Haiteng Deng
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View article: Serum proteome profiling identified thrombospondin-1 and lactoferrin as biomarkers of relapsed multiple myeloma
Serum proteome profiling identified thrombospondin-1 and lactoferrin as biomarkers of relapsed multiple myeloma Open
Introduction Multiple myeloma (MM) remains an incurable hematologic malignancy characterized by inevitable relapse despite advances in novel therapeutics. Identifying reliable biomarkers for relapsed/refractory MM (RRMM) is crucial to impr…
View article: Streptococcus pneumoniae synchronizes the states of cell wall peptidoglycan acetylation and genome methylation by programmed DNA inversions
Streptococcus pneumoniae synchronizes the states of cell wall peptidoglycan acetylation and genome methylation by programmed DNA inversions Open
Bacterial cell wall peptidoglycan (PG) consists of alternating β-(1,4) linked N- acetylmuramic acid (NAM) and N- acetylglucosamine (NAG). The C-6 hydroxyl group of NAM is acetylated by transmembrane O -acetyltransferases post PG biosynthes…
View article: Zero-Shot De Novo Peptide Sequencing with Open Post-Translational Modification Discovery
Zero-Shot De Novo Peptide Sequencing with Open Post-Translational Modification Discovery Open
Proteins play essential roles in biology, yet identifying their precise sequences and modifications remains challenging. De novo peptide sequencing offers a powerful solution by directly inferring sequences from mass spectrometry data with…
View article: <scp>CD38</scp>‐Targeting Peptide Vaccine Ameliorates Aging‐Associated Phenotypes in Mice
<span>CD38</span>‐Targeting Peptide Vaccine Ameliorates Aging‐Associated Phenotypes in Mice Open
Antiaging vaccines have recently been found to elicit long‐term benefits in slowing the aging process. Meanwhile, high CD38 expression in organs is an aging characteristic contributing to a decreased NAD + /NADH ratio. Thus, in the current…
View article: Peptides in Cosmetics: From Pharmaceutical Breakthroughs to Skincare Innovations
Peptides in Cosmetics: From Pharmaceutical Breakthroughs to Skincare Innovations Open
Peptides are molecules composed of two or more amino acids linked by peptide bonds, and they play essential biological roles. In recent decades, peptides have become pivotal bioactive ingredients in pharmaceuticals and cosmetics due to the…
View article: TMEDs Mediate Versatile Cargo Transport in Vesicle-dependent Unconventional Secretion
TMEDs Mediate Versatile Cargo Transport in Vesicle-dependent Unconventional Secretion Open
Unconventional protein secretion (UcPS) exports diverse signal peptide-lacking cargoes, yet its cargo selectivity remains poorly understood. Here, we identify TMED proteins as key regulators of vesicle-dependent UcPS, mediating selective c…
View article: Atomically Precise Fcc-Amorphous Homometal Heterojunction with ∼1 nm Size
Atomically Precise Fcc-Amorphous Homometal Heterojunction with ∼1 nm Size Open
The emerging of ultrasmall gold nanoparticles (nanoclusters) with atomic precision provides opportunities for precisely studying crystalline-amorphous heterostructures, despite the construction of such structures being challenging. In this…
View article: Unique Gluing Effect of ASXL1 K351 Monoubiquitination Stimulates PR-DUB-Mediated Nucleosomal H2AK119Ub Deubiquitination
Unique Gluing Effect of ASXL1 K351 Monoubiquitination Stimulates PR-DUB-Mediated Nucleosomal H2AK119Ub Deubiquitination Open
Protein ubiquitination plays a critical role in regulating fundamental biological processes through both proteolytic and nonproteolytic mechanisms. While classically known for its role in targeting proteins for degradation, ubiquitination …
View article: Therapeutic Potential of Qilianxiaopi Formula: Targeting ADAM17-Mediated Chronic Inflammation in Atrophic Gastritis
Therapeutic Potential of Qilianxiaopi Formula: Targeting ADAM17-Mediated Chronic Inflammation in Atrophic Gastritis Open
Background: Gastric cancer (GC) is a leading cause of mortality worldwide, particularly in China. Chronic atrophic gastritis (CAG) and intestinal metaplasia (IM) are recognized as precancerous conditions contributing to GC development. Qil…
View article: Policy Frameworks for Transparent Chain-of-Thought Reasoning in Large Language Models
Policy Frameworks for Transparent Chain-of-Thought Reasoning in Large Language Models Open
Chain-of-Thought (CoT) reasoning enhances large language models (LLMs) by decomposing complex problems into step-by-step solutions, improving performance on reasoning tasks. However, current CoT disclosure policies vary widely across diffe…
View article: Oncogenic RAS induces a distinctive form of non-canonical autophagy mediated by the P38-ULK1-PI4KB axis
Oncogenic RAS induces a distinctive form of non-canonical autophagy mediated by the P38-ULK1-PI4KB axis Open
Cancer cells with RAS mutations exhibit enhanced autophagy, essential for their proliferation and survival, making it a potential target for therapeutic intervention. However, the regulatory differences between RAS-induced autophagy and ph…
View article: High-Accuracy De Novo Prediction for N- and O-linked Glycopeptides Across Multiple Fragmentation Techniques
High-Accuracy De Novo Prediction for N- and O-linked Glycopeptides Across Multiple Fragmentation Techniques Open
N- and O-glycosylation, the most intricate post-translational modifications of proteins, is essential for regulating biological functions. Glycoproteomics faces substantial challenges, particularly in the analysis of O-glycans due to its d…
View article: Development of nucleus-targeted histone-tail-based photoaffinity probes to profile the epigenetic interactome in native cells
Development of nucleus-targeted histone-tail-based photoaffinity probes to profile the epigenetic interactome in native cells Open
Dissection of the physiological interactomes of histone post-translational modifications (hPTMs) is crucial for understanding epigenetic regulatory pathways. Peptide- or protein-based histone photoaffinity tools expanded the ability to pro…
View article: Tgm2‐Catalyzed Covalent Cross‐Linking of <scp>IκBα</scp> Drives <scp>NF</scp>‐<scp>κB</scp> Nuclear Translocation to Promote <scp>SASP</scp> in Senescent Microglia
Tgm2‐Catalyzed Covalent Cross‐Linking of <span>IκBα</span> Drives <span>NF</span>‐<span>κB</span> Nuclear Translocation to Promote <span>SASP</span> in Senescent Microglia Open
Microglia, as resident immune cells in the central nervous system (CNS), play a crucial role in maintaining homeostasis and phagocytosing metabolic waste in the brain. Senescent microglia exhibit decreased phagocytic capacity and increased…
View article: Transcriptional Dichotomy Underpins Zygotic Genome Activation and Totipotency Reacquisition
Transcriptional Dichotomy Underpins Zygotic Genome Activation and Totipotency Reacquisition Open
View article: The SpxA1-TenA toxin-antitoxin system regulates epigenetic variations of Streptococcus pneumoniae by targeting protein synthesis
The SpxA1-TenA toxin-antitoxin system regulates epigenetic variations of Streptococcus pneumoniae by targeting protein synthesis Open
Human pathogen Streptococcus pneumoniae forms multiple epigenetically and phenotypically distinct intra-populations by invertase PsrA-driven inversions of DNA methyltransferase hsdS genes in the colony opacity-determinant ( cod ) locus. As…
View article: Clinical Effects of Surgical Delay in Older Patients with Intertrochanteric Fractures: Analysis from the National Inpatient Sample Database
Clinical Effects of Surgical Delay in Older Patients with Intertrochanteric Fractures: Analysis from the National Inpatient Sample Database Open
The clinical effect of surgery timing in older patients with intertrochanteric fractures (IFs) is controversial. Our objective was to assess the association between surgery timing and in-hospital mortality and postoperative complications i…
View article: Oncogenic RAS Induces a Distinctive Form of Non-Canonical Autophagy Mediated by the P38-ULK1-PI4KB Axis
Oncogenic RAS Induces a Distinctive Form of Non-Canonical Autophagy Mediated by the P38-ULK1-PI4KB Axis Open
SUMMARY Cancer cells with RAS mutations exhibit enhanced autophagy, essential for their proliferation and survival, making it a potential target for therapeutic intervention. However, the regulatory differences between RAS-induced autophag…
View article: Nicotinamide mononucleotide protects STAT1 from oxidative stress‐induced degradation to prevent colorectal tumorigenesis
Nicotinamide mononucleotide protects STAT1 from oxidative stress‐induced degradation to prevent colorectal tumorigenesis Open
Colitis, accompanied by the accumulation of reactive oxygen species (ROS) in the intestinal tract, is a risk factor for colorectal cancer (CRC). Our previous studies indicate that nicotinamide mononucleotide (NMN) replenishment reduces chr…
View article: Innenrücktitelbild: Gapped and Rotated Grain Boundary Revealed in Ultra‐Small Au Nanoparticles for Enhancing Electrochemical CO<sub>2</sub> Reduction (Angew. Chem. 3/2025)
Innenrücktitelbild: Gapped and Rotated Grain Boundary Revealed in Ultra‐Small Au Nanoparticles for Enhancing Electrochemical CO<sub>2</sub> Reduction (Angew. Chem. 3/2025) Open
View article: Inside Back Cover: Gapped and Rotated Grain Boundary Revealed in Ultra‐Small Au Nanoparticles for Enhancing Electrochemical CO<sub>2</sub> Reduction (Angew. Chem. Int. Ed. 3/2025)
Inside Back Cover: Gapped and Rotated Grain Boundary Revealed in Ultra‐Small Au Nanoparticles for Enhancing Electrochemical CO<sub>2</sub> Reduction (Angew. Chem. Int. Ed. 3/2025) Open
View article: Development of a new paradigm model for deciphering action mechanism of Danhong injection using a combination of isothermal shift assay and database interrogation
Development of a new paradigm model for deciphering action mechanism of Danhong injection using a combination of isothermal shift assay and database interrogation Open
View article: Cover Picture: Atomically Precise Nanometer‐Sized Pt Catalysts with an Additional Photothermy Functionality (Angew. Chem. Int. Ed. 25/2024)
Cover Picture: Atomically Precise Nanometer‐Sized Pt Catalysts with an Additional Photothermy Functionality (Angew. Chem. Int. Ed. 25/2024) Open
The largest organic-ligand-protected Pt nanoclusters with atomic precision were reported by Lingwen Liao, Jun Yang, and Zhikun Wu et al. in their Research Article (e202402565). The as-obtained Pt23 nanoclusters via a mixture ligand protect…
View article: KLF12 interacts with TRIM27 to affect cisplatin resistance and cancer metastasis in esophageal squamous cell carcinoma by regulating L1CAM expression
KLF12 interacts with TRIM27 to affect cisplatin resistance and cancer metastasis in esophageal squamous cell carcinoma by regulating L1CAM expression Open
Krüppel-like factor 12 (KLF12) has been characterized as a transcriptional repressor, and previous studies have unveiled its roles in angiogenesis, neural tube defect, and natural killer (NK) cell proliferation. However, the contribution o…
View article: Titelbild: Atomically Precise Nanometer‐Sized Pt Catalysts with an Additional Photothermy Functionality (Angew. Chem. 25/2024)
Titelbild: Atomically Precise Nanometer‐Sized Pt Catalysts with an Additional Photothermy Functionality (Angew. Chem. 25/2024) Open
The largest organic-ligand-protected Pt nanoclusters with atomic precision were reported by Lingwen Liao, Jun Yang, and Zhikun Wu et al. in their Research Article (e202402565). The as-obtained Pt23 nanoclusters via a mixture ligand protect…
View article: HER2 phosphorylation induced by TGF-β promotes mammary morphogenesis and breast cancer progression
HER2 phosphorylation induced by TGF-β promotes mammary morphogenesis and breast cancer progression Open
Transforming growth factor β (TGF-β) and HER2 signaling collaborate to promote breast cancer progression. However, their molecular interplay is largely unclear. TGF-β can activate mitogen-activated protein kinase (MAPK) and AKT, but the un…
View article: MCT1-governed pyruvate metabolism is essential for antibody class-switch recombination through H3K27 acetylation
MCT1-governed pyruvate metabolism is essential for antibody class-switch recombination through H3K27 acetylation Open
View article: Co-Transcriptional Rna Processing Boosts Zygotic Gene Activation
Co-Transcriptional Rna Processing Boosts Zygotic Gene Activation Open
View article: Comparison of Lipid Profiles of Male and Female Silkworm (Bombyx Mori) Pupaethrough High-Resolution Mass Spectrometry-Based Lipidomics and Chemometrics
Comparison of Lipid Profiles of Male and Female Silkworm (Bombyx Mori) Pupaethrough High-Resolution Mass Spectrometry-Based Lipidomics and Chemometrics Open
View article: Untargeted Screening and Differential Analysis of Bioactive Compounds in Male and Female Silkworm (Bombyx Mori) Pupae Through Orbitrap Exploris Mass Spectrometry
Untargeted Screening and Differential Analysis of Bioactive Compounds in Male and Female Silkworm (Bombyx Mori) Pupae Through Orbitrap Exploris Mass Spectrometry Open