Huan Yang
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View article: Inflammatory macrophages drive smooth muscle dedifferentiation via YAP signaling in murine deep vein thrombosis
Inflammatory macrophages drive smooth muscle dedifferentiation via YAP signaling in murine deep vein thrombosis Open
Background Deep vein thrombosis (DVT) is a common clinical problem characterized by the formation of blood clots in deep veins. The contribution of venous smooth muscle cells (SMCs) to the onset of DVT, particularly the mechanisms driving …
View article: MAIT cell enrichment in Lynch syndrome is associated with immune surveillance and colorectal cancer risk
MAIT cell enrichment in Lynch syndrome is associated with immune surveillance and colorectal cancer risk Open
Tissue microenvironment characteristics associated with elevated risk of colorectal cancer (CRC) in Lynch syndrome (LS) are poorly characterized. We applied the multimodal single cell sequencing platform ExCITE-seq to define the colonic ce…
View article: MAIT cell enrichment in Lynch syndrome is associated with immune surveillance and colorectal cancer risk
MAIT cell enrichment in Lynch syndrome is associated with immune surveillance and colorectal cancer risk Open
View article: Redirecting E3 ubiquitin ligases for targeted protein degradation with heterologous recognition domains
Redirecting E3 ubiquitin ligases for targeted protein degradation with heterologous recognition domains Open
View article: Unique quantitative electroencephalography differences and related behavioral dynamics in Crohn’s disease
Unique quantitative electroencephalography differences and related behavioral dynamics in Crohn’s disease Open
Crohn's disease (CD) is a major type of inflammatory bowel disease (IBD) characterized by idiopathic, chronic inflammation with a patchy transmural inflammatory pattern. CD patients experience a decreased quality of life due to symptoms su…
View article: Targeting the autoreactive CD8+ T-cell receptor in type 1 diabetes: Insights from scRNA-seq for immunotherapy
Targeting the autoreactive CD8+ T-cell receptor in type 1 diabetes: Insights from scRNA-seq for immunotherapy Open
Type 1 Diabetes (T1D) is an autoimmune disease characterized by the attack and destruction of Pancreatic islet beta cells by T cells. Understanding the role of T-cell receptor (TCR) in the development of T1D is of paramount importance. Thi…
View article: Two distinct regulatory pathways govern Cct2-Atg8 binding in the process of solid aggrephagy
Two distinct regulatory pathways govern Cct2-Atg8 binding in the process of solid aggrephagy Open
View article: Myeloid-Specific Thrombospondin-1 Deficiency Exacerbates Aortic Rupture via Broad Suppression of Extracellular Matrix Proteins
Myeloid-Specific Thrombospondin-1 Deficiency Exacerbates Aortic Rupture via Broad Suppression of Extracellular Matrix Proteins Open
Rationale Rupture of abdominal aortic aneurysms (AAA) is associated with high mortality. However, the precise molecular and cellular drivers of AAA rupture remain elusive. Our prior study showed that global and myeloid-specific deletion of…
View article: TRAJ23 Gene Targeting as a Therapeutic Strategy for Type 1 Diabetes: Implications from NOD Mouse Model Studies
TRAJ23 Gene Targeting as a Therapeutic Strategy for Type 1 Diabetes: Implications from NOD Mouse Model Studies Open
Type 1 Diabetes (T1D) is an autoimmune disease characterized by the attack and destruction of Pancreatic islet beta cells by T cells. Understanding the role of T-cell receptor (TCR) in the development of T1D is of paramount importance. Thi…
View article: Single-cell integrative analysis reveals consensus cancer cell states and clinical relevance in breast cancer
Single-cell integrative analysis reveals consensus cancer cell states and clinical relevance in breast cancer Open
View article: Analysis of the Current Situation of Stigma Among Elderly Hemodialysis Patients and its Influencing Factors
Analysis of the Current Situation of Stigma Among Elderly Hemodialysis Patients and its Influencing Factors Open
Objective: To understand the current situation of stigma among elderly hemodialysis patients and to analyze its influencing factors. Methods: Convenience sampling was used to select 242 elderly patients undergoing hemodialysis in one of th…
View article: Reduction of Abdominal Aortic Aneurysm Rupture By Modulating Smooth Muscle Cell Phenotype Switching
Reduction of Abdominal Aortic Aneurysm Rupture By Modulating Smooth Muscle Cell Phenotype Switching Open
View article: Macrophage-mediated downregulation of lncRNA Carmn in mouse abdominal aortic aneurysm
Macrophage-mediated downregulation of lncRNA Carmn in mouse abdominal aortic aneurysm Open
View article: Correction to: Construction of a competitive endogenous RNA network and analysis of potential regulatory axis targets in glioblastoma
Correction to: Construction of a competitive endogenous RNA network and analysis of potential regulatory axis targets in glioblastoma Open
View article: Thrombospondin-1 in vascular development, vascular function, and vascular disease
Thrombospondin-1 in vascular development, vascular function, and vascular disease Open
View article: Identification and verification of a novel anoikis-related gene signature with prognostic significance in clear cell renal cell carcinoma
Identification and verification of a novel anoikis-related gene signature with prognostic significance in clear cell renal cell carcinoma Open
View article: A vein wall cell atlas of murine venous thrombosis determined by single-cell RNA sequencing
A vein wall cell atlas of murine venous thrombosis determined by single-cell RNA sequencing Open
Deep vein thrombosis (DVT) is a common clinical problem, but its cellular and molecular mechanisms remain incompletely understood. In this study, we performed single-cell RNA sequencing on mouse inferior vena cava (IVC) 24 h after thrombus…
View article: Upregulation of Receptor Interacting Protein Kinase-3 Augments Abdominal Aortic Aneurysms
Upregulation of Receptor Interacting Protein Kinase-3 Augments Abdominal Aortic Aneurysms Open
View article: Retinal Photoreceptor Protection in an AMD-Related Mouse Model by Selective Sigma-1 or Sigma-2 Receptor Modulation
Retinal Photoreceptor Protection in an AMD-Related Mouse Model by Selective Sigma-1 or Sigma-2 Receptor Modulation Open
The structurally and genetically distinct sigma-1 receptor (S1R) and sigma-2 receptor (S2R) comprise a unique class of drug binding sites. Their alleles are associated with human diseases involving neuronal systems, such as age-related mac…
View article: Integrin subunit alpha V is a potent prognostic biomarker associated with immune infiltration in lower-grade glioma
Integrin subunit alpha V is a potent prognostic biomarker associated with immune infiltration in lower-grade glioma Open
As a member of integrin receptor family, ITGAV (integrin subunit α V) is involved in a variety of cell biological processes and overexpressed in various cancers, which may be a potential prognostic factor. However, its prognostic value and…
View article: Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells
Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells Open
Reactivation of fetal hemoglobin expression by the downregulation of BCL11A is a promising treatment for β-hemoglobinopathies. A detailed understanding of BCL11A-mediated repression of γ-globin gene (HBG1/2) transcription is lacking, as st…
View article: Moxibustion attenuates inflammation and alleviates axial spondyloarthritis in mice: Possible role of APOE in the inhibition of the Wnt pathway
Moxibustion attenuates inflammation and alleviates axial spondyloarthritis in mice: Possible role of APOE in the inhibition of the Wnt pathway Open
View article: Endothelial Dysfunction in the Pathogenesis of Abdominal Aortic Aneurysm
Endothelial Dysfunction in the Pathogenesis of Abdominal Aortic Aneurysm Open
Abdominal aortic aneurysm (AAA), defined as a focal dilation of the abdominal aorta beyond 50% of its normal diameter, is a common and potentially life-threatening vascular disease. The molecular and cellular mechanisms underlying AAA path…
View article: Deciphering Cell-Cell Communication in Abdominal Aortic Aneurysm From Single-Cell RNA Transcriptomic Data
Deciphering Cell-Cell Communication in Abdominal Aortic Aneurysm From Single-Cell RNA Transcriptomic Data Open
Cell-cell communication coordinates cellular differentiation, tissue homeostasis, and immune responses in states of health and disease. In abdominal aortic aneurysm (AAA), a relatively common and potentially life-threatening vascular disea…
View article: Investigating the role of receptor interacting protein kinase 3 in venous thrombosis
Investigating the role of receptor interacting protein kinase 3 in venous thrombosis Open
In mice, the vein wall responded to deep vein thrombosis induction with elevation of RIPK3 without showing markers of necroptosis and apoptosis. Studies using genetic or pharmacological inhibition of RIPK3 suggest that this cell death medi…
View article: High Expression of C1ORF112 Predicts a Poor Outcome: A Potential Target for the Treatment of Low-Grade Gliomas
High Expression of C1ORF112 Predicts a Poor Outcome: A Potential Target for the Treatment of Low-Grade Gliomas Open
Background: Glioma is the most common primary tumor of the central nervous system and is associated with poor overall survival, creating an urgent need to identify survival-associated biomarkers. C1ORF112, an alpha-helical protein, is over…
View article: m6A regulator‐mediated RNA methylation modification patterns and immune microenvironment infiltration characterization in severe asthma
m6A regulator‐mediated RNA methylation modification patterns and immune microenvironment infiltration characterization in severe asthma Open
N6‐methyladenosine (m6A) modification is one of the most prevalent RNA modification forms of eukaryotic mRNA and is an important post‐transcriptional mechanism for regulating genes. However, the role of m6A modification in the regulation o…
View article: MLKL and CaMKII Are Involved in RIPK3-Mediated Smooth Muscle Cell Necroptosis
MLKL and CaMKII Are Involved in RIPK3-Mediated Smooth Muscle Cell Necroptosis Open
Receptor interacting protein kinase 3 (RIPK3)-mediated smooth muscle cell (SMC) necroptosis has been shown to contribute to the pathogenesis of abdominal aortic aneurysms (AAAs). However, the signaling steps downstream from RIPK3 during SM…
View article: Increased Susceptibility and Intrinsic Apoptotic Signaling in Neurons by Induced HDAC3 Expression
Increased Susceptibility and Intrinsic Apoptotic Signaling in Neurons by Induced HDAC3 Expression Open
Collectively, these results indicate that HDAC3-induced toxicity to neurons is mediated by the intrinsic apoptotic pathway.
View article: Interleukin-22: a potential therapeutic target in atherosclerosis
Interleukin-22: a potential therapeutic target in atherosclerosis Open