Huayu Tian
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View article: Interleukin-6: A Potential Biomarker for Dysmenorrhea and Disease Severity in Adenomyosis
Interleukin-6: A Potential Biomarker for Dysmenorrhea and Disease Severity in Adenomyosis Open
Background The pathogenesis of adenomyosis remains incompletely understood, and no well-established biomarkers related to its inflammatory mediators have been identified. Aim This retrospective study aimed to investigate the association be…
View article: CRCs-CAFs crosstalk-targeted nano-delivery system reprograms tumor microenvironment for oxaliplatin resistance reversing and liver metastasis inhibition in colorectal cancer
CRCs-CAFs crosstalk-targeted nano-delivery system reprograms tumor microenvironment for oxaliplatin resistance reversing and liver metastasis inhibition in colorectal cancer Open
View article: Recent advances and challenges of injectable hydrogels in drug delivery
Recent advances and challenges of injectable hydrogels in drug delivery Open
Injectable hydrogels, serving as multifunctional biomaterials, exhibit exceptional shear-thinning behavior, tunable mechanical properties, and biocompatibility, attributed to their dynamic porous network structure and biomimetic microenvir…
View article: The impact of Bifidobacterium breve BBr60 (BBr60) on metabolic and gastrointestinal health in healthy adults: A combined in vitro metabolomic and randomized, double-blind, placebo-controlled study
The impact of Bifidobacterium breve BBr60 (BBr60) on metabolic and gastrointestinal health in healthy adults: A combined in vitro metabolomic and randomized, double-blind, placebo-controlled study Open
NCT06196892 (ClinicalTrials.gov).
View article: Opportunities and Challenges of Biomaterials in Brain Disease
Opportunities and Challenges of Biomaterials in Brain Disease Open
In recent years, biomaterials have made rapid progress in the application of brain diseases. This review critically examines the latest progress of biomaterials for the diagnosis, treatment, and monitoring of brain diseases, highlighting t…
View article: Disease Landscape-Guided Design of Neutrophil-Specific Reporters for Early and Accurate Pneumonia Detection in Vivo and in Urine
Disease Landscape-Guided Design of Neutrophil-Specific Reporters for Early and Accurate Pneumonia Detection in Vivo and in Urine Open
Accurate and early detection of pneumonia is crucial for effective treatment; however, current diagnostic methods often lack the necessary specificity and sensitivity, particularly in the early stages. Herein, we begin with a comprehensive…
View article: Protective effects of Bifidobacterium longum subsp. longum BL21 against cyclophosphamide-induced reproductive dysfunction in zebrafish
Protective effects of Bifidobacterium longum subsp. longum BL21 against cyclophosphamide-induced reproductive dysfunction in zebrafish Open
This study aimed to investigate the effects of probiotic Bifidobacterium longum subsp. longum BL21 on reproductive health in zebrafish ( Danio rerio ), focusing on hormonal modulation, sperm vitality, and overall reproductive function impr…
View article: Polyoxazoline‐Based Gene Delivery System Mediated Tumor Vascular Normalization and Extracellular Matrix Degradation to Inhibit Cancer Growth, Recurrence, and Metastasis
Polyoxazoline‐Based Gene Delivery System Mediated Tumor Vascular Normalization and Extracellular Matrix Degradation to Inhibit Cancer Growth, Recurrence, and Metastasis Open
Gene therapy has brought hope for curing major diseases including cancer. However, an efficient and safe delivery system is key for successful gene therapy. In this study, PPERD (i.e., OHC‐PEG‐CHO/PEtOx 0.2 ‐PEI 0.73 ‐PRGD 0.07 /DNA), poly…
View article: Nuclear‐Targeted Material Enabled Intranuclear MicroRNA Imaging for Tracking Gene Editing Process
Nuclear‐Targeted Material Enabled Intranuclear MicroRNA Imaging for Tracking Gene Editing Process Open
Gene editing technology based on clustered regularly interspaced short palindromic repeats/associated protein (CRISPR/Cas) systems serves as an efficient tool in cancer therapy. Tracking the gene editing process can help identify the progr…
View article: Nuclear‐Targeted Material Enabled Intranuclear MicroRNA Imaging for Tracking Gene Editing Process
Nuclear‐Targeted Material Enabled Intranuclear MicroRNA Imaging for Tracking Gene Editing Process Open
Gene editing technology based on clustered regularly interspaced short palindromic repeats/associated protein (CRISPR/Cas) systems serves as an efficient tool in cancer therapy. Tracking the gene editing process can help identify the progr…
View article: Soot particles generated by n-heptane and n-heptane/OME3 in an inverse diffusion flame: A comparative analysis of physical properties and oxidative reactivity
Soot particles generated by n-heptane and n-heptane/OME3 in an inverse diffusion flame: A comparative analysis of physical properties and oxidative reactivity Open
View article: A Polymeric mRNA Vaccine Featuring Enhanced Site‐Specific mRNA Delivery and Inherent STING‐Stimulating Performance for Tumor Immunotherapy
A Polymeric mRNA Vaccine Featuring Enhanced Site‐Specific mRNA Delivery and Inherent STING‐Stimulating Performance for Tumor Immunotherapy Open
The development of mRNA delivery carriers with innate immune stimulation functions has emerged as a focal point in the field of mRNA vaccines. Nonetheless, the expression of mRNA in specific sites and innate immune stimulation at specific …
View article: Precisely Deliver Toll-Like Receptor Agonists Using a Dual-Responsive Nanovaccine for Effective Cancer Immunotherapy
Precisely Deliver Toll-Like Receptor Agonists Using a Dual-Responsive Nanovaccine for Effective Cancer Immunotherapy Open
View article: MIL-100(Fe)-Based Co-Delivery Platform as Cascade Synergistic Chemotherapy and Immunotherapy Agents for Colorectal Cancer via cGAS-STING Pathway
MIL-100(Fe)-Based Co-Delivery Platform as Cascade Synergistic Chemotherapy and Immunotherapy Agents for Colorectal Cancer via cGAS-STING Pathway Open
View article: Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing
Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing Open
View article: Metabolism of cancer cells and immune cells in the initiation, progression, and metastasis of cancer
Metabolism of cancer cells and immune cells in the initiation, progression, and metastasis of cancer Open
The metabolism of cancer and immune cells plays a crucial role in the initiation, progression, and metastasis of cancer. Cancer cells often undergo metabolic reprogramming to sustain their rapid growth and proliferation, along with meeting…
View article: An Activatable Semiconducting Nanoprobe for Early and Accurate Diagnosis of Liver Injury
An Activatable Semiconducting Nanoprobe for Early and Accurate Diagnosis of Liver Injury Open
Liver injury, caused by factors like viral hepatitis and drug overdose, poses a significant health risk, with current diagnostic methods lacking specificity, increasing the need for more precise molecular imaging techniques. Herein, we pre…
View article: Advancing cancer immunotherapy: the promise of self-photoconversion reporters for immune cell migration tracking
Advancing cancer immunotherapy: the promise of self-photoconversion reporters for immune cell migration tracking Open
Immune cell migration holds great promise for the activation and coordination of immune responses against tumors. Cells such as dendritic cells capture tumor antigens and migrate to lymph nodes (LNs), where they activate T cells. This proc…
View article: A Green and Low-Cost Preparation of Polyacrylonitrile Fibers with Imine Dioxime and Amidoxime Groups for Efficient and Selective Gold Recovery
A Green and Low-Cost Preparation of Polyacrylonitrile Fibers with Imine Dioxime and Amidoxime Groups for Efficient and Selective Gold Recovery Open
View article: Study on the Effect of Coupled Internal and External EGR on Homogeneous Charge Compression Ignition under High Pressure Rise Rate
Study on the Effect of Coupled Internal and External EGR on Homogeneous Charge Compression Ignition under High Pressure Rise Rate Open
This paper investigated the effects of exhaust gas recirculation (EGR) on homogeneous charge compression ignition (HCCI) combustion in internal combustion engines. The exhaust valve closing (EVC) timings were scanned to obtain a set of bas…
View article: Experimental Investigation on the Effects of Direct Injection Timing on the Combustion, Performance and Emission Characteristics of Methanol/Gasoline Dual-Fuel Spark Turbocharged Ignition (DFSI) Engine with Different Injection Pressures under High Load
Experimental Investigation on the Effects of Direct Injection Timing on the Combustion, Performance and Emission Characteristics of Methanol/Gasoline Dual-Fuel Spark Turbocharged Ignition (DFSI) Engine with Different Injection Pressures under High Load Open
The exceptional properties of methanol, such as its high octane number and latent heat of evaporation, make it an advantageous fuel for efficient utilization in dual-fuel combustion techniques. The aim of this study is to investigate the e…
View article: Experimental Study on Macroscopic Spray and Fuel Film Characteristics of E40 in a Constant Volume Chamber
Experimental Study on Macroscopic Spray and Fuel Film Characteristics of E40 in a Constant Volume Chamber Open
In the modern industrial field, there is a strong emphasis on energy-saving and emission reduction. Increasing the amount of ethanol in ethanol–gasoline blends has the potential to replace fossil fuel gasoline more effectively, improving e…
View article: CD47KO/CRT dual-bioengineered cell membrane-coated nanovaccine combined with anti-PD-L1 antibody for boosting tumor immunotherapy
CD47KO/CRT dual-bioengineered cell membrane-coated nanovaccine combined with anti-PD-L1 antibody for boosting tumor immunotherapy Open
Tumor vaccines trigger tumor-specific immune responses to prevent or treat tumors by activating the hosts' immune systems, and therefore, these vaccines have potential clinical applications. However, the low immunogenicity of the tumor ant…
View article: Synthesis of P-/N-Containing Bamboo-Activated Carbon toward Enhanced Thermal Stability and Flame Retardancy of Polylactic Acid
Synthesis of P-/N-Containing Bamboo-Activated Carbon toward Enhanced Thermal Stability and Flame Retardancy of Polylactic Acid Open
A P-/N-containing bamboo-activated carbon (BACm) was successfully synthesized by steam activation of bamboo charcoal and chemical grafting to as-prepared activated carbon using the reaction of phosphoric acid and urea. Characterizations of…
View article: Multifunctional drug delivery nanoparticles based on MIL-100 (Fe) for photoacoustic imaging-guided synergistic chemodynamic/chemo/photothermal breast cancer therapy
Multifunctional drug delivery nanoparticles based on MIL-100 (Fe) for photoacoustic imaging-guided synergistic chemodynamic/chemo/photothermal breast cancer therapy Open
View article: Gene-guided OX40L anchoring to tumor cells for synergetic tumor “self-killing” immunotherapy
Gene-guided OX40L anchoring to tumor cells for synergetic tumor “self-killing” immunotherapy Open
View article: Reactive oxygen species activated by mitochondria-specific camptothecin prodrug for enhanced chemotherapy
Reactive oxygen species activated by mitochondria-specific camptothecin prodrug for enhanced chemotherapy Open
Camptothecin (CPT) has attracted much attention due to its potent antitumor activities. However, the undesirable physicochemical properties, including poor water-solubility, unstable lactone ring and severe adverse effects limit its furthe…
View article: Sepsis Treatment Strategies Based on Nanomaterials<sup>※</sup>
Sepsis Treatment Strategies Based on Nanomaterials<sup>※</sup> Open
View article: CD47KO/CRT Dual-Bioengineered Cell Membrane-Coated Nanovaccine Combined with Anti-PD-L1 Antibody for Boosting Tumor Immunotherapy
CD47KO/CRT Dual-Bioengineered Cell Membrane-Coated Nanovaccine Combined with Anti-PD-L1 Antibody for Boosting Tumor Immunotherapy Open
View article: Anion Receptor-Mediated Multicomponent Synergistic Self-Assembly of Porphyrin for Efficient Phototherapy Elicit Tumor Immunotherapy
Anion Receptor-Mediated Multicomponent Synergistic Self-Assembly of Porphyrin for Efficient Phototherapy Elicit Tumor Immunotherapy Open