Haihui Huang
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View article: Efficacy and Safety of Rezafungin Versus Caspofungin for the Treatment of Candidemia and Invasive Candidiasis in a China Cohort of a Double‐Blind, Randomised, Phase 3 Trial ( <scp>ReSTORE</scp> China)
Efficacy and Safety of Rezafungin Versus Caspofungin for the Treatment of Candidemia and Invasive Candidiasis in a China Cohort of a Double‐Blind, Randomised, Phase 3 Trial ( <span>ReSTORE</span> China) Open
Background The global double‐blind, randomised, Phase 3 ReSTORE trial (NCT03667690) demonstrated noninferiority of rezafungin versus caspofungin for all‐cause mortality at Day 30 and global cure at Day 14 in patients with candidemia and/or…
View article: A novel β-carboline alkaloid derivative targeting MDM2-p53 pathway suppresses colorectal cancer progression
A novel β-carboline alkaloid derivative targeting MDM2-p53 pathway suppresses colorectal cancer progression Open
Z-7 is a promising candidate for CRC therapy, particularly in patients with functional p53 and elevated MDM2, warranting further clinical evaluation.
View article: Rezafungin Versus Caspofungin for the Treatment of Candidemia and Invasive Candidiasis: Results from the Double-blind, Randomized, Phase 3 ReSTORE Trial Including the China Extension Study
Rezafungin Versus Caspofungin for the Treatment of Candidemia and Invasive Candidiasis: Results from the Double-blind, Randomized, Phase 3 ReSTORE Trial Including the China Extension Study Open
Background Rezafungin is approved for use in adults with candidemia and/or invasive candidiasis (IC) based on data from the ReSTORE trial (NCT03667690), which demonstrated noninferior efficacy to caspofungin. For regulatory purposes, an ad…
View article: Bioinformatics analysis and preliminary validation of autophagy-related genes in asthma disease
Bioinformatics analysis and preliminary validation of autophagy-related genes in asthma disease Open
View article: Trends and hotspots in autoimmune hepatitis research: based on bibliometric analysis
Trends and hotspots in autoimmune hepatitis research: based on bibliometric analysis Open
Background Autoimmune Hepatitis (AIH) is a chronic inflammatory liver disease characterized by a sustained inflammatory response in the liver, usually associated with abnormalities in the immune system.The purpose of this study was to util…
View article: Bacteriophage therapy: a possible alternative therapy against antibiotic-resistant strains of Klebsiella pneumoniae
Bacteriophage therapy: a possible alternative therapy against antibiotic-resistant strains of Klebsiella pneumoniae Open
Klebsiella pneumoniae is a notorious, Gram-negative pathogen and is a leading cause of healthcare settings and community-acquired infections. This is the commensal of human microbiota and can invade and cause infections in different body p…
View article: Effectiveness and safety of ceftazidime-avibactam in Chinese patients with hospital-acquired pneumonia, including ventilator-associated pneumonia: A Phase 4, multi-centre, open-label study
Effectiveness and safety of ceftazidime-avibactam in Chinese patients with hospital-acquired pneumonia, including ventilator-associated pneumonia: A Phase 4, multi-centre, open-label study Open
View article: Underlying mechanisms and treatment of acetaminophen‑induced liver injury (Review)
Underlying mechanisms and treatment of acetaminophen‑induced liver injury (Review) Open
Acetaminophen (APAP) is safe at therapeutic doses; however, when ingested in excess, it accumulates in the liver and leads to severe hepatotoxicity, which in turn may trigger acute liver failure (ALF). This is known as APAP poisoning and i…
View article: The Art of Retention: Advancing Sustainable Management Through Age-Diverse Turnover Modeling
The Art of Retention: Advancing Sustainable Management Through Age-Diverse Turnover Modeling Open
In the diverse modern workforce, understanding employee turnover across different age groups is critical for effective human resource management. Existing research often treats employees as a homogeneous group, potentially overlooking nuan…
View article: Research on the innovation of early warning mechanisms of major public health emergencies for poverty alleviation and marginal populations: a case study of Fujian Province
Research on the innovation of early warning mechanisms of major public health emergencies for poverty alleviation and marginal populations: a case study of Fujian Province Open
Poverty alleviation is critical for sustainable development. Establishing a major public health emergency warning and prevention mechanism for poverty alleviation and marginal populations can effectively determine the overall risk situatio…
View article: Comparison of efficacy and safety of different suction pressure for speeding non-ventilated lung collapse in uniport video-assisted thoracoscopic surgery: a randomized-controlled trial
Comparison of efficacy and safety of different suction pressure for speeding non-ventilated lung collapse in uniport video-assisted thoracoscopic surgery: a randomized-controlled trial Open
Chinese Clinical Trial Registry number, ChiCTR2200062991. Registered on 26/08/2022.
View article: Consensus for antifungal stewardship in China (2024 edition)
Consensus for antifungal stewardship in China (2024 edition) Open
This consensus is the first to propose a set of AFS metrics suitable for China, which helps to establish AFS standards in China and is also the first AFS consensus in Asia, and may improve the standard of clinical diagnosis and treatment o…
View article: Short Text Classification Model based on Pre-trained Language Model with Feature Fusion
Short Text Classification Model based on Pre-trained Language Model with Feature Fusion Open
In response to the low accuracy of Chinese short text classification in the current data mining field and the defects of existing deep learning models with more model parameters and higher time complexity, this paper proposes a new text cl…
View article: ALOX5AP is a new prognostic indicator in acute myeloid leukemia
ALOX5AP is a new prognostic indicator in acute myeloid leukemia Open
View article: Editorial: Integrative analysis for complex disease biomarker discovery
Editorial: Integrative analysis for complex disease biomarker discovery Open
EDITORIAL article Front. Bioeng. Biotechnol., 21 August 2023Sec. Preclinical Cell and Gene Therapy Volume 11 - 2023 | https://doi.org/10.3389/fbioe.2023.1273084
View article: Enhancement of β-Lactam-Mediated Killing of Gram-Negative Bacteria by Lysine Hydrochloride
Enhancement of β-Lactam-Mediated Killing of Gram-Negative Bacteria by Lysine Hydrochloride Open
Antibiotic resistance among Gram-negative pathogens is a serious medical problem. The present work describes a new study in which a nontoxic nutrient increases the lethal action of clinically important β-lactams.
View article: FlowMap: Path Generation for Automated Vehicles in Open Space Using Traffic Flow
FlowMap: Path Generation for Automated Vehicles in Open Space Using Traffic Flow Open
There is extensive literature on perceiving road structures by fusing various sensor inputs such as lidar point clouds and camera images using deep neural nets. Leveraging the latest advance of neural architects (such as transformers) and …
View article: ALOX5AP is a new prognostic indicator in acute myeloid leukemia
ALOX5AP is a new prognostic indicator in acute myeloid leukemia Open
Background To identify the expression and methylation patterns of ALOX5AP in bone marrow (BM) samples of acute myeloid leukemia (AML) patients, and further explore its clinical significance. Methods Eighty-two de novo AML patients and 20 h…
View article: BEST: A blockchain sharding scheme based on nodes performance for enhancing both security and effiency
BEST: A blockchain sharding scheme based on nodes performance for enhancing both security and effiency Open
Sharding technology is seen as the most likely solution to the scalability of blockchain, by dividing nodes into smaller groups called shards that transactions can be processed in parallel. However, most sharding scheme adopted random shar…
View article: Safety of oral nemonoxacin: A systematic review of clinical trials and postmarketing surveillance
Safety of oral nemonoxacin: A systematic review of clinical trials and postmarketing surveillance Open
Background: Postmarketing safety analysis is an effective supplement for new drugs in clinical practice. Therefore, we aimed to systematically assess the safety of oral nemonoxacin malate, the first approved C-8-methoxy non-fluorinated qui…
View article: Development of a risk prediction model for bloodstream infection in patients with fever of unknown origin
Development of a risk prediction model for bloodstream infection in patients with fever of unknown origin Open
View article: Rezafungin versus caspofungin for treatment of candidaemia and invasive candidiasis (ReSTORE): a multicentre, double-blind, double-dummy, randomised phase 3 trial
Rezafungin versus caspofungin for treatment of candidaemia and invasive candidiasis (ReSTORE): a multicentre, double-blind, double-dummy, randomised phase 3 trial Open
View article: A novel meta-analysis based on data augmentation and elastic data shared lasso regularization for gene expression
A novel meta-analysis based on data augmentation and elastic data shared lasso regularization for gene expression Open
Background Gene expression analysis can provide useful information for analyzing complex biological mechanisms. However, many reported findings are unrepeatable due to small sample sizes relative to a large number of genes and the low sign…
View article: Clinical Pharmacology and Utility of Contezolid in Chinese Patients with Complicated Skin and Soft-Tissue Infections
Clinical Pharmacology and Utility of Contezolid in Chinese Patients with Complicated Skin and Soft-Tissue Infections Open
This study aimed to build a population pharmacokinetic (PopPK) model for contezolid tablet (MRX-I) in healthy subjects and adults with complicated skin and soft-tissue infections (cSSTIs) to further evaluate the efficacy and safety of cont…
View article: Erratum to: Integrating molecular interactions and gene expression to identify biomarkers to predict response to tumor necrosis factor inhibitor therapies in rheumatoid arthritis patients
Erratum to: Integrating molecular interactions and gene expression to identify biomarkers to predict response to tumor necrosis factor inhibitor therapies in rheumatoid arthritis patients Open
Integrating molecular interactions and gene expression to identify biomarkers to predict response to tumor necrosis factor inhibitor
View article: Integrating molecular interactions and gene expression to identify biomarkers to predict response to tumor necrosis factor inhibitor therapies in rheumatoid arthritis patients1
Integrating molecular interactions and gene expression to identify biomarkers to predict response to tumor necrosis factor inhibitor therapies in rheumatoid arthritis patients1 Open
BACKGROUND: Targeted therapy using anti-TNF (tumor necrosis factor) is the first option for patients with rheumatoid arthritis (RA). Anti-TNF therapy, however, does not lead to meaningful clinical improvement in many RA patients. To predic…
View article: A global perspective on improving patient care in uncomplicated urinary tract infection: expert consensus and practical guidance
A global perspective on improving patient care in uncomplicated urinary tract infection: expert consensus and practical guidance Open
Management of uUTIs in female patients can be improved without increasing complexity, including simplified diagnosis and empirical antimicrobial prescribing based on patient characteristics, including a review of recent antimicrobial use a…
View article: A <i>Post Hoc</i> Analysis of Two Phase III Trials Showing the Efficacy and Tolerability of Ceftobiprole in East Asian Patients
A <i>Post Hoc</i> Analysis of Two Phase III Trials Showing the Efficacy and Tolerability of Ceftobiprole in East Asian Patients Open
Aim: To evaluate the efficacy and safety of ceftobiprole in patients from East Asia. Materials & methods: A post hoc analysis was conducted of two randomized, double-blind, Phase III studies in patients with community-…
View article: Defense of COVID-19 by Human Organoids
Defense of COVID-19 by Human Organoids Open
View article: Issue Information
Issue Information Open
explores several fascinating editorials written by today's experts in the fi eld.Because new developments are being introduced each day, there's much to be learned-examination, analysis creation, information retrieval, man-computer interac…