Hajer Abdelkafi
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View article: CCDC 1046867: Experimental Crystal Structure Determination
CCDC 1046867: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1046866: Experimental Crystal Structure Determination
CCDC 1046866: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Structure–Activity Relationship Studies of Retro-1 Analogues against Shiga Toxin
Structure–Activity Relationship Studies of Retro-1 Analogues against Shiga Toxin Open
High-throughput screening has shown that Retro-1 inhibits ricin and Shiga toxins by diminishing their intracellular trafficking via the retrograde route, from early endosomes to the Golgi apparatus. To improve the activity of Retro-1, a st…
View article: Structure-Activity Relationship Studies of Retro-1 Analogues Against Shiga Toxin
Structure-Activity Relationship Studies of Retro-1 Analogues Against Shiga Toxin Open
The Retro-1 molecule was identified in a high-throughput screening as an inhibitor of ricin and Shiga toxins by diminishing their intracellular trafficking via the retrograde route, from early endosomes to the Golgi apparatus. In or…
View article: Structure-Activity Relationship Studies of Retro-1 Analogues Against Shiga Toxin
Structure-Activity Relationship Studies of Retro-1 Analogues Against Shiga Toxin Open
The Retro-1 molecule was identified in a high-throughput screening as an inhibitor of ricin and Shiga toxins by diminishing their intracellular trafficking via the retrograde route, from early endosomes to the Golgi apparatus. In order to …
View article: Aryl transition metal chemical warheads for protein bioconjugation
Aryl transition metal chemical warheads for protein bioconjugation Open
Bioorthogonal organometallic chemistry using aryl transition metal reagents as coupling partners is a burgeoning field that holds great promise notably for the study of proteins.
View article: Total Syntheses of Mycolactone A/B and its Analogues for the Exploration of the Biology of Buruli Ulcer
Total Syntheses of Mycolactone A/B and its Analogues for the Exploration of the Biology of Buruli Ulcer Open
Buruli ulcer, classified as a neglected tropical disease by the World Health Organization, is caused by a mycobacterium which secretes a macrolidic exotoxin called mycolactone A/B. In this article, several synthetic strategies for the prep…
View article: Inhibitors of retrograde trafficking active against ricin and Shiga toxins also protect cells from several viruses, Leishmania and Chlamydiales
Inhibitors of retrograde trafficking active against ricin and Shiga toxins also protect cells from several viruses, Leishmania and Chlamydiales Open
View article: Regioselective Halogenation of 1,4-Benzodiazepinones via CH Activation
Regioselective Halogenation of 1,4-Benzodiazepinones via CH Activation Open
This article reports an efficient CH activation process for regioselective halogenation of 1,4-benzodiazepinones. Direct halogenation with NXS (X = Br, I) affords halogenated benzodiazepinones on the central aromatic ring whereas catalyst …
View article: Inside Cover: Synthesis, Chiral Separation, Absolute Configuration Assignment, and Biological Activity of Enantiomers of Retro‐1 as Potent Inhibitors of Shiga Toxin (ChemMedChem 7/2015)
Inside Cover: Synthesis, Chiral Separation, Absolute Configuration Assignment, and Biological Activity of Enantiomers of Retro‐1 as Potent Inhibitors of Shiga Toxin (ChemMedChem 7/2015) Open
Graphical Abstract The inside cover picture shows Retro-1, a benzodiazepine that blocks the retrograde transport in host cells of Shiga toxins, the virulence factors produced by pathogenic strains of E. coli responsible for food poisoning …
View article: CCDC 1014605: Experimental Crystal Structure Determination
CCDC 1014605: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …