Haixia Yang
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View article: Green Extraction of Lotus Leaf (Nelumbo nucifera Gaertn) Polyphenols: Unraveling the Mechanism of Ultrasound-Assisted Deep Eutectic Solvents
Green Extraction of Lotus Leaf (Nelumbo nucifera Gaertn) Polyphenols: Unraveling the Mechanism of Ultrasound-Assisted Deep Eutectic Solvents Open
Deep eutectic solvents (DESs) have attracted considerable attention in recent years because of their cost-effectiveness, safety, and sustainability. In this study, we developed 19 DESs for the extraction of antioxidant polyphenolic compoun…
View article: Comparison of organ dysfunction patterns in pediatric hemophagocytic lymphohistiocytosis and sepsis: incidence, adverse outcomes, and cluster characteristics
Comparison of organ dysfunction patterns in pediatric hemophagocytic lymphohistiocytosis and sepsis: incidence, adverse outcomes, and cluster characteristics Open
Background Hemophagocytic lymphohistiocytosis (HLH) and severe sepsis share similarities in their clinical manifestations, and both have high risks of developing multiple organ dysfunction syndrome (MODS). The aim of this study was to inve…
View article: Clinical analysis of Pneumocystis jirovecii pneumonia in children with malignant disease
Clinical analysis of Pneumocystis jirovecii pneumonia in children with malignant disease Open
View article: Aucklandia lappa Decne.: a review of its botany, cultivation, ethnopharmacology, phytochemistry, pharmacology, and practical applications
Aucklandia lappa Decne.: a review of its botany, cultivation, ethnopharmacology, phytochemistry, pharmacology, and practical applications Open
Aucklandia lappa Decne. (ALD), a synonym of Saussurea costus (Falc.) Lipsch., is a traditional Chinese medicinal herb extensively cultivated in China. Aucklandiae Radix (AR, known as “Muxiang” in China), derived from the dried root of ALD,…
View article: Salvianolic acid A from Salvia miltiorrhiza identified as a cap-dependent endonuclease inhibitor for pathogenic arenaviruses
Salvianolic acid A from Salvia miltiorrhiza identified as a cap-dependent endonuclease inhibitor for pathogenic arenaviruses Open
Negative-stranded segmented RNA viruses (NSVs) employ a cap-snatching mechanism for transcription, which makes cap-dependent endonuclease (CEN) an attractive target for drug development. Pathogenic arenaviruses pose a serious threat to hum…
View article: Comparison of different ginsenosides with C-3 or C-6 sugar moieties on activities in alcohol-induced liver injury mice
Comparison of different ginsenosides with C-3 or C-6 sugar moieties on activities in alcohol-induced liver injury mice Open
View article: Advances in Nanotechnology Research in Food Production, Nutrition, and Health
Advances in Nanotechnology Research in Food Production, Nutrition, and Health Open
Nanotechnology, as a burgeoning interdisciplinary field, has a significant application potential in food nutrition and human health due to its distinctive structural characteristics and surface effects. This paper methodically examines the…
View article: Valorization of broccoli waste: Unlocking its potential as a functional food ingredient for sustainable nutrition
Valorization of broccoli waste: Unlocking its potential as a functional food ingredient for sustainable nutrition Open
Key nutrients-including carbohydrates, proteins, dietary fiber, vitamins, and an array of phytochemicals such as glucosinolates and phenolic compounds-are detailed alongside their associated health benefits, including antioxidant, anti-inf…
View article: Hydrophobic residue substitutions enhance the stability and <i>in vivo</i> immunogenicity of respiratory syncytial virus fusion protein
Hydrophobic residue substitutions enhance the stability and <i>in vivo</i> immunogenicity of respiratory syncytial virus fusion protein Open
Respiratory syncytial virus (RSV) entry into host cells is facilitated by viral fusion, wherein the metastable RSV fusion (F) protein undergoes a conformational change from a prefusion state to a highly stable postfusion structure. The pre…
View article: Structure−activity relationship of ginsenoside derivatives with different glycosides and double bond position on anti-aging bioactivities
Structure−activity relationship of ginsenoside derivatives with different glycosides and double bond position on anti-aging bioactivities Open
View article: Gut Microbiota Mitigates Liver Injury and Fibrosis via Activation of the CYP Eicosanoid Pathway
Gut Microbiota Mitigates Liver Injury and Fibrosis via Activation of the CYP Eicosanoid Pathway Open
View article: Extensive Nail Changes Are a Possible Clue Indicating Multisystem Involvement in Childhood Langerhans Cell Histiocytosis: A Case Report and Literature Review
Extensive Nail Changes Are a Possible Clue Indicating Multisystem Involvement in Childhood Langerhans Cell Histiocytosis: A Case Report and Literature Review Open
Introduction: Langerhans cell histiocytosis (LCH) is a rare myeloid neoplasm that can involve nearly any organ, leading to multisystem damage. Nail involvement in LCH is particularly uncommon. Here we report a case of a young boy with mult…
View article: Severe immune-mediated myocarditis caused by sintilimab combined with gemcitabine: a case report and literature review
Severe immune-mediated myocarditis caused by sintilimab combined with gemcitabine: a case report and literature review Open
Following the approval of sintilimab for lung cancer immunotherapy in China in June 2021, real-world clinical practice has confirmed its efficacy and safety. Although there have been limited reports of immune-related myocarditis associated…
View article: Gut Microbiota Protects Against Liver Injury and Fibrosis via Activation of the CYP Eicosanoid Pathway
Gut Microbiota Protects Against Liver Injury and Fibrosis via Activation of the CYP Eicosanoid Pathway Open
View article: A comprehensive review on bioactive compounds from <i>Lycium</i> seeds: extraction, characterization, bioactivities, and applications
A comprehensive review on bioactive compounds from <i>Lycium</i> seeds: extraction, characterization, bioactivities, and applications Open
View article: A Comprehensive Review on Dietary Polysaccharides as Prebiotics, Synbiotics, and Postbiotics in Infant Formula and Their Influences on Gut Microbiota
A Comprehensive Review on Dietary Polysaccharides as Prebiotics, Synbiotics, and Postbiotics in Infant Formula and Their Influences on Gut Microbiota Open
Human milk contains an abundance of nutrients which benefit the development and growth of infants. However, infant formula has to be used when breastfeeding is not possible. The large differences between human milk and infant formula in pr…
View article: Reinforced identity confers cells with cancer hallmarks
Reinforced identity confers cells with cancer hallmarks Open
Genetic alterations trigger tumorigenesis in a cell type-specific manner, but the biological basis for this, remains unclear. Here we define reinforced original cell identity established by interaction between genetic alterations and origi…
View article: Investigating the non-covalent interactions between rutin and superoxide dismutase: Focus on thermal stability, structure, and in vitro digestion
Investigating the non-covalent interactions between rutin and superoxide dismutase: Focus on thermal stability, structure, and in vitro digestion Open
View article: A Review on In Vivo Research Dehydration Models and Application of Rehydration Strategies
A Review on In Vivo Research Dehydration Models and Application of Rehydration Strategies Open
Background: Dehydration, a common condition where the amount water lost from the body exceeds intake, disrupts metabolic processes and negatively impacts health and performance. Rehydration, the process of restoring body fluids and electro…
View article: Blood‐Brain Barrier‐Penetrating Metal‐Organic Framework Antioxidant Nanozymes for Targeted Ischemic Stroke Therapy
Blood‐Brain Barrier‐Penetrating Metal‐Organic Framework Antioxidant Nanozymes for Targeted Ischemic Stroke Therapy Open
Overproduction of reactive oxygen species (ROS) during reperfusion in ischemic stroke (IS) severely impedes neuronal survival and results in high rates of morbidity and disability. The effective blood‐brain barrier (BBB) penetration and br…
View article: A new mechanism of respiratory syncytial virus entry inhibition by small-molecule to overcome K394R-associated resistance
A new mechanism of respiratory syncytial virus entry inhibition by small-molecule to overcome K394R-associated resistance Open
Infection with respiratory syncytial virus (RSV) is a major cause of acute lower respiratory tract disease in young children and older people. Despite intensive efforts over the past few decades, no direct-acting small-molecule agents agai…
View article: Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract
Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract Open
View article: Natural bioactive compounds as potential sources for alleviation and treatment of androgenetic alopecia: A research advance
Natural bioactive compounds as potential sources for alleviation and treatment of androgenetic alopecia: A research advance Open
Alopecia is a common chronic skin disease, which can be categorized as androgenetic alopecia (AGA), scarring line alopecia, genetic alopecia, and chemical alopecia due to the different reasons. Among which AGA caused by metabolism of the a…
View article: Enhancing cancer immunotherapy via inhibition of soluble epoxide hydrolase
Enhancing cancer immunotherapy via inhibition of soluble epoxide hydrolase Open
Cancer therapy, including immunotherapy, is inherently limited by chronic inflammation-induced tumorigenesis and toxicity within the tumor microenvironment. Thus, stimulating the resolution of inflammation may enhance immunotherapy and imp…
View article: Bioavailability and mechanisms of dietary polyphenols affected by non-thermal processing technology in fruits and vegetables
Bioavailability and mechanisms of dietary polyphenols affected by non-thermal processing technology in fruits and vegetables Open
View article: Comparison Analysis of Bioactive Metabolites in Soybean, Pea, Mung Bean, and Common Beans and Reveal the Potential Variations of Their Antioxidant Property
Comparison Analysis of Bioactive Metabolites in Soybean, Pea, Mung Bean, and Common Beans and Reveal the Potential Variations of Their Antioxidant Property Open
View article: Comparison Analysis of Basic Nutrients and Bioactive Compounds in Four Varieties of Black Wolfberry Seed by Metabolomics Analysis
Comparison Analysis of Basic Nutrients and Bioactive Compounds in Four Varieties of Black Wolfberry Seed by Metabolomics Analysis Open
View article: Phytochemicals in Chronic Disease Prevention
Phytochemicals in Chronic Disease Prevention Open
Chronic diseases, also known as noncommunicable diseases (NCD), are characterized by long durations and a slow progression of the associated medical conditions [...]
View article: Natural aporphine alkaloids: A comprehensive review of phytochemistry, pharmacokinetics, anticancer activities, and clinical application
Natural aporphine alkaloids: A comprehensive review of phytochemistry, pharmacokinetics, anticancer activities, and clinical application Open
This review aims to comprehensively summarize the phytochemistry, pharmacokinetics, and bioavailability of seven subtypes of AAs and their derivatives from various plants and highlight their anticancer bioactivities and mechanisms of actio…
View article: Structure-activity relationship, bioactivities, molecular mechanisms, and clinical application of nuciferine on inflammation-related diseases
Structure-activity relationship, bioactivities, molecular mechanisms, and clinical application of nuciferine on inflammation-related diseases Open
Nuciferine aporphine alkaloid mainly exists in Nelumbo nucifera Gaertn and is a beneficial to human health, such as anti-obesity, lowering blood lipid, prevention of diabetes and cancer, closely associated with inflammation. Importantly, n…