Håkan Åhlström
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View article: Supervoxel-based image-to-biomarker conversions - An initial study on morphological age prediction from whole-body MRI and its clinical relevance in the UK Biobank
Supervoxel-based image-to-biomarker conversions - An initial study on morphological age prediction from whole-body MRI and its clinical relevance in the UK Biobank Open
Biological aging remains a central focus of research, from the scale of sub-cellular processes to whole-organism tissue morphology and function. In this work, we developed a novel and quantitatively interpretable method for the prediction …
View article: Hormonal adaptations to weight loss: Responses to an oral glucose load 4 weeks after obesity surgery and low‐energy diet
Hormonal adaptations to weight loss: Responses to an oral glucose load 4 weeks after obesity surgery and low‐energy diet Open
Aims In addition to weight loss, obesity surgery (OS) leads to metabolic improvements that seem at least partly independent of weight loss and are also mediated by various endocrine pathways and the brain. For the first time, we compared t…
View article: Impact of genetic variants linked to liver fat and liver volume on MRI-mapped body composition
Impact of genetic variants linked to liver fat and liver volume on MRI-mapped body composition Open
Liver fat and liver volume are common metabolic traits with a strong genetic component, yet the extent to which they exert organ-specific vs. systemic effects remains poorly defined. By integrating genome-wide association analyses a…
View article: Plasma proteomic and metabolomic profiling of coronary and carotid atherosclerosis in the SCAPIS study—differences and similarities
Plasma proteomic and metabolomic profiling of coronary and carotid atherosclerosis in the SCAPIS study—differences and similarities Open
Funding Agencies|European Research Council [ERC-STG-2018-801965]; Swedish Research Council [VR 2019-01471, 2019-01236]; Swedish Heart-Lung Foundation [Hjart-Lungfonden] [20190505, 20200173]; Swedish Government [ALFGBG-991828]; Swedish coun…
View article: Causal effects of obesity on estimated glomerular filtration rate: a Mendelian randomization and image data analysis study
Causal effects of obesity on estimated glomerular filtration rate: a Mendelian randomization and image data analysis study Open
Background Obesity has been associated with onset and progression of chronic kidney disease (CKD) but causal relationship remains uncertain. This study investigated how obesity causally affects estimated glomerular filtration rate. Methods…
View article: Towards prediction of morphological heart age from computed tomography angiography
Towards prediction of morphological heart age from computed tomography angiography Open
Age prediction from medical images or other health-related non-imaging data is an important approach to data-driven aging research, providing knowledge of how much information a specific tissue or organ carries about the chronological age …
View article: Proteomic signatures for fibrosis in MASLD: a biopsy-proven dual-cohort study
Proteomic signatures for fibrosis in MASLD: a biopsy-proven dual-cohort study Open
A biomarker model including ACE2, HGF and IGFBP7 shows promise in distinguishing between low-stage and significant fibrosis.
View article: Enhanced glomerular thrombosis in pronated animals with ARDS
Enhanced glomerular thrombosis in pronated animals with ARDS Open
Background Prone positioning is part of the management of acute respiratory distress syndrome (ARDS) and has been demonstrated to successfully improve the ventilation–perfusion match and reduce mortality in patients with severe respiratory…
View article: Inclusion of tumor periphery in radiomics analysis of magnetic resonance images does not improve predictions of preoperative therapy response in patients with rectal cancer
Inclusion of tumor periphery in radiomics analysis of magnetic resonance images does not improve predictions of preoperative therapy response in patients with rectal cancer Open
View article: Whole-body tumor segmentation from FDG-PET/CT: Leveraging a segmentation prior from tissue-wise projections
Whole-body tumor segmentation from FDG-PET/CT: Leveraging a segmentation prior from tissue-wise projections Open
View article: Author Correction: Integration of whole-body [18F]FDG PET/MRI with non-targeted metabolomics can provide new insights on tissue-specific insulin resistance in type 2 diabetes
Author Correction: Integration of whole-body [18F]FDG PET/MRI with non-targeted metabolomics can provide new insights on tissue-specific insulin resistance in type 2 diabetes Open
View article: Supplementary Table S1 from Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients
Supplementary Table S1 from Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients Open
Representativeness of Study Participants
View article: Supplementary Table S8 from Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients
Supplementary Table S8 from Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients Open
Proteomics analysis of plasma one week post CAR-T infusion in relation to CRS
View article: Supplementary Figure S11 from Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients
Supplementary Figure S11 from Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients Open
Supplementary Figure S11. Expression of genes included in the single-cell polyfunctionality strength index analysis in individual patients
View article: Supplementary Table S4 from Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients
Supplementary Table S4 from Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients Open
Biomarkers for CD8 and CD4 clusters
View article: Supplementary Figure S12 from Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients
Supplementary Figure S12 from Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients Open
Supplementary Figure S12. Single-cell polyfunctionality in CD4+ CAR-Ts
View article: Supplementary Figure S4 from Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients
Supplementary Figure S4 from Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients Open
Supplementary Figure S4. Parameters associated with treatment-related toxicity.
View article: Supplementary Table S7 from Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients
Supplementary Table S7 from Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients Open
DEGs R vs NR CD8 CAR-T
View article: Supplementary Table S13 from Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients
Supplementary Table S13 from Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients Open
Patient cohort characteristics
View article: Supplementary Figure S10 from Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients
Supplementary Figure S10 from Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients Open
Supplementary Figure S10. A) Overview of the CAR-T production process. B) Expansion of the CAR-T product over time for responders (R; n=9) and non-responders (NR; n=15) during ex vivo CAR-T manufacturing. Values are shown as mean ± SEM. Tw…
View article: Supplementary Table S7 from Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients
Supplementary Table S7 from Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients Open
DEGs R vs NR CD8 CAR-T
View article: Supplementary Table S15 from Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients
Supplementary Table S15 from Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients Open
Univariate and multivariate analysis of OS and PFS of lymphoma patients including patient characteristics and clinical procedures
View article: Supplementary Figure S7 from Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients
Supplementary Figure S7 from Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients Open
Supplementary Figure S7. Cluster specifications of single-cell RNA sequenced CAR-T infusion products
View article: Supplementary Figure S12 from Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients
Supplementary Figure S12 from Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients Open
Supplementary Figure S12. Single-cell polyfunctionality in CD4+ CAR-Ts
View article: Supplementary Figure S2 from Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients
Supplementary Figure S2 from Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients Open
Supplementary Figure S2. Infusion of two CAR-T doses instead of one did not impact response or survival
View article: Supplementary Figure S3 from Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients
Supplementary Figure S3 from Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients Open
Supplementary Figure S3. Responding patients had a better OS and PFS compared to nonresponding patients.
View article: Supplementary Table S10 from Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients
Supplementary Table S10 from Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients Open
Proteomics analysis of plasma before CAR-T infusion in relation to CRS
View article: A detailed analysis of body composition in relation to cardiopulmonary exercise test indices
A detailed analysis of body composition in relation to cardiopulmonary exercise test indices Open
View article: Supplementary Table S6 from Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients
Supplementary Table S6 from Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients Open
Gene list used for computing AUCell signatures
View article: Supplementary Table S9 from Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients
Supplementary Table S9 from Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients Open
Proteomics analysis of plasma three week post CAR-T infusion in relation to CRS