Haiqing Zhong
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View article: Radiation‐Induced Photovoltaic Effect in Multilayer Dion–Jacobson Hybrid Perovskite Ferroelectric Toward High‐Performance Self‐Driven X‐Ray Detection
Radiation‐Induced Photovoltaic Effect in Multilayer Dion–Jacobson Hybrid Perovskite Ferroelectric Toward High‐Performance Self‐Driven X‐Ray Detection Open
Multilayered hybrid perovskite ferroelectrics (MHPF) have demonstrated remarkable potential for self‐driven X‐ray detection owing to their intrinsic spontaneous polarization, high absorption coefficient, and superior semiconducting propert…
View article: Small molecular chelator for comprehensive regulation of tumor lactate levels in synergy with photodynamic therapy for cancer treatment
Small molecular chelator for comprehensive regulation of tumor lactate levels in synergy with photodynamic therapy for cancer treatment Open
View article: Multiple Interactions in Polar Lead‐Free Perovskites toward Highly Stable X‐Ray Detection
Multiple Interactions in Polar Lead‐Free Perovskites toward Highly Stable X‐Ray Detection Open
Lead‐free halide perovskites have emerged as a promising class of high‐performance “green” X‐ray detecting semiconductors due to their nontoxicity and strong X‐ray absorption. However, ion migration caused by high operating electric field …
View article: Lactate dehydrogenase B noncanonically promotes ferroptosis defense in KRAS-driven lung cancer
Lactate dehydrogenase B noncanonically promotes ferroptosis defense in KRAS-driven lung cancer Open
Ferroptosis is an oxidative, non-apoptotic cell death frequently inactivated in cancer, but the underlying mechanisms in oncogene-specific tumors remain poorly understood. Here, we discover that lactate dehydrogenase (LDH) B, but not the c…
View article: Multiple Interlayer Interactions Enable Highly Stable X-ray Detection in 2D Hybrid Perovskites
Multiple Interlayer Interactions Enable Highly Stable X-ray Detection in 2D Hybrid Perovskites Open
Metal halide perovskites have outperformed conventional inorganic semiconductors in direct X-ray detection due to their ease of synthesis and intriguing photoelectric properties. However, the operational instability caused by severe ion mi…
View article: CCDC 2252914: Experimental Crystal Structure Determination
CCDC 2252914: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2252915: Experimental Crystal Structure Determination
CCDC 2252915: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2252913: Experimental Crystal Structure Determination
CCDC 2252913: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Erratum to: Membrane fusion reverse micelle platforms as potential oral nanocarriers for efficient internalization of free hydrophilic peptides
Erratum to: Membrane fusion reverse micelle platforms as potential oral nanocarriers for efficient internalization of free hydrophilic peptides Open
View article: Correction: Apo-Form Selective Inhibition of IDO for Tumor Immunotherapy
Correction: Apo-Form Selective Inhibition of IDO for Tumor Immunotherapy Open
Liu, W., Y. Zou, K. Li, H. Zhong, L. Yu, S. Ge, Y. Lai, X. Dong, Q. Xu, and W. Guo. 2022. Apo-form selective inhibition of IDO for tumor immunotherapy. J. Immunol. 209: 180–191.
View article: Author correction to “DNA damage repair promotion in colonic epithelial cells by andrographolide downregulated cGAS‒STING pathway activation and contributed to the relief of CPT-11-induced intestinal mucositis” [Acta Pharmaceutica Sinica B 12 (2022) 262–273]
Author correction to “DNA damage repair promotion in colonic epithelial cells by andrographolide downregulated cGAS‒STING pathway activation and contributed to the relief of CPT-11-induced intestinal mucositis” [Acta Pharmaceutica Sinica B 12 (2022) 262–273] Open
[This corrects the article DOI: 10.1016/j.apsb.2021.03.043.].
View article: A non-canonical function of LDHB promotes SLC7A11-mediated glutathione metabolism and protects against glutaminolysis-dependent ferroptosis in<i>KRAS</i>-driven lung cancer
A non-canonical function of LDHB promotes SLC7A11-mediated glutathione metabolism and protects against glutaminolysis-dependent ferroptosis in<i>KRAS</i>-driven lung cancer Open
Ferroptosis, a form of non-apoptotic cell death program driven by excessive lipid peroxidation and an important mechanism of tumor suppression, is frequently dysregulated in cancer. However, the mechanisms underlying impaired ferroptosis i…
View article: Peptide nano-blanket impedes fibroblasts activation and subsequent formation of pre-metastatic niche
Peptide nano-blanket impedes fibroblasts activation and subsequent formation of pre-metastatic niche Open
There is evidence to suggest that the primary tumor induces the formation of a pre-metastatic niche in distal organs by stimulating the production of pro-metastatic factors. Given the fundamental role of the pre-metastatic niche in the dev…
View article: Therapeutic nucleus-access BNCT drug combined CD47-targeting gene editing in glioblastoma
Therapeutic nucleus-access BNCT drug combined CD47-targeting gene editing in glioblastoma Open
View article: Lactate-Driving Pt Nanoflower with Positive Chemotaxis for Deep Intratumoral Penetration
Lactate-Driving Pt Nanoflower with Positive Chemotaxis for Deep Intratumoral Penetration Open
View article: Therapeutic Nucleus-Access BNCT Drug Combined CD47-Targeting Gene Editing in Glioblastoma
Therapeutic Nucleus-Access BNCT Drug Combined CD47-Targeting Gene Editing in Glioblastoma Open
Glioblastoma is the most common brain primary malignant tumor with the highest mortality. Boron neutron capture therapy (BNCT) can efficiently kill cancer cells on the cellular scale, with high accuracy, short course and low side-effects, …
View article: Peptide nano-blanket impedes fibroblasts activation and subsequent formation of pre-metastatic niche
Peptide nano-blanket impedes fibroblasts activation and subsequent formation of pre-metastatic niche Open
In various types of malignant tumors, metastasis is responsible for most of the tumor-induced death. Though emerging technologies provided early detection of tumor metastasis or even warning of high metastatic risk before the actual occurr…
View article: Design, Synthesis, and Evaluation of <i>o</i>-(Biphenyl-3-ylmethoxy)nitrophenyl Derivatives as PD-1/PD-L1 Inhibitors with Potent Anticancer Efficacy <i>In Vivo</i>
Design, Synthesis, and Evaluation of <i>o</i>-(Biphenyl-3-ylmethoxy)nitrophenyl Derivatives as PD-1/PD-L1 Inhibitors with Potent Anticancer Efficacy <i>In Vivo</i> Open
Two series of novel o-(biphenyl-3-ylmethoxy)nitrophenyl compounds (A1-31 and B1-17) were designed as programmed cell death protein 1 (PD-1)/PD-ligand 1 (PD-L1) inhibitors. All compounds showed significant inhibitory ac…
View article: DNA damage repair promotion in colonic epithelial cells by andrographolide downregulated cGAS‒STING pathway activation and contributed to the relief of CPT-11-induced intestinal mucositis
DNA damage repair promotion in colonic epithelial cells by andrographolide downregulated cGAS‒STING pathway activation and contributed to the relief of CPT-11-induced intestinal mucositis Open
Gastrointestinal mucositis is one of the most debilitating side effects of the chemotherapeutic agent irinotecan (CPT-11). Andrographolide, a natural bicyclic diterpenoid lactone, has been reported to possess anti-colitis activity. In this…
View article: Targeting IL-21 to tumor-reactive T cells enhances memory T cell responses and anti-PD-1 antibody therapy
Targeting IL-21 to tumor-reactive T cells enhances memory T cell responses and anti-PD-1 antibody therapy Open
T cell rejuvenation by PD-1/PD-L1 blockade, despite emerging as a highly promising therapy for advanced cancers, is only beneficial for a minority of treated patients. There is evidence that a lack of efficient T cell activation may be res…
View article: Discovery of a potent apo-IDO1 inhibitor for cancer immunotherapy
Discovery of a potent apo-IDO1 inhibitor for cancer immunotherapy Open
BACKGROUND AND PURPOSE Pharmacological inhibition of indoleamine-2,3-dioxygenase 1 activity is now considered to be a potential therapeutic tool for cancer therapy. However, the anti-cancer efficacy may be the biggest obstacle for the clin…
View article: Discovery of secondary sulphonamides as IDO1 inhibitors with potent antitumour effects <i>in vivo</i>
Discovery of secondary sulphonamides as IDO1 inhibitors with potent antitumour effects <i>in vivo</i> Open
Indoleamine 2,3-dioxygenase 1 (IDO1) as a key rate-limiting enzyme in the kynurenine pathway of tryptophan metabolism plays an important role in tumour immune escape. Herein, a variety of secondary sulphonamides were synthesised and evalua…
View article: 5-Androstenediol prevents radiation injury in mice by promoting NF-κB signaling and inhibiting AIM2 inflammasome activation
5-Androstenediol prevents radiation injury in mice by promoting NF-κB signaling and inhibiting AIM2 inflammasome activation Open
In the present study, the therapeutic effects of 5-androstenediol on radiation-induced myeloid suppression and tissue damage in mice and the possible mechanism were explored. The mice were subjected to whole-body irradiation, and 5-androst…
View article: Mitochondrial DNA variants modulate genetic susceptibility to Parkinson's disease in Han Chinese
Mitochondrial DNA variants modulate genetic susceptibility to Parkinson's disease in Han Chinese Open