Haixiang Sun
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View article: Characterization and evaluation of Fe2+ and Mn2+ in reservoirs and sediments in the Jianghuai Region
Characterization and evaluation of Fe2+ and Mn2+ in reservoirs and sediments in the Jianghuai Region Open
A dynamic monitoring study of water quality and sediment was conducted in August 2024 at four drinking water reservoirs in Hefei City (Dafangying, Dongpu, Modun, and Zhongxing Reservoirs). Monitoring results indicate: (1) Compared to the s…
View article: Correlation of telomere length and DNA damage markers with severity and associated depressive states in patients with OSAS
Correlation of telomere length and DNA damage markers with severity and associated depressive states in patients with OSAS Open
Objective Investigation of the correlation of peripheral blood leukocyte relative telomere length (RTL) and DNA damage markers with severity and related depressive states in patients with obstructive sleep apnea syndrome (OSAS). Methods A …
View article: Automated Quantification of Trophectoderm Morphology in Human Blastocysts via Instance Segmentation
Automated Quantification of Trophectoderm Morphology in Human Blastocysts via Instance Segmentation Open
Segmenting individual trophectoderm (TE) cells is essential for developing quantitative metrics to assess the developmental potential of human blastocyst. The elongated shape and circular arrangement of TE cells lead to continuously varyin…
View article: Mevalonate metabolites boost aged oocyte quality through prenylation of small GTPases
Mevalonate metabolites boost aged oocyte quality through prenylation of small GTPases Open
Declining oocyte quality is the major contributor to female subfertility in aged mammals. Currently, there are no effective interventions to ameliorate aged oocyte quality. Here we found that oocytes at metaphase I from the cumulus-oocyte …
View article: Targeting aerobic glycolysis combats tyrosine kinase inhibitor resistance of hepatocellular carcinoma
Targeting aerobic glycolysis combats tyrosine kinase inhibitor resistance of hepatocellular carcinoma Open
Hepatocellular carcinoma (HCC) represents the predominant form of primary liver cancer and is frequently identified at a late stage, necessitating systemic therapy. However, resistance to first‐line tyrosine kinase inhibitor therapies, suc…
View article: Blastocyst selection through an interpretable artificial intelligence method versus traditional morphology grading: study protocol for a randomised controlled trial
Blastocyst selection through an interpretable artificial intelligence method versus traditional morphology grading: study protocol for a randomised controlled trial Open
Introduction The quality of the blastocyst (day 5/6 embryo) selected for transfer is critical for the success of in vitro fertilisation (IVF) treatment. Embryologists perform blastocyst evaluation by observing the morphology of each blasto…
View article: Retraction Note: High levels of fatty acid-binding protein 5 excessively enhances fatty acid synthesis and proliferation of granulosa cells in polycystic ovary syndrome
Retraction Note: High levels of fatty acid-binding protein 5 excessively enhances fatty acid synthesis and proliferation of granulosa cells in polycystic ovary syndrome Open
View article: Deep learning-based prediction of individualized Real-time FSH doses in GnRH agonist long protocols
Deep learning-based prediction of individualized Real-time FSH doses in GnRH agonist long protocols Open
This is the first study to apply a cross-temporal and cross-feature deep learning framework for daily, individualized FSH dose prediction across the full duration of COS. The model demonstrated superior performance over conventional approa…
View article: <sup>18</sup> F-FDG PET/CT Predicts the Prognosis of Patients with Hepatocellular Carcinoma Undergoing Liver Transplantation
<sup>18</sup> F-FDG PET/CT Predicts the Prognosis of Patients with Hepatocellular Carcinoma Undergoing Liver Transplantation Open
Introduction: In addition to radical resection, liver transplantation (LTx) is an effective treatment for hepatocellular carcinoma (HCC). However, tumor recurrence limits the efficacy of LTx in some patients. This study investigated the ro…
View article: Subcutaneous delivery of icariin via a gelatin methacryloyl (GelMA) hydrogel sustained-release system improves ovarian function in reproductively aged mice
Subcutaneous delivery of icariin via a gelatin methacryloyl (GelMA) hydrogel sustained-release system improves ovarian function in reproductively aged mice Open
Ovarian aging is characterized by a progressive decline in oocyte quality and quantity with age. Icariin (ICA), a flavonoid compound derived from Epimedium species, has demonstrated potential as an agent for ovarian restoration. In …
View article: CDC42 deficiency leads to endometrial stromal cell senescence in recurrent implantation failure
CDC42 deficiency leads to endometrial stromal cell senescence in recurrent implantation failure Open
STUDY QUESTION Does the downregulation of cell division cycle 42 (CDC42) protein in endometrial stroma lead to endometrial senescence in patients with recurrent implantation failure (RIF), and what is the potential mechanism? SUMMARY ANSWE…
View article: Convergence on CaMK4: a key modulator of autism-associated signaling pathways in neurons
Convergence on CaMK4: a key modulator of autism-associated signaling pathways in neurons Open
View article: Convergence on CaMK4: A Key Modulator of Autism-Associated Signaling Pathways in Neurons
Convergence on CaMK4: A Key Modulator of Autism-Associated Signaling Pathways in Neurons Open
Although the precise underlying cause(s) of autism spectrum disorder remain unclear, more than 1000 rare genetic variations are associated with the condition. For many people living with profound autism, this genetic heterogeneity has impe…
View article: The impact of long-acting GnRHa pretreatment on the clinical pregnancy outcomes of hormone replacement therapy-frozen embryo transfer in RIF patients with PCOS: a retrospective clinical study
The impact of long-acting GnRHa pretreatment on the clinical pregnancy outcomes of hormone replacement therapy-frozen embryo transfer in RIF patients with PCOS: a retrospective clinical study Open
Background Several studies have demonstrated that pre-treatment with long-acting Gonadotropin-Releasing Hormone agonists (GnRHa) can significantly enhance the clinical pregnancy rate among recurrent implantation failure (RIF) patients. Inv…
View article: Anlotinib potentiates anti‐PD1 immunotherapy via transferrin receptor‐dependent CD8<sup>+</sup> T‐cell infiltration in hepatocellular carcinoma
Anlotinib potentiates anti‐PD1 immunotherapy via transferrin receptor‐dependent CD8<sup>+</sup> T‐cell infiltration in hepatocellular carcinoma Open
Background The therapeutic potential of immune checkpoint blockade (ICB) extends across various cancers; however, its effectiveness in treating hepatocellular carcinoma (HCC) is frequently curtailed by both inherent and developed resistanc…
View article: Elevated levels of KLF12 impair trophoblast syncytialization via GCM1 downregulation
Elevated levels of KLF12 impair trophoblast syncytialization via GCM1 downregulation Open
Objective: Placental dysfunction is a major contributor to miscarriages in humans. We observed elevated expression of Kruppel-like factor 12 (KLF12) in placental villi of women who experienced miscarriage compared to that in women with hea…
View article: Transplantation of human endometrial perivascular stem cells with hydroxy saffron yellow A promotes uterine repair in rats
Transplantation of human endometrial perivascular stem cells with hydroxy saffron yellow A promotes uterine repair in rats Open
Background Intrauterine adhesions (IUAs) jeopardise uterine function in women, which is a great challenge in the clinic. Previous studies have shown that endometrial perivascular cells (En-PSCs) can improve the healing of scarred uteri and…
View article: Single-cell analysis reveals a subpopulation of adipose progenitor cells that impairs glucose homeostasis
Single-cell analysis reveals a subpopulation of adipose progenitor cells that impairs glucose homeostasis Open
Adipose progenitor cells (APCs) are heterogeneous stromal cells and help to maintain metabolic homeostasis. However, the influence of obesity on human APC heterogeneity and the role of APC subpopulations on regulating glucose homeostasis r…
View article: The relationship between duration of infertility and clinical outcomes of intrauterine insemination for younger women: a retrospective clinical study
The relationship between duration of infertility and clinical outcomes of intrauterine insemination for younger women: a retrospective clinical study Open
Background The objective of this research was to elucidate the association between the length of infertility and the outcomes of intrauterine insemination (IUI) in women of varying ages - a topic that has been the subject of investigation …
View article: RETRACTED ARTICLE: High levels of fatty acid-binding protein 5 excessively enhances fatty acid synthesis and proliferation of granulosa cells in polycystic ovary syndrome
RETRACTED ARTICLE: High levels of fatty acid-binding protein 5 excessively enhances fatty acid synthesis and proliferation of granulosa cells in polycystic ovary syndrome Open
Background Polycystic ovary syndrome (PCOS) is one of the most complex endocrine disorders in women of reproductive age. Abnormal proliferation of granulosa cells (GCs) is an important cause of PCOS. This study aimed to explore the role of…
View article: PRMT5 deficiency disturbs Nur77 methylation to inhibit endometrial stromal cell differentiation in recurrent implantation failure
PRMT5 deficiency disturbs Nur77 methylation to inhibit endometrial stromal cell differentiation in recurrent implantation failure Open
Various posttranslational modifications (PTMs) have been implicated in endometrial stromal cell (EnSC) differentiation, but the potential role of PTM crosstalk has not been identified. Here, we report that protein arginine methyltransferas…
View article: Dysregulation of endometrial stromal serotonin homeostasis leading to abnormal phosphatidylcholine metabolism impairs decidualization in patients with recurrent implantation failure
Dysregulation of endometrial stromal serotonin homeostasis leading to abnormal phosphatidylcholine metabolism impairs decidualization in patients with recurrent implantation failure Open
STUDY QUESTION Does abnormal serotonin homeostasis contribute to impaired endometrial decidualization in patients with recurrent implantation failure (RIF)? SUMMARY ANSWER Abnormal serotonin homeostasis in patients with RIF, which is accom…
View article: Gestational Progesterone Restores Menstrual Cycle in PCOS Patients via Enhancing Ovary Estrogen Production
Gestational Progesterone Restores Menstrual Cycle in PCOS Patients via Enhancing Ovary Estrogen Production Open
View article: Effect of Elevated Progesterone Levels on hCG Trigger Day on Clinical Pregnancy Outcome in Short-Acting GnRHa Downregulated Cycles
Effect of Elevated Progesterone Levels on hCG Trigger Day on Clinical Pregnancy Outcome in Short-Acting GnRHa Downregulated Cycles Open
In the luteal phase short-acting GnRHa downregulated IVF-ET cycles, the elevated serum P levels on the hCG day did not affect the CPR of cleavage-stage embryo transfer but reduced the CPR of blastocyst transfer.
View article: Decreased HAT1 expression in granulosa cells disturbs oocyte meiosis during mouse ovarian aging
Decreased HAT1 expression in granulosa cells disturbs oocyte meiosis during mouse ovarian aging Open
Background With advanced maternal age, abnormalities during oocyte meiosis increase significantly. Aneuploidy is an important reason for the reduction in the quality of aged oocytes. However, the molecular mechanism of aneuploidy in aged o…
View article: MGA-seq: robust identification of extrachromosomal DNA and genetic variants using multiple genetic abnormality sequencing
MGA-seq: robust identification of extrachromosomal DNA and genetic variants using multiple genetic abnormality sequencing Open
Genomic abnormalities are strongly associated with cancer and infertility. In this study, we develop a simple and efficient method — multiple genetic abnormality sequencing (MGA-Seq) — to simultaneously detect structural variation, copy nu…
View article: Oocytes orchestrate protein prenylation for mitochondrial function through selective inactivation of cholesterol biosynthesis in murine species
Oocytes orchestrate protein prenylation for mitochondrial function through selective inactivation of cholesterol biosynthesis in murine species Open
View article: Krüppel-like factor 12 regulates aging ovarian granulosa cell apoptosis by repressing SPHK1 transcription and sphingosine-1-phosphate (S1P) production
Krüppel-like factor 12 regulates aging ovarian granulosa cell apoptosis by repressing SPHK1 transcription and sphingosine-1-phosphate (S1P) production Open
View article: Targeting <scp>CD301</scp> <sup>+</sup> macrophages inhibits endometrial fibrosis and improves pregnancy outcome
Targeting <span>CD301</span> <sup>+</sup> macrophages inhibits endometrial fibrosis and improves pregnancy outcome Open
Macrophages are a key and heterogeneous cell population involved in endometrial repair and regeneration during the menstrual cycle, but their role in the development of intrauterine adhesion (IUA) and sequential endometrial fibrosis remain…
View article: Decidual macrophages derived NO downregulates PD-L1 in trophoblasts leading to decreased Treg cells in recurrent miscarriage
Decidual macrophages derived NO downregulates PD-L1 in trophoblasts leading to decreased Treg cells in recurrent miscarriage Open
Introduction Placental trophoblasts contribute to regulatory T (Treg) function via the programmed cell death-1 (PD-1)/PD-1 ligand 1 (PD-L1) pathway during normal pregnancy. Decreased expression of PD-L1 in trophoblasts was closely associat…