Explanipedia

Lab-on-a-chip technologies: The future of precision medicine and high-throughput biomolecular analysis Open

Jie Hu, Hao Bai, Haichen Lv, Yongchao Yao · 2025

Multidisciplinary management of concurrent small cell lung cancer and hepatocellular carcinoma: A rare case report with long-term survival Open

Ying Li, Xu Zhang, Yiqian Wang, Haichen Lv, Shilei Zhao , et al. · 2025

Rationale: Coexisting small cell lung cancer (SCLC) and hepatocellular carcinoma (HCC) is extraordinarily uncommon; in elderly patients with cardiac dysfunction it demands highly individualized, cardio-conscious care. Patient concerns: A 7…

Balancing the benefits and risks of colchicine use among patients with atherosclerotic cardiovascular disease: an umbrella review of meta-analyses of randomised controlled trials Open

Rui-Han Bao, Na Zhao, Xiaofeng Jiang, Zihan Cong, Jun Liu , et al. · 2025

Young Age at Hysterectomy and Elevated Hypertension Risk: A Combined Observational and Mendelian Randomization Study Open

Weiren Yan, Wang Jiahui, Xu Ke, Xianglin Liu, Lijia Xu , et al. · 2025

Hysterectomy is associated with an increased risk of hypertension, particularly among women who undergo the procedure at a younger age.

Association between hysterectomy status and hypertension: Results from NHANES 2007– 2018 and two-sample Mendelian randomization study Open

Weiren Yan, Jiahui Wang, Ke Xu, Xianglin Liu, Xinsheng Li , et al. · 2024

Background Previous observational studies have shown an association between hysterectomy status and the risk of developing hypertension, but the exact relationship between the two is unclear. The aim of our study was to conduct an observat…

Diagnostic performance of adenosine-stress dynamic CT myocardial perfusion imaging in detecting myocardial ischemia in patients with intermediate coronary stenosis Open

Yiwen Li, Fu Jia, Shuang Liu, Da Yin, Haichen Lv , et al. · 2024

Objective: This study aimed to investigate the diagnostic performance of CT myocardial perfusion imaging (CT-MPI) in detecting myocardial ischemia in patients with intermediate coronary stenosis (50%–70%) using fractional flow reserve (FFR…

Drug-Coated Balloon for de-novo Coronary Artery Lesions Exceeding 2.5 mm in Diameter: Optical Coherence Tomography Analysis and Clinical Follow-Up Open

Yuguo Liu, Bo Zhang, Haichen Lv, Yifan Zhu, Xuchen Zhou , et al. · 2024

This is the first and largest prospective study to assess the outcomes of DCB treatment for de-novo coronary lesions exceeding 2.5 mm in diameter and the detection of significant vessel enlargement and dissection healing guide by OCT. DCB …

Prognostic Value of Fibrinogen-to-Albumin Ratio in Coronary Three-Vessel Disease Open

X.T. Li, Zhongzhen Wang, Yifan Zhu, Haichen Lv, Xuchen Zhou , et al. · 2023

Higher level of FAR was associated with all-cause mortality and MACCE among patients with TVD. FAR could help to improve the prognostic performance of the traditional risk factors for TVD patients.

Predictive value of high sensitivity C-reactive protein in three-vessel disease patients with and without type 2 diabetes Open

Lei Guo, Haichen Lv, Junjie Wang, Bo Zhang, Yifan Zhu , et al. · 2023

Background Diabetes mellitus (DM) and atherosclerosis are multifactorial conditions and share a common inflammatory basis. Three-vessel disease (TVD) represents a major challenge for coronary intervention. Nonetheless, the predictive value…

Remnant Cholesterol to Lymphocyte Ratio as a New Predictor of Prognosis in Patients with Unstable Angina Undergoing Percutaneous Coronary Intervention Open

Hui Xi, Biyang Zhang, Tienan Sun, Jingrui Zhang, Haichen Lv · 2023

Background: Inflammatory cells and remnant cholesterol (RC) play an important role in the development and progression of cardiovascular diseases. In order to understand their contribution to cardiovascular diseases, we proposed the RC to l…

Good coronary collateral circulation is not associated with better prognosis in patients with chronic total occlusion, regardless of treatment strategy Open

Zeya Li, Yingdong Wang, Shanshan Wu, Jingnan Xiao, Lei Guo , et al. · 2022

Good CCC was not associated with a lower risk of cardiac death or MACEs among patients with CTO, regardless of whether the patients received CTO revascularization treatment.

Research On Maize Disease Identification Methods In Complex Environments Based On Cascade Networks And Two-Stage Transfer Learning Open

Hongxin Liu, Haichen Lv, Jiajun Li, Yongshuo Liu, Limiao Deng · 2022

Achieving accurate and reliable maize disease identification in complex environments is a huge challenge. This is because disease images obtained from natural environments are often in complex contexts that may contain elements similar to …

Systemic Immune-Inflammation Index Predicts Long-Term Outcomes in Patients with Three-Vessel Coronary Disease After Revascularization: Results from a Large Cohort of 3561 Patients Open

Ji Zhao, Haichen Lv, Da Yin, Xuchen Zhou, Hao Zhu , et al. · 2022

In TVD patients after revascularization, increased SII is an independent prognostic factor for long-term outcomes of MACCE and death. Compared to traditional risk factors, SII improved the risk prediction of major cardiovascular events in …

Research on Maize Disease Identification Methods in Complex Environments Based on Cascade Networks and Two-stage Transfer Learning Open

Hongxin Liu, Haichen Lv, Jiajun Li, Yongshuo Liu, Limiao Deng · 2022

BACKGROUND: Achieving accurate and reliable maize disease identification in complex environments is a huge challenge. This is because disease images obtained from natural environments are often in complex contexts that may contain elements…

Chronic Total Occlusion Percutaneous Coronary Intervention in Patients With Prior Coronary Artery Bypass Graft: Current Evidence and Future Perspectives Open

Lei Guo, Haichen Lv, Xiaomeng Yin · 2022

Coronary chronic total occlusion (CTO), which occurs in 18. 4–52% of all patients referred for coronary angiography, represents one of the last barriers in coronary intervention. Approximately half of all patients with prior coronary arter…

Gender-Based Long-Term Outcomes After Revascularization for Three-Vessel Coronary Disease: A Propensity Score-Matched Analysis of a Large Cohort Open

Yuguo Liu, Yifan Zhu, Junjie Wang, Da Yin, Haichen Lv , et al. · 2022

For patients with TVD after coronary revascularization, there were no gender-based differences in the long-term outcomes and female gender was not an independent predictor of MACCE.

Sex differences in long-term outcomes after revascularization for three-vessel coronary disease Open

Yuguo Liu, Yifan Zhu, Junjie Wang, Haichen Lv, Shaoke Meng , et al. · 2022

Background: To investigate the impact of gender on long-term outcomes of after revascularization in patients with three-vessel disease (TVD), a severe type of coronary artery disease (CAD).Methods: A total of 3776 patients with TVD who und…

Predictors of Adverse Events Among Chronic Total Occlusion Patients Undergoing Successful Percutaneous Coronary Intervention and Medical Therapy Open

Le Yang, Lei Guo, Haichen Lv, Xiaodong Liu, Lei Zhong , et al. · 2021

Heart failure was predictor for composite cardiovascular events in patients with CTO after successful recanalization. Male gender, diabetes mellitus, heart failure, J-CTO score and multivessel disease were predictors of MACE in CTO patient…

Long-Term Outcomes of Successful Recanalization Compared With Optimal Medical Therapy for Coronary Chronic Total Occlusions in Patients With and Without Left Ventricular Systolic Dysfunction Open

Lei Guo, Shaoke Meng, Haichen Lv, Lei Zhong, Jian Wu , et al. · 2021

Background: The number of coronary chronic total occlusion (CTO) patients with left ventricular (LV) systolic dysfunction is significant, but the clinical outcomes of these patients are rarely reported. The present retrospective cohort stu…

The Prevalence, Distribution, and Extent of Subclinical Atherosclerosis and Its Relation With Serum Uric Acid in Hypertension Population Open

Fei Liu, Simei Hui, Tesfaldet H. Hidru, Yinong Jiang, Ying Zhang , et al. · 2021

Background: Data are limited on the prevalence, distribution, and extent of subclinical atherosclerosis (SCA) in populations with primary hypertension and an in-depth evaluation is required to explore the impact of elevated serum uric acid…

Corrigendum: Long-Term Outcomes of Successful Revascularization for Patients With Coronary Chronic Total Occlusions: A Report of 1,655 Patients Open

Lei Guo, Xiaoyan Zhang, Haichen Lv, Lei Zhong, Jian Wu , et al. · 2021

[This corrects the article DOI: 10.3389/fcvm.2020.00116.].

Correction to: Long‑term outcomes of medical therapy versus successful recanalisation for coronary chronic total occlusions in patients with and without type 2 diabetes mellitus Open

Lei Guo, Junjie Wang, Huaiyu Ding, Shaoke Meng, Xiaoyan Zhang , et al. · 2021

A Three-Dimensional Microfluidic Device for Monitoring Cancer and Chemotherapy-Associated Platelet Activation Open

Zhujing Hao, Haichen Lv, Ruopeng Tan, Xiaolei Yang, Yang Liu , et al. · 2021

Platelet activation and the risk of thrombosis are increased in cancer patients, especially after chemotherapy. Our previous studies indicated that chemotherapy-induced platelet activation is largely due to endothelial cell damage. Thus, s…

Corrigendum: Impact of Renal Function on Long-Term Clinical Outcomes in Patients With Coronary Chronic Total Occlusions: Results From an Observational Single-Center Cohort Study During the Last 12 Years Open

Lei Guo, Huaiyu Ding, Haichen Lv, Xiaoyan Zhang, Lei Zhong , et al. · 2021

Corrigendum: Impact of Renal Function on Long-Term Clinical Outcomes in Patients With Coronary Chronic Total Occlusions: Results From an Observational Single-Center Cohort Study During the Last 12 YearsLei Guo 1*†, Huaiyu Ding 1†, Haichen …

Impact of Renal Function on Long-Term Clinical Outcomes in Patients With Coronary Chronic Total Occlusions: Results From an Observational Single-Center Cohort Study During the Last 12 Years Open

Lei Guo, Huaiyu Ding, Haichen Lv, Xiaoyan Zhang, Lei Zhong , et al. · 2020

Background: The number of coronary chronic total occlusion (CTO) patients with renal insufficiency is huge, and limited data are available on the impact of renal insufficiency on long-term clinical outcomes in CTO patients. We aimed to inv…

Platelets Promote Ang II (Angiotensin II)-Induced Atrial Fibrillation by Releasing TGF-β1 (Transforming Growth Factor-β1) and Interacting With Fibroblasts Open

Yang Liu, Haichen Lv, Ruopeng Tan, Xiangbo An, Xiao‐Hui Niu , et al. · 2020

Hypertension is a risk factor of atrial fibrillation (AF), and a certain number of patients with hypertension were found with an enlarged left atrium. Platelet activation is found in patients with hypertension or pressure overload/Ang II (…

Long-Term Outcomes of Successful Revascularization for Patients With Coronary Chronic Total Occlusions: A Report of 1,655 Patients Open

Lei Guo, Xiaoyan Zhang, Haichen Lv, Lei Zhong, Jian Wu , et al. · 2020

Background: To date, the benefit of successful revascularization of chronic total occlusions (CTOs) on prognosis remains uncertain, and there is a paucity of data on the impact of successful revascularization for CTO patients on long-term …

Long-term outcomes of medical therapy versus successful recanalisation for coronary chronic total occlusions in patients with and without type 2 diabetes mellitus Open

Lei Guo, Junjie Wang, Huaiyu Ding, Shaoke Meng, Xiaoyan Zhang , et al. · 2020

Percutaneous Coronary Intervention in Elderly Patients with Coronary Chronic Total Occlusions: Current Evidence and Future Perspectives Open

Lei Guo, Haichen Lv, Rongchong Huang · 2020

The proportion of the elderly in the total population of the world is growing, and the number of elderly patients with coronary chronic total occlusions (CTO) is huge. The elderly patients often have more extensive coronary artery disease,…

A case report: high dose melphalan as a conditioning regimen for multiple myeloma induces sinus arrest Open

Liangliang Ma, Ying Liu, Sixun Jia, Haichen Lv, Meiyun Fang , et al. · 2020

High dose melphalan is commonly used as a conditioning regimen for autologous stem cell transplantation in multiple myeloma. There are reports of adverse cardiac events with melphalan manifested by supraventricular tachycardia and atrial f…

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