Hailey S. Butman
YOU?
Author Swipe
View article: Metabolic Activation versus Masked Prodrugs: Bisubstrate Mimic Inhibitors of CoaBC’s PPCS Activity in <i>Mycobacterium tuberculosis</i> and <i>Staphylococcus aureus</i>
Metabolic Activation versus Masked Prodrugs: Bisubstrate Mimic Inhibitors of CoaBC’s PPCS Activity in <i>Mycobacterium tuberculosis</i> and <i>Staphylococcus aureus</i> Open
The bifunctional bacterial CoaBC is a coenzyme A (CoA) biosynthetic protein that serves as a validated bactericidal target in Mycobacterium tuberculosis (Mtb). In Staphylococcus aureus, it is the target of the natural product…
View article: Phenyl urea based adjuvants for β-lactam antibiotics against methicillin resistant Staphylococcus aureus
Phenyl urea based adjuvants for β-lactam antibiotics against methicillin resistant Staphylococcus aureus Open
View article: Development of phenyl‐urea‐based small molecules that target penicillin‐binding protein 4
Development of phenyl‐urea‐based small molecules that target penicillin‐binding protein 4 Open
Staphylococcus aureus has the ability to invade cortical bone osteocyte lacuno‐canalicular networks (OLCNs) and cause osteomyelitis. It was recently established that the cell wall transpeptidase, penicillin‐binding protein 4 (PBP4), is cru…
View article: Vitamin in the Crosshairs: Targeting Pantothenate and Coenzyme A Biosynthesis for New Antituberculosis Agents
Vitamin in the Crosshairs: Targeting Pantothenate and Coenzyme A Biosynthesis for New Antituberculosis Agents Open
Despite decades of dedicated research, there remains a dire need for new drugs against tuberculosis (TB). Current therapies are generations old and problematic. Resistance to these existing therapies results in an ever-increasing burden of…