Haitong Hou
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View article: Shugoshin holds the potential to inhibit APC/C and thereby prevents separase activation
Shugoshin holds the potential to inhibit APC/C and thereby prevents separase activation Open
Accurate chromosome segregation during mitosis and meiosis depends on shugoshin protein which localizes at the centromere of chromosomes. Sgo1, a meiosis-specific shugoshin in fission yeast, collaborates with the PP2A phosphatase enzyme to…
View article: Bromodomain protein BRD4 directs mitotic cell division of mouse fibroblasts by inhibiting DNA damage
Bromodomain protein BRD4 directs mitotic cell division of mouse fibroblasts by inhibiting DNA damage Open
Bromodomain protein BRD4 binds to acetylated histones to regulate transcription. BRD4 also drives cancer cell proliferation. However, the role of BRD4 in normal cell growth has remained unclear. Here, we investigated this question by using…
View article: BRD4 directs mitotic cell division by inhibiting DNA damage
BRD4 directs mitotic cell division by inhibiting DNA damage Open
SUMMARY BRD4 binds to acetylated histones to regulate transcription and drive cancer cell proliferation. However, the role of BRD4 in normal cell growth remains to be elucidated. Here we investigated the question by using mouse embryonic f…