Haizea Hernández-Eguiazu
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View article: Phospho-Ser235-Rps6 and Il-6 Define a Peripheral Inflammatory Signature in Idiopathic and Lrrk2 G2019s-Associated Parkinson’S Disease: A Functional Validation
Phospho-Ser235-Rps6 and Il-6 Define a Peripheral Inflammatory Signature in Idiopathic and Lrrk2 G2019s-Associated Parkinson’S Disease: A Functional Validation Open
View article: In-depth mass-spectrometry reveals phospho-RAB12 as a blood biomarker of G2019S LRRK2-driven Parkinson’s disease
In-depth mass-spectrometry reveals phospho-RAB12 as a blood biomarker of G2019S LRRK2-driven Parkinson’s disease Open
Leucine-rich repeat kinase 2 (LRRK2) inhibition is a promising disease-modifying therapy for LRRK2-associated Parkinson’s disease (L2PD) and idiopathic PD. However, pharmacodynamic readouts and progression biomarkers for clinical trials ai…
View article: In-depth mass-spectrometry reveals phospho-RAB12 as a blood biomarker of G2019S LRRK2-driven Parkinson’s
In-depth mass-spectrometry reveals phospho-RAB12 as a blood biomarker of G2019S LRRK2-driven Parkinson’s Open
Leucine-rich repeat kinase 2 (LRRK2) inhibition is a promising disease-modifying therapy for LRRK2-associated Parkinson’s disease (L2PD) and idiopathic PD (iPD). Yet, pharmaco-dynamic readouts and progression biomarkers for disease modific…
View article: Elevated cholesterol in <i>ATAD3</i> mutants is a compensatory mechanism that leads to membrane cholesterol aggregation
Elevated cholesterol in <i>ATAD3</i> mutants is a compensatory mechanism that leads to membrane cholesterol aggregation Open
Aberrant cholesterol metabolism causes neurological disease and neurodegeneration, and mitochondria have been linked to perturbed cholesterol homeostasis via the study of pathological mutations in the ATAD3 gene cluster. However, whether t…
View article: Elevated urine BMP phospholipids in LRRK2 and VPS35 mutation carriers with and without Parkinson’s disease
Elevated urine BMP phospholipids in LRRK2 and VPS35 mutation carriers with and without Parkinson’s disease Open
View article: Elevated urine BMP phospholipids in LRRK2 and VPS35 mutation carriers with and without Parkinson's disease
Elevated urine BMP phospholipids in LRRK2 and VPS35 mutation carriers with and without Parkinson's disease Open
Participant demographic and clinical characteristics, and urine BMP phospholipid levels. For each participant, sample collection site is provided as: BCN (Barcelona), VIE (Vienna), DND (Dundee), or SSB (San Sebastian). Al…
View article: Elevated urine BMP phospholipids in LRRK2 and VPS35 mutation carriers with and without Parkinson's disease
Elevated urine BMP phospholipids in LRRK2 and VPS35 mutation carriers with and without Parkinson's disease Open
Participant demographic and clinical characteristics, and urine BMP phospholipid levels. For each participant, sample collection site is provided as: BCN (Barcelona), VIE (Vienna), DND (Dundee), or SSB (San Sebastian). Al…
View article: Elevated urine BMP phospholipids in LRRK2 and VPS35 mutation carriers with and without Parkinson’s disease
Elevated urine BMP phospholipids in LRRK2 and VPS35 mutation carriers with and without Parkinson’s disease Open
Elevated urine bis(monoacylglycerol)phosphate (BMP) levels have been found in gain-of-kinase function LRRK2 G2019S mutation carriers. Here, we have expanded urine BMP analysis to other Parkinson’s disease (PD) associated mutations and foun…
View article: Defects of Nutrient Signaling and Autophagy in Neurodegeneration
Defects of Nutrient Signaling and Autophagy in Neurodegeneration Open
Graphical Abstract Schematic Representation Highlighting the Mechanisms of Nutrient Sensing and Autophagy Under Physiological Conditions.
View article: A More Homogeneous Phenotype in Parkinson's Disease Related to R1441G Mutation in the LRRK2 Gene
A More Homogeneous Phenotype in Parkinson's Disease Related to R1441G Mutation in the LRRK2 Gene Open
Parkinson's disease (PD) is characterized by a great clinical heterogeneity. Nevertheless, the biological drivers of this heterogeneity have not been completely elucidated and are likely to be complex, arising from interactions between gen…