Haiyun Zhang
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View article: Combining AlphaFold—based AI docking with omics technologies preliminarily unveils the mechanism of Guominkang in treating allergic rhinitis
Combining AlphaFold—based AI docking with omics technologies preliminarily unveils the mechanism of Guominkang in treating allergic rhinitis Open
Allergic rhinitis (AR) is a common immune-mediated chronic inflammatory disease with a complex pathogenesis involving multiple responses of the immune system and epigenetic changes. In recent years, DNA methylation, a key epigenetic mechan…
View article: Multi-omics and machine learning identify novel biomarkers and therapeutic targets of COVID-19
Multi-omics and machine learning identify novel biomarkers and therapeutic targets of COVID-19 Open
Introduction COVID-19 has caused over 7 million deaths worldwide since its onset in 2019, and the virus remains a significant health threat. Identifying sensitive and specific biomarkers, along with elucidating immune-mediated mechanisms, …
View article: Synergistic enhancement effect of straw-earthworms in the reduction of sulfamethoxazole and antibiotic resistance genes
Synergistic enhancement effect of straw-earthworms in the reduction of sulfamethoxazole and antibiotic resistance genes Open
Soil antibiotic pollution is a global concern. It has been confirmed that straw or earthworm can enhance microbial degradation of antibiotics in soil. However, in the C/N transformation processes of soil ecosystems, straw and earthworms ar…
View article: Nitrogen Fertilizer Reduction in Rice–Eel Co-Culture System Improves the Soil Microbial Diversity and Its Functional Stability
Nitrogen Fertilizer Reduction in Rice–Eel Co-Culture System Improves the Soil Microbial Diversity and Its Functional Stability Open
The ecological rice–eel co-culture system is not only beneficial for enhancing productivity and sustainability in agriculture but also plays a crucial role in promoting environmental health. In the present study, based on the long-term pos…
View article: Generating 2-hydroxyl quinoline from quinoline through a single mono-oxygenation by Delftia lacustris
Generating 2-hydroxyl quinoline from quinoline through a single mono-oxygenation by Delftia lacustris Open
View article: Advances in cytokine gene polymorphisms in tuberculosis
Advances in cytokine gene polymorphisms in tuberculosis Open
Tuberculosis (TB), especially pulmonary tuberculosis (PTB), is a prevalent infectious disease affecting the respiratory system and is characterized by high morbidity, disability, and mortality rates that significantly impact the quality of…
View article: Monocytes Expressing <scp>IL</scp>‐<scp>36G</scp> Play a Crucial Role in Atopic Dermatitis
Monocytes Expressing <span>IL</span>‐<span>36G</span> Play a Crucial Role in Atopic Dermatitis Open
Atopic dermatitis ( ad ) is a chronic inflammatory skin disease, with recent studies indicating that immune cells, such as monocytes and inflammatory cytokines, play a crucial role. By retrieving datasets from public databases and analysin…
View article: Diagnostic value of neutrophil-to-lymphocyte ratio, fibrinogen-to-albumin ratio and red blood cell distribution width in tuberculosis combined with other bacterial infections
Diagnostic value of neutrophil-to-lymphocyte ratio, fibrinogen-to-albumin ratio and red blood cell distribution width in tuberculosis combined with other bacterial infections Open
View article: Prediction of influenza virus infection based on deep learning and peripheral blood proteomics: A diagnostic study
Prediction of influenza virus infection based on deep learning and peripheral blood proteomics: A diagnostic study Open
Preliminary results showed that SAA2 is an important molecular marker specific to influenza infection.
View article: Bioinformatics and Network Pharmacology Identify the Therapeutic Role of Guominkang in Allergic Asthma by Inhibiting PI3K/Akt Signaling
Bioinformatics and Network Pharmacology Identify the Therapeutic Role of Guominkang in Allergic Asthma by Inhibiting PI3K/Akt Signaling Open
Based on our findings, GMK potentially acts via the PI3K/Akt pathway and alleviates allergic symptoms in AA.
View article: The Roles of Paracoccus Huijuniae for Enhancing Denitrification with N-Methyl Pyrrolidone as the Electron Donor
The Roles of Paracoccus Huijuniae for Enhancing Denitrification with N-Methyl Pyrrolidone as the Electron Donor Open
View article: Synergistic Enhancement Effect of Straw-Earthworms in the Reduction of Sulfamethoxazole and Antibiotic Resistance Genes
Synergistic Enhancement Effect of Straw-Earthworms in the Reduction of Sulfamethoxazole and Antibiotic Resistance Genes Open
View article: Effects of a Vegetable Eel Co-Culture System on the Soil Ammonia-Oxidizing Microbial Community
Effects of a Vegetable Eel Co-Culture System on the Soil Ammonia-Oxidizing Microbial Community Open
(1) Background: A vegetable eel co-culture system is an economically efficient way of agricultural cultivation, which can have an impact on the soil microbial environment and play a pivotal role in the soil nutrient cycle, but there is lit…
View article: Diagnostic value of neutrophil-to-lymphocyte ratio, fibrinogen-to-albumin ratio and red blood cell distribution width in tuberculosis combined with bacterial infection
Diagnostic value of neutrophil-to-lymphocyte ratio, fibrinogen-to-albumin ratio and red blood cell distribution width in tuberculosis combined with bacterial infection Open
Objective: To investigate the clinical significance of neutrophil-to-lymphocyte ratio (NLR), fibrinogen-to-albumin ratio (FAR), and red blood cell distribution width (RDW) in pulmonary tuberculosis (PTB) combined with bacterial infection o…
View article: The eATP/P2×7R Axis Drives Quantum Dot‐Nanoparticle Induced Neutrophil Recruitment in the Pulmonary Microcirculation
The eATP/P2×7R Axis Drives Quantum Dot‐Nanoparticle Induced Neutrophil Recruitment in the Pulmonary Microcirculation Open
Exposure to nanoparticles (NPs) is frequently associated with adverse cardiovascular effects. In contrast, NPs in nanomedicine hold great promise for precise lung‐specific drug delivery, especially considering the extensive pulmonary capil…
View article: The Trend of the Treatment of Advanced Hepatocellular Carcinoma: Combination of Immunotherapy and Targeted Therapy
The Trend of the Treatment of Advanced Hepatocellular Carcinoma: Combination of Immunotherapy and Targeted Therapy Open
View article: Unveiling potential drug targets for lung squamous cell carcinoma through the integration of druggable genome and genome-wide association data
Unveiling potential drug targets for lung squamous cell carcinoma through the integration of druggable genome and genome-wide association data Open
Background: Lung squamous cell carcinoma (LSCC) is a major subtype of lung cancer with poor prognosis and low survival rate. Compared with lung adenocarcinoma, yet no FDA-approved targeted-therapy has been found for lung squamous cell carc…
View article: Insights from the Gaussian Process Method for the Fast Radio Burst–associated X-Ray Burst of SGR 1935+2154
Insights from the Gaussian Process Method for the Fast Radio Burst–associated X-Ray Burst of SGR 1935+2154 Open
The Gaussian process method is employed to analyze the light curves of bursts detected by Insight-HXMT, Neutron Star Interior Composition Explorer (NICER), and Gravitational Wave High-energy Electromagnetic Counterpart All-sky Monitor from…
View article: O-Glycosylated RNA Identification and Site-specific Prediction by Solid-phase Chemoenzymatic TnORNA method and PONglyRNA tool
O-Glycosylated RNA Identification and Site-specific Prediction by Solid-phase Chemoenzymatic TnORNA method and PONglyRNA tool Open
Recent studies have shown that the cell surface undergoes post-transcriptional modification by N-linked glycosylation. However, the question of whether RNA can be glycosylated by O-glycans remains to be explored. The presence of O-glycosyl…
View article: The unexpected effect of the compound microbial agent NP-M2 on microbial community dynamics in a nonylphenol-contaminated soil: the self-stability of soil ecosystem
The unexpected effect of the compound microbial agent NP-M2 on microbial community dynamics in a nonylphenol-contaminated soil: the self-stability of soil ecosystem Open
Background Nonylphenol (NP) is widely recognized as a crucial environmental endocrine-disrupting chemical and persistent toxic substance. The remediation of NP-contaminated sites primarily relies on biological degradation. Compound microbi…
View article: Effects of Different Organic Materials on the Remediation and Improvement of Secondary Salinized Greenhouse Soil
Effects of Different Organic Materials on the Remediation and Improvement of Secondary Salinized Greenhouse Soil Open
Soil secondary salinization has seriously affected the greenhouse vegetable production in China. To improve the secondary salinization greenhouse soil and enhance the soil physical-chemical properties in an eco-environmental way, different…
View article: Insights from the Gaussian Processes Method for the FRB-associated X-ray Burst of SGR 1935+2154
Insights from the Gaussian Processes Method for the FRB-associated X-ray Burst of SGR 1935+2154 Open
Gaussian processes method is employed to analyze the light curves of bursts detected by Insight-HXMT, NICER, and GECAM from SGR 1935+2154 between 2020 to 2022. It is found that a stochastically driven damped simple harmonic oscillator (SHO…
View article: Diverse temporal and spatial mechanisms work, partially through Stanniocalcin-1, V-ATPase and senescence, to activate the extracellular ATP-mediated drug resistance in human cancer cells
Diverse temporal and spatial mechanisms work, partially through Stanniocalcin-1, V-ATPase and senescence, to activate the extracellular ATP-mediated drug resistance in human cancer cells Open
Introduction Resistance to drug therapies is associated with a large majority of cancer-related deaths. ATP-binding cassette (ABC) transporter-mediated drug efflux, epithelial-mesenchymal transition (EMT), cancer stem cells (CSCs), glutath…
View article: Generating 2-Hydroxyl Quinoline from Quinoline Through a Single Mono-Oxygenation by Delftia Lacustris
Generating 2-Hydroxyl Quinoline from Quinoline Through a Single Mono-Oxygenation by Delftia Lacustris Open
View article: Addition of Earthworm to Continuous Cropping Soil Inhibits the Fusarium Wilt in Watermelon
Addition of Earthworm to Continuous Cropping Soil Inhibits the Fusarium Wilt in Watermelon Open
View article: A Mechanistic Study on Removal Efficiency of Neonicotinoids by Biochars with Various Fabrication Methods
A Mechanistic Study on Removal Efficiency of Neonicotinoids by Biochars with Various Fabrication Methods Open
View article: Large-Scale Spatial Distribution and Variablity of Agricultural and Forestry Soil Goganic Carbon On Chongming Island, China
Large-Scale Spatial Distribution and Variablity of Agricultural and Forestry Soil Goganic Carbon On Chongming Island, China Open
View article: Fate of Organic Nitrogen in Amino Acids During Alternating Denitrification and Nitrification
Fate of Organic Nitrogen in Amino Acids During Alternating Denitrification and Nitrification Open
View article: Effects of Different Organic Materials on the Remediation and Improvement of Secondary Salinized Greenhouse Soil
Effects of Different Organic Materials on the Remediation and Improvement of Secondary Salinized Greenhouse Soil Open
View article: Mitochondrial-targeted and ROS-responsive nanocarrier via nose-to-brain pathway for ischemic stroke treatment
Mitochondrial-targeted and ROS-responsive nanocarrier via nose-to-brain pathway for ischemic stroke treatment Open
Oxidative stress injury and mitochondrial dysfunction are major obstacles to neurological functional recovery after ischemic stroke. The development of new approaches to simultaneously diminish oxidative stress and resist mitochondrial dys…