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View article: Single-cell dissection of chronic lung allograft dysfunction reveals convergent and distinct fibrotic mechanisms
Single-cell dissection of chronic lung allograft dysfunction reveals convergent and distinct fibrotic mechanisms Open
Chronic lung allograft dysfunction (CLAD) is the leading cause of mortality after lung transplantation, yet its molecular mechanisms remain poorly understood. To elucidate the pathogenesis of CLAD, we conducted a comprehensive single-cell …
View article: Impact of professionalism education integrated with mini-CEX on clinical competency in obstetrics and gynecology clerkships: A brief report
Impact of professionalism education integrated with mini-CEX on clinical competency in obstetrics and gynecology clerkships: A brief report Open
Background: This study aimed to evaluate the effectiveness of integrating professional education with Mini-CEX in improving clinical competency in Obstetrics and Gynecology (OBGYN) clerkships. Materials and Methods: A total of 116 clinical…
View article: Advances in the detection methods for assessing the viability of cryopreserved samples
Advances in the detection methods for assessing the viability of cryopreserved samples Open
Since the beginning of the 21st century, modern medical technology has advanced rapidly, and the cryomedicine has also seen significant progress. Notable developments include the application of cryomedicine in assisted reproduction and the…
View article: Inhibition of the cGAS‑STING Pathway Reduces Cisplatin-Induced Inner Ear Hair Cell Damage
Inhibition of the cGAS‑STING Pathway Reduces Cisplatin-Induced Inner Ear Hair Cell Damage Open
Although cisplatin is a widely used chemotherapeutic agent, it is severely toxic and causes irreversible hearing loss, restricting its application in clinical settings. This study aimed to determine the molecular mechanism underlying cispl…
View article: Case report: Microsurgical resection of a giant triple dumbbell shaped jugular foramen Schwannoma via retrosigmoid and transcervical approach
Case report: Microsurgical resection of a giant triple dumbbell shaped jugular foramen Schwannoma via retrosigmoid and transcervical approach Open
The surgical management of extensive jugular foramen schwannomas presents a formidable challenge, aiming for gross total resection while minimizing complications. Here, we present a case with giant triple dumbbell-shaped jugular Foramen Sc…
View article: Inducible CCR2+ nonclassical monocytes mediate the regression of cancer metastasis
Inducible CCR2+ nonclassical monocytes mediate the regression of cancer metastasis Open
A major limitation of immunotherapy is the development of resistance resulting from cancer-mediated inhibition of host lymphocytes. Cancer cells release CCL2 to recruit classical monocytes expressing its receptor CCR2 for the promotion of …
View article: Integrative single cell analysis to decode transcriptomic heterogeneity in pulmonary fibrosis across diverse pathologies
Integrative single cell analysis to decode transcriptomic heterogeneity in pulmonary fibrosis across diverse pathologies Open
Studies using single-cell transcriptional profiling of human samples have provided invaluable mechanistic insights into the development of various acute and chronic fibrotic lung states. However, the lack of data harmonization has impeded …
View article: Discovery of Dehydrogenated Imipridone Derivatives as Activators of Human Caseinolytic Protease P
Discovery of Dehydrogenated Imipridone Derivatives as Activators of Human Caseinolytic Protease P Open
Based on the founding member of imipridones, ONC201, a class of dehydrogenated imipridone derivatives was designed, synthesized, and evaluated in a series of biochemical and biological assays as human caseinolytic protease P (hClpP) activa…
View article: Case report: Suspicious laryngeal mass: a case of laryngeal lymphoma misdiagnosed as chronic inflammation
Case report: Suspicious laryngeal mass: a case of laryngeal lymphoma misdiagnosed as chronic inflammation Open
This case report aims to highlight the importance of considering lymphoma as a potential differential diagnosis in patients presenting with laryngeal mass and associated cervical lymphadenopathy, particularly those with a history of chroni…
View article: Synaptic mechanisms underlying the elevated sympathetic outflow in fructose-induced hypertension
Synaptic mechanisms underlying the elevated sympathetic outflow in fructose-induced hypertension Open
Metabolic syndrome is associated with cardiovascular dysfunction, including elevated sympathetic outflow. However, the underlying brain mechanisms are unclear. The nucleus tractus solitarius (NTS) critically regulates autonomic reflexes re…
View article: A multi-variable predictive warning model for cervical cancer using clinical and SNPs data
A multi-variable predictive warning model for cervical cancer using clinical and SNPs data Open
Introduction Cervical cancer is the fourth most common cancer among female worldwide. Early detection and intervention are essential. This study aims to construct an early predictive warning model for cervical cancer and precancerous lesio…
View article: The prognostic significance of POD24 in peripheral T-cell lymphoma
The prognostic significance of POD24 in peripheral T-cell lymphoma Open
POD24 is a prognostic factor associated with unfavorable outcomes in patients with PTCL and can be used to identify high-risk patients and guide treatment decisions.
View article: Glutathione carbon dots as an intracellular reactive oxygen species scavenger for reducing cisplatin‐induced ototoxicity
Glutathione carbon dots as an intracellular reactive oxygen species scavenger for reducing cisplatin‐induced ototoxicity Open
It is widely recognized that platinum‐based chemotherapy, particularly cisplatin therapy, can cause ototoxicity. At present, there are no Food and Drug Administration‐approved drugs to prevent or alleviate ototoxicity. Ototoxicity is gener…
View article: Phase Ib study of sabatolimab (<scp>MBG453</scp>), a novel immunotherapy targeting <scp>TIM‐3</scp> antibody, in combination with decitabine or azacitidine in high‐ or very high‐risk myelodysplastic syndromes
Phase Ib study of sabatolimab (<span>MBG453</span>), a novel immunotherapy targeting <span>TIM‐3</span> antibody, in combination with decitabine or azacitidine in high‐ or very high‐risk myelodysplastic syndromes Open
The safety and efficacy of sabatolimab, a novel immunotherapy targeting T-cell immunoglobulin domain and mucin domain-3 (TIM-3), was assessed in combination with hypomethylating agents (HMAs) in patients with HMA-naive revised Internationa…
View article: The role of lung-restricted autoantibodies in the development of primary and chronic graft dysfunction
The role of lung-restricted autoantibodies in the development of primary and chronic graft dysfunction Open
Lung transplantation is a life-saving treatment for both chronic end-stage lung diseases and acute respiratory distress syndrome, including those caused by infectious agents like COVID-19. Despite its increasing utilization, outcomes post-…
View article: Serum albumin as a prognostic predictor reflecting host immunity in patients with non–small cell lung cancer
Serum albumin as a prognostic predictor reflecting host immunity in patients with non–small cell lung cancer Open
Objective Serum albumin (ALB) can transport nutrients to circulating and local immune cells by passing through blood vessels and has attracted attention as a prognostic predictor of non–small cell lung cancer (NSCLC) because it reflects th…
View article: <scp>OS</scp> and <scp>DFS</scp> are affected by different diagnostic methods and hysterectomy procedures in endometrial cancer patients: A single‐center retrospective study
<span>OS</span> and <span>DFS</span> are affected by different diagnostic methods and hysterectomy procedures in endometrial cancer patients: A single‐center retrospective study Open
Purpose We aimed to evaluate whether hysteroscopy increases the risk of intraperitoneal dissemination or worsens the prognosis of endometrial carcinoma (EC) patients and whether radical hysterectomy (RH) improves overall survival (OS) or d…
View article: Prognostic value of prelymphodepletion absolute lymphocyte counts in relapsed/refractory diffuse large B-cell lymphoma patients treated with chimeric antigen receptor T cells
Prognostic value of prelymphodepletion absolute lymphocyte counts in relapsed/refractory diffuse large B-cell lymphoma patients treated with chimeric antigen receptor T cells Open
Introduction Chimeric antigen receptor (CAR) T cell therapy has achieved unprecedented efficacy recently. However, the factors related to responses and durable remission are elusive. This study was to investigate the impact of pre-lymphode…
View article: Sabatolimab (<scp>MBG453</scp>) model‐informed drug development for dose selection in patients with myelodysplastic syndrome/acute myeloid leukemia and solid tumors
Sabatolimab (<span>MBG453</span>) model‐informed drug development for dose selection in patients with myelodysplastic syndrome/acute myeloid leukemia and solid tumors Open
Sabatolimab is a novel immunotherapy with immuno‐myeloid activity that targets T‐cell immunoglobulin domain and mucin domain‐3 (TIM‐3) on immune cells and leukemic blasts. It is being evaluated for the treatment of myeloid malignancies in …
View article: Anti–G Protein–Coupled Receptor, Class C Group 5 Member D Chimeric Antigen Receptor T Cells in Patients With Relapsed or Refractory Multiple Myeloma: A Single-Arm, Phase Ⅱ Trial
Anti–G Protein–Coupled Receptor, Class C Group 5 Member D Chimeric Antigen Receptor T Cells in Patients With Relapsed or Refractory Multiple Myeloma: A Single-Arm, Phase Ⅱ Trial Open
PURPOSE G protein–coupled receptor, class C group 5 member D (GPRC5D) is considered to be a promising surface target for multiple myeloma (MM) immunotherapy. Here, we report the efficacy and safety of anti-GPRC5D chimeric antigen receptor …
View article: A Rare Case of Deceptive Maxillary Ameloblastoma
A Rare Case of Deceptive Maxillary Ameloblastoma Open
Ameloblastoma (AM) is a rare epithelium-derived odontogenic tumor, mostly involving the mandible and less often the maxilla. Most AMs are benign and characterized by indolence and local invasiveness, with a high recurrence rate. Herein, we…
View article: Platelet closure time in the evaluation of efficacy of CAR-T cell therapy in relapsed/refractory multiple myeloma
Platelet closure time in the evaluation of efficacy of CAR-T cell therapy in relapsed/refractory multiple myeloma Open
Purpose In recent years, many studies of platelet function in multiple myeloma (MM) patients have been reported. However, the role of platelet function in relapse/refractory (R/R) MM after chimeric antigen receptor T (CAR-T) cell therapy r…
View article: Sequential gene expression analysis of cervical malignant transformation identifies RFC4 as a novel diagnostic and prognostic biomarker
Sequential gene expression analysis of cervical malignant transformation identifies RFC4 as a novel diagnostic and prognostic biomarker Open
Background Cervical squamous cell carcinoma (SCC) is known to arise through increasingly higher-grade squamous intraepithelial lesions (SILs) or cervical intraepithelial neoplasias (CINs). This study aimed to describe sequential molecular …
View article: IL-1β–dependent extravasation of preexisting lung-restricted autoantibodies during lung transplantation activates complement and mediates primary graft dysfunction
IL-1β–dependent extravasation of preexisting lung-restricted autoantibodies during lung transplantation activates complement and mediates primary graft dysfunction Open
Preexisting lung-restricted autoantibodies (LRAs) are associated with a higher incidence of primary graft dysfunction (PGD), although it remains unclear whether LRAs can drive its pathogenesis. In syngeneic murine left lung transplant reci…
View article: Efficacy and safety of CD19-specific CAR-T cell-based therapy in secondary central nervous system lymphoma
Efficacy and safety of CD19-specific CAR-T cell-based therapy in secondary central nervous system lymphoma Open
Encouraging response has been achieved in relapsed/refractory (R/R) B-cell lymphoma treated by chimeric antigen receptor T (CAR-T) cells. The efficacy and safety of CAR-T cells in central nervous system lymphoma (CNSL) are still elusive. H…
View article: CD11b suppresses TLR activation of nonclassical monocytes to reduce primary graft dysfunction after lung transplantation
CD11b suppresses TLR activation of nonclassical monocytes to reduce primary graft dysfunction after lung transplantation Open
Primary graft dysfunction (PGD) is the leading cause of postoperative mortality in lung transplant recipients and the most important risk factor for development of chronic lung allograft dysfunction. The mechanistic basis for the variabili…
View article: Design, Synthesis, and Biological Evaluations of DOT1L Peptide Mimetics Targeting the Protein–Protein Interactions between DOT1L and MLL-AF9/MLL-ENL
Design, Synthesis, and Biological Evaluations of DOT1L Peptide Mimetics Targeting the Protein–Protein Interactions between DOT1L and MLL-AF9/MLL-ENL Open
On the basis of a previously identified DOT1L peptide mimetic (compound 3), a series of novel peptide mimetics were designed and synthesized. These compounds can potently bind to AF9 and ENL either in cell-free binding assays or in leukemi…