Hanqing Hu
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View article: MRI‐Derived Lymph Nodes Morphological and Topological Structure (LNs‐MTS) Model for Evaluating Immune Status and Prognosis in Rectal Cancer
MRI‐Derived Lymph Nodes Morphological and Topological Structure (LNs‐MTS) Model for Evaluating Immune Status and Prognosis in Rectal Cancer Open
Tumor‐draining lymph nodes (LNs) immune status critically influences cancer progression and treatment response, yet reliable non‐invasive assessment remains clinically unavailable. To address this critical gap, an MRI‐derived LNs morpholog…
View article: Effective Identification of Variety and Origin of Chenpi Using Hyperspectral Imaging Assisted with Chemometric Models
Effective Identification of Variety and Origin of Chenpi Using Hyperspectral Imaging Assisted with Chemometric Models Open
Geographical origins and varietal characteristics can significantly affect the quality of Citri Reticulatae Pericarpium (Chenpi), making rapid and accurate identification essential for consumer protection. To overcome the inefficiency and …
View article: In‐Depth Analysis of the Necessity and Optimization Strategies for Adjuvant Radiotherapy Following Neoadjuvant Immunotherapy in the New Era of Esophageal Cancer Treatment
In‐Depth Analysis of the Necessity and Optimization Strategies for Adjuvant Radiotherapy Following Neoadjuvant Immunotherapy in the New Era of Esophageal Cancer Treatment Open
As immunotherapy rises to prominence in cancer treatment, the therapeutic approach to esophageal cancer is undergoing significant transformations. This review emphasizes the necessity and optimization pathways for adjuvant postoperative ra…
View article: Short-term outcomes of KangDuo surgical robot- versus Da Vinci surgical robot-assisted radical resection of colorectal cancer: a prospective cohort study
Short-term outcomes of KangDuo surgical robot- versus Da Vinci surgical robot-assisted radical resection of colorectal cancer: a prospective cohort study Open
The study was registered at www.chictr.org.cn (Registration number: ChiCTR2200063172, Data of Registration: 2022-09-01).
View article: Lysosomes’ fallback strategies: more than just survival or death
Lysosomes’ fallback strategies: more than just survival or death Open
Lysosomes are heterogeneous, acidic organelles whose proper functionality is critically dependent on maintaining the integrity of their membranes and the acidity within their lumen. When subjected to stress, the lysosomal membrane can beco…
View article: Construction and Bioinformatics Analysis of the miRNA-mRNA Regulatory Network in Liver regeneration in rats
Construction and Bioinformatics Analysis of the miRNA-mRNA Regulatory Network in Liver regeneration in rats Open
Background: Hepatocellular carcinoma (HCC) is one of the most common and aggressive malignant tumors. Partial hepatectomy (PHx) is currently the primary treatment for HCC, but many patients suffer from poor liver reserve function and insuf…
View article: Genome-wide discovery of circulating cell-free DNA methylation biomarkers for colorectal cancer detection
Genome-wide discovery of circulating cell-free DNA methylation biomarkers for colorectal cancer detection Open
Background Colorectal polyp is known a precursor of colorectal cancer (CRC) that holds an increased risk for progression to CRC. Circulating cell-free DNA (cfDNA) methylation has shown favorable performance in the detection and monitoring …
View article: Construction of a prognostic nomogram for early-onset colorectal cancer patients ： a population-based study in the SEER database and China
Construction of a prognostic nomogram for early-onset colorectal cancer patients ： a population-based study in the SEER database and China Open
Background The prognosis of early-onset colorectal cancer (EOCRC) remains largely constrained by clinical heterogeneity. The aim of this paper was to construct a targeted prognostic nomogram combining multi-indicator to individually predic…
View article: DEF6 has potential to be a biomarker for cancer prognosis: A pan-cancer analysis
DEF6 has potential to be a biomarker for cancer prognosis: A pan-cancer analysis Open
Introduction DEF6 is a gene associated with the immune system and is thought to play a crucial role in autoimmunity. There are few DEF6 -related studies in cancer, and it is assumed that DEF6 is a proto-oncogene. There is currently no pan-…
View article: Additional file 2 of Genome-wide discovery of circulating cell-free DNA methylation biomarkers for colorectal cancer detection
Additional file 2 of Genome-wide discovery of circulating cell-free DNA methylation biomarkers for colorectal cancer detection Open
Additional file 2. Supplementary Table S2 The sequence information on 47 CpGs in the range of 25bp upstream and downstream.
View article: Additional file 3 of Genome-wide discovery of circulating cell-free DNA methylation biomarkers for colorectal cancer detection
Additional file 3 of Genome-wide discovery of circulating cell-free DNA methylation biomarkers for colorectal cancer detection Open
Additional file 3. Supplementary Table S3 The processed tissue MethylTarget sequencing data.
View article: Additional file 4 of Genome-wide discovery of circulating cell-free DNA methylation biomarkers for colorectal cancer detection
Additional file 4 of Genome-wide discovery of circulating cell-free DNA methylation biomarkers for colorectal cancer detection Open
Additional file 4. Supplementary Table S4 The processed cfDNA MethylTarget sequencing data.
View article: Fusobacterium nucleatum and colorectal cancer: From phenomenon to mechanism
Fusobacterium nucleatum and colorectal cancer: From phenomenon to mechanism Open
Colorectal cancer(CRC) is the third most frequent malignant tumor. The gut microbiome acts as a vital component of CRC etiology. Fusobacterium nucleatum(Fn) is a key member of colorectal cancer-associated bacteria. But we lack a systematic…
View article: Gut microbiota display alternative profiles in patients with early-onset colorectal cancer
Gut microbiota display alternative profiles in patients with early-onset colorectal cancer Open
Background The incidence of early-onset colorectal cancer (EOCRC) is increasing worldwide. This study aimed to explore whether there is an alternative gut microbiota profile in patients with early-onset colorectal cancer. Methods A total o…
View article: Application of the Xi robotic platform for familial adenomatous polyposis with ultra-low rectal cancer: exploration of minimally invasive and refined therapies
Application of the Xi robotic platform for familial adenomatous polyposis with ultra-low rectal cancer: exploration of minimally invasive and refined therapies Open
When a Familial adenomatous polyposis (FAP) patient's rectal polyp undergoes malignant transformation, the surgeon needs to consider how to balance the quality of surgery with the patient's quality of life. Here we present a case of roboti…
View article: A Preoperative Scoring System to Predict the Risk of Inadequate Lymph Node Count in Rectal Cancer
A Preoperative Scoring System to Predict the Risk of Inadequate Lymph Node Count in Rectal Cancer Open
Purpose The aim of this study was to develop and validate a preoperative scoring system to stratify rectal cancer (RC) patients with different risks of inadequate lymph node examination. Methods A total of 1,375 stage I–III RC patients bet…
View article: Key Role of Heat Shock Protein Expression Induced by Ampicillin in Citrus Defense against Huanglongbing: A Transcriptomics Study
Key Role of Heat Shock Protein Expression Induced by Ampicillin in Citrus Defense against Huanglongbing: A Transcriptomics Study Open
Citrus Huanglongbing (HLB) is a serious disease for the citrus industry. Earlier studies showed that ampicillin (Amp) can reduce titers of the pathogen which causes HLB and the bacteria Candidatus Liberibacter asiaticus (CLas) in HLB-affec…
View article: Substrate pH Influences the Nutrient Absorption and Rhizosphere Microbiome of Huanglongbing-Affected Grapefruit Plants
Substrate pH Influences the Nutrient Absorption and Rhizosphere Microbiome of Huanglongbing-Affected Grapefruit Plants Open
The substrate pH directly affects nutrient availability in the rhizosphere and nutrient uptake by plants. Macronutrients such as nitrogen, potassium, calcium, magnesium, and sulfur are highly available at pH 6.0–6.5, while micronutrients b…
View article: Nomogram to Predict the Risk of Postoperative Anxiety and Depression in Colorectal Cancer Patients
Nomogram to Predict the Risk of Postoperative Anxiety and Depression in Colorectal Cancer Patients Open
The current study constructed the risk nomogram for postoperative anxiety and depression and could help clinicians determine high-risk patients to some extent.
View article: Effects of β-carotene on glucose metabolism dysfunction in human subjects and type 2 diabetic rats
Effects of β-carotene on glucose metabolism dysfunction in human subjects and type 2 diabetic rats Open
Deep Science is an innovative and digital platform for publishing articles with the features: Preprint + Open Peer Review, which improves the transparency of peer review. In addition, Deep Science also adopts a scoring system to help reade…
View article: How Best to Play the Role of Tumor Deposits in Stage III Colon Cancer?
How Best to Play the Role of Tumor Deposits in Stage III Colon Cancer? Open
Background The purpose of this study is to comprehensively evaluate the prognostic role of tumor deposits (TD) in stage III colon cancer. Methods 24,600 CC patients with III stage colon cancer were collected from the Surveillance, Epidemio…
View article: Exploration of a Modified Stage for pN0 Colon Cancer Patients
Exploration of a Modified Stage for pN0 Colon Cancer Patients Open
Purpose: Exploring a modified stage (mStage) for pN0 colon cancer patients. Methods: 39637 pN0 colon cancer patients were collected from the SEER database (2010-2015) (development cohort) and 455 pN0 colon cancer patients from the Second A…
View article: Nomogram for Predicting Occurrence of Synchronous Liver Metastasis in Colorectal Cancer: A Single-center Retrospective Study Based on Pathological Factors
Nomogram for Predicting Occurrence of Synchronous Liver Metastasis in Colorectal Cancer: A Single-center Retrospective Study Based on Pathological Factors Open
PurposeThe purpose of this study was to explore the risk factors for liver metastasis (LM) of colorectal cancer (CRC) and to construct a nomogram for predicting the occurrence of synchronous LM based on baseline and pathological informatio…
View article: Nomogram to Predict the Occurrence and Prognosis of Distant Metastasis in T1N0 Colon Cancer: A SEER Data-Based Study
Nomogram to Predict the Occurrence and Prognosis of Distant Metastasis in T1N0 Colon Cancer: A SEER Data-Based Study Open
The population-based nomogram could help clinicians predict the occurrence and prognosis of DM in T1N0 CC patients and provide a reference to perform appropriate metastatic screening plans and rational therapeutic options for the special p…
View article: Transarterial Chemoembolization Combined With Radiofrequency Ablation Versus Repeat Hepatectomy for Recurrent Hepatocellular Carcinoma After Curative Resection: A 10-Year Single-Center Comparative Study
Transarterial Chemoembolization Combined With Radiofrequency Ablation Versus Repeat Hepatectomy for Recurrent Hepatocellular Carcinoma After Curative Resection: A 10-Year Single-Center Comparative Study Open
Background The purpose of this study was to compare the efficacy and safety of transarterial chemoembolization (TACE) in combination with radiofrequency ablation (RFA) (TACE-RFA) and repeat hepatectomy in the treatment of recurrent hepatoc…
View article: Role of Phenotypes of Circulating Tumor Cells in the Diagnosis and Treatment of Colorectal Cancer
Role of Phenotypes of Circulating Tumor Cells in the Diagnosis and Treatment of Colorectal Cancer Open
The positive rate of M-CTCs was associated with tumor size, T stage, TNM stage, vascular invasion, and CEA. As the disease progressed, the proportion of M-CTCs gradually increased, and the survival performance was worse in patients with a …
View article: Nomogram to Predict the Risk of Postoperative Anxiety and Depression in Colorectal Cancer Patients
Nomogram to Predict the Risk of Postoperative Anxiety and Depression in Colorectal Cancer Patients Open
To develop and validate the risk nomogram to predict the likelihood of postoperative anxiety and depression in colorectal cancer (CRC) patients. A total of 602 CRC patients from the Second Affiliated Hospital of Harbin Medical University w…
View article: Genomic Analysis Reveals Heterogeneity Between Lesions in Synchronous Primary Right-Sided and Left-Sided Colon Cancer
Genomic Analysis Reveals Heterogeneity Between Lesions in Synchronous Primary Right-Sided and Left-Sided Colon Cancer Open
Background: The synchronous primary right-sided and left-sided colon cancer (sRL-CC) is a peculiar subtype of colorectal cancer. However, the genomic landscape of sRL-CC remains elusive. Methods: Twenty-eight paired tumor samples and their…