Haizhong Zhu
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View article: High-throughput screening identifies non-nucleoside inhibitors of the SARS-CoV-2 polymerase with novel mechanisms
High-throughput screening identifies non-nucleoside inhibitors of the SARS-CoV-2 polymerase with novel mechanisms Open
View article: Minimising the payload solvent exposed hydrophobic surface area optimises the antibody-drug conjugate properties
Minimising the payload solvent exposed hydrophobic surface area optimises the antibody-drug conjugate properties Open
Glucocorticoid receptor modulators (GRMs) are an established and successful compound class for the treatment of multiple diseases. In addition, they are an area of high interest as payloads for antibody-drug conjugate s(ADCs) in both immun…
View article: Minimising the payload solvent exposed hydrophobic surface area optimises the antibody-drug conjugate properties
Minimising the payload solvent exposed hydrophobic surface area optimises the antibody-drug conjugate properties Open
Minimising solvent exposed hydrophobic surface area of payload is identified as a critical design parameter for optimising ADC drug-like properties.
View article: Correction: Minimising the payload solvent exposed hydrophobic surface area optimises the antibody–drug conjugate properties
Correction: Minimising the payload solvent exposed hydrophobic surface area optimises the antibody–drug conjugate properties Open
Correction for ‘Minimising the payload solvent exposed hydrophobic surface area optimises the antibody–drug conjugate properties’ by Adrian D. Hobson et al. , RSC Med. Chem. , 2024, https://doi.org/10.1039/d3md00540b.
View article: Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site
Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site Open
View article: 3D Modeling of the Cadastre and the Spatial Representation of Property
3D Modeling of the Cadastre and the Spatial Representation of Property Open
An emerging technology, three-dimensional (3D) cadastres as extensions to the current parcel-based or two-dimensional (2D) cadastre, has been developed to meet the management of 3D urban land use and 3D properties. This chapter provides a …
View article: Chromokinesins NOD and KID Use Distinct ATPase Mechanisms and Microtubule Interactions to Perform a Similar Function
Chromokinesins NOD and KID Use Distinct ATPase Mechanisms and Microtubule Interactions to Perform a Similar Function Open
Chromokinesins NOD and KID have similar DNA binding domains and functions during cell division, while their motor domain sequences show significant variations. It has been unclear whether these motors have similar structure, chemistry, and…
View article: X-Ray diffraction images for the crystal structure of the motor domain of human kinesin family member 22
X-Ray diffraction images for the crystal structure of the motor domain of human kinesin family member 22 Open
This dataset underlies Protein Data Bank entry 3BFN. Diffraction images are accompanied by HKL-3000 data reduction scripts and output files.
View article: X-Ray diffraction images for the crystal structure of the motor domain of human kinesin family member 22
X-Ray diffraction images for the crystal structure of the motor domain of human kinesin family member 22 Open
This dataset underlies Protein Data Bank entry 3BFN. Diffraction images are accompanied by HKL-3000 data reduction scripts and output files.
View article: Structural Analysis of a Human Mitotic Kinesin and Its Potential Binding Site for a Small Molecule Inhibitor
Structural Analysis of a Human Mitotic Kinesin and Its Potential Binding Site for a Small Molecule Inhibitor Open
View article: The catalytic inactivation of the N-half of human hexokinase 2 and structural and biochemical characterization of its mitochondrial conformation
The catalytic inactivation of the N-half of human hexokinase 2 and structural and biochemical characterization of its mitochondrial conformation Open
The high proliferation rate of tumor cells demands high energy and metabolites that are sustained by a high glycolytic flux known as the ‘Warburg effect’. The activation and further metabolism of glucose is initiated by hexokinase, a focal…
View article: Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein
Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein Open
View article: Erratum: The EED protein–protein interaction inhibitor A-395 inactivates the PRC2 complex
Erratum: The EED protein–protein interaction inhibitor A-395 inactivates the PRC2 complex Open
View article: SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding
SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding Open
View article: The EED protein–protein interaction inhibitor A-395 inactivates the PRC2 complex
The EED protein–protein interaction inhibitor A-395 inactivates the PRC2 complex Open
View article: Turning a Substrate Peptide into a Potent Inhibitor for the Histone Methyltransferase SETD8
Turning a Substrate Peptide into a Potent Inhibitor for the Histone Methyltransferase SETD8 Open
SETD8 is a histone H4-K20 methyltransferase that plays an essential role in the maintenance of genomic integrity during mitosis and in DNA damage repair, making it an intriguing target for cancer research. While some small molecule inhibit…
View article: Structural Analysis of a Specialized Type III Secretion System Peptidoglycan-cleaving Enzyme
Structural Analysis of a Specialized Type III Secretion System Peptidoglycan-cleaving Enzyme Open
The Gram-negative bacterium enteropathogenic Escherichia coli uses a syringe-like type III secretion system (T3SS) to inject virulence or "effector" proteins into the cytoplasm of host intestinal epithelial cells. To assemble, the T3SS mus…