Haining Luo
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View article: The prevalence of intimate partner violence against women diagnosed with infertility in China: a national cross-sectional study
The prevalence of intimate partner violence against women diagnosed with infertility in China: a national cross-sectional study Open
Globally, this is the first national-level study to examine IPV against infertile women, revealing a high prevalence rate in China. The findings underscored the need for gender-transformative interventions and policy measures, including im…
View article: A novel loss-of-function SYCP2 variant causes asthenoteratozoospermia in infertile males
A novel loss-of-function SYCP2 variant causes asthenoteratozoospermia in infertile males Open
Background: Infertility is a multiplex disorder in the reproductive system. Unexplained infertility affects 2%-3% of reproductive-aged couples. Male factors contribute to about half of all infertility cases. About 15% of these cases are pr…
View article: Detection of novel organophosphorus flame retardants and plasticizers in children urines: Associations with oxidative stress damage and thyroid nodule risk
Detection of novel organophosphorus flame retardants and plasticizers in children urines: Associations with oxidative stress damage and thyroid nodule risk Open
Organophosphorus flame retardants and plasticizers (OPFRs) are prevalent and raise health concerns due to their endocrine-disrupting properties. Clinically detectable thyroid nodules are less common in children than in adults but pose a hi…
View article: Predicting anastomotic leak in patients with esophageal squamous cell cancer treated with neoadjuvant chemoradiotherapy using a nomogram based on CT radiomic and clinicopathologic factors
Predicting anastomotic leak in patients with esophageal squamous cell cancer treated with neoadjuvant chemoradiotherapy using a nomogram based on CT radiomic and clinicopathologic factors Open
We developed and validated a nomogram based on radiomics and clinicopathologic characteristics. This predictive model could be a powerful tool to predict AL occurrence in patients with ESCC treated with NCRT.
View article: Age-specific reference ranges and variation of anti-mülerian hormone in healthy Chinese women of reproductive and perimenopausal age: a nationwide population-based prospective multicenter cross-sectional study
Age-specific reference ranges and variation of anti-mülerian hormone in healthy Chinese women of reproductive and perimenopausal age: a nationwide population-based prospective multicenter cross-sectional study Open
This study established the age-specific serum AMH reference ranges for healthy Chinese women of reproductive and premenopausal age, and observed that the consistent decrease of AMH after 20 years accelerated around the beginning of perimen…
View article: Single-Cell RNA Sequencing Reveals That C5AR1 in Follicle Monocyte Cells Could Predict the Development of POI
Single-Cell RNA Sequencing Reveals That C5AR1 in Follicle Monocyte Cells Could Predict the Development of POI Open
Our findings revealed that the interaction between monocytes and granulocytes may contribute to the development of POI. We found that POI lacked HLA-DRB5 expression and had impaired antigen processing and presentation activities. To a cert…
View article: Single-cell RNA sequencing reveals common interactions between follicle immune cells and granulosa cells in premature ovarian insufficiency patients
Single-cell RNA sequencing reveals common interactions between follicle immune cells and granulosa cells in premature ovarian insufficiency patients Open
This study aims to investigate the follicle microenvironment of individuals with premature ovarian insufficiency (POI), normal ovarian reserve (normal), and advanced maternal age (AMA), and identify potential therapeutic targets. A total o…
View article: Observed Effects on Very Early Pregnancy Linked to Ambient PM<sub>2.5</sub> Exposure in China among Women Undergoing <i>In Vitro</i> Fertilization-Embryo Transfer
Observed Effects on Very Early Pregnancy Linked to Ambient PM<sub>2.5</sub> Exposure in China among Women Undergoing <i>In Vitro</i> Fertilization-Embryo Transfer Open
The adverse effect of ambient PM2.5 exposure on very early pregnancy (VEP) remains controversial among epidemiological studies but is supported by toxicological evidence. We adopted a multicenter retrospective cohort of 141,040 cycles to e…
View article: The impact of coronavirus disease 2019 on frozen-thawed embryo transfer outcomes
The impact of coronavirus disease 2019 on frozen-thawed embryo transfer outcomes Open
Background Coronavirus disease 2019 (COVID-19) has raised concerns about its potential effects on human fertility, particularly among individuals undergoing assisted reproductive therapy (ART). However, the impact of COVID-19 on female rep…
View article: Predicting anastomotic leak in patients with esophageal squamous cell cancer treated with neoadjuvant chemoradiotherapy using a nomogram based on CT radiomic and clinicopathologic factors
Predicting anastomotic leak in patients with esophageal squamous cell cancer treated with neoadjuvant chemoradiotherapy using a nomogram based on CT radiomic and clinicopathologic factors Open
Background Anastomotic leak (AL) is a common complication in patients with operable esophageal squamous cell carcinoma (ESCC) treated with neoadjuvant chemoradiotherapy (NCRT) and radical esophagectomy. Therefore, this study aimed to estab…
View article: Thyroid Hormone Biomonitoring: A Review on Their Metabolism and Machine-Learning Based Analysis on Effects of Endocrine Disrupting Chemicals
Thyroid Hormone Biomonitoring: A Review on Their Metabolism and Machine-Learning Based Analysis on Effects of Endocrine Disrupting Chemicals Open
The thyroid is an essential endocrine organ in human body, and thyroid hormones (THs) are pivotal signaling molecules and mediators in various physiological processes. THs, particularly in their free form, play a critical role in regulatin…
View article: Single-cell RNA sequencing reveals the follicle microenvironment of patients with premature ovarian insufficiency
Single-cell RNA sequencing reveals the follicle microenvironment of patients with premature ovarian insufficiency Open
Background Premature ovarian insufficiency (POI) has a highly heterogeneous etiology, but its pathogenesis remains unclear. Methods To investigate the follicle microenvironment of POI patients and identify potential targeted therapeutic st…
View article: Bushen Tiaochong Recipe induces resistance to apoptosis in oocytes by activating the JNK pathway, inhibiting mitochondrial autophagy and promoting mitochondrial fusion
Bushen Tiaochong Recipe induces resistance to apoptosis in oocytes by activating the JNK pathway, inhibiting mitochondrial autophagy and promoting mitochondrial fusion Open
Background: The mechanisms underlying ovarian function regulation and decline have been a hot topic of research. Based on the traditional Chinese medicine concept of "pattern differentiation-physiologic system-pathway analysis," a systemat…
View article: COVID-19 vaccine hesitancy and associated factors among infertile couples undergoing assisted reproductive treatment
COVID-19 vaccine hesitancy and associated factors among infertile couples undergoing assisted reproductive treatment Open
Although periconception vaccination is important to maternal and neonatal health, little is known about the COVID-19 vaccine hesitancy among infertile couples seeking fertility treatment. Thus, we conducted this survey among infertile pati…
View article: Shortened ovarian stimulation duration may not affect oocyte developmental competence: a retrospective study
Shortened ovarian stimulation duration may not affect oocyte developmental competence: a retrospective study Open
Background: In recent years, an increasing number of scholars have begun to pay attention to the effect of gonadotropin (Gn) on the quality of oocytes and embryos. Some studies have focused on the relationship between Gn time and in vitro …
View article: The association of serum phthalate metabolites with biomarkers of ovarian reserve in women of childbearing age
The association of serum phthalate metabolites with biomarkers of ovarian reserve in women of childbearing age Open
Phthalates (PAEs) are widely used plasticizers drawing increasing concern due to reproductive toxicity. However, studies on serum PAEs metabolites (mPAEs) and their associations with human ovarian function remain very scarce. In this study…
View article: New AMH cutoff values for warning of decreased ovarian response based on MCL characteristics in young women: a retrospective study using a propensity score-matching analysis
New AMH cutoff values for warning of decreased ovarian response based on MCL characteristics in young women: a retrospective study using a propensity score-matching analysis Open
Background: Menstrual cycle length (MCL) and ovarian response varies widely among women of childbearing age, we tried to provide AMH cutoffs for "normal" and "weakened" ovarian responses to them, which give an early warning of the onset of…
View article: New AMH cutoff values for warning of decreased ovarian response based on MCL characteristics in young women: a retrospective study using a propensity score-matching analysis
New AMH cutoff values for warning of decreased ovarian response based on MCL characteristics in young women: a retrospective study using a propensity score-matching analysis Open
Background: Menstrual cycle length (MCL) and ovarian response varies widely among women of childbearing age, we tried to provide AMH cutoffs for "normal" and "weakened" ovarian responses to them, which give an early warning of the onset of…
View article: Serum anti-Müllerian hormone levels are associated with early miscarriage in the IVF/ICSI fresh cycle
Serum anti-Müllerian hormone levels are associated with early miscarriage in the IVF/ICSI fresh cycle Open
Background Anti-Müllerian hormone (AMH) is used as a biomarker to estimate ovarian reserve. The relationship between AMH and early miscarriage of in vitro fertilization (IVF) is still inconclusive. This study aimed to explore whether serum…
View article: Hysteroscopic resection of type 3 fibroids improve pregnancy outcomes in infertile women: a case-control study
Hysteroscopic resection of type 3 fibroids improve pregnancy outcomes in infertile women: a case-control study Open
Background: Evaluate the effect of hysteroscopic resection of type 3 fibroids on pregnancy outcomes in infertile women. Methods: Patients who underwent IVF-ICSI in our unit were divided into type 3 fibroids group and hysteroscopic myomecto…