Faruck Lukmanul Hakkim
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View article: EPCO-13. EZHIP SELECTIVELY REPRESSES GENOME STABILITY PROGRAMS IN NEURAL STEM CELLS TO PROMOTE EPIGENETIC VULNERABILITY AND TRANSFORMATION
EPCO-13. EZHIP SELECTIVELY REPRESSES GENOME STABILITY PROGRAMS IN NEURAL STEM CELLS TO PROMOTE EPIGENETIC VULNERABILITY AND TRANSFORMATION Open
BACKGROUND Posterior fossa group A ependymomas (PFAs) and diffuse midline gliomas (DMGs) are lethal pediatric brain tumors characterized by global loss of H3K27me3. This epigenetic disruption is caused by either EZHIP overexpression or H3.…
View article: H3F3A K27M Mutations Drives a Repressive Transcriptome by Modulating Chromatin Accessibility, Independent of H3K27me3 in Diffuse Midline Glioma
H3F3A K27M Mutations Drives a Repressive Transcriptome by Modulating Chromatin Accessibility, Independent of H3K27me3 in Diffuse Midline Glioma Open
Background Heterozygous histone H3.3K27M mutation is a primary oncogenic driver of Diffuse Midline Glioma (DMG). H3.3K27M inhibits the Polycomb Repressive Complex 2 (PRC2) methyltransferase complex, leading to a global reduction and redist…
View article: CCRG-02. THE DIFFUSE MIDLINE GLIOMA MUTATIONS, H3.3 K27M AND G34R/V, INHIBIT MITOTIC PHOSPHORYLATION OF SERINE 31, LEADING TO TUMOR FORMATION THROUGH INCREASED CHROMOSOMAL INSTABILITY
CCRG-02. THE DIFFUSE MIDLINE GLIOMA MUTATIONS, H3.3 K27M AND G34R/V, INHIBIT MITOTIC PHOSPHORYLATION OF SERINE 31, LEADING TO TUMOR FORMATION THROUGH INCREASED CHROMOSOMAL INSTABILITY Open
Diffuse midline gliomas (DMG) are high-grade pediatric gliomas that frequently harbor heterozygous histone H3.3 K27M, G34R, or G34V mutations. These mutations alter histone methylations, although the precise mechanism(s) of gliomagenesis r…
View article: CSIG-15. DEFINING THE ROLE OF HISTONE H3 K27 METHYLATION AND H3.3 S31 PHOSPHORYLATION IN H3.3K27M MUTANT DIFFUSE MIDLINE GLIOMAS
CSIG-15. DEFINING THE ROLE OF HISTONE H3 K27 METHYLATION AND H3.3 S31 PHOSPHORYLATION IN H3.3K27M MUTANT DIFFUSE MIDLINE GLIOMAS Open
Diffuse midline gliomas (DMG) are aggressive high-grade gliomas that characteristically occurs in children. Heterozygous K27M mutation occurs in histone H3.3 as early events in DMG and are sufficient to drive a global reduction of H3K27 me…
View article: HGG-30. H3.3 G34R/V mutations disrupt H3.3 mitotic phosphorylation leading to high-grade glioma formation through the induction of chromosomal instability
HGG-30. H3.3 G34R/V mutations disrupt H3.3 mitotic phosphorylation leading to high-grade glioma formation through the induction of chromosomal instability Open
Pediatric high-grade gliomas (pHGG) are among the most lethal of all human cancers. Histone H3.3 G34R/V mutations are an early event in these tumors and show reduced H3.3 K36 trimethylation; implicating epigenetic dysregulation in tumorige…
View article: The histone H3.3 K27M mutation found in diffuse midline gliomas coordinately disrupts adjacent H3.3 Ser31 phosphorylation and the fidelity of chromosome segregation
The histone H3.3 K27M mutation found in diffuse midline gliomas coordinately disrupts adjacent H3.3 Ser31 phosphorylation and the fidelity of chromosome segregation Open
During the cell cycle, differential phosphorylation of select histone H3 serine/threonine residues regulates chromatin structure, necessary for both dynamic transcriptional control and proper chromosome segregation 1-2 . Histone H3.3 conta…
View article: Frankincense diterpenes as a bio-source for drug discovery
Frankincense diterpenes as a bio-source for drug discovery Open
Numerous diterpenoids including cembrane, prenylaromadendrane, and the verticillane-type have been isolated from various Boswellia resins. Cembrane-type diterpenoids occupy a crucial position in pharmaceutical chemistry and related …
View article: Exploiting the Metabolism of the Gut Microbiome as a Vehicle for Targeted Drug Delivery to the Colon
Exploiting the Metabolism of the Gut Microbiome as a Vehicle for Targeted Drug Delivery to the Colon Open
The prevalence of colon-associated diseases has increased significantly over the past several decades, as evidenced by accumulated literature on conditions such as Crohn’s disease, irritable bowel syndrome, colorectal cancer, and ulcerativ…
View article: Glycyrrhetinic acid: a promising scaffold for the discovery of anticancer agents
Glycyrrhetinic acid: a promising scaffold for the discovery of anticancer agents Open
Numerous semisynthetic GA derivatives illustrated excellent cytotoxic effects toward various cancer cells. Notably the C-3(OH) at ring A along with C30-CO2H at ring E as vital structural features, make GA v…
View article: Boswellic acids: privileged structures to develop lead compounds for anticancer drug discovery
Boswellic acids: privileged structures to develop lead compounds for anticancer drug discovery Open
Introduction: Cancer has been identified to be the second major cause of death internationally as exemplified by ca. 9.6 million deaths in 2018 along with ca. 18 million new patients in 2018 that have been recorded. Natural boswelli…
View article: CCDC 1830861: Experimental Crystal Structure Determination
CCDC 1830861: Experimental Crystal Structure Determination Open
View article: Correction: Frankincense essential oil suppresses melanoma cancer through down regulation of Bcl-2/Bax cascade signaling and ameliorates heptotoxicity via phase I and II drug metabolizing enzymes
Correction: Frankincense essential oil suppresses melanoma cancer through down regulation of Bcl-2/Bax cascade signaling and ameliorates heptotoxicity via phase I and II drug metabolizing enzymes Open
This article has been corrected: Due to errors during image selection, identical images were used for panels D and E in Figure 1D. In Figure 7A, the brain images for ‘healthy’ and ‘treated’ are also accidental duplicates. Additionally, the…
View article: Nucleic Acid Aptamers as a Potential Nucleus Targeted Drug Delivery System
Nucleic Acid Aptamers as a Potential Nucleus Targeted Drug Delivery System Open
Background: Nucleus targeted drug delivery provides several opportunities for the treatment of fatal diseases such as cancer. However, the complex nucleocytoplasmic barriers pose significant challenges for delivering a drug directly and ef…
View article: In Vivo Anti Cancer Potential of Pyrogallol in Murine Model of Colon Cancer
In Vivo Anti Cancer Potential of Pyrogallol in Murine Model of Colon Cancer Open
Background: Colon cancer is aggressive and it causes 0.5 million deaths per year. Practicing natural medicines for cancer treatment is safer than conventional drugs. World health organization emphasizes on the importance of practicing natu…
View article: Frankincense essential oil suppresses melanoma cancer through down regulation of Bcl-2/Bax cascade signaling and ameliorates heptotoxicity via phase I and II drug metabolizing enzymes
Frankincense essential oil suppresses melanoma cancer through down regulation of Bcl-2/Bax cascade signaling and ameliorates heptotoxicity via phase I and II drug metabolizing enzymes Open
[This corrects the article DOI: 10.18632/oncotarget.26930.].
View article: Mechanochemical syntheses, crystal structures, and photo-luminescent properties of a new hydrazone and its nickel and cadmium complexes
Mechanochemical syntheses, crystal structures, and photo-luminescent properties of a new hydrazone and its nickel and cadmium complexes Open
This work is funded by DST-SERB, India, Under EMEQ scheme (SB/EMEQ-164/2014).
View article: Induction of HT-29 Colon Cancer Cells Apoptosis by Pyrogallol with Growth Inhibiting Efficacy Against Drug-Resistant Helicobacter pylori
Induction of HT-29 Colon Cancer Cells Apoptosis by Pyrogallol with Growth Inhibiting Efficacy Against Drug-Resistant Helicobacter pylori Open
Background: Colon cancer is the most aggressive form of cancers, that causes 0.5 million deaths per year around the globe. Targeting colon cancer by conventional therapeutic options elicits toxicity. Traditional medicines take a lead to al…
View article: Potential of Aucklandia Lappa Decne Ethanolic Extract to Trigger Apoptosis of Human T47D and Hela Cells
Potential of Aucklandia Lappa Decne Ethanolic Extract to Trigger Apoptosis of Human T47D and Hela Cells Open
Breast and cervical cancers are global health concerns and major cause of deaths among women. Current treatments such as chemotherapy are associated with several drawbacks that limit their effectiveness. Several anticancer remedies have be…
View article: CCDC 1514573: Experimental Crystal Structure Determination
CCDC 1514573: Experimental Crystal Structure Determination Open
View article: CCDC 1545316: Experimental Crystal Structure Determination
CCDC 1545316: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Role of Dietary Crocin in In Vivo Melanoma Tumor Remission
Role of Dietary Crocin in In Vivo Melanoma Tumor Remission Open
Background: Melanoma is a deadly form of malignancy. Early diagnosis might pave the way to cure but its aggressive nature leads to rapid dissemination and colonization of distant organs. Dietary herbs may play a significant role in prevent…
View article: Assessment of in vitro cytotoxicity of saffron (Crocus sativus L.) on cervical cancer cells (HEp-2) and their in vivo pre-clinical toxicity in normal swiss albino mice
Assessment of in vitro cytotoxicity of saffron (Crocus sativus L.) on cervical cancer cells (HEp-2) and their in vivo pre-clinical toxicity in normal swiss albino mice Open
Cervical cancer is the second leading cause of death in women followed by breast cancer. Chemotherapy is the most feasible format to handle but their clinical consequences such as tumor relapse, drug resistance accompanied with severe toxi…
View article: Molecular Mechanism of Crocin Induced Caspase Mediated MCF-7 Cell Death: In Vivo Toxicity Profiling and Ex Vivo Macrophage Activation
Molecular Mechanism of Crocin Induced Caspase Mediated MCF-7 Cell Death: In Vivo Toxicity Profiling and Ex Vivo Macrophage Activation Open
Our study delineated involvement of pro-apoptotic and caspase mediated MCF-7 cell death by CSE and crocin at the molecular level accompanied with extensive DNA damage. Further we found that normal swiss albino mice can tolerate the maximum…
View article: Chemical composition and anti-proliferative effect of Oman's Ganoderma applanatum on breast cancer and cervical cancer cells
Chemical composition and anti-proliferative effect of Oman's Ganoderma applanatum on breast cancer and cervical cancer cells Open
To evaluate the anti-proliferative potential of Oman's Ganoderma applanatum on triple negative breast cancer cells (MDA-MB-231), cervical cancer cells (HEp-2) and Vero cells (normal) and its chemical profiling of G. applanatum. The cytotox…
View article: IN VITRO DPPH RADICAL SCAVENGING AND ANTI-BACTERIAL ACTIVITY OF OMAN’S CYMBOPOGON
IN VITRO DPPH RADICAL SCAVENGING AND ANTI-BACTERIAL ACTIVITY OF OMAN’S CYMBOPOGON Open
Objective: The objective of this work is to evaluate antioxidant and anti-microbial activity of methanolic extract of Omani Cymbopogan schoenanthus . Methods: Antibacterial activity of mehanolic extract of Cymbopogan was evalu…
View article: Frankincense derived heavy terpene cocktail boosting breast cancer cell (MDA-MB-231) death in vitro
Frankincense derived heavy terpene cocktail boosting breast cancer cell (MDA-MB-231) death in vitro Open
Objective: To investigate the anti-cancer effect of frankincense derived heavy oil obtained by Soxhlet extraction method on breast cancer cells (MDA-MB-231), and to study its chemical profile using gas chromatography mass spectrometry anal…