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View article: Mammal placental phenotypes are predictable from microRNA repertoires
Mammal placental phenotypes are predictable from microRNA repertoires Open
Despite >100 million years of mammal diversification, similar placental morphologies have independently evolved multiple times, presenting a long-standing evolutionary puzzle: what genetic mechanisms lead to convergent forms? MicroRNAs (mi…
View article: A bovine 3D endometrium-on-a-chip reveals the role of conceptus-derived proteins, CAPG and PDI, in conceptus–endometrial communication
A bovine 3D endometrium-on-a-chip reveals the role of conceptus-derived proteins, CAPG and PDI, in conceptus–endometrial communication Open
Early embryo loss affects all mammalian species, including humans, and agriculturally important food-producing mammals such as cattle. The developing conceptus (embryo and extraembryonic membranes) secretes proteins that can modify the end…
View article: An evolutionarily conserved microRNA, miR-185, regulates key pathways that may contribute to implantation failure.
An evolutionarily conserved microRNA, miR-185, regulates key pathways that may contribute to implantation failure. Open
Recurrent implantation failure (RIF) is defined after three or more good quality embryo transfers following in vitro fertilisation without a successful pregnancy outcome. Many factors contribute to RIF however, the endometrial contribution…
View article: Ruminating on Bovine Implantation: Its Importance in Fertility, Food Production, Conservation, and Health
Ruminating on Bovine Implantation: Its Importance in Fertility, Food Production, Conservation, and Health Open
Implantation in cattle is a key developmental checkpoint for pregnancy success. It involves careful spatiotemporal changes to the transcriptional landscape of the endometrium, with the heterogeneous nature of the endometrium increasing the…
View article: Biosensor capability of the endometrium is mediated in part, by altered miRNA cargo from conceptus‐derived extracellular vesicles
Biosensor capability of the endometrium is mediated in part, by altered miRNA cargo from conceptus‐derived extracellular vesicles Open
We tested the hypothesis that the biosensor capability of the endometrium is mediated in part, by the effect of different cargo contained in the extracellular vesicles secreted by the conceptus during the peri‐implantation period of pregna…
View article: The embryo-derived protein PDI is highly conserved among placental mammals and alters the function of the endometrium in species with different implantation strategies
The embryo-derived protein PDI is highly conserved among placental mammals and alters the function of the endometrium in species with different implantation strategies Open
Pregnancy establishment in mammals requires a complex sequence of events, including bi-lateral embryo-maternal communication, leading up to implantation. This is the time when most pregnancy loss occurs in mammals (including humans and foo…
View article: Biosensor capability of the endometrium is mediated in part, by altered miRNA cargo from conceptus-derived extracellular vesicles
Biosensor capability of the endometrium is mediated in part, by altered miRNA cargo from conceptus-derived extracellular vesicles Open
We tested the hypothesis that the biosensor capability of the endometrium is mediated in part, by the effect of different cargo contained in the extracellular vesicles secreted by the conceptus during the peri-implantation period of pregna…
View article: Understanding conceptus–maternal interactions: what tools do we need to develop?
Understanding conceptus–maternal interactions: what tools do we need to develop? Open
Communication between the maternal endometrium and developing embryo/conceptus is critical to support successful pregnancy to term. Studying the peri-implantation period of pregnancy is critical as this is when most pregnancy loss occurs i…
View article: Differences in binding preferences for XIST partners are observed in mammals with different early pregnancy morphologies
Differences in binding preferences for XIST partners are observed in mammals with different early pregnancy morphologies Open
In comparison to protein-coding genes, long non-coding RNAs (lncRNAs) are poorly conserved between species at the sequence level yet they often perform conserved and essential regulatory roles. The lncRNA XIST mediates X chromosome inactiv…
View article: Review: Endometrial function in pregnancy establishment in cattle
Review: Endometrial function in pregnancy establishment in cattle Open
The endometrium is fundamentally required for successful pregnancy in ruminants and species where the posthatching conceptus undergoes a protracted elongation and peri-implantation phase of pregnancy. Moreover, there are substantial waves …
View article: A burst of genomic innovation at the origin of placental mammals mediated embryo implantation
A burst of genomic innovation at the origin of placental mammals mediated embryo implantation Open
View article: Transcriptional response of endometrial cells to insulin, cultured using microfluidics
Transcriptional response of endometrial cells to insulin, cultured using microfluidics Open
Obesity is a rapidly growing public health issue among women of reproductive age associated with decreased reproductive function including implantation failure. This can result from a myriad of factors including impaired gametes and endome…
View article: MicroRNAs emerging coordinate with placental mammals alter pathways in endometrial epithelia important for endometrial function
MicroRNAs emerging coordinate with placental mammals alter pathways in endometrial epithelia important for endometrial function Open
We tested the hypothesis that conserved placental mammal-specific microRNAs and their targets facilitate endometrial receptivity to implantation. Expression of miR-340-5p, -542-3p, and -671-5p was regulated by exposure of endometrial epith…
View article: A burst of genomic innovation at the origin of placental mammals mediated embryo implantation.
A burst of genomic innovation at the origin of placental mammals mediated embryo implantation. Open
The origin of embryo implantation in mammals ~148 million years ago was a dramatic shift in reproductive strategy, yet the molecular changes that established mammal implantation are largely unknown. Although progesterone receptor signallin…
View article: Sex bias in utero alters ovarian reserve but not uterine capacity in female offspring
Sex bias in utero alters ovarian reserve but not uterine capacity in female offspring Open
Environmental stressors to which a fetus is exposed affect a range of physiological functions in postnatal offspring. We aimed to determine the in utero effect of steroid hormones on the reproductive potential of female offspring using a p…
View article: Sex-bias in utero alters ovarian reserve but not uterine capacity in female offspring
Sex-bias in utero alters ovarian reserve but not uterine capacity in female offspring Open
Environmental stressors to which a foetus is exposed, affect a range of physiological functions in post-natal offspring. Such stressors include disproportionate steroid hormone concentrations in the uterine environment. We aimed to determi…
View article: Placental mammal derived microRNAs alter pathways in the endometrial epithelia important for endometrial function
Placental mammal derived microRNAs alter pathways in the endometrial epithelia important for endometrial function Open
We tested the hypothesis that a panel of placental mammal-specific miRNAs and their targets play important to establish receptivity to implantation and their dysregulated expression may be a feature in women with early pregnancy loss. Rela…
View article: Insulin exposed endometrial epithelial cells cultured in a microfluidic device alters transcripts involved in translation that may contribute to reduced implantation capacity of the endometrium
Insulin exposed endometrial epithelial cells cultured in a microfluidic device alters transcripts involved in translation that may contribute to reduced implantation capacity of the endometrium Open
Obesity is a rapidly growing public health issue among women of reproductive age. It is also associated with decreased reproductive function including implantation failure. Implantation failure can result from a myriad of factors including…
View article: A burst of regulatory and protein innovation at the origin of placental mammals drove the emergence of placenta and underpins divergent early pregnancy strategies in modern mammals
A burst of regulatory and protein innovation at the origin of placental mammals drove the emergence of placenta and underpins divergent early pregnancy strategies in modern mammals Open
Summary paragraph The origin of live birth in mammals ∼148 million years ago was a dramatic shift in reproductive strategy, yet the molecular changes that established mammal viviparity are largely unknown. Although progesterone receptor si…
View article: Endometrium On-a-Chip Reveals Insulin- and Glucose-induced Alterations in the Transcriptome and Proteomic Secretome
Endometrium On-a-Chip Reveals Insulin- and Glucose-induced Alterations in the Transcriptome and Proteomic Secretome Open
The molecular interactions between the maternal environment and the developing embryo are key for early pregnancy success and are influenced by factors such as maternal metabolic status. Our understanding of the mechanism(s) through which …
View article: Endometrium-on-a-chip reveals the endometrial transcriptome, and protein content of secretome are altered by changes in circulating concentrations of insulin and glucose<i>in vitro</i>
Endometrium-on-a-chip reveals the endometrial transcriptome, and protein content of secretome are altered by changes in circulating concentrations of insulin and glucose<i>in vitro</i> Open
The molecular interactions between the maternal environment and developing embryo that are key for early pregnancy success are known to be influenced by factors such as the metabolic status. We are, however, limited in our understanding of…
View article: The role of CAPG in molecular communication between the embryo and the uterine endometrium: Is its function conserved in species with different implantation strategies?
The role of CAPG in molecular communication between the embryo and the uterine endometrium: Is its function conserved in species with different implantation strategies? Open
During the preimplantation period of pregnancy in eutherian mammals, transcriptional and proteomic changes in the uterine endometrium are required to facilitate receptivity to an implanting blastocyst. These changes are mediated, in part, …
View article: Protein Synthesis by Day 16 Bovine Conceptuses during the Time of Maternal Recognition of Pregnancy
Protein Synthesis by Day 16 Bovine Conceptuses during the Time of Maternal Recognition of Pregnancy Open
Interferon Tau (IFNT), the conceptus-derived pregnancy recognition signal in cattle, significantly modifies the transcriptome of the endometrium. However, the endometrium also responds to IFNT-independent conceptus-derived products. The ai…
View article: The role of CAPG in molecular communication between the embryo and the uterine endometrium: Is its function conserved in species with different implantation strategies?
The role of CAPG in molecular communication between the embryo and the uterine endometrium: Is its function conserved in species with different implantation strategies? Open
During the pre-implantation period of pregnancy in eutherian mammals, changes to the uterine endometrium are required (both at the transcriptional and protein level) to facilitate the endometrium becoming receptive to an implanting embryo.…