improves kidney fibrosis by alleviating ER stress and mitochondrial calcium overload Open
Background and Aims Renal fibrosis is the terminal pathological manifestation of most chronic kidney diseases (CKDs). Inhibitors targeting phosphodiesterase 5 (PDE5) have been used to treat erectile dysfunction and pulmonary arterial hyper…
View article: Effects of long-acting recombinant porcine FSH on reproductive performance and production efficiency of gilts and weaned sows
Effects of long-acting recombinant porcine FSH on reproductive performance and production efficiency of gilts and weaned sows Open
To enhance production efficiency, equine chorionic gonadotropin (eCG) plays a crucial role in promoting follicular development in the reproductive management of sows; however, eCG is a heterologous protein derived from pregnant mare serum.…
View article: The crucial role of SPP1 in osteoporosis, osteoarthritis, and cancer
The crucial role of SPP1 in osteoporosis, osteoarthritis, and cancer Open
Osteopontin (OPN), also known as secreted phosphoprotein 1(SPP1), is a highly glycosylated and phosphorylated acidic protein, which is a multifunctional glycoprotein expressed in numerous cell types. SPP1 is involved in the attachment of o…
View article: Fraxin Alleviates Atherosclerosis by Inhibiting Oxidative Stress and Inflammatory Responses via the TLR4/PI3K/Akt Pathway
Fraxin Alleviates Atherosclerosis by Inhibiting Oxidative Stress and Inflammatory Responses via the TLR4/PI3K/Akt Pathway Open
Fraxin is a bioactive compound derived from Cortex Fraxini. It is known for its diverse biological activities and numerous benefits, including anti-inflammatory, antioxidant, analgesic, antimicrobial, antiviral, and immunomodulatory effect…
View article: Development of Recombinant Follicle-Stimulating Hormone for the Superovulation of Cattle: A Review
Development of Recombinant Follicle-Stimulating Hormone for the Superovulation of Cattle: A Review Open
Embryo transfer technology is extensively utilized in cattle breeding, with superovulation serving as its foundation. Superovulation currently relies on the administration of exogenous hormones to stimulate follicular development and matur…
View article: 3D-EDiffMG: 3D equivariant diffusion-driven molecular generation to accelerate drug discovery
3D-EDiffMG: 3D equivariant diffusion-driven molecular generation to accelerate drug discovery Open
Structural optimization of lead compounds is a crucial step in drug discovery. One optimization strategy is to modify the molecular structure of a scaffold to improve both its biological activities and absorption, distribution, metabolism,…
View article: Psychological consistency network characteristics and influencing factors in patients after percutaneous coronary intervention treatment
Psychological consistency network characteristics and influencing factors in patients after percutaneous coronary intervention treatment Open
BACKGROUND A psychological sense of coherence (SOC) in percutaneous coronary intervention (PCI) patients is important for disease prognosis, and there is considerable variation between their symptoms. In contrast, network analysis provides…
View article: Development of highly bioactive long-acting recombinant porcine FSH for batch production management of sows
Development of highly bioactive long-acting recombinant porcine FSH for batch production management of sows Open
To improve the economic benefits, exogenous hormones are used to control follicular development and synchronize ovulation in the batch flow management of gilts and weaned sows. Equine chorionic gonadotropin (eCG) is widely used to stimulat…
View article: 5‐hydroxymethylcytosine features of portal venous blood predict metachronous liver metastases of colorectal cancer and reveal phosphodiesterase 4 as a therapeutic target
5‐hydroxymethylcytosine features of portal venous blood predict metachronous liver metastases of colorectal cancer and reveal phosphodiesterase 4 as a therapeutic target Open
Metachronous liver metastases (MLM) are characterised by high incidence and high mortality in clinical colorectal cancer treatment. Currently traditional clinical methods cannot effectively predict and prevent the occurrence of metachronou…
View article: Epigallocatechin-3-gallate inhibits the collagen accumulation of oral submucous fibrosis induced by arecoline
Epigallocatechin-3-gallate inhibits the collagen accumulation of oral submucous fibrosis induced by arecoline Open
Objective Oral submucous fibrosis (OSF) is a chronic oral mucosal disease, which exerts a profound impact on patients’ daily life and currently lacks efficacious therapeutic interventions. Epigallocatechin-3-gallate (EGCG), the abundant po…
View article: The Impact of Lockdown Policies and Corruption on the Early Stage of COVID-19 Transmission in China
The Impact of Lockdown Policies and Corruption on the Early Stage of COVID-19 Transmission in China Open
Lockdown policies have emerged as crucial tools in curbing transmission and preventing overwhelming healthcare systems since the early stage of COVID-19. To understand the effectiveness of lockdown policies and interaction with other facto…
View article: Discovery of wedelolactone from Eclipta Prostrata (L.) Linn. as a natural PDE4 inhibitor with potent anti-psoriasis effects
Discovery of wedelolactone from Eclipta Prostrata (L.) Linn. as a natural PDE4 inhibitor with potent anti-psoriasis effects Open
Psoriasis is a chronic inflammatory disorder for which phosphodiesterase-4 (PDE4) inhibitors have emerged as promising therapeutic agents due to an ability to regulate inflammatory signaling pathways. In this study 1200 methanolic extracts…
View article: Moracin M derivative targeting PDE4 for the treatment of psoriasis
Moracin M derivative targeting PDE4 for the treatment of psoriasis Open
Phosphodiesterase-4 (PDE4), a member of the phosphodiesterase superfamily, has highly important roles in cyclic nucleotide signaling pathways and a variety of skin disorders. Blocking PDE4 activity with PDE4 inhibitors increases intracellu…
View article: A Bait-and-Hook Hydrogel for Net Tumor Cells to Enhance Chemotherapy and Mitigate Metastatic Dissemination
A Bait-and-Hook Hydrogel for Net Tumor Cells to Enhance Chemotherapy and Mitigate Metastatic Dissemination Open
Background: Lung cancer is an aggressive disease with rapid progression and a high rate of metastasis, leading to a significantly poor prognosis for many patients. While chemotherapy continues to serve as a cornerstone treatment for a larg…
View article: Combination therapy with GalNAc-siRNA drugs targeting both PCSK9 and APOC3 resulted in enhanced lipid lowering in mice
Combination therapy with GalNAc-siRNA drugs targeting both PCSK9 and APOC3 resulted in enhanced lipid lowering in mice Open
Introduction Aggressive lowering of both atherogenic low-density lipoprotein cholesterol (LDL-C) and triglyceride-rich lipoproteins (TRLs) could reduce residual atherosclerotic cardiovascular disease (ASCVD) risk. Drugs targeting PCSK9 or …
View article: Discovery and Optimization of 4-(Imidazo[1,2-a]pyrimidin-3-yl)thiazol-2-amine Derivatives as Novel Phosphodiesterase 4 Inhibitors
Discovery and Optimization of 4-(Imidazo[1,2-a]pyrimidin-3-yl)thiazol-2-amine Derivatives as Novel Phosphodiesterase 4 Inhibitors Open
Phosphodiesterases (PDEs) are important intracellular enzymes that hydrolyze the second messengers cAMP and/or cGMP. Now several studies have shown that PDE4 received particular attention due to it represents the most prominent cAMP-metabo…
View article: Discovery of Oxidized <i>p</i>-Terphenyls as Phosphodiesterase 4 Inhibitors from Marine-Derived Fungi
Discovery of Oxidized <i>p</i>-Terphenyls as Phosphodiesterase 4 Inhibitors from Marine-Derived Fungi Open
Four new p-terphenyl derivatives, talaroterphenyls A-D (1-4), together with three biosynthetically related known ones (5-7), were obtained from the mangrove sediment-derived Talaromyces sp. SCSIO 41412. Compounds 1-3 are rare p-terphenyls,…
View article: Discovery of highly potent phosphodiesterase-1 inhibitors by a combined-structure free energy perturbation approach
Discovery of highly potent phosphodiesterase-1 inhibitors by a combined-structure free energy perturbation approach Open
Accurate receptor/ligand binding free energy calculations can greatly accelerate drug discovery by identifying highly potent ligands. By simulating the change from one compound structure to another, the relative binding free energy (RBFE) …
View article: [Oral submucosal fibrosis induced by active components in areca nut: a network pharmacology-based analysis and validation of the mechanism].
[Oral submucosal fibrosis induced by active components in areca nut: a network pharmacology-based analysis and validation of the mechanism]. Open
The main active ingredients including arecoline, arecaine, and guvacine are capable of activating the PI3K-Akt and MAPK pathways to promote the expressions of inflammatory mediators IL-6 and IL-8 and induce collagen hyperplasia, thus leadi…
View article: Regulation of Burkholderia cenocepacia virulence by the fatty acyl-CoA ligase DsfR as a response regulator of quorum sensing signal
Regulation of Burkholderia cenocepacia virulence by the fatty acyl-CoA ligase DsfR as a response regulator of quorum sensing signal Open
Quorum sensing (QS) is a cell-to-cell communication mechanism mediated by small diffusible signaling molecules. Previous studies showed that RpfR controls Burkholderia cenocepacia virulence as a cis-2-dodecenoic acid (BDSF) QS signal recep…
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Chemical Biology & Drug Design is a peer-reviewed scientific journal that is dedicated to the advancement of innovative science, technology and medicine with a focus on the multidisciplinary fields of chemical biology and drug design.It is…
View article: Design, Synthesis, and Evaluation of Dihydropyrimidine Derivatives as Selective PDE1 Inhibitors for the Treatment of Liver Fibrosis
Design, Synthesis, and Evaluation of Dihydropyrimidine Derivatives as Selective PDE1 Inhibitors for the Treatment of Liver Fibrosis Open
Liver fibrosis is a common pathological feature of most chronic liver diseases with no effective drugs available. Phosphodiesterase 1 (PDE1), a subfamily of the PDE super enzyme, might work as a potent target for liver fibrosis by regulati…
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Chemical Biology & Drug Design is a peer-reviewed scientific journal that is dedicated to the advancement of innovative science, technology and medicine with a focus on the multidisciplinary fields of chemical biology and drug design.It is…
View article: The application of drug behavior management methods in the treatment of dental fear and oral diseases in children: A review
The application of drug behavior management methods in the treatment of dental fear and oral diseases in children: A review Open
Oral behavior management methods include basic behavior management methods and drug behavior management methods. In many cases, dental treatment that cannot be done simply through basic behavior management is not possible. The uncooperativ…
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Chemical Biology & Drug Design is a peer-reviewed scientific journal that is dedicated to the advancement of innovative science, technology and medicine with a focus on the multidisciplinary fields of chemical biology and drug design.It is…