Haiqing Zhao
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View article: Electrostatic Interaction Determines the Docking Specificity and the Formation of Functional Cx36 Gap Junction Channels
Electrostatic Interaction Determines the Docking Specificity and the Formation of Functional Cx36 Gap Junction Channels Open
Connexin36 (Cx36) is broadly expressed in neurons and serves as the principal protein to form interneuronal gap junctions (GJs), also known as electrical synapses. Recent high-resolution structures of human Cx36 GJ have revealed crucial el…
View article: Cost-effectiveness analysis of benmelstobart and anlotinib plus chemotherapy versus standard chemotherapy in first-line treatment for extensive-stage small cell lung cancer: Perspectives from the United States and China
Cost-effectiveness analysis of benmelstobart and anlotinib plus chemotherapy versus standard chemotherapy in first-line treatment for extensive-stage small cell lung cancer: Perspectives from the United States and China Open
Background Benmelstobart combined with anlotinib and chemotherapy has demonstrated significant clinical advantages in extending progression-free survival and overall survival compared to chemotherapy alone in patients with extensive-stage …
View article: <i>Pde10a</i> gates light responses in the SCN to regulate circadian photoentrainment
<i>Pde10a</i> gates light responses in the SCN to regulate circadian photoentrainment Open
Light is the principal cue for synchronizing the circadian clock. A common feature of the clock among all organisms is the lack of responsiveness to light during the daytime. To understand the interaction between the circadian clock and li…
View article: A stress-sensing circuit signals to the central pacemaker to reprogram circadian rhythms
A stress-sensing circuit signals to the central pacemaker to reprogram circadian rhythms Open
The circadian system provides a temporal framework for animals to anticipate environmental events, including threats. However, the effects of stressors on the circadian system remain poorly understood. Here, we demonstrate that, in mice, s…
View article: Light modulates glucose and lipid homeostasis via the sympathetic nervous system
Light modulates glucose and lipid homeostasis via the sympathetic nervous system Open
Light is an important environmental factor for vision and for diverse physiological and psychological functions. Light can also modulate glucose metabolism. Here, we show that in mice, light is critical for glucose and lipid homeostasis by…
View article: Light modulates glucose and lipid homeostasis via the sympathetic nervous system
Light modulates glucose and lipid homeostasis via the sympathetic nervous system Open
Light is an important environmental factor for vision, and for diverse physiological and psychological functions. Light can also modulate glucose metabolism. Here, we show that in mice, light is critical for glucose and lipid homeostasis b…
View article: Phosphodiesterase 5A regulates the vomeronasal pump in mice
Phosphodiesterase 5A regulates the vomeronasal pump in mice Open
Summary The vomeronasal organ (VNO) is a specialized chemoreceptive structure in many vertebrates that detects chemical stimuli, mostly pheromones, which often elicit innate behaviors such as mating and aggression. Previous studies in rode…
View article: Light affects the prefrontal cortex via intrinsically photosensitive retinal ganglion cells
Light affects the prefrontal cortex via intrinsically photosensitive retinal ganglion cells Open
The ventromedial prefrontal cortex (vmPFC) is a part of the limbic system engaged in the regulation of social, emotional, and cognitive states, which are characteristically impaired in disorders of the brain such as schizophrenia and depre…
View article: WITHDRAWN: Light affects the prefrontal cortex via intrinsically photosensitive retinal ganglion cells
WITHDRAWN: Light affects the prefrontal cortex via intrinsically photosensitive retinal ganglion cells Open
Withdrawal Statement This manuscript has been withdrawn by bioRxiv following a formal request by the NIH Intramural Research Integrity Office owing to lack of author consent.
View article: Satellite glia modulate sympathetic neuron survival, activity, and autonomic function
Satellite glia modulate sympathetic neuron survival, activity, and autonomic function Open
Satellite glia are the major glial cells in sympathetic ganglia, enveloping neuronal cell bodies. Despite this intimate association, the extent to which sympathetic functions are influenced by satellite glia in vivo remains unclear. Here, …
View article: Author response: Satellite glia modulate sympathetic neuron survival, activity, and autonomic function
Author response: Satellite glia modulate sympathetic neuron survival, activity, and autonomic function Open
View article: Effects of dietary intake of Colla corii asini on skin parameters and appearance: Results of a 12-week randomized, controlled, open-labeled trial
Effects of dietary intake of Colla corii asini on skin parameters and appearance: Results of a 12-week randomized, controlled, open-labeled trial Open
Background: As a traditional Chinese medicine, the Colla corii asini (CCA), obtained from the skin of Equus animus L, has been used to nourish blood in China for more than 2000 years. The beneficial role of CCA supplementation in beauty ha…
View article: Diversity of satellite glia in sympathetic and sensory ganglia
Diversity of satellite glia in sympathetic and sensory ganglia Open
Satellite glia are the major glial type found in sympathetic and sensory ganglia in the peripheral nervous system, and specifically, contact neuronal cell bodies. Sympathetic and sensory neurons differ in morphological, molecular, and elec…
View article: Satellite glia are essential modulators of sympathetic neuron survival, activity, and autonomic function
Satellite glia are essential modulators of sympathetic neuron survival, activity, and autonomic function Open
Satellite glia are the major glial cells in sympathetic ganglia, enveloping neuronal cell bodies. Despite this intimate association, how satellite glia contribute to sympathetic functions remain unclear. Here, we show that satellite glia a…
View article: Diversity of satellite glia in sympathetic and sensory ganglia
Diversity of satellite glia in sympathetic and sensory ganglia Open
Satellite glia are the major glial type found in ganglia of the peripheral nervous system and wrap around cell bodies of sympathetic and sensory neurons that are very diverse. Other than their close physical association with peripheral neu…
View article: BONE DEVELOPMENT AND FRACTURE HEALING IS NORMAL IN MICE THAT HAVE A DEFECT IN THE DEVELOPMENT OF THE LYMPHATIC SYSTEM
BONE DEVELOPMENT AND FRACTURE HEALING IS NORMAL IN MICE THAT HAVE A DEFECT IN THE DEVELOPMENT OF THE LYMPHATIC SYSTEM Open
Ectopic lymphatics form in bone and promote bone destruction in diseases such as Gorham-Stout disease, generalized lymphatic anomaly, and kaposiform lymphangiomatosis. However, the role lymphatics serve in normal bone development and repai…
View article: Atoh7-independent specification of retinal ganglion cell identity
Atoh7-independent specification of retinal ganglion cell identity Open
Atoh7 promotes retinal ganglion survival and is not required for specification of most retinal ganglion cells.
View article: Atoh7-independent specification of retinal ganglion cell identity
Atoh7-independent specification of retinal ganglion cell identity Open
Retinal ganglion cells (RGCs), which relay visual information from the eye to the brain, are the first cell type generated during retinal neurogenesis. Loss of function of the transcription factor Atoh7 , which is expressed in multipotent …
View article: Retinal innervation tunes circuits that drive nonphotic entrainment to food
Retinal innervation tunes circuits that drive nonphotic entrainment to food Open
View article: DCTN5 mutant mice reveal a role for dynactin in lens biogenesis
DCTN5 mutant mice reveal a role for dynactin in lens biogenesis Open
View article: Intravenous Administration of Multipotent Stromal Cells and Bone Allograft Modification to Enhance Allograft Healing
Intravenous Administration of Multipotent Stromal Cells and Bone Allograft Modification to Enhance Allograft Healing Open
Aim: This study investigated a coordinated strategy of revitalizing bone allograft with circulating multipotent stromal cells (MSCs). Materials & methods: After chemotactic and releasing assessments, stromal cell-derived fact…
View article: Light Affects Mood and Learning through Distinct Retina-Brain Pathways
Light Affects Mood and Learning through Distinct Retina-Brain Pathways Open
View article: Absence of CFAP69 Causes Male Infertility due to Multiple Morphological Abnormalities of the Flagella in Human and Mouse
Absence of CFAP69 Causes Male Infertility due to Multiple Morphological Abnormalities of the Flagella in Human and Mouse Open
View article: Eye-Drops for Activation of DREADDs
Eye-Drops for Activation of DREADDs Open
Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are an important tool for modulating and understanding neural circuits. Depending on the DREADD system used, DREADD-targeted neurons can be activated or repressed in v…
View article: Expression of potassium-dependent sodium-calcium exchanger in the murine lens
Expression of potassium-dependent sodium-calcium exchanger in the murine lens Open
View article: The Na+/Ca2+, K+ exchanger NCKX4 is required for efficient cone-mediated vision
The Na+/Ca2+, K+ exchanger NCKX4 is required for efficient cone-mediated vision Open
Calcium (Ca2+) plays an important role in the function and health of neurons. In vertebrate cone photoreceptors, Ca2+ controls photoresponse sensitivity, kinetics, and light adaptation. Despite the critical role of Ca2+ in supporting the f…
View article: A subset of ipRGCs regulates both maturation of the circadian clock and segregation of retinogeniculate projections in mice
A subset of ipRGCs regulates both maturation of the circadian clock and segregation of retinogeniculate projections in mice Open
The visual system consists of two major subsystems, image-forming circuits that drive conscious vision and non-image-forming circuits for behaviors such as circadian photoentrainment. While historically considered non-overlapping, recent e…
View article: Cilia- and Flagella-Associated Protein 69 Regulates Olfactory Transduction Kinetics in Mice
Cilia- and Flagella-Associated Protein 69 Regulates Olfactory Transduction Kinetics in Mice Open
Animals detect odorous chemicals through specialized olfactory sensory neurons (OSNs) that transduce odorants into neural electrical signals. We identified a novel and evolutionarily conserved protein, cilia- and flagella-associated protei…
View article: Lamin B1 is required for mature neuron-specific gene expression during olfactory sensory neuron differentiation
Lamin B1 is required for mature neuron-specific gene expression during olfactory sensory neuron differentiation Open
B-type lamins are major constituents of the nuclear lamina in all metazoan cells, yet have specific roles in the development of certain cell types. Although they are speculated to regulate gene expression in developmental contexts, a direc…
View article: Author response: The Na+/Ca2+, K+ exchanger NCKX4 is required for efficient cone-mediated vision
Author response: The Na+/Ca2+, K+ exchanger NCKX4 is required for efficient cone-mediated vision Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract Calcium (Ca2+) plays an important role in the f…