Hongcui Cao
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View article: Prolonged resuscitation and systemic management of multi-organ dysfunction in a neonate with severe asphyxia: a case report
Prolonged resuscitation and systemic management of multi-organ dysfunction in a neonate with severe asphyxia: a case report Open
Severe neonatal asphyxia can lead to multiple organ dysfunction syndrome (MODS) and increase mortality and disability risks. This case report describes the successful resuscitation and management of a neonate who experienced 15 min of seve…
View article: Dynamic Analysis of a Nonlocal and Delayed Reaction-Diffusion Zika Virus Model with Spatial Heterogeneity
Dynamic Analysis of a Nonlocal and Delayed Reaction-Diffusion Zika Virus Model with Spatial Heterogeneity Open
View article: Mesenchymal stem cell-derived extracellular vesicles attenuate periductal fibrosis by inhibiting Th17 differentiation in human liver multilineage organoids and Mdr2−/− mice
Mesenchymal stem cell-derived extracellular vesicles attenuate periductal fibrosis by inhibiting Th17 differentiation in human liver multilineage organoids and Mdr2−/− mice Open
View article: Human placenta mesenchymal stromal cells alleviate intestinal inflammation and repair intestinal barrier function by activating AMPK-FXR pathway
Human placenta mesenchymal stromal cells alleviate intestinal inflammation and repair intestinal barrier function by activating AMPK-FXR pathway Open
Crohn's disease (CD) has a complex pathogenesis; there is currently no effective treatment. Mesenchymal stromal cells (MSCs) are a potential therapeutic option for CD. It is important to systematically evaluate the safety and effectiveness…
View article: Association between early antibiotic treatment after admission and mortality of acute-on-chronic liver failure patients with bacterial infection: A multicenter retrospective study
Association between early antibiotic treatment after admission and mortality of acute-on-chronic liver failure patients with bacterial infection: A multicenter retrospective study Open
Bacterial infection is a significant risk factor in the onset and development of acute-on-chronic liver failure (ACLF). Although early broad-spectrum antibiotic treatment is recommended, the optimal time to initiate antibiotic therapy rema…
View article: Standardized Sample Acquisition for Microbiome Profiling in Large-Scale Experiments (S-SAMPLE): An Initiative
Standardized Sample Acquisition for Microbiome Profiling in Large-Scale Experiments (S-SAMPLE): An Initiative Open
View article: Relationship Between Nucleos(t)ide analogue antiviral response time and prognosis in Chronic Hepatitis B: conclusions depend on baseline viral load and HBeAg status
Relationship Between Nucleos(t)ide analogue antiviral response time and prognosis in Chronic Hepatitis B: conclusions depend on baseline viral load and HBeAg status Open
Introduction Current guidelines for changing antiviral therapy regimens do not consider different baseline statuses. This study aimed to investigate whether significant prognostic differences exist among patients achieving virological resp…
View article: Ginsenoside Rg1 exerts anti-arrhythmic effect by inhibiting I <sub>CaL</sub> through cAMP-PKA and PI3K-AKT signaling pathways in rat ventricular myocytes after myocardial ischemia-reperfusion injury
Ginsenoside Rg1 exerts anti-arrhythmic effect by inhibiting I <sub>CaL</sub> through cAMP-PKA and PI3K-AKT signaling pathways in rat ventricular myocytes after myocardial ischemia-reperfusion injury Open
Objective Ginsenoside Rg1 has demonstrated beneficial effects in myocardial ischemia-reperfusion (I/R) injury. However, its potential anti-arrhythmic role in ventricular arrhythmias remains unclear. Methods In this study, a whole-cell patc…
View article: The association between ten anthropometric measures and osteoporosis and osteopenia among postmenopausal women
The association between ten anthropometric measures and osteoporosis and osteopenia among postmenopausal women Open
View article: Spatiotemporal distribution patterns of the two ecotypes of Coilia nasus in the middle-lower Yangtze River, China
Spatiotemporal distribution patterns of the two ecotypes of Coilia nasus in the middle-lower Yangtze River, China Open
Introduction Different ecotypes exhibit distinct life histories and occupy various environmental conditions for local adaptation. Coilia nasus , an anadromous fish, resides in offshore waters of the Pacific Northwest and reproduces in conn…
View article: The association between eight complete blood count-derived inflammatory markers and muscle health
The association between eight complete blood count-derived inflammatory markers and muscle health Open
Background Most studies have evaluated sarcopenia and muscle health solely based on muscle mass. This study comprehensively examined the associations between eight inflammatory indicators and muscle mass and strength, with the aim of ident…
View article: Optimizing Multi-Dimensional SCADA Report Generation Using LSO-GAN for Web-Based Applications
Optimizing Multi-Dimensional SCADA Report Generation Using LSO-GAN for Web-Based Applications Open
View article: Editorial: Assessing the Prognosis of Patients With <scp>HBV</scp> and <scp>ACLF</scp>—Comorbidities Matter. Authors' Reply
Editorial: Assessing the Prognosis of Patients With <span>HBV</span> and <span>ACLF</span>—Comorbidities Matter. Authors' Reply Open
View article: Contribution of fracture healing in paediatric DMP zone fracture patients using the pry lever technique
Contribution of fracture healing in paediatric DMP zone fracture patients using the pry lever technique Open
Background This study describes the efficacy of applying the prying lever technique to distal radial metaphyseal symphysis diaphysis joining region (DMP) fractures in children, and reports that the technique has an ameliorative effect on t…
View article: <scp>aCCI</scp>‐<scp>HBV</scp>‐<scp>ACLF</scp>: A Novel Predictive Model for Hepatitis B Virus‐Related Acute‐On‐Chronic Liver Failure
<span>aCCI</span>‐<span>HBV</span>‐<span>ACLF</span>: A Novel Predictive Model for Hepatitis B Virus‐Related Acute‐On‐Chronic Liver Failure Open
Background Early identification of hepatitis B virus‐related acute‐on‐chronic liver failure (HBV‐ACLF) holds crucial importance in guiding clinical management and reducing mortality. However, existing scoring systems often overlook patient…
View article: Tail index estimation for tail adversarial stable time series with an application to high‐dimensional tail clustering
Tail index estimation for tail adversarial stable time series with an application to high‐dimensional tail clustering Open
For stationary time series with regularly varying marginal distributions, an important problem is to estimate the associated tail index which characterizes the power‐law behavior of the tail distribution. For this, various results have bee…
View article: MIR194-2HG, a miRNA host gene activated by HNF4A, inhibits gastric cancer by regulating microRNA biogenesis
MIR194-2HG, a miRNA host gene activated by HNF4A, inhibits gastric cancer by regulating microRNA biogenesis Open
The dysregulated MIR194-2HG/BTF3L4 axis is responsible for GC progression. Targeting HNF4A to inhibit miR-192/194 expression may be a promising strategy for overcoming GC.
View article: Serum metabonomics reveal the effectiveness of human placental mesenchymal stem cell therapy for primary sclerosing cholangitis
Serum metabonomics reveal the effectiveness of human placental mesenchymal stem cell therapy for primary sclerosing cholangitis Open
View article: Organoids: development and applications in disease models, drug discovery, precision medicine, and regenerative medicine
Organoids: development and applications in disease models, drug discovery, precision medicine, and regenerative medicine Open
Organoids are miniature, highly accurate representations of organs that capture the structure and unique functions of specific organs. Although the field of organoids has experienced exponential growth, driven by advances in artificial int…
View article: ROS-responsive nanoparticle delivery of obeticholic acid mitigate primary sclerosing cholangitis
ROS-responsive nanoparticle delivery of obeticholic acid mitigate primary sclerosing cholangitis Open
Primary sclerosing cholangitis (PSC) is a challenging cholestatic liver disease marked by progressive bile duct inflammation and fibrosis that has no FDA-approved therapy. Although obeticholic acid (OCA) has been sanctioned for PSC, its cl…
View article: The use of matrine to inhibit osteosarcoma cell proliferation via the regulation of the MAPK/ERK signaling pathway
The use of matrine to inhibit osteosarcoma cell proliferation via the regulation of the MAPK/ERK signaling pathway Open
Background Matrine is an alkaloid extracted from Sophorus beans of the legume family, and it has significant effects and a variety of pharmacological activities. Osteosarcoma(OS) is a common malignant bone tumor that is characterized by hi…
View article: Human Hepatobiliary Organoids: Recent Advances in Drug Toxicity Verification and Drug Screening
Human Hepatobiliary Organoids: Recent Advances in Drug Toxicity Verification and Drug Screening Open
Many drug and therapeutic modalities have emerged over the past few years. However, successful commercialization is dependent on their safety and efficacy evaluations. Several preclinical models are available for drug-screening and safety …
View article: Serum metabolomics reveals the effectiveness of human placental mesenchymal stem cell therapy for Crohn's disease
Serum metabolomics reveals the effectiveness of human placental mesenchymal stem cell therapy for Crohn's disease Open
Mesenchymal stem cell (MSC) therapy offers a promising cure for Crohn's disease (CD), however, its therapeutic effects vary significantly due to individual differences. Therefore, identifying easily detectable biomarkers is essential to as…
View article: Vedolizumab for the prevention of intestinal acute GVHD after allogeneic hematopoietic stem cell transplantation: a randomized phase 3 trial
Vedolizumab for the prevention of intestinal acute GVHD after allogeneic hematopoietic stem cell transplantation: a randomized phase 3 trial Open
View article: Mesenchymal stem cells alleviate mouse liver fibrosis by inhibiting pathogenic function of intrahepatic B cells
Mesenchymal stem cells alleviate mouse liver fibrosis by inhibiting pathogenic function of intrahepatic B cells Open
Background and Aims: The immunomodulatory characteristics of mesenchymal stem cells (MSCs) make them a promising therapeutic approach for liver fibrosis (LF). Here, we postulated that MSCs could potentially suppress the pro-fibrotic activi…
View article: Hippocampal HDAC6 promotes POCD by regulating NLRP3-induced microglia pyroptosis via HSP90/HSP70 in aged mice
Hippocampal HDAC6 promotes POCD by regulating NLRP3-induced microglia pyroptosis via HSP90/HSP70 in aged mice Open
Our findings suggest that hippocampal HDAC6 promotes POCD by regulating NLRP3-induced microglia pyroptosis via HSP90/HSP70 in aged mice.
View article: MSCs alleviate LPS-induced acute lung injury by inhibiting the proinflammatory function of macrophages in mouse lung organoid–macrophage model
MSCs alleviate LPS-induced acute lung injury by inhibiting the proinflammatory function of macrophages in mouse lung organoid–macrophage model Open
Acute lung injury (ALI) is an inflammatory disease associated with alveolar injury, subsequent macrophage activation, inflammatory cell infiltration, and cytokine production. Mesenchymal stem cells (MSCs) are beneficial for application in …
View article: Corrigendum to “A novel HIF2A mutation causes dyslipidemia and promotes hepatic lipid accumulation” [Pharmacol. Res. 194 (2023) 106851]
Corrigendum to “A novel HIF2A mutation causes dyslipidemia and promotes hepatic lipid accumulation” [Pharmacol. Res. 194 (2023) 106851] Open
View article: MSC-derived exosomes attenuate hepatic fibrosis in primary sclerosing cholangitis through inhibition of Th17 differentiation
MSC-derived exosomes attenuate hepatic fibrosis in primary sclerosing cholangitis through inhibition of Th17 differentiation Open
View article: Mesenchymal stem cells shift the pro-inflammatory phenotype of neutrophils to ameliorate acute lung injury
Mesenchymal stem cells shift the pro-inflammatory phenotype of neutrophils to ameliorate acute lung injury Open
Background Mesenchymal stem cell (MSC) treatment plays a major role in the management of acute lung injury (ALI), and neutrophils are the initial line of defense against ALI. However, the effect of MSCs on neutrophils in ALI remains mostly…