Haitao Yu
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View article: Vaginal microbiome and sexually-transmitted pathogens in Chinese reproductive-age women: a multicentre cross-sectional and longitudinal cohort study
Vaginal microbiome and sexually-transmitted pathogens in Chinese reproductive-age women: a multicentre cross-sectional and longitudinal cohort study Open
Sexually transmitted infections (STIs) are associated with vaginal dysbiosis, and co-infections are common but understudied. In this study, 6217 reproductive-age women are recruited from 38 study centres across China at baseline and 2738 p…
View article: Benchmarking the Thinking Mode of Multimodal Large Language Models in Clinical Tasks
Benchmarking the Thinking Mode of Multimodal Large Language Models in Clinical Tasks Open
A recent advancement in Multimodal Large Language Models (MLLMs) research is the emergence of "reasoning MLLMs" that offer explicit control over their internal thinking processes (normally referred as the "thinking mode") alongside the sta…
View article: Optical caustics associated with the primary rainbow for coated, spheroidal droplets
Optical caustics associated with the primary rainbow for coated, spheroidal droplets Open
View article: Replacing Helper Lipids With Cationic Lipids Enhances mRNA Lipid Nanoparticles Stability in Solution
Replacing Helper Lipids With Cationic Lipids Enhances mRNA Lipid Nanoparticles Stability in Solution Open
Messenger RNA lipid nanoparticles (mRNA‐LNPs) have achieved remarkable success in clinical vaccination efforts to curb the COVID‐19 pandemic, and have attracted tremendous interest from both industry and academia to broaden their biomedica…
View article: Impact of mixed silages of licorice aerial parts and whole plant corn on nutrient digestibility, rumen fermentation, and gastrointestinal microbiota in Simmental cattle
Impact of mixed silages of licorice aerial parts and whole plant corn on nutrient digestibility, rumen fermentation, and gastrointestinal microbiota in Simmental cattle Open
Introduction Licorice aerial parts are widely cultivated in China but often underutilized due to nutrient loss during haymaking. Ensiling with whole-plant corn may enhance their nutritional value and utilization in ruminant diets. Methods …
View article: Polyphenol‐Mediated Engineering of Lipid Nanoparticles With Crystalline Mesophases
Polyphenol‐Mediated Engineering of Lipid Nanoparticles With Crystalline Mesophases Open
Lipids self‐assemble into lipid nanoparticles (LNPs) with different crystalline mesophases, including lamellar and nonlamellar (e.g., cubic and hexagonal) mesophases. Although various additives can modulate lipid curvature, the formation o…
View article: Genome identification of the DREB gene family in Lycium barbarum and expression analysis in response to leaf blight infection
Genome identification of the DREB gene family in Lycium barbarum and expression analysis in response to leaf blight infection Open
Background To analyze the characteristics of members of the dehydration responsive element binding protein (DREB) transcription factor family in Lycium barbarum and their response patterns during L. barbarum leaf blight stress, bioinformat…
View article: Size-dependent cellular association of cubosomes as nanocarriers
Size-dependent cellular association of cubosomes as nanocarriers Open
Cubosomes feature in the growing arsenal of lipid nanocarriers for drug delivery applications. Particle size has been shown to significantly influence the performance of vaccines and chemotherapeutics using other types of nanoparticles. Ho…
View article: Effects of Different Ratios of Mixed Silage of Licorice Stems and Leaves and Whole Corn on Fermentation Quality, Microbial Diversity, and Aerobic Stability
Effects of Different Ratios of Mixed Silage of Licorice Stems and Leaves and Whole Corn on Fermentation Quality, Microbial Diversity, and Aerobic Stability Open
This experiment aimed to investigate the effects of varying proportions of mixed silage on fermentation quality, microbial diversity, and aerobic stability. The mixed silage samples (G10Y0, G9Y1, G8Y2, G7Y3, G6Y4, G5Y5, G4Y6, G3Y7, G2Y8, G…
View article: Ultrathin MWCNT/Ti3C2Tx Hybrid Films for Electromagnetic Interference Shielding
Ultrathin MWCNT/Ti3C2Tx Hybrid Films for Electromagnetic Interference Shielding Open
The disordered assembly and low conductivity of carbon nanotubes are the main problems that limit the application of electromagnetic interference (EMI) shielding. In this work, an ordered lamellar assembly structure of multiwalled carbon n…
View article: RNA-seq reveals changes in the transcriptome of the breast muscle of adult female chickens in response to heat stress
RNA-seq reveals changes in the transcriptome of the breast muscle of adult female chickens in response to heat stress Open
Our findings will enrich the research on heat stress resistance in chicken skeletal muscle, while also providing a theoretical basis for the genetic improvement of heat stress resistance in chickens.
View article: Protective Role of Indole-3-Acetic Acid Against Salmonella Typhimurium: Inflammation Moderation and Intestinal Microbiota Restoration
Protective Role of Indole-3-Acetic Acid Against Salmonella Typhimurium: Inflammation Moderation and Intestinal Microbiota Restoration Open
Indole-3-acetic acid (IAA), a metabolite derived from microbial tryptophan metabolism, plays a crucial role in regulating intestinal homeostasis. However, the influence and potential applications of IAA in the context of animal pathogen in…
View article: U. Parvum serovars exhibit distinct pathogenicity in Chinese women of childbearing age: a multicentre cross-sectional study
U. Parvum serovars exhibit distinct pathogenicity in Chinese women of childbearing age: a multicentre cross-sectional study Open
gov ; ID: NCT04694495; Registration Date: 2021-01-05).
View article: Methylome and transcriptome joint analyses identify differentially expressed genes based on purebred and crossbred Tianjin-monkey Chicken
Methylome and transcriptome joint analyses identify differentially expressed genes based on purebred and crossbred Tianjin-monkey Chicken Open
Tianjin-monkey Chicken is a locally bred naked neck poultry with limited population size. Herein, we intended to identify potential breed-related genes based on methylome and transcriptome analyses. Tianjin-monkey Chicken and Hy-line Brown…
View article: Cytotoxicity and cell membrane interactions of choline-based ionic liquids: Comparing amino acids, acetate, and geranate anions
Cytotoxicity and cell membrane interactions of choline-based ionic liquids: Comparing amino acids, acetate, and geranate anions Open
Ionic liquids (ILs) have found diverse applications in research and industry. Biocompatible ILs, a subset considered less toxic than traditional ILs, have expanded their applications into biomedical fields. However, there is limited unders…
View article: Ionizable Lipid Containing Nanocarriers for Antimicrobial Agent Delivery
Ionizable Lipid Containing Nanocarriers for Antimicrobial Agent Delivery Open
Antimicrobial resistance (AMR) poses a global health crisis demanding innovative solutions. Traditional antibiotics, though pivotal over the past century in combating bacterial infections, face diminished efficacy against evolving bacteria…
View article: Lyotropic Liquid Crystalline Phase Nanostructure and Cholesterol Enhance Lipid Nanoparticle Mediated mRNA Transfection in Macrophages
Lyotropic Liquid Crystalline Phase Nanostructure and Cholesterol Enhance Lipid Nanoparticle Mediated mRNA Transfection in Macrophages Open
Macrophages are unique immune cells attracting growing attention as a potential candidate for cell‐based therapy for infectious diseases and cancer. Strategies that can reprogramme or gene‐edit macrophages hold potential across a spectrum …
View article: RNA-Seq reveals transcriptome changes to heat stress in the breast muscle of adult female chickens
RNA-Seq reveals transcriptome changes to heat stress in the breast muscle of adult female chickens Open
Background Heat stress has caused significant impacts on the poultry industry globally. Tianjin-monkey Chicken (TM) is a local naked neck chicken genetic resource in China, characterized by its heat stress resistance due to a low feather c…
View article: Microbiota-derived indoles alleviate intestinal inflammation and modulate microbiome by microbial cross-feeding
Microbiota-derived indoles alleviate intestinal inflammation and modulate microbiome by microbial cross-feeding Open
View article: Surface Nanodroplet‐Confined Engineering of Gold (I) ‐Thiolate Nanostructures
Surface Nanodroplet‐Confined Engineering of Gold (I) ‐Thiolate Nanostructures Open
Gold(I)‐thiolate complexes have served as primary building blocks for diverse Au nanostructure synthesis strategies. A delicate approach to characterize and control Au(I)‐thiolate motif formation and assembly on the surface is needed as it…
View article: Correlating structure and activity of pepsin enzyme in H2O and D2O for the study of gastric digestion
Correlating structure and activity of pepsin enzyme in H2O and D2O for the study of gastric digestion Open
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View article: pH‐Dependent Lyotropic Liquid Crystalline Mesophase and Ionization Behavior of Phytantriol‐Based Ionizable Lipid Nanoparticles
pH‐Dependent Lyotropic Liquid Crystalline Mesophase and Ionization Behavior of Phytantriol‐Based Ionizable Lipid Nanoparticles Open
Self‐assembled lipid nanoparticles (LNPs), serving as essential nanocarriers in recent COVID‐19 mRNA vaccines, provide a stable and versatile platform for delivering a wide range of biological materials. Notably, LNPs with unique inverse m…
View article: Long-Term Application of Microbial Fungicides to Root Irrigation Promotes the Formation of Soil Humic Acid by Regulating the Microbial Community Structure
Long-Term Application of Microbial Fungicides to Root Irrigation Promotes the Formation of Soil Humic Acid by Regulating the Microbial Community Structure Open
View article: Cell interactions with lipid nanoparticles possessing different internal nanostructures: Liposomes, bicontinuous cubosomes, hexosomes, and discontinuous micellar cubosomes
Cell interactions with lipid nanoparticles possessing different internal nanostructures: Liposomes, bicontinuous cubosomes, hexosomes, and discontinuous micellar cubosomes Open
The non-lamellar LLCNPs showed significantly higher cellular interactions compared to liposomes, with cubosomes exhibiting the highest level. However, there was no significant difference in relative cell uptake between cubosomes, hexosomes…
View article: Multi-Omics Analysis Reveals the Gut Microbiota Characteristics of Diarrheal Piglets Treated with Gentamicin
Multi-Omics Analysis Reveals the Gut Microbiota Characteristics of Diarrheal Piglets Treated with Gentamicin Open
The involvement of alterations in gut microbiota composition due to the use of antibiotics has been widely observed. However, a clear picture of the influences of gentamicin, which is employed for the treatment of bacterial diarrhea in ani…
View article: Engineering and Purification of Microcin C7 Variants Resistant to Trypsin and Analysis of Their Biological Activity
Engineering and Purification of Microcin C7 Variants Resistant to Trypsin and Analysis of Their Biological Activity Open
Microcin C7 (McC) as a viable form of antimicrobial has gained substantial attention due to its distinctive antimicrobial activity, by targeting aspartyl tRNA synthetase. McC can be a potential solution against pathogenic microbial infecti…
View article: Synergistic effects of multiple pesticides on the flight ability of honey bees (<i>Apis cerana</i>F.)
Synergistic effects of multiple pesticides on the flight ability of honey bees (<i>Apis cerana</i>F.) Open
Pesticides cause risks in the environment for Asian honey bees ( Apis cerana ). Imidacloprid (I), chlorpyrifos (C) and glyphosate (G) are among the most-widely used pesticides in the world. It is not clear on how these pesticides and combi…
View article: The effects of nano-iron on volatile compounds and phytoestrogens in the Flowering Process of Trifolium pratense
The effects of nano-iron on volatile compounds and phytoestrogens in the Flowering Process of Trifolium pratense Open
Fe fertilizer is usually used to accelerate the growth and development of plants and trigger the accumulation of specific secondary metabolites to promote resistance and/or immunity of plants. Flowering is a critical process for plant grow…
View article: Correlating Structure and Activity of Pepsin Enzyme in H2O and D2O for The Study of Gastric Digestion
Correlating Structure and Activity of Pepsin Enzyme in H2O and D2O for The Study of Gastric Digestion Open
Pepsin is an aspartic acid protease and the first protease that proteins encounter in the gastrointestinal tract. In vitro digestion assays on proteins including those found in food, or as oral protein and peptide drugs, often involve diff…
View article: Sequential droplet reactions for surface-bound gold nanocrater array
Sequential droplet reactions for surface-bound gold nanocrater array Open