Haihua Liu
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View article: Nomogram for predicting secondary surgery in patients with concomitant exotropia
Nomogram for predicting secondary surgery in patients with concomitant exotropia Open
View article: Fluridone promotes the germination of Polygonatum cyrtonema seeds by modulating hormone signal transduction, phenylpropanoid biosynthesis, and energy metabolism
Fluridone promotes the germination of Polygonatum cyrtonema seeds by modulating hormone signal transduction, phenylpropanoid biosynthesis, and energy metabolism Open
Polygonatum cyrtonema Hua functions as a highly valued medicinal herb. However, the seeds of P. cyrtonema exhibit morphophysiological dormancy. In this study, P. cyrtonema seeds were treated with a range of fluridone concentrations (0, 50,…
View article: Metabolomics Approach Revealed Polyunsaturated Fatty Acid Disorders as Pathogenesis for Chronic Pancreatitis−Induced Osteoporosis in Mice
Metabolomics Approach Revealed Polyunsaturated Fatty Acid Disorders as Pathogenesis for Chronic Pancreatitis−Induced Osteoporosis in Mice Open
Background: Osteoporosis is frequently observed in patients with chronic pancreatitis, and both conditions are closely associated with systemic metabolic disorders. However, the underlying mechanisms linking chronic pancreatitis and osteop…
View article: Knocking Down Ferredoxin 1 Inhibits the Progression of Colorectal Cancer and Regulates Cuproptosis via Mediating the Hippo Signaling Pathway
Knocking Down Ferredoxin 1 Inhibits the Progression of Colorectal Cancer and Regulates Cuproptosis via Mediating the Hippo Signaling Pathway Open
Cuproptosis is a form of programmed cell death dependent on mitochondrial respiration and is crucial in cancer treatment. The study attempted to screen cuproptosis‐associated genes in colorectal cancer (CRC) and reveal regulatory pathways.…
View article: Observations of Negative Sprites and Halos Over a Coastal Thunderstorm in South China
Observations of Negative Sprites and Halos Over a Coastal Thunderstorm in South China Open
View article: Combining Transcriptome and Metabolome Analyses to Reveal the Response of Rheum Officinale Baill. To Smut Disease and Preliminary Exploration of Ronpr1 Gene Function
Combining Transcriptome and Metabolome Analyses to Reveal the Response of Rheum Officinale Baill. To Smut Disease and Preliminary Exploration of Ronpr1 Gene Function Open
View article: Effect of Helicobacter pylori-related chronic gastritis on gastrointestinal microorganisms and brain neurotransmitters in mice
Effect of Helicobacter pylori-related chronic gastritis on gastrointestinal microorganisms and brain neurotransmitters in mice Open
The effects of Helicobacter pylori (Hp)-related chronic gastritis on gastrointestinal microorganisms or brain neurotransmitters are not fully understood. Here, this study selected SPF C57BL/6 mice to set up a Hp-related chronic gastritis e…
View article: Comparative transcriptome analysis provides novel insights into the seed germination of Panax japonicus, an endangered species in China
Comparative transcriptome analysis provides novel insights into the seed germination of Panax japonicus, an endangered species in China Open
View article: Enhanced recovery after liver transplantation—a prospective analysis focusing on quality assessment
Enhanced recovery after liver transplantation—a prospective analysis focusing on quality assessment Open
We developed an ERAS protocol in LTx, consisting of preoperative, perioperative and postoperative management and assessed the quality using benchmarks from IQTIG. Our study revealed that the proposed ERAS approach in LTx is feasible offeri…
View article: Establishing a New Liver Transplant Unit in China—First Affiliated Hospital of the University of Science and Technology of China, Hefei, Anhui, People’s Republic of China
Establishing a New Liver Transplant Unit in China—First Affiliated Hospital of the University of Science and Technology of China, Hefei, Anhui, People’s Republic of China Open
View article: Hierarchical lncRNA regulatory network in early-onset severe preeclampsia
Hierarchical lncRNA regulatory network in early-onset severe preeclampsia Open
Our results suggest that the differential expression of lncRNAs may perturb the lncRNA-TF-DEG hierarchical regulatory network, leading to the dysregulation of many genes involved in EOSPE. Our study provides a new strategy and a valuable r…
View article: Sodium tanshinone IIA sulfonate protects vascular relaxation in ApoE-knockout mice by inhibiting the SYK-NLRP3 inflammasome-MMP2/9 pathway
Sodium tanshinone IIA sulfonate protects vascular relaxation in ApoE-knockout mice by inhibiting the SYK-NLRP3 inflammasome-MMP2/9 pathway Open
View article: Combined transcriptome and metabolome analyses reveal the effects of selenium on the growth and quality of Lilium lancifolium
Combined transcriptome and metabolome analyses reveal the effects of selenium on the growth and quality of Lilium lancifolium Open
Lilium lancifolium Thunb ( L. lancifolium ) is an important medicinal and edible plant with outstanding functionality for selenium (Se) biofortification. However, the molecular response of L. lancifolium to exogenous Se has not been fully …
View article: FGF21 overexpression alleviates VSMC senescence in diabetic mice by modulating the SYK-NLRP3 inflammasome-PPARγ-catalase pathway
FGF21 overexpression alleviates VSMC senescence in diabetic mice by modulating the SYK-NLRP3 inflammasome-PPARγ-catalase pathway Open
Diabetes accelerates vascular senescence, which is the basis for atherosclerosis and stiffness. The activation of the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome and oxidative stress are closely associated with …
View article: RETRACTED: Efficacy of Electronic Cigarettes vs Varenicline and Nicotine Chewing Gum as an Aid to Stop Smoking
RETRACTED: Efficacy of Electronic Cigarettes vs Varenicline and Nicotine Chewing Gum as an Aid to Stop Smoking Open
Importance Electronic cigarettes (ECs) are often used by smokers as an aid to stopping smoking, but evidence is limited regarding their efficacy compared with nicotine replacement therapy (NRT), and no evidence is available on how their ef…
View article: Antioxidant System and Endoplasmic Reticulum Stress in Cataracts
Antioxidant System and Endoplasmic Reticulum Stress in Cataracts Open
View article: Small extracellular vesicles-transported lncRNA TDRKH-AS1 derived from AOPPs-treated trophoblasts initiates endothelial cells pyroptosis through PDIA4/DDIT4 axis in preeclampsia
Small extracellular vesicles-transported lncRNA TDRKH-AS1 derived from AOPPs-treated trophoblasts initiates endothelial cells pyroptosis through PDIA4/DDIT4 axis in preeclampsia Open
Background Substantial studies have demonstrated that oxidative stress placenta and endothelial injury are considered to inextricably critical events in the pathogenesis of preeclampsia (PE). Systemic inflammatory response and endothelial …
View article: Pathogen detection and analysis in patients with sepsis complicated with new- onset atrial fibrillation: a retrospective observational study
Pathogen detection and analysis in patients with sepsis complicated with new- onset atrial fibrillation: a retrospective observational study Open
Background: Patients with sepsis are prone to complications such as cardiac damage and arrhythmia, of which atrial fibrillation (AF) is the most common. Previous studies have found that some pathogenic microorganisms infected by sepsis pat…
View article: Additional file 2 of Small extracellular vesicles-transported lncRNA TDRKH-AS1 derived from AOPPs-treated trophoblasts initiates endothelial cells pyroptosis through PDIA4/DDIT4 axis in preeclampsia
Additional file 2 of Small extracellular vesicles-transported lncRNA TDRKH-AS1 derived from AOPPs-treated trophoblasts initiates endothelial cells pyroptosis through PDIA4/DDIT4 axis in preeclampsia Open
Additional file 2: Table S1. Clinical Characteristics of Normal Pregnancies and Preeclamptic.
View article: Additional file 3 of Small extracellular vesicles-transported lncRNA TDRKH-AS1 derived from AOPPs-treated trophoblasts initiates endothelial cells pyroptosis through PDIA4/DDIT4 axis in preeclampsia
Additional file 3 of Small extracellular vesicles-transported lncRNA TDRKH-AS1 derived from AOPPs-treated trophoblasts initiates endothelial cells pyroptosis through PDIA4/DDIT4 axis in preeclampsia Open
Additional file 3: Table S2. Differentially expressed genes (DEGs) in sEVs derived from AOPPs-treated HTR8/SVneo cells. p value of both DESeq2 and edgeR less than 0.05 is considered to be differentially expressed genes.
View article: Additional file 6 of Small extracellular vesicles-transported lncRNA TDRKH-AS1 derived from AOPPs-treated trophoblasts initiates endothelial cells pyroptosis through PDIA4/DDIT4 axis in preeclampsia
Additional file 6 of Small extracellular vesicles-transported lncRNA TDRKH-AS1 derived from AOPPs-treated trophoblasts initiates endothelial cells pyroptosis through PDIA4/DDIT4 axis in preeclampsia Open
Additional file 6: Table S5. Enriched KEGG pathways of DEGs induced by overexpression TDRKH-AS1 in HUVECs.
View article: Additional file 4 of Small extracellular vesicles-transported lncRNA TDRKH-AS1 derived from AOPPs-treated trophoblasts initiates endothelial cells pyroptosis through PDIA4/DDIT4 axis in preeclampsia
Additional file 4 of Small extracellular vesicles-transported lncRNA TDRKH-AS1 derived from AOPPs-treated trophoblasts initiates endothelial cells pyroptosis through PDIA4/DDIT4 axis in preeclampsia Open
Additional file 4: Table S3. Enriched KEGG pathways of DEGs in sEVs derived from AOPPs-treated HTR8/SVneo cells.
View article: Additional file 8 of Small extracellular vesicles-transported lncRNA TDRKH-AS1 derived from AOPPs-treated trophoblasts initiates endothelial cells pyroptosis through PDIA4/DDIT4 axis in preeclampsia
Additional file 8 of Small extracellular vesicles-transported lncRNA TDRKH-AS1 derived from AOPPs-treated trophoblasts initiates endothelial cells pyroptosis through PDIA4/DDIT4 axis in preeclampsia Open
Additional file 8: Table S7. Proteins interacting with TDRKH-AS1 detected by Mass Spectrometry and enriched KEGG pathways.
View article: Additional file 5 of Small extracellular vesicles-transported lncRNA TDRKH-AS1 derived from AOPPs-treated trophoblasts initiates endothelial cells pyroptosis through PDIA4/DDIT4 axis in preeclampsia
Additional file 5 of Small extracellular vesicles-transported lncRNA TDRKH-AS1 derived from AOPPs-treated trophoblasts initiates endothelial cells pyroptosis through PDIA4/DDIT4 axis in preeclampsia Open
Additional file 5: Table S4. Differentially expressed genes (DEGs) induced by overexpression TDRKH-AS1 in HUVECs. p value of both DESeq2 and edgeR less than 0.05 is considered to be differentially expressed genes.
View article: Additional file 7 of Small extracellular vesicles-transported lncRNA TDRKH-AS1 derived from AOPPs-treated trophoblasts initiates endothelial cells pyroptosis through PDIA4/DDIT4 axis in preeclampsia
Additional file 7 of Small extracellular vesicles-transported lncRNA TDRKH-AS1 derived from AOPPs-treated trophoblasts initiates endothelial cells pyroptosis through PDIA4/DDIT4 axis in preeclampsia Open
Additional file 7: Table S6. Inflammatory and pyroptosis associated genes collected from Gene Ontology (GO), MSigDB and genecards databases.
View article: Effects of different doses of ropivacaine on postoperative analgesia, incidence of complications and stress factors in patients undergoing total knee arthroplasty
Effects of different doses of ropivacaine on postoperative analgesia, incidence of complications and stress factors in patients undergoing total knee arthroplasty Open
Purpose: To study the influence of various doses of ropivacaine (Ropi) on postoperative analgesia, incidence of complications and stress factors in patients undergoing total knee arthroplasty (TKA).
Methods: One hundred and fifty (150) pa…
View article: Development and Validation of a Nomogram for Predicting Second Surgery in Patients with Concomitant Esotropia
Development and Validation of a Nomogram for Predicting Second Surgery in Patients with Concomitant Esotropia Open
The proposed nomogram can serve as a predictive tool for prognostic evaluation of CE surgery.
View article: Tissue metabolomics identified new biomarkers for the diagnosis and prognosis prediction of pancreatic cancer
Tissue metabolomics identified new biomarkers for the diagnosis and prognosis prediction of pancreatic cancer Open
Pancreatic cancer (PC) is burdened with a low 5-year survival rate and high mortality due to a severe lack of early diagnosis methods and slow progress in treatment options. To improve clinical diagnosis and enhance the treatment effects, …
View article: Gastrointestinal Polyps and Tumors Detection Based on Multi-scale Feature-fusion with WCE Sequences
Gastrointestinal Polyps and Tumors Detection Based on Multi-scale Feature-fusion with WCE Sequences Open
Wireless Capsule Endoscopy(WCE) has been widely used for the screening of gastrointestinal(GI) diseases, especially the small intestine, due to its advantages of non-invasive and painless imaging of the entire digestive tract.However, the …
View article: Gut Microbiome and the Role of Metabolites in the Study of Graves’ Disease
Gut Microbiome and the Role of Metabolites in the Study of Graves’ Disease Open
Graves’ disease (GD) is an autoimmune thyroid disease (AITD), which is one of the most common organ-specific autoimmune disorders with an increasing prevalence worldwide. But the etiology of GD is still unclear. A growing number of studies…