Haihan Song
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View article: Cross-country inequalities and trends in the global burden of COVID- 19-induced Guillain-Barré syndrome, 2020 to 2021: a population-based study
Cross-country inequalities and trends in the global burden of COVID- 19-induced Guillain-Barré syndrome, 2020 to 2021: a population-based study Open
Background: This groundbreaking study is the first to meticulously analyze the disability burden of COVID-19-induced Guillain-Barré Syndrome (GBS) in 204 countries and regions from 2020 to 2021, with a detailed breakdown by etiology, age, …
View article: Nuclear factor IA‑mediated transcriptional regulation of crystallin αB inhibits hepatocellular carcinoma progression
Nuclear factor IA‑mediated transcriptional regulation of crystallin αB inhibits hepatocellular carcinoma progression Open
Hepatocellular carcinoma (HCC) is a highly invasive malignant tumor with limited therapeutic options. In the present study, bioinformatics analysis, including differential expression analysis, functional enrichment, protein-protein interac…
View article: FCGR1A Alleviates Ischemic Stroke-induced Injury by Promoting Anti-Inflammatory Microglial Polarization via the AMPK–mTOR Signaling Pathway
FCGR1A Alleviates Ischemic Stroke-induced Injury by Promoting Anti-Inflammatory Microglial Polarization via the AMPK–mTOR Signaling Pathway Open
Background: Ischemic stroke triggers inflammatory responses that lead to neuronal damage, with microglial polarization significantly influencing post-stroke inflammation. This study explores the role of Fc gamma receptor Ia (FCGR1A) in mic…
View article: Global burden of prostate cancer: age-period-cohort analysis from 1990 to 2021 and projections until 2040
Global burden of prostate cancer: age-period-cohort analysis from 1990 to 2021 and projections until 2040 Open
View article: FBLN1 regulates ferroptosis in acute respiratory distress syndrome by reducing free ferrous iron by inhibiting the TGF-β/Smad pathway
FBLN1 regulates ferroptosis in acute respiratory distress syndrome by reducing free ferrous iron by inhibiting the TGF-β/Smad pathway Open
Background Acute respiratory distress syndrome (ARDS) / acute lung injury (ALI) is a serious medical disease characterized by pulmonary dysfunction and inflammation. This study aims to determine the main molecular modules linked to ARDS an…
View article: Hippo cooperates with p53 to regulate lung airway mucous cell metaplasia
Hippo cooperates with p53 to regulate lung airway mucous cell metaplasia Open
Airway mucous cell metaplasia is a significant feature of many chronic airway diseases, such as chronic obstructive pulmonary disease, cystic fibrosis and asthma. However, the mechanisms underlying this process remain poorly understood. He…
View article: Analysis of metastasis‑related risk factors and clinical relevance in adult soft‑tissue sarcoma
Analysis of metastasis‑related risk factors and clinical relevance in adult soft‑tissue sarcoma Open
Metastasis occurs in nearly 50% of cases of adult soft-tissue sarcoma (ASTS), leading to a dismal prognosis, with a 2-year survival rate of ~30%. Consequently, a prognostic model that incorporates metastatic characteristics may be instrume…
View article: Not a cluster of grapes, but bananas: Cord-like three-dimensional structure of cysts in ADPKD supports tubular obstruction hypothesis
Not a cluster of grapes, but bananas: Cord-like three-dimensional structure of cysts in ADPKD supports tubular obstruction hypothesis Open
We investigated the three-dimensional structure of the kidneys of mouse models of autosomal dominant polycystic kidney disease (ADPKD), a progressive genetic kidney disease and one of the leading causes of end-stage renal disease. We perfo…
View article: SPDEF drives pancreatic adenocarcinoma progression via transcriptional upregulation of <i>S100A16 </i>and activation of the PI3K/AKT signaling pathway
SPDEF drives pancreatic adenocarcinoma progression via transcriptional upregulation of <i>S100A16 </i>and activation of the PI3K/AKT signaling pathway Open
Pancreatic adenocarcinoma (PAAD) is a notably aggressive malignancy with limited treatment options and an unfavorable prognosis for patients. We aimed to investigate molecular mechanisms by which Sam's pointed domain-containing ETS transcr…
View article: Burden of renal anemia in 204 countries and territories, 1990-2021 : results from the Global Burden of Disease Study 2021
Burden of renal anemia in 204 countries and territories, 1990-2021 : results from the Global Burden of Disease Study 2021 Open
Renal anemia has inflicted a certain degree of loss on global health. However, there are no systematically analyses on the burden of renal anemia. We analyzed global prevalence and years lived with disability (YLDs) of renal anemia from 19…
View article: Metabolites of intestinal fora can be used as diagnostic and progressive markers for mild cognitive impairment
Metabolites of intestinal fora can be used as diagnostic and progressive markers for mild cognitive impairment Open
Purpose The aim of the work was to analyze the metabolites of the intestinal microbiota from the patients with mild cognitive impairment (MCI) and progressive MCI due to Alzheimer’s disease (AD). Method Two cohorts were established. The fi…
View article: Global, Regional, and National Burden of Peripheral Nervous System Malignant Tumors in 204 Countries and Territories, 1990-2021: A Systematic Analysis from the Global Burden of Disease Study 2021
Global, Regional, and National Burden of Peripheral Nervous System Malignant Tumors in 204 Countries and Territories, 1990-2021: A Systematic Analysis from the Global Burden of Disease Study 2021 Open
View article: Red Cell Distribution Width is Related to Mild Cognitive Impairment: A Cross-Sectional Study of Community Residents
Red Cell Distribution Width is Related to Mild Cognitive Impairment: A Cross-Sectional Study of Community Residents Open
Background and Objective: Previous literature has reported that red cell distribution width (RDW) correlated with Alzheimer’s disease (AD), but the correlation with mild cognitive impairment (MCI) was not clear. This study aimed to investi…
View article: Development and validation of a newly developed nomogram for predicting the risk of deep vein thrombosis after surgery for lower limb fractures in elderly patients
Development and validation of a newly developed nomogram for predicting the risk of deep vein thrombosis after surgery for lower limb fractures in elderly patients Open
Background Prevention of deep vein thrombosis (DVT) is indispensable in the treatment of lower limb fractures during the perioperative period. This study aimed to develop and validate a novel model for predicting the risk of DVT in elderly…
View article: A Novel Prognostic Signature for Combined T-cell Exhaustion and Mitochondrial Dysfunction in Hepatocellular Carcinoma
A Novel Prognostic Signature for Combined T-cell Exhaustion and Mitochondrial Dysfunction in Hepatocellular Carcinoma Open
Hepatocellular carcinoma (HCC) is a common lethal gastrointestinal cancer worldwide. Despite the involvement of T-cell exhaustion and mitochondrial dysfunction in HCC progression, there are no reliable biomarkers for these processes. In th…
View article: Oral liposomal delivery of an activatable budesonide prodrug reduces colitis in experimental mice
Oral liposomal delivery of an activatable budesonide prodrug reduces colitis in experimental mice Open
Inflammatory bowel disease (IBD) is one of the most common intestinal disorders, with increasing global incidence and prevalence. Numerous therapeutic drugs are available but require intravenous administration and are associated with high …
View article: A new immune signature for survival prediction and immune checkpoint molecules in non-small cell lung cancer
A new immune signature for survival prediction and immune checkpoint molecules in non-small cell lung cancer Open
Background Immune checkpoint blockade (ICB) therapy has brought remarkable clinical benefits to patients with advanced non-small cell lung carcinoma (NSCLC). However, the prognosis remains largely variable. Methods The profiles of immune-r…
View article: Understanding the Contribution of Lactate Metabolism in Cancer Progress: A Perspective from Isomers
Understanding the Contribution of Lactate Metabolism in Cancer Progress: A Perspective from Isomers Open
Lactate mediates multiple cell-intrinsic effects in cancer metabolism in terms of development, maintenance, and metastasis and is often correlated with poor prognosis. Its functions are undertaken as an energy source for neighboring carcin…
View article: Lactate Is Answerable for Brain Function and Treating Brain Diseases: Energy Substrates and Signal Molecule
Lactate Is Answerable for Brain Function and Treating Brain Diseases: Energy Substrates and Signal Molecule Open
Research to date has provided novel insights into lactate's positive role in multiple brain functions and several brain diseases. Although notable controversies and discrepancies remain, the neurobiological role and the metabolic mechanism…
View article: Combinatorial nanococktails via self-assembling lipid prodrugs for synergistically overcoming drug resistance and effective cancer therapy
Combinatorial nanococktails via self-assembling lipid prodrugs for synergistically overcoming drug resistance and effective cancer therapy Open
Background Combinatorial systemic chemotherapy is a powerful treatment paradigm against cancer, but it is fraught with problems due to the emergence of chemoresistance and additive systemic toxicity. In addition, coadministration of indivi…
View article: Impaired Memory B-Cell Response to Influenza Immunization in Patients With Common Variable Immunodeficiency (CVID)
Impaired Memory B-Cell Response to Influenza Immunization in Patients With Common Variable Immunodeficiency (CVID) Open
Background: Common variable immunodeficiency (CVID) is a heterogeneous primary immunodeficiency characterized by low serum antibody levels and recurrent infections. The cellular response to immunization in patients with CVID has not been f…
View article: Prediction and Identification of Power Performance Using Polygenic Models of Three Single-Nucleotide Polymorphisms in Chinese Elite Athletes
Prediction and Identification of Power Performance Using Polygenic Models of Three Single-Nucleotide Polymorphisms in Chinese Elite Athletes Open
Objective: The manuscript aims to explore the relationship between power performance and SNPs of Chinese elite athletes and to create polygenic models. Methods: One hundred three Chinese elite athletes were divided into the power group ( n…
View article: Nomogram for Predicting Bone Development State of Female Children and Adolescents–A Fast Screening Approach Based on Pubes Stages for Growth and Development
Nomogram for Predicting Bone Development State of Female Children and Adolescents–A Fast Screening Approach Based on Pubes Stages for Growth and Development Open
Objective: To develop a nomogram for predicting bone development state (BDS) of female children and adolescents in a large scale. Methods: Four hundred forty-seven female students were designated as the training cohort to develop the predi…
View article: Anlotinib suppresses MLL-rearranged acute myeloid leukemia cell growth through inhibiting SETD1A/AKT-mediated DNA damage response
Anlotinib suppresses MLL-rearranged acute myeloid leukemia cell growth through inhibiting SETD1A/AKT-mediated DNA damage response Open
Background: Leukemias driven by chromosomal translocation of the mixed-lineage leukemia gene (MLL) are highly prevalent in hematological malignancy. The poor survival rate and lack of an effective targeted therapy for patients with MLL-rea…
View article: Early Recruitment of IL-10-Producing B Cells Into Alveoli Improved the Resolution of Acute Lung Injury
Early Recruitment of IL-10-Producing B Cells Into Alveoli Improved the Resolution of Acute Lung Injury Open
Background: Acute lung injury (ALI) is characterized by rapid induction of inflammation at the alveolar-capillary membrane, and immunosuppressive mechanisms were shown to contribute to its resolution. Despite the central role of lymphocyte…
View article: Prognostic Analysis of Patients with Ebola Virus Disease
Prognostic Analysis of Patients with Ebola Virus Disease Open
These results suggest that age, chest pain, coma, confusion and viral load are associated with the prognosis of EVD, in which viral load could be one of the most important factors for the survival of the disease.