Hajime Isomoto
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View article: #287 Effective muscle index based on muscle mass and quality to diagnose sarcopenia and predict renal survival in CKD patients
#287 Effective muscle index based on muscle mass and quality to diagnose sarcopenia and predict renal survival in CKD patients Open
Background and Aims Sarcopenia is highly prevalent in CKD patients due to specific pathophysiologies such as chronic inflammation and uremic toxin accumulation, and is strongly associated with renal dysfunction and poor prognosis. Muscle q…
View article: Muscle Quality Assessed by the Phase Angle Can Predict Renal Prognosis in Patients with Chronic Kidney Disease
Muscle Quality Assessed by the Phase Angle Can Predict Renal Prognosis in Patients with Chronic Kidney Disease Open
Background/Objectives: Muscle quality reflects functional characteristics beyond muscle mass and may offer prognostic insights in patients with chronic kidney disease (CKD). This study investigated whether muscle quality predicts sarcopeni…
View article: Nationwide epidemiological survey of acute pancreatitis in Japan, 2021: the impact of the COVID-19 pandemic and revised clinical guidelines
Nationwide epidemiological survey of acute pancreatitis in Japan, 2021: the impact of the COVID-19 pandemic and revised clinical guidelines Open
Objectives This study aimed to clarify the current clinico-epidemiological characteristics of acute pancreatitis (AP) in Japan. Methods We conducted a two-stage nationwide survey of patients with AP treated at selected hospitals in 2021, d…
View article: A novel peroral cholangioscopy of gallbladder carcinosarcoma: a case report
A novel peroral cholangioscopy of gallbladder carcinosarcoma: a case report Open
View article: Clinical application of targeted α-emitter therapy in gastroenteropancreatic neuroendocrine neoplasms
Clinical application of targeted α-emitter therapy in gastroenteropancreatic neuroendocrine neoplasms Open
Effective therapeutic strategies for advanced gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) remain challenging, including a lack of response to therapy and post-treatment relapse. The rapid development of targeted radionuclide…
View article: Gastric inverted polyp successfully resected by underwater endoscopic mucosal resection
Gastric inverted polyp successfully resected by underwater endoscopic mucosal resection Open
A 47‐year‐old man, who underwent an annual esophagogastroduodenoscopy as part of his routine check‐up, was found to have a small subepithelial lesion on the posterior wall of the gastric body in 2013. The lesion gradually increased in size…
View article: Comparative assessment of the effects of dotinurad and febuxostat on the renal function in chronic kidney disease patients with hyperuricemia
Comparative assessment of the effects of dotinurad and febuxostat on the renal function in chronic kidney disease patients with hyperuricemia Open
Although hyperuricemia is associated with chronic kidney disease (CKD), the impact of uric acid (UA)-lowering drugs on CKD has been controversial. Previous investigations have primarily included xanthine oxidase inhibitors; therefore, rese…
View article: Back to the Physiology: Renal Tubular Handling of Uric Acid and Emerging Strategies for Managing Hyperuricemia
Back to the Physiology: Renal Tubular Handling of Uric Acid and Emerging Strategies for Managing Hyperuricemia Open
Hyperuricemia is a common comorbidity of chronic kidney disease (CKD) and contributes to kidney dysfunction through mechanisms involving glomerular, tubular, and vascular injuries. Although hyperuricemia has traditionally been classified i…
View article: Utility of POCUS-Based Screening for Steatotic Liver in Preventive Medicine: A Cross-Sectional Study
Utility of POCUS-Based Screening for Steatotic Liver in Preventive Medicine: A Cross-Sectional Study Open
View article: C3 p.Asp1115Asn Variant-associated Atypical Hemolytic Uremic Syndrome with Spontaneous Remission Triggered by Influenza and COVID-19
C3 p.Asp1115Asn Variant-associated Atypical Hemolytic Uremic Syndrome with Spontaneous Remission Triggered by Influenza and COVID-19 Open
The clinical manifestations of atypical hemolytic uremic syndrome (aHUS) vary depending on the genetic background. A 19-year-old man with the C3 p.Asp1115Asn variant experienced 2 episodes of recurrent aHUS following respiratory tract infe…
View article: Recent Advances in Gastrointestinal Cancer Endoscopic Diagnosis and Treatment: Focusing on Older Adults
Recent Advances in Gastrointestinal Cancer Endoscopic Diagnosis and Treatment: Focusing on Older Adults Open
Recent advances in endoscopic equipment have improved the diagnosis of gastrointestinal tumors. Image-enhanced endoscopy, including narrow-band imaging, blue light imaging, and linked color imaging, has unified magnifying observation class…
View article: The C/C Genotype of rs1231760 in RGS2 Is a Risk Factor for the Progression of H. pylori-Positive Atrophic Gastritis by Increasing RGS2 Expression
The C/C Genotype of rs1231760 in RGS2 Is a Risk Factor for the Progression of H. pylori-Positive Atrophic Gastritis by Increasing RGS2 Expression Open
Background: Chronic gastritis caused by Helicobacter pylori (H. pylori) infection can progress to gastric cancer through atrophic gastritis (AG). The risk of gastric cancer increases with the progression of AG. Therefore, investigating the…
View article: Comparative Study of Endoscopic Treatment for Intrahepatic and Common Bile Duct Stones Using Peroral Cholangioscopy
Comparative Study of Endoscopic Treatment for Intrahepatic and Common Bile Duct Stones Using Peroral Cholangioscopy Open
Objectives: Although peroral cholangioscopy has improved the endoscopic treatment of difficult stones, the treatment of intrahepatic stones remains challenging. The incidence of cholangitis is high when peroral cholangioscopy is used to tr…
View article: Internal Medicine <i>Year in Review 2023</i>
Internal Medicine <i>Year in Review 2023</i> Open
The year 2023 marked a significant change for Internal Medicine, as the number of submissions related to the novel coronavirus infection (COVID-19) declined significantly and interest shifted to other disease fields and research areas. Our…
View article: Esophageal Achalasia: Diagnosis and Treatment Strategies in Japan
Esophageal Achalasia: Diagnosis and Treatment Strategies in Japan Open
View article: Docking Proteins Upregulate IL-1β Expression in Lower Esophageal Sphincter Muscle in Esophageal Achalasia
Docking Proteins Upregulate IL-1β Expression in Lower Esophageal Sphincter Muscle in Esophageal Achalasia Open
Background/Objectives: Esophageal achalasia is an archetypal esophageal motility disorder characterized by abnormal peristalsis of the esophageal body and impaired lower esophageal sphincter (LES) relaxation. Methods: In this study, the mR…
View article: #258 Does muscle quality affect the accuracy of eGFR?
#258 Does muscle quality affect the accuracy of eGFR? Open
Background and Aims Appropriate assessment of glomerular filtration rate (GFR) is the key to manage chronic kidney disease (CKD). The clearance of exogenous tracers, such as inulin and iothalamate, is the best way to measure GFR. However, …
View article: Cytokine Profile in Predicting the Effectiveness of Advanced Therapy for Ulcerative Colitis: A Narrative Review
Cytokine Profile in Predicting the Effectiveness of Advanced Therapy for Ulcerative Colitis: A Narrative Review Open
Cytokine-targeted therapies have shown efficacy in treating patients with ulcerative colitis (UC), but responses to these advanced therapies can vary. This variability may be due to differences in cytokine profiles among patients with UC. …
View article: The Potential of Narrow-Band Imaging as a Novel Light Source for Photodynamic Therapy for Superficial Cancers via Endoscopes
The Potential of Narrow-Band Imaging as a Novel Light Source for Photodynamic Therapy for Superficial Cancers via Endoscopes Open
NBI is a promising PDT light source for superficial cancers via endoscopes.
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View article: Advanced diagnostic endoscopy in the upper gastrointestinal tract: Review of the Japan Gastroenterological Endoscopic Society core sessions
Advanced diagnostic endoscopy in the upper gastrointestinal tract: Review of the Japan Gastroenterological Endoscopic Society core sessions Open
The Japan Gastroenterological Endoscopy Society (JGES) held four serial symposia between 2021 and 2022 on state‐of‐the‐art issues related to advanced diagnostic endoscopy of the upper gastrointestinal tract. This review summarizes the four…
View article: Fusion Imaging Objectively Demonstrates Improved Pancreas Visualization through Manipulation Techniques: A Prospective Interventional Study
Fusion Imaging Objectively Demonstrates Improved Pancreas Visualization through Manipulation Techniques: A Prospective Interventional Study Open
Objective Abdominal ultrasonography (AUS) is used to screen for abdominal diseases owing to its low cost, safety, and accessibility. However, the detection rate of pancreatic disease using AUS is unsatisfactory. We evaluated the visualizat…
View article: Multicenter study of invasive gastric cancer detected after 10 years of <i>Helicobacter pylori</i> eradication in Japan: Clinical, endoscopic, and histopathologic characteristics
Multicenter study of invasive gastric cancer detected after 10 years of <i>Helicobacter pylori</i> eradication in Japan: Clinical, endoscopic, and histopathologic characteristics Open
Objectives Gastric cancer can be diagnosed even in patients long after Helicobacter pylori eradication. Most cases involve intramucosal lesions; however, some are invasive and require surgery. To clarify appropriate long‐term surveillance …
View article: Prognostic Factors for Severe-to-Fatal Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis: A Multicenter Prospective Cohort Study
Prognostic Factors for Severe-to-Fatal Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis: A Multicenter Prospective Cohort Study Open
The prognostic factors associated with severe-to-fatal post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) remain unclear despite the extensive number of studies on PEP. In total, 3739 ERCP patients with biliary d…
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View article: Partial Stent-in-Stent Method with an Uncovered Self-Expandable Metallic Stent for Unresectable Malignant Hilar Bile Duct Obstruction
Partial Stent-in-Stent Method with an Uncovered Self-Expandable Metallic Stent for Unresectable Malignant Hilar Bile Duct Obstruction Open
(1) Background: There is controversy regarding stent placement for unresectable malignant hilar biliary obstruction (UMHBO). We mainly use the partial stent-in-stent (PSIS) method with an uncovered self-expandable metallic stent (UCSEMS) b…
View article: Autophagy-Related Gene ATG7 Polymorphism Could Potentially Serve as a Biomarker of the Progression of Atrophic Gastritis
Autophagy-Related Gene ATG7 Polymorphism Could Potentially Serve as a Biomarker of the Progression of Atrophic Gastritis Open
Cytotoxin-associated gene A (CagA) is an oncoprotein that H. pylori injects into the host’s gastric epithelial cells and that induces proinflammatory cytokines, such as interleukin (IL)-18 and IL-1β. As a result, it leads to atrophic gastr…
View article: Serum Activin A Is a Novel Biomarker of Endoscopic Activity in Ulcerative Colitis
Serum Activin A Is a Novel Biomarker of Endoscopic Activity in Ulcerative Colitis Open
The serum activin A level is a potential novel biomarker of endoscopic activity in UC.
View article: Safety and Diagnostic Yield of Endoscopic Ultrasound-Guided Fine-Needle Biopsy for Hypervascular Pancreatic Lesions
Safety and Diagnostic Yield of Endoscopic Ultrasound-Guided Fine-Needle Biopsy for Hypervascular Pancreatic Lesions Open
Endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) is a common technique for diagnosing pancreatic lesions with high accuracy and a low incidence of procedural adverse events. However, occasional adverse events, particularly bleedin…
View article: Outcomes of Endoscopic Intervention Using Over-the-Scope Clips for Anastomotic Leakage Involving Secondary Fistula after Gastrointestinal Surgery: A Japanese Multicenter Case Series
Outcomes of Endoscopic Intervention Using Over-the-Scope Clips for Anastomotic Leakage Involving Secondary Fistula after Gastrointestinal Surgery: A Japanese Multicenter Case Series Open
Background: The over-the-scope clip (OTSC) is a highly effective clipping device for refractory gastrointestinal disease. However, Japanese data from multicenter studies for anastomotic leakage (AL) involving a secondary fistula after gast…