Haixia Zheng
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View article: Decomposing genetic effects of social connectedness and depression on youth behaviors and long-term clinical outcomes
Decomposing genetic effects of social connectedness and depression on youth behaviors and long-term clinical outcomes Open
Importance Lacking social connectedness is associated with broad morbidity. Yet the underlying mechanisms remain obscures, especially given its entanglement with depressive symptoms. Clarifying whether social connectedness confers unique r…
View article: Polygenic score for C-reactive protein is associated with accelerated cortical thinning and increased psychopathology in adolescents: a population-based longitudinal cohort study.
Polygenic score for C-reactive protein is associated with accelerated cortical thinning and increased psychopathology in adolescents: a population-based longitudinal cohort study. Open
Adolescence is a critical neurodevelopmental window characterized by rapid cortical thinning, during which vulnerability to psychiatric disorders significantly increases. Although increased rates of cortical thinning have been associated w…
View article: Impact of family care on sleep quality in perimenopausal women: mediating roles of anxiety and depression
Impact of family care on sleep quality in perimenopausal women: mediating roles of anxiety and depression Open
Anxiety and depression are mediating variables between family care and sleep quality in perimenopausal women. It is recommended that hospital and community staff pay attention to the role of good family care in perimenopausal women, active…
View article: Association between red blood cell distribution width-to-albumin ratio and prognosis in post-cardiac arrest patients: data from the MIMIC-IV database
Association between red blood cell distribution width-to-albumin ratio and prognosis in post-cardiac arrest patients: data from the MIMIC-IV database Open
Background Cardiac arrest (CA) triggers a systemic inflammatory response, resulting in brain and cardiovascular dysfunction. The red blood cell distribution width (RDW)-to-albumin ratio (RAR) has been widely explored in various inflammatio…
View article: Structural brain correlates in major depressive disorder, anxiety disorders, and post-traumatic stress disorder: a diffusion tensor imaging meta-analysis
Structural brain correlates in major depressive disorder, anxiety disorders, and post-traumatic stress disorder: a diffusion tensor imaging meta-analysis Open
The high comorbidity of major depressive disorder (MDD), anxiety disorders (ANX), and post-traumatic stress disorder (PTSD) complicates the study of their structural neural correlates, particularly in white matter (WM) alterations. Using f…
View article: The Impact of Family Care on Sleep Quality in Perimenopausal Women: Mediating Roles of Anxiety and Depression
The Impact of Family Care on Sleep Quality in Perimenopausal Women: Mediating Roles of Anxiety and Depression Open
Background Family systems theory posits that the family serves as the most intimate social support network, offering patients practical care, companionship, and emotional communication. Effective family functioning can significantly enhanc…
View article: VIRES: Video Instance Repainting via Sketch and Text Guided Generation
VIRES: Video Instance Repainting via Sketch and Text Guided Generation Open
We introduce VIRES, a video instance repainting method with sketch and text guidance, enabling video instance repainting, replacement, generation, and removal. Existing approaches struggle with temporal consistency and accurate alignment w…
View article: Thinking Before Looking: Improving Multimodal LLM Reasoning via Mitigating Visual Hallucination
Thinking Before Looking: Improving Multimodal LLM Reasoning via Mitigating Visual Hallucination Open
Multimodal large language models (MLLMs) have advanced the integration of visual and linguistic modalities, establishing themselves as the dominant paradigm for visual-language tasks. Current approaches like chain of thought (CoT) reasonin…
View article: Leptin’s Inverse Association With Brain Morphology and Depressive Symptoms: A Discovery and Confirmatory Study Across 2 Independent Samples
Leptin’s Inverse Association With Brain Morphology and Depressive Symptoms: A Discovery and Confirmatory Study Across 2 Independent Samples Open
The inverse association between leptin and cortical surface area in brain regions that are important for emotion processing and leptin's association with atypical depressive symptoms support the hypothesis that metabolic processes may be r…
View article: Increased expression of ER stress, inflammasome activation, and mitochondrial biogenesis-related genes in peripheral blood mononuclear cells in major depressive disorder
Increased expression of ER stress, inflammasome activation, and mitochondrial biogenesis-related genes in peripheral blood mononuclear cells in major depressive disorder Open
A subset of major depressive disorder (MDD) is characterized by immune system dysfunction, but the intracellular origin of these immune changes remains unclear. Here we tested the hypothesis that abnormalities in the endoplasmic reticulum …
View article: Impact of hs-CRP concentration on brain structure alterations and cognitive trajectory in Alzheimer’s disease
Impact of hs-CRP concentration on brain structure alterations and cognitive trajectory in Alzheimer’s disease Open
Introduction Present study was to investigate hs-CRP concentration, brain structural alterations, and cognitive function in the context of AD [Subjective cognitive decline (SCD), mild cognitive impairment (MCI), and AD]. Methods We retrosp…
View article: The effects of cytomegalovirus on brain structure following sport-related concussion
The effects of cytomegalovirus on brain structure following sport-related concussion Open
The neurotrophic herpes virus cytomegalovirus is a known cause of neuropathology in utero and in immunocompromised populations. Cytomegalovirus is reactivated by stress and inflammation, possibly explaining the emerging evidence linking it…
View article: Active learning impairments in substance use disorders when resolving the explore-exploit dilemma: A replication and extension of previous computational modeling results
Active learning impairments in substance use disorders when resolving the explore-exploit dilemma: A replication and extension of previous computational modeling results Open
Background Substance use disorders (SUDs) represent a major public health risk. Yet, our understanding of the mechanisms that maintain these disorders remains incomplete. In a recent computational modeling study, we found initial evidence …
View article: Cytomegalovirus antibodies are associated with mood disorders, suicide, markers of neuroinflammation, and microglia activation in postmortem brain samples
Cytomegalovirus antibodies are associated with mood disorders, suicide, markers of neuroinflammation, and microglia activation in postmortem brain samples Open
Cytomegalovirus (CMV) is a common, neurotrophic herpesvirus that can be reactivated by inflammation and cause neurological disease. CMV replication can in turn worsen inflammation, raising the possibility that poorly controlled CMV infecti…
View article: Slower Learning Rates from Negative Outcomes in Substance Use Disorder over a 1-Year Period and Their Potential Predictive Utility
Slower Learning Rates from Negative Outcomes in Substance Use Disorder over a 1-Year Period and Their Potential Predictive Utility Open
Computational modelling is a promising approach to parse dysfunctional cognitive processes in substance use disorders (SUDs), but it is unclear how much these processes change during the recovery period. We assessed 1-year follow-up data o…
View article: Elevated Systemic Inflammation Is Associated with Reduced Corticolimbic White Matter Integrity in Depression
Elevated Systemic Inflammation Is Associated with Reduced Corticolimbic White Matter Integrity in Depression Open
(1) Background: Growing evidence indicates that inflammation can induce neural circuit dysfunction and plays a vital role in the pathogenesis of major depressive disorder (MDD). Nevertheless, whether inflammation affects the integrity of w…
View article: Slower Learning Rates from Negative Outcomes in Substance Use Disorder over a 1-Year Period and their Potential Predictive Utility
Slower Learning Rates from Negative Outcomes in Substance Use Disorder over a 1-Year Period and their Potential Predictive Utility Open
Computational modelling is a promising approach to parse dysfunctional cognitive processes in substance use disorders (SUDs), but it is unclear how much these processes change during the recovery period. We assessed 1-year follow-up data o…
View article: Association between cytomegalovirus infection, reduced gray matter volume, and resting-state functional hypoconnectivity in major depressive disorder: a replication and extension
Association between cytomegalovirus infection, reduced gray matter volume, and resting-state functional hypoconnectivity in major depressive disorder: a replication and extension Open
Human cytomegalovirus (HCMV) is a neurotropic herpes virus known to cause neuropathology in patients with impaired immunity. Previously, we reported a reduction in the gray matter volume (GMV) of several brain regions in two independent sa…
View article: Replicable association between human cytomegalovirus infection and reduced white matter fractional anisotropy in major depressive disorder
Replicable association between human cytomegalovirus infection and reduced white matter fractional anisotropy in major depressive disorder Open
Major depressive disorder (MDD) is associated with reductions in white matter microstructural integrity as measured by fractional anisotropy (FA), an index derived from diffusion tensor imaging (DTI). The neurotropic herpesvirus, human cyt…
View article: Viral shedding and immunological features of children COVID-19 patients
Viral shedding and immunological features of children COVID-19 patients Open
Background SARS-CoV-2 could infect people at all ages, and the viral shedding and immunological features of children COVID-19 patients were analyzed. Methods Epidemiological information and clinical data were collected from 35 children pat…
View article: Viral shedding and immunological features of children COVID-19 patients
Viral shedding and immunological features of children COVID-19 patients Open
Background SARS-CoV-2 could infect people at all ages, and the viral shedding and immunological features of children COVID-19 patients were analyzed. Methods Epidemiological information and clinical data were collected from 35 children pat…
View article: Viral shedding and immunological features of children COVID-19 patients
Viral shedding and immunological features of children COVID-19 patients Open
Background SARS-CoV-2 could infect people at all ages, and the viral shedding and immunological features of children COVID-19 patients were analyzed. Methods Epidemiological information and clinical data were collected from 35 children pat…