Hai Ning Shi
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View article: Unveiling the role of Jagged2 in hypoxic pulmonary arterial hypertension: A NOX2‐mediated pathway
Unveiling the role of Jagged2 in hypoxic pulmonary arterial hypertension: A NOX2‐mediated pathway Open
Hypoxic pulmonary arterial hypertension (PAH) is a severe cardiovascular condition involving vascular remodeling and inflammation. Jagged2 (Jag2) has been implicated in various pathologies but its role in PAH remains unclear. We integrated…
View article: Type 2 cytokines act on enteric sensory neurons to promote parasitic host defense 9411
Type 2 cytokines act on enteric sensory neurons to promote parasitic host defense 9411 Open
Description Despite the profound influence neuronal mediators have on immune cells, our understanding of how inflammation influences enteric neuron function remains incomplete. We reanalyzed multiple single-cell RNA-sequencing datasets of …
View article: Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense
Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense Open
Enteric nervous system (ENS)–derived neuropeptides modulate immune cell function, yet our understanding of how inflammatory cues directly influence enteric neuron responses during infection is considerably lacking. Here, we characterized a…
View article: Esculetin Alleviates Inflammation, Oxidative Stress and Apoptosis in Intestinal Ischemia/Reperfusion Injury via Targeting SIRT3/AMPK/mTOR Signaling and Regulating Autophagy
Esculetin Alleviates Inflammation, Oxidative Stress and Apoptosis in Intestinal Ischemia/Reperfusion Injury via Targeting SIRT3/AMPK/mTOR Signaling and Regulating Autophagy Open
In a word, esculetin activated SIRT3/AMPK/mTOR signaling and autophagy to protect against inflammation, oxidative stress and apoptosis in intestinal I/R injury.
View article: Biological and immunological significance of DLL3 expression in different tumor tissues: a pan-cancer analysis
Biological and immunological significance of DLL3 expression in different tumor tissues: a pan-cancer analysis Open
DLL3 can be used as a stand-alone prognostic factor for many tumor types, and that the level of its expression will have a different prognostic impact for various tumor types. DLL3 expression across numerous cancer types was related to TMB…
View article: Immune-related gene signature associates with immune landscape and predicts prognosis accurately in patients with skin cutaneous melanoma
Immune-related gene signature associates with immune landscape and predicts prognosis accurately in patients with skin cutaneous melanoma Open
Skin cutaneous melanoma (SKCM) is the skin cancer that causes the highest number of deaths worldwide. There is growing evidence that the tumour immune microenvironment is associated with cancer prognosis, however, there is little research …
View article: Design and Performance Research of a New Dual-Excitation Uniform Eddy Current Probe
Design and Performance Research of a New Dual-Excitation Uniform Eddy Current Probe Open
A dual-excitation uniform eddy current probe, composed of two excitation coils placed tangentially and one detection coil placed horizontally, is developed to solve the difficulties of detection rate and direction recognition of crack defe…
View article: Microstructure and Wear Resistance of Fe60 Laser Cladding Coating Assisted by Steady Magnetic Field–Mechanical Vibration Coupling Field
Microstructure and Wear Resistance of Fe60 Laser Cladding Coating Assisted by Steady Magnetic Field–Mechanical Vibration Coupling Field Open
Fe60 laser cladding coating was prepared on the surface of 45 steel with the assistance of alternating magnetic field–mechanical vibration coupling field. The XRD results show that the coating is mainly composed of solid solution Ni-Cr-Fe,…
View article: Maternal Influences and Intervention Strategies on the Development of Food Allergy in Offspring
Maternal Influences and Intervention Strategies on the Development of Food Allergy in Offspring Open
Food allergies and other immune-mediated diseases have become serious health concerns amongst infants and children in developed and developing countries. The absence of available cures limits disease management to allergen avoidance and sy…
View article: Role of p40<i><sup>phox</sup></i> in host defense against <i>Citrobacter</i><i>rodentium</i> infection
Role of p40<i><sup>phox</sup></i> in host defense against <i>Citrobacter</i><i>rodentium</i> infection Open
NADPH oxidase (NOX) is a membrane‐bound enzyme complex that generates reactive oxygen species (ROS). Mutations in NOX subunit genes have been implicated in the pathogenesis of inflammatory bowel disease (IBD), indicating a crucial role for…
View article: Determination of narciclasine in mouse blood by UPLC-MS/MS and its application to a pharmacokinetic study
Determination of narciclasine in mouse blood by UPLC-MS/MS and its application to a pharmacokinetic study Open
Narciclasine is a 7-hydroxy derivative of lycorisidine. It was the first alkaloid isolated from the stem of narcissus (Amaryllidaceae) in 1967. Six mice were given narciclasine (5 mg/kg) by intravenous administration. A UPLC-MS/MS method w…
View article: The Anti-Inflammatory Immune Response in Early <i>Trichinella spiralis</i> Intestinal Infection Depends on Serine Protease Inhibitor–Mediated Alternative Activation of Macrophages
The Anti-Inflammatory Immune Response in Early <i>Trichinella spiralis</i> Intestinal Infection Depends on Serine Protease Inhibitor–Mediated Alternative Activation of Macrophages Open
Trichinella spiralis is recognized for its ability to regulate host immune responses via excretory/secretory (ES) products. Serine protease inhibitors (serpins) play an important role in ES product-mediated immunoregulatory effects during …
View article: Hyaluronan-induced alterations of the gut microbiome protects mice against <i>Citrobacter rodentium</i> infection and intestinal inflammation
Hyaluronan-induced alterations of the gut microbiome protects mice against <i>Citrobacter rodentium</i> infection and intestinal inflammation Open
Hyaluronan is a glycosaminoglycan polymer that has been shown to play an important role in homeostasis of the gastrointestinal tract. However, its mechanistic significance in gastrointestinal epithelial barrier elements remain unexplored. …
View article: Intestinal helminth infection enhances bacteria-induced recruitment of neutrophils to the airspace
Intestinal helminth infection enhances bacteria-induced recruitment of neutrophils to the airspace Open
Intestinal helminth infections elicit Th2-type immunity, which influences host immune responses to additional threats, such as allergens, metabolic disease, and other pathogens. Th2 immunity involves a shift of the CD4 + T-cell population …
View article: T helper cell cytokines modulate intestinal stem cell renewal and differentiation
T helper cell cytokines modulate intestinal stem cell renewal and differentiation Open
Raw data of immunofluorescence assays and FACS plots
View article: The effect of exposure to high altitude and low oxygen on intestinal microbial communities in mice
The effect of exposure to high altitude and low oxygen on intestinal microbial communities in mice Open
This experiment was conducted to investigate the effect of exposure to high altitude and low oxygen on intestinal microbial communities using mice as an animal model. Fecal microbiota from mice housed in a control environment representing …
View article: Helminth infection protects against high fat diet-induced obesity via induction of alternatively activated macrophages
Helminth infection protects against high fat diet-induced obesity via induction of alternatively activated macrophages Open
Epidemiological studies indicate an inverse correlation between the prevalence of the so-called western diseases, such as obesity and metabolic syndrome, and the exposure to helminths. Obesity, a key risk factor for many chronic health pro…
View article: T helper cells modulate intestinal stem cell renewal and differentiation
T helper cells modulate intestinal stem cell renewal and differentiation Open
In the small intestine, a cellular niche of diverse accessory cell types supports the rapid generation of mature epithelial cell types through self-renewal, proliferation, and differentiation of intestinal stem cells (ISCs). However, not m…
View article: A single-cell survey of the small intestinal epithelium
A single-cell survey of the small intestinal epithelium Open
Intestinal epithelial cells absorb nutrients, respond to microbes, function as a barrier and help to coordinate immune responses. Here we report profiling of 53,193 individual epithelial cells from the small intestine and organoids of mice…
View article: p40phox-Deficient Mice Exhibit Impaired Bacterial Clearance and Enhanced Pro-inflammatory Responses during Salmonella enterica serovar Typhimurium Infection
p40phox-Deficient Mice Exhibit Impaired Bacterial Clearance and Enhanced Pro-inflammatory Responses during Salmonella enterica serovar Typhimurium Infection Open
Salmonella enterica serovar Typhimurium (S. Typhimurium) is a major cause of acute gastroenteritis in humans. During infection, reactive oxygen species (ROS), generated from NADPH oxidase (a multisubunit enzyme complex), are required for p…