Haiyang Sun
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View article: The association between vitamin D and restless legs syndrome following acute ischemic stroke
The association between vitamin D and restless legs syndrome following acute ischemic stroke Open
View article: Endogenous IL-33 inhibits apoptosis in non-small cell lung cancer cells by regulating BCL2/BAX via the ERK1/2 pathway
Endogenous IL-33 inhibits apoptosis in non-small cell lung cancer cells by regulating BCL2/BAX via the ERK1/2 pathway Open
View article: CDMPred: a tool for predicting cancer driver missense mutations with high-quality passenger mutations
CDMPred: a tool for predicting cancer driver missense mutations with high-quality passenger mutations Open
Most computational methods for predicting driver mutations have been trained using positive samples, while negative samples are typically derived from statistical methods or putative samples. The representativeness of these negative sample…
View article: DDX18 Facilitates the Tumorigenesis of Lung Adenocarcinoma by Promoting Cell Cycle Progression through the Upregulation of CDK4
DDX18 Facilitates the Tumorigenesis of Lung Adenocarcinoma by Promoting Cell Cycle Progression through the Upregulation of CDK4 Open
Lung adenocarcinoma (LUAD) is the most prevalent and aggressive subtype of lung cancer, exhibiting a dismal prognosis with a five-year survival rate below 5%. DEAD-box RNA helicase 18 (DDX18, gene symbol DDX18), a crucial regulator of RNA …
View article: Towards Effective Measures for Curbing the Illegal Wildlife Trade: A Comprehensive Approach with ARIMA Modeling and Responsible Party Evaluation
Towards Effective Measures for Curbing the Illegal Wildlife Trade: A Comprehensive Approach with ARIMA Modeling and Responsible Party Evaluation Open
Illegal wildlife trade has become an urgent global problem that threatens global ecosystems, biodiversity and sustainable development. This problem requires us to propose comprehensive measures to significantly curb illegal wildlife trade.…
View article: Associations of anxiety and depression with restless leg syndrome: a systematic review and meta-analysis
Associations of anxiety and depression with restless leg syndrome: a systematic review and meta-analysis Open
Background The levels of anxiety and depression among patients with restless leg syndrome (RLS) are controversial. The aim of this systematic review and meta-analysis was to compare the levels of depression and anxiety among individuals wi…
View article: Association between dietary sugar intake and depression in US adults: a cross-sectional study using data from the National Health and Nutrition Examination Survey 2011–2018
Association between dietary sugar intake and depression in US adults: a cross-sectional study using data from the National Health and Nutrition Examination Survey 2011–2018 Open
View article: Dot1l cooperates with Npm1 to repress endogenous retrovirus MERVL in embryonic stem cells
Dot1l cooperates with Npm1 to repress endogenous retrovirus MERVL in embryonic stem cells Open
Dot1l is a histone methyltransferase without a SET domain and is responsible for H3K79 methylation, which marks active transcription. In contradiction, Dot1l also participates in silencing gene expression. The target regions and mechanism …
View article: Association between dietary caffeine intake and severe headache or migraine in US adults
Association between dietary caffeine intake and severe headache or migraine in US adults Open
View article: Blocking Dectin-1 prevents colorectal tumorigenesis by suppressing prostaglandin E2 production in myeloid-derived suppressor cells and enhancing IL-22 binding protein expression
Blocking Dectin-1 prevents colorectal tumorigenesis by suppressing prostaglandin E2 production in myeloid-derived suppressor cells and enhancing IL-22 binding protein expression Open
Dectin-1 (gene Clec7a ), a receptor for β-glucans, plays important roles in the host defense against fungi and immune homeostasis of the intestine. Although this molecule is also suggested to be involved in the regulation of tumorigenesis,…
View article: EccBase: A high-quality database for exploration and characterization of extrachromosomal circular DNAs in cancer
EccBase: A high-quality database for exploration and characterization of extrachromosomal circular DNAs in cancer Open
Extrachromosomal circular DNAs (eccDNAs) are widely observed in eukaryotes. Previous studies have demonstrated that eccDNAs are essential to cancer progression, and found that they can not only express in normal cells to regulate RNA, but …
View article: Development and verification of the Menopause Emotional Symptom Questionnaire
Development and verification of the Menopause Emotional Symptom Questionnaire Open
View article: Blocking DCIR mitigates colitis and prevents colorectal tumors by enhancing the GM-CSF-STAT5 pathway
Blocking DCIR mitigates colitis and prevents colorectal tumors by enhancing the GM-CSF-STAT5 pathway Open
Dendritic cell immunoreceptor (DCIR; Clec4a2), a member of the C-type lectin receptor family, plays important roles in homeostasis of the immune and bone systems. However, the intestinal role of this molecule is unclear. Here, we show that…
View article: CDMPred: A Tool for Predicting Cancer Driver Mutations with High-Quality Passenger Mutations and Ensemble Learning
CDMPred: A Tool for Predicting Cancer Driver Mutations with High-Quality Passenger Mutations and Ensemble Learning Open
Background Benchmark datasets are of great importance for model construction and must be representative of the phenomenon being investigated. Currently available computational methods for predicting driver mutations have been trained with …
View article: The C-type lectin receptor Clec1A plays an important role in the development of experimental autoimmune encephalomyelitis by enhancing antigen presenting ability of dendritic cells and inducing inflammatory cytokine IL-17
The C-type lectin receptor Clec1A plays an important role in the development of experimental autoimmune encephalomyelitis by enhancing antigen presenting ability of dendritic cells and inducing inflammatory cytokine IL-17 Open
Clec1A, a member of C-type lectin receptor family, has a carbohydrate recognition domain in its extracellular region, but no known signaling motif in the cytoplasmic domain. Clec1a is highly expressed in endothelial cells and weakly in den…
View article: Ten-year time trends in preterm birth during a sociodemographic transition period: a retrospective cohort study in Shenzhen, China
Ten-year time trends in preterm birth during a sociodemographic transition period: a retrospective cohort study in Shenzhen, China Open
Objectives To investigate time trends of preterm birth and estimate the contributions of risk factors to the changes in preterm birth rates over a decade (2009–2018) of transitional period in Shenzhen, China. Design Retrospective cohort st…
View article: Effectiveness comparisons of different Chinese herbal injection therapies for acute cerebral infarction
Effectiveness comparisons of different Chinese herbal injection therapies for acute cerebral infarction Open
Background: Acute cerebral infarction (ACI) has a high incidence, recurrence rate, and mortality. Chinese herbal injections (CHIs) are widely used in the substitution therapy of ACI. Due to the lack of randomized trials comparing the effic…
View article: Efficacy and safety of Shufeng Jiedu capsule for coronavirus disease 2019 (COVID-19)
Efficacy and safety of Shufeng Jiedu capsule for coronavirus disease 2019 (COVID-19) Open
Background: From the end of 2019 to the present, coronavirus disease 2019 (COVID-19) has put considerable pressure on the worlds medical system and caused significant mortality and economic losses around the world. In China, the Shufeng Ji…
View article: Ginsenoside Rg3 for Chemotherapy-Induced Myelosuppression: A Meta-Analysis and Systematic Review
Ginsenoside Rg3 for Chemotherapy-Induced Myelosuppression: A Meta-Analysis and Systematic Review Open
Patients with advanced cancer often undergo myelosuppression after receiving chemotherapy. However, severe myelosuppression results in treatment delay, and some can even be life-threatening. At present, cancer patients undergoing chemother…
View article: Characterization of Oral Microbiome and Exploration of Potential Biomarkers in Patients with Pancreatic Cancer
Characterization of Oral Microbiome and Exploration of Potential Biomarkers in Patients with Pancreatic Cancer Open
Pancreatic cancer (PC) is highly malignant and lacks an effective therapeutic schedule, hence that early diagnosis is of great importance to achieve a good prognosis. Oral bacteria have been proved to be associated with pancreatic cancer, …
View article: Ginsenoside Rg3 (Shenyi Capsule) Combined with Chemotherapy for Digestive System Cancer in China: A Meta-Analysis and Systematic Review
Ginsenoside Rg3 (Shenyi Capsule) Combined with Chemotherapy for Digestive System Cancer in China: A Meta-Analysis and Systematic Review Open
Objective . In China, ginsenoside Rg3 is often used in combination with chemotherapy to treat digestive system cancer. We here performed a meta-analysis and systematic review to provide a much needed high-quality evaluation of the efficacy…
View article: Improving Law Enforcement Daily Deployment Through Machine Learning-Informed Optimization under Uncertainty
Improving Law Enforcement Daily Deployment Through Machine Learning-Informed Optimization under Uncertainty Open
Urban law enforcement agencies are under great pressure to respond to emergency incidents effectively while operating within restricted budgets. Minutes saved on emergency response times can save lives and catch criminals, and a responsive…
View article: Myeloid C-type lectin receptors in skin/mucoepithelial diseases and tumors
Myeloid C-type lectin receptors in skin/mucoepithelial diseases and tumors Open
Myeloid C-type lectin receptors (CLRs), which consist of an extracellular carbohydrate recognition domain and intracellular signal transducing motif such as the immunoreceptor tyrosine-based activation motif (ITAM) or immunoreceptor tyrosi…
View article: The interaction effects between TLR4 and MMP9 gene polymorphisms contribute to aortic aneurysm risk in a Chinese Han population
The interaction effects between TLR4 and MMP9 gene polymorphisms contribute to aortic aneurysm risk in a Chinese Han population Open
View article: Serum matrix metalloproteinase-9 is a valuable biomarker for identification of abdominal and thoracic aortic aneurysm: a case-control study
Serum matrix metalloproteinase-9 is a valuable biomarker for identification of abdominal and thoracic aortic aneurysm: a case-control study Open
View article: Exosome-Transmitted lncARSR Promotes Sunitinib Resistance in Renal Cancer by Acting as a Competing Endogenous RNA
Exosome-Transmitted lncARSR Promotes Sunitinib Resistance in Renal Cancer by Acting as a Competing Endogenous RNA Open
View article: Self: A Perspective from psychological counseling and therapy
Self: A Perspective from psychological counseling and therapy Open
\n\t心理咨询和治疗离不开对自我的关注,精神分析、行为疗法和认知疗法对自我的关注局限于认知或行为层面,而新兴的正念疗法填补了对自我身体和感受层面关注的空白。具身认知和具身自我实验,以及认知神经科学研究也证明了身体、感知觉和认知情绪的密切关系,及其与自我的息息相关。本文在整合已有心理疗法和实验研究的基础上,提出一种整体观的自我结构,即自我是理性（符号机能、认知情绪）、感性（非符号机能、感知觉）、身体（生理机能）的综合体,缺一不可。
View article: Atmospheric Environment Five Dimensional Representation Model
Atmospheric Environment Five Dimensional Representation Model Open
Modern simulation applications need physically consistent atmospheric environment representation. The consistency, standardized and effective atmospheric environment data representation are critical for simulation applications, it is the b…