Huilin Yang
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View article: Endolysin significantly improves symptoms with atopic dermatitis: bridging the gap from research to clinical practice
Endolysin significantly improves symptoms with atopic dermatitis: bridging the gap from research to clinical practice Open
Background Atopic Dermatitis (AD), a chronic inflammatory skin disease characterized by pruritus, dryness, redness, edema, scratching, and lichenification, ranks as the leading cause of non-fatal skin disease burden globally. Current thera…
View article: Drilling Condition Identification Method for Imbalanced Datasets
Drilling Condition Identification Method for Imbalanced Datasets Open
To address the challenges posed by class imbalance and temporal dependency in drilling condition data and enhance the accuracy of condition identification, this study proposes an integrated method combining feature engineering, data resamp…
View article: PP2Ac Regulates Autophagy via Mediating mTORC1 and ULK1 During Osteoclastogenesis in the Subchondral Bone of Osteoarthritis
PP2Ac Regulates Autophagy via Mediating mTORC1 and ULK1 During Osteoclastogenesis in the Subchondral Bone of Osteoarthritis Open
The molecular mechanism underlying abnormal osteoclastogenesis triggering subchondral bone remodeling in osteoarthritis (OA) is still unclear. Here, single‐cell and bulk transcriptomics sequencing analyses are performed on GEO datasets to …
View article: Identification and Validation of Prognostic Markers for Endometriosis-Associated Ovarian Cancer
Identification and Validation of Prognostic Markers for Endometriosis-Associated Ovarian Cancer Open
Background: Growing evidence suggests that endometriosis (EMs) is a risk factor for endometriosis-associated ovarian cancer (EAOC). The aim was to identify and validate gene signatures associated with EMs that may serve as potential…
View article: Hematoma-like dynamic hydrogelation through natural glycopeptide molecular recognition for infected bone fracture repair
Hematoma-like dynamic hydrogelation through natural glycopeptide molecular recognition for infected bone fracture repair Open
Infected bone fractures remain a major clinical challenge for orthopedic surgeons. From a tissue regeneration perspective, biomaterial scaffolds with antibacterial and osteoinductive activities are highly desired, while advanced materials …
View article: BMP-2 functional polypeptides relieve osteolysis via bi-regulating bone formation and resorption coupled with macrophage polarization
BMP-2 functional polypeptides relieve osteolysis via bi-regulating bone formation and resorption coupled with macrophage polarization Open
View article: Bioinformatics-Based Research on Key Genes and Pathways of Intervertebral Disc Degeneration
Bioinformatics-Based Research on Key Genes and Pathways of Intervertebral Disc Degeneration Open
Objective To find out the pathways and key genes and to reveal disc degeneration pathogenesis based on bioinformatic analyses. Design The GSE70362 dataset was downloaded from the GEO (Gene Expression Omnibus) database. Differentially expre…
View article: Advice on Standardized Diagnosis and Treatment for Spinal Diseases during the Coronavirus Disease 2019 Pandemic
Advice on Standardized Diagnosis and Treatment for Spinal Diseases during the Coronavirus Disease 2019 Pandemic Open
Coronavirus disease 2019 (COVID-19) outbreak started in December 2019 that caused difficulties for clinical work. Practical work experience in our spinal outpatient and emergency department during the COVID-19 pandemic is summarized in thi…
View article: Meta-analysis of FOXP3 gene rs3761548 and rs2232365 polymorphism and multiple sclerosis susceptibility
Meta-analysis of FOXP3 gene rs3761548 and rs2232365 polymorphism and multiple sclerosis susceptibility Open
Background Multiple sclerosis (MS) is a common autoimmune disease of the central nervous system (CNS), and is associated with genetic factors. FOXP3 gene polymorphism has been reported as the risk factor for MS, however, previous studies h…
View article: Long non-coding RNA Taurine upregulated gene 1 promotes osteosarcoma cell metastasis by mediating HIF-1α via miR-143-5p
Long non-coding RNA Taurine upregulated gene 1 promotes osteosarcoma cell metastasis by mediating HIF-1α via miR-143-5p Open
Early aggressive metastasis of osteosarcoma (OS) leads to rapid progression and poor prognosis. Increasing evidence has demonstrated that long non-coding RNAs (lncRNAs) could serve as crucial regulators to modulate tumour metastasis. In th…
View article: Geographical heterogeneity in prevalence of subclinical malaria infections at sentinel endemic sites of Myanmar
Geographical heterogeneity in prevalence of subclinical malaria infections at sentinel endemic sites of Myanmar Open
View article: Outdoor Air Pollution and Hip Fracture in UK
Outdoor Air Pollution and Hip Fracture in UK Open
View article: Upregulation of SIRT1 by Kartogenin Enhances Antioxidant Functions and Promotes Osteogenesis in Human Mesenchymal Stem Cells
Upregulation of SIRT1 by Kartogenin Enhances Antioxidant Functions and Promotes Osteogenesis in Human Mesenchymal Stem Cells Open
Osteoarthritis is a chronic degenerative joint disease involving both articular cartilage and subchondral bone. Kartogenin (KGN) was recently identified to improve in vivo cartilage repair; however, its effect on bone formation is unknown.…
View article: Transforming growth factor β and its role in heart disease
Transforming growth factor β and its role in heart disease Open
Myocardial infarction (MI) is a major form of heart disease that leads to immediate cardiomyocyte death due to ischemia and eventually fibrosis and scar formation and further dysfunction of myocardium and heart failure. Extracellular matri…
View article: Prognostic value of microRNA-9 in cancers: a systematic review and meta-analysis
Prognostic value of microRNA-9 in cancers: a systematic review and meta-analysis Open
Recent studies revealed that different microRNA-9 (miR-9) expressions were associated with prognoses of different cancers. We conducted this meta-analysis to evaluate the prognostic value of miR-9. PubMed, Embase, Web of Science, and Cochr…
View article: Icariin attenuates titanium-particle inhibition of bone formation by activating the Wnt/β-catenin signaling pathway in vivo and in vitro
Icariin attenuates titanium-particle inhibition of bone formation by activating the Wnt/β-catenin signaling pathway in vivo and in vitro Open
View article: The Association of rs4753426 Polymorphism inthe Melatonin Receptor 1B (MTNR1B) Gene andSusceptibility to Adolescent Idiopathic Scoliosis:A Systematic Review and Meta-analysis
The Association of rs4753426 Polymorphism inthe Melatonin Receptor 1B (MTNR1B) Gene andSusceptibility to Adolescent Idiopathic Scoliosis:A Systematic Review and Meta-analysis Open
Background: Adolescent idiopathic scoliosis (AIS) is a tridimensional structural deformity of the spine that may deteriorate progressively, leading to significant functional limitations and pain problems. Several previous studies have impl…
View article: The Transforming Growth Factor-β1 (TGF-β1) Gene Polymorphisms (TGF-β1 T869C and TGF-β1 T29C) and Susceptibility to Postmenopausal Osteoporosis
The Transforming Growth Factor-β1 (TGF-β1) Gene Polymorphisms (TGF-β1 T869C and TGF-β1 T29C) and Susceptibility to Postmenopausal Osteoporosis Open
OR = 1.35, 95% CI = 1.03-1.75, P = 0.028); however, there was no significant association between TGF-β1 T869C polymorphism and PMOP risk in Caucasian population. With regard to TGF-β1 T29C polymorphism, significant association was also obs…