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View article: Identification of an Oligostilbene, Vaticanol B, from <i>Dryobalanops aromatica</i> Leaves as an Antiviral Compound against the Hepatitis C Virus
Identification of an Oligostilbene, Vaticanol B, from <i>Dryobalanops aromatica</i> Leaves as an Antiviral Compound against the Hepatitis C Virus Open
Chronic hepatitis C virus (HCV) infection can lead to liver cirrhosis and hepatocellular carcinoma. Although current medications using direct-acting antivirals (DAAs) are highly effective and well-tolerated for treating patients with chron…
View article: Suppression of viral RNA polymerase activity is necessary for persistent infection during the transformation of measles virus into SSPE virus
Suppression of viral RNA polymerase activity is necessary for persistent infection during the transformation of measles virus into SSPE virus Open
Subacute sclerosing panencephalitis (SSPE) is a fatal neurodegenerative disease caused by measles virus (MV), which typically develops 7 to 10 years after acute measles. During the incubation period, MV establishes a persistent infection i…
View article: M protein of subacute sclerosing panencephalitis virus, synergistically with the F protein, plays a crucial role in viral neuropathogenicity
M protein of subacute sclerosing panencephalitis virus, synergistically with the F protein, plays a crucial role in viral neuropathogenicity Open
Subacute sclerosing panencephalitis (SSPE) is a rare fatal neurodegenerative disease caused by a measles virus (MV) variant, SSPE virus, that accumulates mutations during long-term persistent infection of the central nervous system (CNS). …
View article: Virucidal activity of oriental hornet Vespa orientalis venom against hepatitis C virus
Virucidal activity of oriental hornet Vespa orientalis venom against hepatitis C virus Open
WV can inhibit the entry stage of HCV infection at non-cytotoxic concentrations. Therefore, it could be considered a potential candidate for characterization of natural anti-HCV agents targeting the entry step.
View article: Antiviral Activity of Indonesian Medicinal Plants against Hepatitis B Virus
Antiviral Activity of Indonesian Medicinal Plants against Hepatitis B Virus Open
Background: Hepatitis B virus (HBV) infects more than 300 million people globally and is a common cause of liver cancer. Current therapy using reverse transcriptase inhibitors require long-term treatment and the potential risk of developme…
View article: Prevalence and genotype distribution of hepatitis B virus among migrant workers in Lombok Island, Indonesia
Prevalence and genotype distribution of hepatitis B virus among migrant workers in Lombok Island, Indonesia Open
Objective: To examine the potential risk of hepatitis B virus (HBV) spread in Indonesia by migrant workers, based on the molecular characteristics of HBV strains. Methods: Sera collected from migrant workers traveling to their destination …
View article: Antiviral Activity of Cananga odorata Against Hepatitis B Virus.
Antiviral Activity of Cananga odorata Against Hepatitis B Virus. Open
Chronic hepatitis B virus (HBV) infection can lead to liver cirrhosis and hepatocellular carcinoma. Current therapeutic drugs for chronic hepatitis B using pegylated interferons and nucleos(t)ide analogs have limited efficacy. Therefore, t…
View article: In Vitro study of Garcinia celebica L. Stem Barks against Hepatitis C virus and Hepatocellular Carcinoma
In Vitro study of Garcinia celebica L. Stem Barks against Hepatitis C virus and Hepatocellular Carcinoma Open
In this study, we are focused on Garcinia celebica as anti-HCV activity against JFH1 strain genotype 2a. The extraction process employed the use of maceration method. Starting from n-hexane solvent and another residue. The extracts were th…
View article: Anti-Viral Activity of Phyllanthus niruri Against Hepatitis C Virus
Anti-Viral Activity of Phyllanthus niruri Against Hepatitis C Virus Open
Hepatitis C virus (HCV) infection is a global problem that causes liver disease and hepatocellular carcinoma. Although the current standard treatment provided a significant improvement on response rate with sustain virology response more t…
View article: Peroxiredoxin 1, a Novel HBx-Interacting Protein, Interacts with Exosome Component 5 and Negatively Regulates Hepatitis B Virus (HBV) Propagation through Degradation of HBV RNA
Peroxiredoxin 1, a Novel HBx-Interacting Protein, Interacts with Exosome Component 5 and Negatively Regulates Hepatitis B Virus (HBV) Propagation through Degradation of HBV RNA Open
Hepatitis B virus (HBV) infection is a major global health problem. HBx plays important roles in HBV replication and viral carcinogenesis through its interaction with host factors. In this study, we identified Prdx1 as a novel HBx-binding …
View article: Antiviral Activities of <i>Curcuma</i> Genus against Hepatitis C Virus
Antiviral Activities of <i>Curcuma</i> Genus against Hepatitis C Virus Open
Hepatitis C virus (HCV) infection is one of the major public health problems in the world. Even though the new agents are shown to increase the sustained virology response, however, there are still many people who cannot access the therapy…
View article: Antiviral effect of <em>Archidendron pauciflorum</em> leaves extract to hepatitis C virus: An <em>in vitro</em> study in JFH-1 strain
Antiviral effect of <em>Archidendron pauciflorum</em> leaves extract to hepatitis C virus: An <em>in vitro</em> study in JFH-1 strain Open
Background: Hepatitis C virus (HCV) is a leading cause of chronic liver diseases. Drug resistance to the regimen is also increasing. Hence, there is a need for new anti-HCV agents that are less toxic and more efficacious. The aim of this s…
View article: ANTIHEPATITIS C VIRUS ACTIVITY OF INDONESIAN MAHOGANY (TOONA SURENI)
ANTIHEPATITIS C VIRUS ACTIVITY OF INDONESIAN MAHOGANY (TOONA SURENI) Open
Objective: Toona sureni (Indonesian mahogany) is a member of Meliaceae family and locally known as suren. Previous study reported that T. sureni leaves extract exhibited antiviral activity with 50% inhibitory concentration (IC50) value of …
View article: Time-of-addition and Temperature-shift Assays to Determine Particular Step(s) in the Viral Life Cycle that is Blocked by Antiviral Substance(s)
Time-of-addition and Temperature-shift Assays to Determine Particular Step(s) in the Viral Life Cycle that is Blocked by Antiviral Substance(s) Open
Viruses infect their host cells to produce progeny virus particles through the sequential steps of the viral life cycle, such as viral attachment, entry, penetration and post-entry events. This protocol describes time-of-addition and tempe…
View article: Virucidal and Neutralizing Activity Tests for Antiviral Substances and Antibodies
Virucidal and Neutralizing Activity Tests for Antiviral Substances and Antibodies Open
In a narrow definition, virucidal activity represents the activity by which to interact with and physically disrupt viral particles. In a broad definition, it includes the activity by which to functionally inhibit (neutralize) viral infect…
View article: A study on the relationship between HCV NS3 and endogenous IRF-3
A study on the relationship between HCV NS3 and endogenous IRF-3 Open
This study aims to investigate the relationship between hepatitis C virus (HCV) NS3/4A and endogenous interferon regulatory factor-3 (IRF-3). The localization of endogenous IRF-3 protein before and after virus infection was analyzed by imm…
View article: Broad-spectrum antiviral agents: secreted phospholipase A2 targets viral envelope lipid bilayers derived from the endoplasmic reticulum membrane
Broad-spectrum antiviral agents: secreted phospholipase A2 targets viral envelope lipid bilayers derived from the endoplasmic reticulum membrane Open
Hepatitis C virus (HCV), dengue virus (DENV) and Japanese encephalitis virus (JEV) belong to the family Flaviviridae . Their viral particles have the envelope composed of viral proteins and a lipid bilayer acquired from budding through the…
View article: SYNTHESIS AND ANTI-HEPATITIS C VIRUS ACTIVITY OF GALLIC ACID DERIVATIVES WITH CHIRAL CENTER
SYNTHESIS AND ANTI-HEPATITIS C VIRUS ACTIVITY OF GALLIC ACID DERIVATIVES WITH CHIRAL CENTER Open
Objective: In this work, we aim to synthesize gallic acid derivatives with chiral center and to evaluate its anti-hepatitis C virus (anti-HCV) activity.Methods: Synthesis of the target derivatives was started from esterification of commerc…
View article: Antiviral activity of the dichloromethane extracts from Artocarpus heterophyllus leaves against hepatitis C virus
Antiviral activity of the dichloromethane extracts from Artocarpus heterophyllus leaves against hepatitis C virus Open
Objective: To determine anti-viral activities of three Artocarpus species: Artocarpus altilis, Artocarpus camansi, and Artocarpus heterophyllus (A. heterophyllus) against Hepatitis C Virus (HCV). Methods: Antiviral activities of the crude …
View article: STAT1 is essential for the inhibition of hepatitis C virus replication by interferon-λ but not by interferon-α
STAT1 is essential for the inhibition of hepatitis C virus replication by interferon-λ but not by interferon-α Open
Interferon-α (IFN-α) and IFN-λ are structurally distinct cytokines that bind to different receptors, but induce expression of similar sets of genes through Janus kinase (JAK)-signal transducers and activators of transcription (STAT) pathwa…
View article: Seroevidence for a High Prevalence of Subclinical Infection With Avian Influenza A(H5N1) Virus Among Workers in a Live-Poultry Market in Indonesia
Seroevidence for a High Prevalence of Subclinical Infection With Avian Influenza A(H5N1) Virus Among Workers in a Live-Poultry Market in Indonesia Open
This study provides evidence of a high prevalence of avian A(H5N1) virus infection in 2013 among workers at a live-poultry market. However, because no instances of hospitalizations were reported, we can conclude the virus did not manifest …
View article: Promising Anti-Hepatitis C Virus Compounds from Natural Resources
Promising Anti-Hepatitis C Virus Compounds from Natural Resources Open
Hepatitis C virus (HCV) infection is a major worldwide problem, which involves approximately 170 million people. High morbidity of patients is caused by chronic infection, which leads to liver cirrhosis, hepatocellular carcinoma and other …
View article: Hepatitis B Virus Infection in Indonesia 15 Years After Adoption of a Universal Infant Vaccination Program: Possible Impacts of Low Birth Dose Coverage and a Vaccine-Escape Mutant
Hepatitis B Virus Infection in Indonesia 15 Years After Adoption of a Universal Infant Vaccination Program: Possible Impacts of Low Birth Dose Coverage and a Vaccine-Escape Mutant Open
A universal hepatitis B vaccination program for infants was adopted in Indonesia in 1997. Before its implementation, the prevalence of hepatitis B surface antigen (HBsAg)–positive individuals in the general population was approximately 5–1…
View article: Hepatitis C virus NS5A protein interacts with lysine methyltransferase SET and MYND domain‐containing 3 and induces activator protein 1 activation
Hepatitis C virus NS5A protein interacts with lysine methyltransferase SET and MYND domain‐containing 3 and induces activator protein 1 activation Open
Hepatitis C virus (HCV) non‐structural protein 5A (NS5A) is a multifunctional protein that is involved in the HCV life cycle and pathogenesis. In this study, a host protein(s) interacting with NS5A by tandem affinity purification were sear…
View article: Activities of Ficus fistulosa Leave Extract and Fractions against Hepatitis C Virus
Activities of Ficus fistulosa Leave Extract and Fractions against Hepatitis C Virus Open
Hepatitis C Virus (HCV) is a major global disease which often leads to chronicity and is potential to liver failure. There is no anti-HCV vaccine and the high diversity of viral genotypes will probably make it very difficult to develop a v…
View article: Study of Tree-sparrow (Passer montanus) as Natural Spreader of H5N1 Virus
Study of Tree-sparrow (Passer montanus) as Natural Spreader of H5N1 Virus Open
To understand sparrow's ability in spreading H5N1 avian influenza virus, especially compared to backyard chicken, we performed an experimental infection study. Nine sparrows and backyard chickens were inoculated with H5N1 viruses isolated …