Haibing Gao
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View article: Safety and efficacy of GST-HG141, a novel HBV capsid assembly modulator, for the treatment of chronic hepatitis B patients with low-level viremia: a randomized, double-blind, placebo-controlled, multicenter phase II study
Safety and efficacy of GST-HG141, a novel HBV capsid assembly modulator, for the treatment of chronic hepatitis B patients with low-level viremia: a randomized, double-blind, placebo-controlled, multicenter phase II study Open
View article: Ascertaining the association between smoking behaviors and viral hepatitis risk: A Mendelian randomization approach
Ascertaining the association between smoking behaviors and viral hepatitis risk: A Mendelian randomization approach Open
Our study presents strong associations between smoking behavior and an elevated risk of viral hepatitis, highlighting the need for further investigation into this potential connection. These findings underscore the importance of smoking ce…
View article: Reevaluating antiviral thresholds in HBV DNA-negative inactive HBsAg carriers: a multicenter histopathological analysis
Reevaluating antiviral thresholds in HBV DNA-negative inactive HBsAg carriers: a multicenter histopathological analysis Open
HBV DNA negativity does not guarantee histological quiescence in inactive HBsAg carriers aged ≥ 30 years, with 44.9% exhibiting significant liver injury. In this population, LSM > 6.4 Kpa should prompt consideration of liver biopsy and/or …
View article: Reevaluating Antiviral Thresholds in HBV DNA-Negative Inactive HBsAg Carriers: A Multicenter Histopathological Analysis
Reevaluating Antiviral Thresholds in HBV DNA-Negative Inactive HBsAg Carriers: A Multicenter Histopathological Analysis Open
Background The definition of inactive HBsAg carriers (IHC) varies globally, particularly regarding HBV DNA thresholds. Whether HBV DNA negativity reliably predicts histological quiescence remains uncertain. Aims This study evaluated liver …
View article: Future directions of stem cell therapy for liver failure: Insights from a meta-analysis
Future directions of stem cell therapy for liver failure: Insights from a meta-analysis Open
View article: Efficacy and safety of GLS4 with entecavir vs entecavir alone in chronic hepatitis B patients: A multicenter clinical trial
Efficacy and safety of GLS4 with entecavir vs entecavir alone in chronic hepatitis B patients: A multicenter clinical trial Open
The primary analysis at week 48 showed that the antiviral efficacy of GLS4/RTV with ETV was clearly superior to that of ETV monotherapy. GLS4/RTV with ETV was well tolerated; further studies evaluating its safety and efficacy are ongoing. …
View article: PR/SET domain 1 targeting glutathione peroxidase 4 regulates chronic hepatitis B liver fibrosis through ferroptosis
PR/SET domain 1 targeting glutathione peroxidase 4 regulates chronic hepatitis B liver fibrosis through ferroptosis Open
Objective: Addressing the inhibition and reversal of chronic hepatitis B fibrosis is an urgent global challenge, which highlights the critical need to understand its underlying mechanisms. Inhibiting the activation of hepatic stellate cell…
View article: Comparison of lipid profile alterations in chronic hepatitis b patients receiving tenofovir alafenamide or tenofovir disoproxil fumarate
Comparison of lipid profile alterations in chronic hepatitis b patients receiving tenofovir alafenamide or tenofovir disoproxil fumarate Open
This study aimed to compare the serum lipid profiles between tenofovir disoproxil fumarate (TDF) and tenofovir alafenamide (TAF) in the long-term treatment of chronic hepatitis B (CHB). We analyzed data from treatment-naïve CHB patients ad…
View article: Construction of a prediction model for hepatic encephalopathy in acute-on-chronic liver failure patients
Construction of a prediction model for hepatic encephalopathy in acute-on-chronic liver failure patients Open
This study developed and validated a new prediction model for HE in ACLF patients offering a useful tool for early identification of patients with a high risk of HE in clinical settings. However, to ascertain the model's general effectiven…
View article: A comprehensive meta-analysis of stem cell therapy for liver failure: Assessing treatment efficacy and modality
A comprehensive meta-analysis of stem cell therapy for liver failure: Assessing treatment efficacy and modality Open
This comprehensive analysis underscores the potential of MSC therapy in significantly improving survival and clinical outcomes in patients with liver failure, highlighting the superior benefits of allogeneic MSCs and deep vessel plus singl…
View article: LncRNA CCAT2, involving miR-34a/TGF-β1/Smad4 signaling, regulate hepatic stellate cells proliferation
LncRNA CCAT2, involving miR-34a/TGF-β1/Smad4 signaling, regulate hepatic stellate cells proliferation Open
View article: METTL16 regulates m6A methylation on chronic hepatitis B associated gene HLA-DPB1 involved in liver fibrosis
METTL16 regulates m6A methylation on chronic hepatitis B associated gene HLA-DPB1 involved in liver fibrosis Open
The role of genetic factors in the occurrence and progression of CHB (CHB) is still not fully explored. In recent years, genome-wide association studies on CHB patients have demonstrated that a large number of CHB-associated single nucleot…
View article: miR-34a, a physical exercise regulator, involved in LncRNA CCAT2 signaling to regulate hepatic stellate cells proliferation
miR-34a, a physical exercise regulator, involved in LncRNA CCAT2 signaling to regulate hepatic stellate cells proliferation Open
In plasma, miR-34a could be one of potential biomarkers for frailty and is involved in the physiology processes which are benefit from exercise. One of its targets, Smad4 play important role in TGF-β1 pathway which is a dominant factor for…
View article: Explainable machine learning model for predicting spontaneous bacterial peritonitis in cirrhotic patients with ascites
Explainable machine learning model for predicting spontaneous bacterial peritonitis in cirrhotic patients with ascites Open
View article: Identification of miR-4793-3p as a potential biomarker for bacterial infection in patients with hepatitis B virus-related liver cirrhosis: A pilot study
Identification of miR-4793-3p as a potential biomarker for bacterial infection in patients with hepatitis B virus-related liver cirrhosis: A pilot study Open
Hepatitis B virus-related liver cirrhosis (HBV-LC) is susceptible to bacterial infections, which could lead to adverse prognosis in patients. MicroRNAs (miRs/miRNAs) are easily detected in peripheral blood and are involved in multiple live…
View article: Efficacy and safety of GLS4/ritonavir combined with entecavir in HBeAg-positive patients with chronic hepatitis B: interim results from phase 2b, multi-center study
Efficacy and safety of GLS4/ritonavir combined with entecavir in HBeAg-positive patients with chronic hepatitis B: interim results from phase 2b, multi-center study Open
View article: Telbivudine can safely reduce mother-to-child transmission in chronic hepatitis B women after 12 weeks of gestation
Telbivudine can safely reduce mother-to-child transmission in chronic hepatitis B women after 12 weeks of gestation Open
View article: The Identification of Two New ABCB11 Gene Mutations and the Treatment Outcome in a Young Adult with Benign Recurrent Intrahepatic Cholestasis: A Case Report
The Identification of Two New ABCB11 Gene Mutations and the Treatment Outcome in a Young Adult with Benign Recurrent Intrahepatic Cholestasis: A Case Report Open
Introduction: Benign recurrent intrahepatic cholestasis (BRIC) is a rare autosomal recessive disease characterized by recurrent episodes of severe pruritus and jaundice. Although the disease symptom will relieve spontaneously without leavi…
View article: Baseline prognostic factors and statistic model to predict early virological response in lamivudine-treated patients with chronic hepatitis B.
Baseline prognostic factors and statistic model to predict early virological response in lamivudine-treated patients with chronic hepatitis B. Open
Lamivudine is a potent nucleoside analogue used in treating chronic hepatitis B (CHB). However, resistance to the drug remains a problem. We analyzed all lamivudine recipients in this trial to determine the baseline characteristics and a m…