Haiyoung Jung
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View article: Maternal ingestion of polyethylene microplastics results in reduced antiviral responses by dysregulating the immune system in their progeny
Maternal ingestion of polyethylene microplastics results in reduced antiviral responses by dysregulating the immune system in their progeny Open
Recent evidence of a potential link between environmental plastic waste and increased incidence of infectious diseases suggests that plastic particles in the environment can provide a habitat for various pathogenic microorganisms. Environm…
View article: Helixor A enhances natural killer cell activity by induction of PAI-1 expression through the p38/MAPK signaling pathway
Helixor A enhances natural killer cell activity by induction of PAI-1 expression through the p38/MAPK signaling pathway Open
Helixor A, an anticancer drug, has an immunostimulatory effect that increases T and natural killer (NK) cell activity in patients with cancer and endometriosis. However, the molecular mechanisms underlying its effect on NK cells in these p…
View article: Therapeutic Effects of TN13 Peptide on Acute Respiratory Distress Syndrome and Sepsis Models In Vivo
Therapeutic Effects of TN13 Peptide on Acute Respiratory Distress Syndrome and Sepsis Models In Vivo Open
Background/Objectives: Regulation of acute inflammatory responses is crucial for host mortality and morbidity induced by pathogens. The pathogenesis of acute respiratory distress syndrome (ARDS) and sepsis are associated with systemic infl…
View article: Resveratrol from Peanut Sprout Extract Promotes NK Cell Activation and Antitumor Activity
Resveratrol from Peanut Sprout Extract Promotes NK Cell Activation and Antitumor Activity Open
Natural killer (NK) cells are innate immune cells that are crucial for anticancer activity and have been developed as an immune cell therapy for leukemia. However, their limited effectiveness against solid tumors has prompted research into…
View article: Integrative transcriptomic analysis identifies emetine as a promising candidate for overcoming acquired resistance to <scp>ALK</scp> inhibitors in lung cancer
Integrative transcriptomic analysis identifies emetine as a promising candidate for overcoming acquired resistance to <span>ALK</span> inhibitors in lung cancer Open
Anaplastic lymphoma kinase (ALK; also known as ALK tyrosine kinase receptor) inhibitors (ALKi) are effective in treating lung cancer patients with chromosomal rearrangement of ALK . However, continuous treatment with ALKis invariably leads…
View article: Advancing Cardiovascular Drug Screening Using Human Pluripotent Stem Cell-Derived Cardiomyocytes
Advancing Cardiovascular Drug Screening Using Human Pluripotent Stem Cell-Derived Cardiomyocytes Open
Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) have emerged as a promising tool for studying cardiac physiology and drug responses. However, their use is largely limited by an immature phenotype and lack of high-throughput a…
View article: Cisplatin Induces Kidney Cell Death<i>via</i>ROS-dependent MAPK Signaling Pathways by Targeting Peroxiredoxin I and II in African Green Monkey (<i>Chlorocebus aethiops sabaeus</i>) Kidney Cells
Cisplatin Induces Kidney Cell Death<i>via</i>ROS-dependent MAPK Signaling Pathways by Targeting Peroxiredoxin I and II in African Green Monkey (<i>Chlorocebus aethiops sabaeus</i>) Kidney Cells Open
The study highlights the involvement of Prx proteins in CDDP-induced nephrotoxicity and emphasizes the central role of ROS in cell death mediation. These insights offer promising avenues for developing clinical interventions to mitigate th…
View article: Contribution of HSP90 Cleavage to the Cytotoxic Effect of Suberoylanilide Hydroxamic Acid <i>In Vivo</i> and the Involvement of TXNIP in HSP90 Cleavage
Contribution of HSP90 Cleavage to the Cytotoxic Effect of Suberoylanilide Hydroxamic Acid <i>In Vivo</i> and the Involvement of TXNIP in HSP90 Cleavage Open
Heat shock protein (HSP) 90 is expressed in most living organisms, and several client proteins of HSP90 are necessary for cancer cell survival and growth. Previously, we found that HSP90 was cleaved by histone deacetylase (HDAC) inhibitors…
View article: Deficiency of thioredoxin-interacting protein results in age-related thrombocytopenia due to megakaryocyte oxidative stress
Deficiency of thioredoxin-interacting protein results in age-related thrombocytopenia due to megakaryocyte oxidative stress Open
We provide evidence that the megakaryopoiesis pathway becomes exhausted with age in Txnip-/- mice with a decrease in terminal, mature MKs that response to thrombocytopenic challenge. Overall, this study demonstrates the role of TXNIP in me…
View article: Understanding NK cell biology for harnessing NK cell therapies: targeting cancer and beyond
Understanding NK cell biology for harnessing NK cell therapies: targeting cancer and beyond Open
Gene-engineered immune cell therapies have partially transformed cancer treatment, as exemplified by the use of chimeric antigen receptor (CAR)-T cells in certain hematologic malignancies. However, there are several limitations that need t…
View article: Natural Killer Cells and Immunotherapy
Natural Killer Cells and Immunotherapy Open
Natural killer (NK) cells are innate immune cells that demonstrate cytolytic activity against tumor cells, virus-infected cells and other physiologically stressed cells, such as senescent cells [...]
View article: IL-17A and Th17 Cells Contribute to Endometrial Cell Survival by Inhibiting Apoptosis and NK Cell Mediated Cytotoxicity of Endometrial Cells via ERK1/2 Pathway
IL-17A and Th17 Cells Contribute to Endometrial Cell Survival by Inhibiting Apoptosis and NK Cell Mediated Cytotoxicity of Endometrial Cells via ERK1/2 Pathway Open
Immune status including the immune cells and cytokine profiles has been implicated in the development of endometriosis. In this study, we analyzed Th17 cells and IL-17A in peritoneal fluid (PF) and endometrial tissues of patients with (n=1…
View article: KLK6/PAR1 Axis Promotes Tumor Growth and Metastasis by Regulating Cross-Talk between Tumor Cells and Macrophages
KLK6/PAR1 Axis Promotes Tumor Growth and Metastasis by Regulating Cross-Talk between Tumor Cells and Macrophages Open
Kallikrein-related peptidase (KLK)6 is associated with inflammatory diseases and neoplastic progression. KLK6 is aberrantly expressed in several solid tumors and regulates cancer development, metastatic progression, and drug resistance. Ho…
View article: Aurantii Fructus Immaturus enhances natural killer cytolytic activity and anticancer efficacy in vitro and in vivo
Aurantii Fructus Immaturus enhances natural killer cytolytic activity and anticancer efficacy in vitro and in vivo Open
Aurantii Fructus Immaturus (AFI), extensively used in traditional herbal medicine, is known to have diverse physiological effects against various diseases, including obesity, diabetes, and cardiovascular disease. However, the effects of AF…
View article: Ginsenoside 20(R)-Rg3 enhances natural killer cell activity by increasing activating receptor expression through the MAPK/ERK signaling pathway
Ginsenoside 20(R)-Rg3 enhances natural killer cell activity by increasing activating receptor expression through the MAPK/ERK signaling pathway Open
Ginseng is one of the most widely used herbal remedies for various diseases worldwide. Ginsenoside Rg3 (G-Rg3), the main component of ginseng, possesses several pharmacological properties, including anti-inflammatory, anti-tumor, antioxida…
View article: Root Extract of a Micropropagated Prunus africana Medicinal Plant Induced Apoptosis in Human Prostate Cancer Cells (PC-3) via Caspase-3 Activation
Root Extract of a Micropropagated Prunus africana Medicinal Plant Induced Apoptosis in Human Prostate Cancer Cells (PC-3) via Caspase-3 Activation Open
Prostate cancer is one of the major causes of cancer-related deaths among men globally. Medicinal plants have been explored as alternative treatment options. Herein, we assessed the in vitro cytotoxic effects of 70% ethanolic root extracts…
View article: Additional file 8 of Ageing and rejuvenation models reveal changes in key microbial communities associated with healthy ageing
Additional file 8 of Ageing and rejuvenation models reveal changes in key microbial communities associated with healthy ageing Open
Additional file 7: Table S6. Relative abundance of phylotypes detected in AK administration samples.
View article: Additional file 2 of Synaptotagmin 11 scaffolds MKK7–JNK signaling process to promote stem-like molecular subtype gastric cancer oncogenesis
Additional file 2 of Synaptotagmin 11 scaffolds MKK7–JNK signaling process to promote stem-like molecular subtype gastric cancer oncogenesis Open
Additional file 2: Supplementary Table 1. Antibody information. Supplementary Table 2. List of 45 genes.
View article: Additional file 5 of Ageing and rejuvenation models reveal changes in key microbial communities associated with healthy ageing
Additional file 5 of Ageing and rejuvenation models reveal changes in key microbial communities associated with healthy ageing Open
Additional file 4: Table S3. Taxa identified by LEfSe analysis in this study. "LogMaxMean" indicates the log of the highest-class average. "Enriched in" indicates the class with the highest mean if the taxa are discriminative. "LDA" indica…
View article: Additional file 7 of Ageing and rejuvenation models reveal changes in key microbial communities associated with healthy ageing
Additional file 7 of Ageing and rejuvenation models reveal changes in key microbial communities associated with healthy ageing Open
Additional file 6: Table S5. Relative abundance of phylotypes detected in ageing and rejuvenation samples.
View article: Additional file 4 of Ageing and rejuvenation models reveal changes in key microbial communities associated with healthy ageing
Additional file 4 of Ageing and rejuvenation models reveal changes in key microbial communities associated with healthy ageing Open
Additional file 3: Table S2. Alpha and beta diversity analysis of the analysed groups in this study.
View article: Emerging Approaches for Solid Tumor Treatment Using CAR-T Cell Therapy
Emerging Approaches for Solid Tumor Treatment Using CAR-T Cell Therapy Open
Cancer immunotherapy is becoming more important in the clinical setting, especially for cancers resistant to conventional chemotherapy, including targeted therapy. Chimeric antigen receptor (CAR)-T cell therapy, which uses patient’s autolo…
View article: SARS-CoV-2 peptides bind to NKG2D and increase NK cell activity
SARS-CoV-2 peptides bind to NKG2D and increase NK cell activity Open
Immune dysregulation is commonly observed in patients with coronavirus disease 2019 (COVID-19). Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces severe lung inflammation and innate immune cell dysregulation. However, th…
View article: Collapsin response mediator protein 4 enhances the radiosensitivity of colon cancer cells through calcium‑mediated cell signaling
Collapsin response mediator protein 4 enhances the radiosensitivity of colon cancer cells through calcium‑mediated cell signaling Open
Radiation therapy is an effective treatment against various types of cancer, but some radiation‑resistant cancer cells remain a major therapeutic obstacle; thus, understanding radiation resistance mechanisms is essential for cancer treatme…
View article: TXNIP Regulates Natural Killer Cell-Mediated Innate Immunity by Inhibiting IFN-γ Production during Bacterial Infection
TXNIP Regulates Natural Killer Cell-Mediated Innate Immunity by Inhibiting IFN-γ Production during Bacterial Infection Open
The function of natural killer (NK) cell-derived interferon-γ (IFN-γ) expands to remove pathogens by increasing the ability of innate immune cells. Here, we identified the critical role of thioredoxin-interacting protein (TXNIP) in the pro…