Haiyang Tang
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View article: Biomechanical study of hybrid-fixed femoral prosthesis in total knee arthroplasty
Biomechanical study of hybrid-fixed femoral prosthesis in total knee arthroplasty Open
The hybrid design maintained initial stability and may allow for potential long-term improvements through bone ingrowth.
View article: Single-distance, phase-only frequency-domain NIRS for vascular oxygenation and tissue metabolism: a Monte Carlo simulation study
Single-distance, phase-only frequency-domain NIRS for vascular oxygenation and tissue metabolism: a Monte Carlo simulation study Open
These results validate single-separation phase-only FD-NIRS as an accurate method for multichromophore quantification (including ), enabling simpler, cost-effective systems without compromising metabolic imaging capability. The approac…
View article: UCHL1 regulates adiponectin receptors in Sertoli cells to maintain testicular homeostatic balance
UCHL1 regulates adiponectin receptors in Sertoli cells to maintain testicular homeostatic balance Open
Disruptions in testicular homeostasis can lead to impaired spermatogenesis and male infertility. Such disturbances may result from various factors, including viral or bacterial infections, toxic injuries, and genetic mutations or deletions…
View article: Association between left ventricular mass and heart failure in chronic kidney disease: a cross-sectional study
Association between left ventricular mass and heart failure in chronic kidney disease: a cross-sectional study Open
Purpose Left ventricular mass (LVM) is an indicator of left ventricular hypertrophy (LVH), and has been studied in a variety of diseases, but the relationship between LVH and its occurrence in heart failure (HF) in patients with chronic ki…
View article: Comparison of flexible ureteroscopy with flexible and navigable suction ureteral access sheath and mini-percutaneous nephrolithotripsy for the treatment of impacted upper ureteral stones: a retrospective study
Comparison of flexible ureteroscopy with flexible and navigable suction ureteral access sheath and mini-percutaneous nephrolithotripsy for the treatment of impacted upper ureteral stones: a retrospective study Open
Background and objective The treatment of impacted upper ureteral stones remains a significant challenge for urologists. Standard treatment protocols often favor Mini-Percutaneous Nephrolithotripsy (Mini-PCNL). It has been supposed to be a…
View article: Development and Validation of a Diagnostic Nomogram for Predicting Hypertension in Patients With Obstructive Sleep Apnea at High Altitude
Development and Validation of a Diagnostic Nomogram for Predicting Hypertension in Patients With Obstructive Sleep Apnea at High Altitude Open
Obstructive sleep apnea (OSA) has been established as one of the independent risk factors for hypertension, and its coexistence substantially raises the risk of cardiovascular incidents. However, existing clinical predictive models mainly …
View article: <i>TPCNet</i>: representation learning for H <scp>i</scp> mapping
<i>TPCNet</i>: representation learning for H <span>i</span> mapping Open
We introduce TPCNet, a neural network predictor that combines convolutional and transformer architectures with positional encodings, for neutral atomic hydrogen (H i) spectral analysis. Trained on synthetic data sets, our models predict co…
View article: TPCNet: Representation learning for HI mapping
TPCNet: Representation learning for HI mapping Open
Data, Analysis Notebooks, and Deep Learning Model Designs for MNRAS Publication This document includes the data, analysis notebooks, and deep learning model designs associated with the study entitled "TPCNet: Representation Learning for HI…
View article: The HIF2α-dependent upregulation of SETDB1 facilitates hypoxia-induced functional and phenotypical changes of pulmonary microvascular endothelial cells
The HIF2α-dependent upregulation of SETDB1 facilitates hypoxia-induced functional and phenotypical changes of pulmonary microvascular endothelial cells Open
Abnormal histone modification plays vital role in pulmonary hypertension (PH). This study reports the regulation and role of a histone 3 lysine 9 (H3K9) methyltransferase, SETDB1, in primarily cultured rat pulmonary microvascular endotheli…
View article: Chimeric Antigen Receptor T Cells Targeting CD19 and GCC in Metastatic Colorectal Cancer
Chimeric Antigen Receptor T Cells Targeting CD19 and GCC in Metastatic Colorectal Cancer Open
Importance Chimeric antigen receptor (CAR) T-cell therapy (CART) has transformed the treatment landscape of hematologic cancer, but has negligible effects for adult solid cancers. In this trial, an autologous CAR T-cell product demonstrate…
View article: N6-methyladenosine-driven miR-143/145-KLF4 circuit orchestrates the phenotypic switch of pulmonary artery smooth muscle cells
N6-methyladenosine-driven miR-143/145-KLF4 circuit orchestrates the phenotypic switch of pulmonary artery smooth muscle cells Open
Pulmonary hypertension (PH) is characterized by vascular remodeling predominantly driven by a phenotypic switching in pulmonary artery smooth muscle cells (PASMCs). However, the underlying mechanisms for this phenotypic alteration remain i…
View article: ChatSOS: Vector Database Augmented Generative Question Answering Assistant in Safety Engineering
ChatSOS: Vector Database Augmented Generative Question Answering Assistant in Safety Engineering Open
With the rapid advancement of natural language processing technologies, generative artificial intelligence techniques, represented by large language models (LLMs), are gaining increasing prominence and demonstrating significant potential f…
View article: Deficiency of the Deubiquitinase UCHL1 Attenuates Pulmonary Arterial Hypertension
Deficiency of the Deubiquitinase UCHL1 Attenuates Pulmonary Arterial Hypertension Open
BACKGROUND: The ubiquitin-proteasome system regulates protein degradation and the development of pulmonary arterial hypertension (PAH), but knowledge about the role of deubiquitinating enzymes in this process is limited. UCHL1 (ubiquitin c…
View article: Rescuing lung development through embryonic inhibition of histone acetylation
Rescuing lung development through embryonic inhibition of histone acetylation Open
A major barrier to the impact of genomic diagnosis in patients with congenital malformations is the lack of understanding regarding how sequence variants contribute to disease pathogenesis and whether this information could be used to gene…
View article: ChatSOS: LLM-based knowledge Q&A system for safety engineering
ChatSOS: LLM-based knowledge Q&A system for safety engineering Open
Recent advancements in large language models (LLMs) have notably propelled natural language processing (NLP) capabilities, demonstrating significant potential in safety engineering applications. Despite these advancements, LLMs face constr…
View article: Editorial: Perspectives in pharmacological therapy targeting cellular metabolic pathways in respiratory diseases
Editorial: Perspectives in pharmacological therapy targeting cellular metabolic pathways in respiratory diseases Open
EDITORIAL article Front. Pharmacol., 27 November 2023Sec. Respiratory Pharmacology Volume 14 - 2023 | https://doi.org/10.3389/fphar.2023.1324586
View article: TAK1 Activation by NLRP3 Deficiency Confers Cardioprotection Against Pressure Overload-Induced Cardiomyocyte Pyroptosis and Hypertrophy
TAK1 Activation by NLRP3 Deficiency Confers Cardioprotection Against Pressure Overload-Induced Cardiomyocyte Pyroptosis and Hypertrophy Open
A comprehensive view of the role of NLRP3/caspase-1/GSDMD-mediated pyroptosis in pressure overload cardiac hypertrophy is presented in this study. Furthermore, mitigation of NLRP3 deficiency-induced pyroptosis confers cardioprotection agai…
View article: SARS-CoV-2 spike protein receptor-binding domain perturbates intracellular calcium homeostasis and impairs pulmonary vascular endothelial cells
SARS-CoV-2 spike protein receptor-binding domain perturbates intracellular calcium homeostasis and impairs pulmonary vascular endothelial cells Open
Exposure to the spike protein or receptor-binding domain (S-RBD) of SARS-CoV-2 significantly influences endothelial cells and induces pulmonary vascular endotheliopathy. In this study, angiotensin-converting enzyme 2 humanized inbred (hACE…
View article: Quantitative Proteomic and Phosphoproteomic Profiling of Lung Tissues from Pulmonary Arterial Hypertension Rat Model
Quantitative Proteomic and Phosphoproteomic Profiling of Lung Tissues from Pulmonary Arterial Hypertension Rat Model Open
Pulmonary arterial hypertension (PAH) is a rare but fatal disease characterized by elevated pulmonary vascular resistance and increased pressure in the distal pulmonary arteries. Systematic analysis of the proteins and pathways involved in…
View article: Aetiological distribution of pulmonary hypertension and the value of transthoracic echocardiography screening in the respiratory department: A retrospective analysis from China
Aetiological distribution of pulmonary hypertension and the value of transthoracic echocardiography screening in the respiratory department: A retrospective analysis from China Open
Methods The aetiological composition and clinical characteristics of patients with pulmonary hypertension (PH) hospitalised in the respiratory department were retrospectively analysed, as well as the correlation between transthoracic echoc…
View article: SOX17 Deficiency Mediates Pulmonary Hypertension: At the Crossroads of Sex, Metabolism, and Genetics
SOX17 Deficiency Mediates Pulmonary Hypertension: At the Crossroads of Sex, Metabolism, and Genetics Open
Rationale: Genetic studies suggest that SOX17 (SRY-related HMG-box 17) deficiency increases pulmonary arterial hypertension (PAH) risk. Objectives: On the basis of pathological roles of estrogen and HIF2α (hypoxia-inducible factor 2α) sign…
View article: SARS-CoV-2 spike protein induces IL-18-mediated cardiopulmonary inflammation via reduced mitophagy
SARS-CoV-2 spike protein induces IL-18-mediated cardiopulmonary inflammation via reduced mitophagy Open
Cardiopulmonary complications are major drivers of mortality caused by the SARS-CoV-2 virus. Interleukin-18, an inflammasome-induced cytokine, has emerged as a novel mediator of cardiopulmonary pathologies but its regulation via SARS-CoV-2…
View article: Research hotspots and theme trends in post-traumatic growth: A co-word analysis based on keywords
Research hotspots and theme trends in post-traumatic growth: A co-word analysis based on keywords Open
This co-word analysis effectively reveals an overview of PTG over the past 15 years. The six research categories deduced from this study can reflect that the research content in the field of PTG is abundant, but some research topics have n…
View article: Nitration-mediated activation of the small GTPase RhoA stimulates cellular glycolysis through enhanced mitochondrial fission
Nitration-mediated activation of the small GTPase RhoA stimulates cellular glycolysis through enhanced mitochondrial fission Open
Mitochondrial fission and a Warburg phenotype of increased cellular glycolysis are involved in the pathogenesis of pulmonary hypertension (PH). The purpose of this study was to determine whether increases in mitochondrial fission are invol…
View article: Sociodemographic factors associated with weight perception of adolescents: A systematic review and meta‐analysis
Sociodemographic factors associated with weight perception of adolescents: A systematic review and meta‐analysis Open
Purpose To systematically assess the main sociodemographic factors associated with weight perception of adolescents. Methodology All studies related to adolescents’ weight perception were retrieved from seven databases from January 2001 to…