Hailong Dong
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View article: Integrated metagenomic and metabolomic analyses reveal tenacissoside G as a potential non-antimicrobial treatment for bovine endometritis
Integrated metagenomic and metabolomic analyses reveal tenacissoside G as a potential non-antimicrobial treatment for bovine endometritis Open
This study provides new insights into the relationship between uterine microbiome and metabolites in bovine endometritis, potentially leading to novel strategies for treating bovine endometritis. Furthermore, tenacissoside G exhibits thera…
View article: Rationale and design of the Colloids infusion for Optimal outcomes In Non-cardiac surgery (COIN) randomized controlled trial
Rationale and design of the Colloids infusion for Optimal outcomes In Non-cardiac surgery (COIN) randomized controlled trial Open
Background Post-induction hypotension is a common complications in surgical patients under general anesthesia. Previous evidence indicated preoperative fluid bolus infusion might improve hemodynamic stability after anesthesia induction. Bu…
View article: Chinese clinical practice guidelines for total intravenous anaesthesia: a systematic review and expert consensus-based recommendations☆
Chinese clinical practice guidelines for total intravenous anaesthesia: a systematic review and expert consensus-based recommendations☆ Open
View article: Investigation of Wind Field Parameters for Long-Span Suspension Bridge Considering Deck Disturbance Effect
Investigation of Wind Field Parameters for Long-Span Suspension Bridge Considering Deck Disturbance Effect Open
This study investigates the wind field characteristics of long-span suspension bridges, with a particular focus on the disturbance effects introduced by the bridge deck on wind measurements. Field data are collected using anemometers insta…
View article: A direct central amygdala–ventral tegmental area GABAergic circuit modulates anaesthesia through dopaminergic disinhibition
A direct central amygdala–ventral tegmental area GABAergic circuit modulates anaesthesia through dopaminergic disinhibition Open
View article: Time‐Dependent Therapeutic Effect of <i>S</i> ‐Ketamine on PTSD Mediated by VTA‐OFC Dopaminergic Neurocircuit
Time‐Dependent Therapeutic Effect of <i>S</i> ‐Ketamine on PTSD Mediated by VTA‐OFC Dopaminergic Neurocircuit Open
Current pharmacotherapies for post‐traumatic stress disorder (PTSD) are limited by delayed onset and side effects. Despite ketamine exhibiting rapid relief of the core symptoms of PTSD, its clinical efficacy varies considerably depending o…
View article: Inhibition of SERT and NMDAR synergistically confers rapid antidepressant effects of ketamine
Inhibition of SERT and NMDAR synergistically confers rapid antidepressant effects of ketamine Open
While N-methyl-d-aspartate receptor (NMDAR) blockade is crucial for the rapid antidepressant effects of ketamine, the involvement of other mechanisms remains contentious, particularly regarding the role of serotonin, a key neurotransmitter…
View article: Principle and calculation method of hydraulic fracturing technique for in-situ stress based on two arbitrary holes
Principle and calculation method of hydraulic fracturing technique for in-situ stress based on two arbitrary holes Open
In order to precisely obtain the magnitude and orientation of in-situ stress in coal mine roadway, the principle and calculation method of hydraulic fracturing technique for in-situ stress with two arbitrary holes were established in this …
View article: Discovery of Small-Molecule PD-L1 Inhibitors via Virtual Screening and Their Immune-Mediated Anti-Tumor Effects
Discovery of Small-Molecule PD-L1 Inhibitors via Virtual Screening and Their Immune-Mediated Anti-Tumor Effects Open
Background/Objectives: Monoclonal antibodies targeting the PD-1/PD-L1 immune checkpoint have achieved clinical success but face drawbacks such as poor oral bioavailability, limited tumor penetration, and immune-related adverse events. Smal…
View article: Intraoperative temporal interference (TI)-noninvasive brain stimulation prevents postoperative delirium in mice
Intraoperative temporal interference (TI)-noninvasive brain stimulation prevents postoperative delirium in mice Open
View article: A Decoy Oligodeoxynucleotides Disturbing Forkhead Box <scp>O3</scp> Mediated <i>ctnna2</i> Transcriptional Repression Prevents Postoperative Neurocognitive Disorder in Mice
A Decoy Oligodeoxynucleotides Disturbing Forkhead Box <span>O3</span> Mediated <i>ctnna2</i> Transcriptional Repression Prevents Postoperative Neurocognitive Disorder in Mice Open
Background Perioperative cognitive disorder (PND) affects up to 31% of surgical patients. Although clinical studies have identified a variety of risk factors, no effective prevention has been developed. From our previous cohort of PND pati…
View article: Research on risk analysis and precaution measure of coal-and- gas outburst in hydraulic tunnel
Research on risk analysis and precaution measure of coal-and- gas outburst in hydraulic tunnel Open
A sudden outburst of powdered coal occurred at the heading face in the No.6 middle coal seam at the inlet section of Shuidaqiao Tunnel in Guizhou Province of China. To scientifically and accurately grasp the gas outburst risk of the coal s…
View article: Multi-omics approach reveals differences in aroma and metabolic characteristics of two types of jackfruits
Multi-omics approach reveals differences in aroma and metabolic characteristics of two types of jackfruits Open
View article: Direct inhibition of cystathionine-β-synthase by isoflurane contributes to delayed neurocognitive recovery after isoflurane general anaesthesia in mice
Direct inhibition of cystathionine-β-synthase by isoflurane contributes to delayed neurocognitive recovery after isoflurane general anaesthesia in mice Open
View article: Orexin signalling in the nucleus accumbens promotes arousal from isoflurane anaesthesia and restores communication between the nucleus accumbens and frontal cortex
Orexin signalling in the nucleus accumbens promotes arousal from isoflurane anaesthesia and restores communication between the nucleus accumbens and frontal cortex Open
View article: Association between the preoperative N-terminal pro-B-type natriuretic peptide and acute kidney injury in gastrointestinal surgery patients managed with enhanced recovery strategy: a retrospective cohort study
Association between the preoperative N-terminal pro-B-type natriuretic peptide and acute kidney injury in gastrointestinal surgery patients managed with enhanced recovery strategy: a retrospective cohort study Open
View article: Feasibility Study of an Indicator of Equivalent Potency of Multiple Anesthetics Normalized by Minimum Alveolar Concentration Derived From Response Surface Models
Feasibility Study of an Indicator of Equivalent Potency of Multiple Anesthetics Normalized by Minimum Alveolar Concentration Derived From Response Surface Models Open
BACKGROUND: Minimum alveolar concentration (MAC) is used as the standard measure of potency for volatile anesthetic agents. However, there is a lack of effective and quantitative indicator of the combined potency of multiple coadministered…
View article: Federated Graph Anomaly Detection Through Contrastive Learning with Global Negative Pairs
Federated Graph Anomaly Detection Through Contrastive Learning with Global Negative Pairs Open
Anomaly detection on attributed graphs has applications in various domains such as finance and email spam detection, thus gaining substantial attention. Distributed scenarios can also involve issues related to anomaly detection in attribut…
View article: Association Between Plasma Amyloid‐Beta 42 Ratio and Postoperative Delirium in Elderly Patients Undergoing Major Abdominal Surgery: Secondary Analysis of a Randomized Controlled Trial
Association Between Plasma Amyloid‐Beta 42 Ratio and Postoperative Delirium in Elderly Patients Undergoing Major Abdominal Surgery: Secondary Analysis of a Randomized Controlled Trial Open
Introduction Cerebrospinal fluid Aβ42 has been proposed as a potential indicator for cerebral β‐amyloidosis and may be involved in the pathophysiology of delirium. Whether perioperative plasma Aβ42 alternation is associated with postoperat…
View article: Gene-modified pig-to-human liver xenotransplantation
Gene-modified pig-to-human liver xenotransplantation Open
View article: Efficacy and safety of PCA-assisted continuous paravertebral block in subacute herpes zoster-associated pain: study protocol for a randomized, controlled, double-blind superiority trial
Efficacy and safety of PCA-assisted continuous paravertebral block in subacute herpes zoster-associated pain: study protocol for a randomized, controlled, double-blind superiority trial Open
Chinese Clinical Trial Registry ChiCTR2300068158. Registered on 9 February 2023.
View article: S-ketamine exposure in early postnatal period induces social deficit mediated by excessive microglial synaptic pruning
S-ketamine exposure in early postnatal period induces social deficit mediated by excessive microglial synaptic pruning Open
View article: The study on effects of acute exposure to high altitude hypoxia on cognitive function in lowlander
The study on effects of acute exposure to high altitude hypoxia on cognitive function in lowlander Open
The investigation of cognitive functions in response to high-altitude exposure has garnered increasing scientific interest. However, it remains unclear whether cognitive abilities are selectively impaired or what are the trends of the func…
View article: Neonatal sevoflurane exposures inhibits DHHC5-mediated palmitoylation of TfR1 in oligodendrocytes, leading to hypomyelination and neurological impairments
Neonatal sevoflurane exposures inhibits DHHC5-mediated palmitoylation of TfR1 in oligodendrocytes, leading to hypomyelination and neurological impairments Open
We discovered that decreased DHHC5 in oligodendrocytes promotes TfR1 associated ferroptosis, resulting in hypomyelination and initiating neuronal ferroptosis, thereby impairing cognition following neonatal sevoflurane exposures. The transi…
View article: Effect of remote ischemic preconditioning on perioperative neurocognitive disorder in elderly patients undergoing major surgery and associated genetic variant analysis: a randomized clinical trial
Effect of remote ischemic preconditioning on perioperative neurocognitive disorder in elderly patients undergoing major surgery and associated genetic variant analysis: a randomized clinical trial Open
View article: Dopamine Drives Feedforward Inhibition to Orexin Feeding System, Mediating Weight Loss Induced by Morphine Addiction
Dopamine Drives Feedforward Inhibition to Orexin Feeding System, Mediating Weight Loss Induced by Morphine Addiction Open
Feeding behavior changes induced by opioid addiction significantly contribute to the worsening opioid crisis. Activation of the reward system has shown to provoke binge eating disorder in individuals with opioid use disorder, whereas prolo…
View article: Bacillus velezensis A-27 as a potential biocontrol agent against Meloidogyne incognita and effects on rhizosphere communities of celery in field
Bacillus velezensis A-27 as a potential biocontrol agent against Meloidogyne incognita and effects on rhizosphere communities of celery in field Open
View article: Rationale and design for the thoracic Paravertebral Adjunctive Dexamethasone Palmitate Reducing chronic pain After cardiac surgery (PANDORA) trial: a parallel-group, double-blinded, randomised controlled, single-centre study
Rationale and design for the thoracic Paravertebral Adjunctive Dexamethasone Palmitate Reducing chronic pain After cardiac surgery (PANDORA) trial: a parallel-group, double-blinded, randomised controlled, single-centre study Open
Introduction Minimally invasive cardiac surgery (MICS) is important for enhanced recovery in cardiac surgery. However, the incidence of chronic postsurgical pain (CPSP) is high and is associated with worsened quality of recovery and life, …
View article: Multi-Omics Approach Reveals Differences in Aroma and Metabolic Characteristics of Two Types of Jackfruits
Multi-Omics Approach Reveals Differences in Aroma and Metabolic Characteristics of Two Types of Jackfruits Open
View article: Distinct Lateral Hypothalamus GABAergic Projections Regulate Sensory and Affective Dimensions of Pain
Distinct Lateral Hypothalamus GABAergic Projections Regulate Sensory and Affective Dimensions of Pain Open