Haipeng Li
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View article: Gut microbiome and its metabolites in liver cirrhosis: mechanisms and clinical implications
Gut microbiome and its metabolites in liver cirrhosis: mechanisms and clinical implications Open
Cirrhosis remains a significant global health burden, causing approximately 1.4–1.5 million deaths each year and contributing to nearly 46 million disability-adjusted life years (DALYs) worldwide. Increasing evidence identifies the gut–liv…
View article: Transcription factor ZNF263 primes human embryonic stem cells for pluripotency dissolution and lineage commitment
Transcription factor ZNF263 primes human embryonic stem cells for pluripotency dissolution and lineage commitment Open
Conventional human embryonic stem cells (hESCs) are capable of self-renewal and simultaneously poised for differentiation. But the mechanisms underlying this primed pluripotent state, which endows them with elevated responsiveness to diffe…
View article: Analysis of the Deformation Mechanism of the Top Slope at the Inlet of the Lijiaxia Hydropower Station Diversion Tunnel
Analysis of the Deformation Mechanism of the Top Slope at the Inlet of the Lijiaxia Hydropower Station Diversion Tunnel Open
After long-term operation of Lijiaxia Hydropower Station in Qinghai Province after reservoir storage, the surface part of the slope body at the top of the inlet of the diversion tunnel shows signs of deformation and tension cracking, which…
View article: Correlation between carotid Doppler ultrasound-derived parameters and cardiac output measurements: a systematic review and meta-analysis
Correlation between carotid Doppler ultrasound-derived parameters and cardiac output measurements: a systematic review and meta-analysis Open
CDU-derived parameters demonstrated positive correlations with CO measurements, providing evidence for the use of CDU-derived parameters as surrogate CO monitors.
View article: Pervasive co-regulation of alternative splicing with transcription initiation and termination.
Pervasive co-regulation of alternative splicing with transcription initiation and termination. Open
Nascent RNA processing requires coordination of transcription and splicing to yield accurate gene products. However, the basis of this co-regulation remains enigmatic. Here, we develop longPASS, a system that accurately identifies and quan…
View article: Clinical application research on the titanium metal metatarsal prosthesis designed through FEA and manufactured by 3D printing
Clinical application research on the titanium metal metatarsal prosthesis designed through FEA and manufactured by 3D printing Open
exploring the therapeutic efficacy of a 3D-printed multiple microporous titanium metatarsal and polyethylene sesamoid prosthesis based on finite element analysis. A patient with defect in the first metatarsal was enrolled. A digital model …
View article: Analysis of the Deformation Mechanism of the Top Slope at the Inlet of the Lijiaxia Hydropower Station Diversion Tunnel
Analysis of the Deformation Mechanism of the Top Slope at the Inlet of the Lijiaxia Hydropower Station Diversion Tunnel Open
After long-term operation of the Lijiaxia Hydropower Station in Qinghai Province, following reservoir impoundment, the upper surface of the slope at the inlet of the diversion tunnel has exhibited noticeable deformation and tension cracks,…
View article: Lymphoplasmapheresis for Steroid‐Refractory Neuromyelitis Optica Spectrum Disorder: A Real‐World Multicenter Study in China
Lymphoplasmapheresis for Steroid‐Refractory Neuromyelitis Optica Spectrum Disorder: A Real‐World Multicenter Study in China Open
Background Lymphoplasmapheresis (LPE), an innovative hemopurification technique that integrates conventional plasma exchange (PE) with lymphopheresis, has demonstrated efficacy in various neuroimmune disorders by removing excessive or dysf…
View article: Transcriptional Diversity in Response to Aging Across Skeletal Muscles
Transcriptional Diversity in Response to Aging Across Skeletal Muscles Open
Aging leads to a gradual decline in muscle function, yet the mechanisms by which different skeletal muscles respond to aging remain unclear. Here, we constructed transcriptional maps of 11 skeletal muscles with extensive transcriptional di…
View article: Beyond BMI: a deeper dive into aortic aneurysm pathogenesis
Beyond BMI: a deeper dive into aortic aneurysm pathogenesis Open
View article: Buoyancy-driven self-purging stills exceeding 1% of thermodynamic limits
Buoyancy-driven self-purging stills exceeding 1% of thermodynamic limits Open
Traditional passive solar stills (PSS) are limited by salt accumulation and low heat recovery efficiency, and their energy-water efficiency (η) has long been less than 0.4% of the thermodynamic limit (TL). This study proposes a revolutiona…
View article: A review of natural compounds to regulate platelet aggregation: molecular mechanism and research advance
A review of natural compounds to regulate platelet aggregation: molecular mechanism and research advance Open
Platelets are a class of blood cells exfoliated from bone marrow megakaryocytes and important participants in the blood. Aggregation is a prominent part of the platelets involved in the hemostasis process, regulated by multiple signaling p…
View article: RecCoT: Enhancing Recommendation via Chain-of-Thought
RecCoT: Enhancing Recommendation via Chain-of-Thought Open
In real-world applications, users always interact with items in multiple aspects, such as through implicit binary feedback (e.g., clicks, dislikes, long views) and explicit feedback (e.g., comments, reviews). Modern recommendation systems …
View article: Sociability genetically separable from social hierarchy in amniotes
Sociability genetically separable from social hierarchy in amniotes Open
View article: Determination of the binding and DK probability of the $$D^{*}_{s0}(2317)$$ from the $$(\bar{D}\bar{K})^-$$ mass distributions in $$\Lambda _{b}\rightarrow \Lambda _{c} (\bar{D}\bar{K})^-$$ decays
Determination of the binding and DK probability of the $$D^{*}_{s0}(2317)$$ from the $$(\bar{D}\bar{K})^-$$ mass distributions in $$\Lambda _{b}\rightarrow \Lambda _{c} (\bar{D}\bar{K})^-$$ decays Open
We study the $$\Lambda _{b}\rightarrow \Lambda _{c}\bar{D}^{0}K^{-}$$ and $$\Lambda _{b}\rightarrow \Lambda _{c}D^{-}\bar{K}^{0}$$ decays which proceed via a Cabibbo and $$N_c$$ favored process o…
View article: Distal protection of endovascular recanalization for symptomatic non-acute occlusion of vertebrobasilar artery
Distal protection of endovascular recanalization for symptomatic non-acute occlusion of vertebrobasilar artery Open
Purpose The research aimed to investigate the safety and efficacy of distal protection of endovascular recanalization for symptomatic non-acute occlusion of the intracranial vertebrobasilar artery. Methods 8 consecutive patients with sympt…
View article: Analysis and identification of PTBP2 as an oncogene in hepatocellular carcinoma
Analysis and identification of PTBP2 as an oncogene in hepatocellular carcinoma Open
Our study demonstrated that HCC tissues exhibited increased levels of PTBP2 expression compared to normal liver tissues. Elevated PTBP2 expression has been identified as closely linked to low survival in patients with HCC and could be a cl…
View article: Endovascular treatment for cerebral venous thrombosis: a multicenter study in China
Endovascular treatment for cerebral venous thrombosis: a multicenter study in China Open
View article: Therapeutic Potential of 20E in Pulmonary Arterial Hypertension: Involvement of Mas Receptor and PI3K/Akt Pathway
Therapeutic Potential of 20E in Pulmonary Arterial Hypertension: Involvement of Mas Receptor and PI3K/Akt Pathway Open
BACKGROUND 20-Hydroxyecdysone (20E), a natural polyhydroxylated steroid found in various edible plants, exhibits diverse pharmacological effects. This study aims to investigate the preventive and therapeutic effects of 20E on pulmonary art…
View article: Mitochondria‑derived peptides: Promising microproteins in cardiovascular diseases (Review)
Mitochondria‑derived peptides: Promising microproteins in cardiovascular diseases (Review) Open
Mitochondria‑derived peptides (MDPs) are a unique class of peptides encoded by short open reading frames in mitochondrial DNA, including the mitochondrial open reading frame of the 12S ribosomal RNA type‑c (MOTS‑c). Recent studies suggest …
View article: N-terminal domain of CTRP9 promotes cardiac fibroblast activation in myocardial infarction via Rap1/Mek/Erk pathway
N-terminal domain of CTRP9 promotes cardiac fibroblast activation in myocardial infarction via Rap1/Mek/Erk pathway Open
Different domains of CTRP9 have distinct cardioprotective effects. gCTRP9 shows beneficial effects, while nCTRP9 promotes cardiac fibrosis. These findings highlight the importance of CTRP9 in cardiac function regulation and suggest prospec…
View article: Association between oxidative balance score and all-cause mortality in stroke survivors
Association between oxidative balance score and all-cause mortality in stroke survivors Open
View article: Tirofiban plus aspirin in perforating artery cerebral infarction beyond time window: Effects on coagulation and clinical effect
Tirofiban plus aspirin in perforating artery cerebral infarction beyond time window: Effects on coagulation and clinical effect Open
View article: Individualized Nutritional Support Improves Cardiac Function and Nutritional Status of Elderly Heart Failure Patients
Individualized Nutritional Support Improves Cardiac Function and Nutritional Status of Elderly Heart Failure Patients Open
Background The quality of life of the patient is diminished by chronic heart failure (CHF), which also costs the healthcare system. This study examined the benefits of individualized nutritional support provided by a specialized nursing te…
View article: Metabolic reprogramming of peritoneal mesothelial cells in peritoneal dialysis–associated fibrosis: therapeutic targets and strategies
Metabolic reprogramming of peritoneal mesothelial cells in peritoneal dialysis–associated fibrosis: therapeutic targets and strategies Open
Peritoneal dialysis (PD) is considered a life-saving treatment for end-stage renal disease. However, prolonged PD use can lead to the development of peritoneal fibrosis (PF), diminishing its efficacy. Peritoneal mesothelial cells (PMCs) ar…
View article: The current clinical landscape of preterm infants less than 32 weeks of gestation receiving delivery room chest compression in Jiangsu Province, China
The current clinical landscape of preterm infants less than 32 weeks of gestation receiving delivery room chest compression in Jiangsu Province, China Open
This multicenter cohort study revealed the clinical landscape of preterm infants (<32 weeks gestational age) receiving DR-CCs, showing lower survival rates without major morbidities compared to those not receiving DR-CCs.
View article: Fine-Grained 1-Day Vulnerability Detection in Binaries via Patch Code Localization
Fine-Grained 1-Day Vulnerability Detection in Binaries via Patch Code Localization Open
1-day vulnerabilities in binaries have become a major threat to software security. Patch presence test is one of the effective ways to detect the vulnerability. However, existing patch presence test works do not perform well in practical s…
View article: LncRNA TCL6 regulates miR-876–5p/MYL2 axis to suppress breast cancer progression
LncRNA TCL6 regulates miR-876–5p/MYL2 axis to suppress breast cancer progression Open
We explored the influence of the TCL6/miR-876-5p axis on breast cancer cell proliferation and migration. Using The Cancer Genome Atlas (TCGA) database, we evaluated the expression of TCL6 in breast cancer patients and studied its effects o…
View article: Analysis of changes in the chemokine CXC ligand 13 in serum and cerebrospinal fluid of patients with neuromyelitis optica
Analysis of changes in the chemokine CXC ligand 13 in serum and cerebrospinal fluid of patients with neuromyelitis optica Open
View article: Distal protection of endovascular recanalization for symptomatic non-acute occlusion of vertebrobasilar artery
Distal protection of endovascular recanalization for symptomatic non-acute occlusion of vertebrobasilar artery Open
Purpose The research aimed to investigate the safety and efficacy of distal protection of endovascular recanalization for symptomatic non-acute occlusion of the intracranial vertebrobasilar artery. Methods 8 consecutive patients with sympt…