Haksoo Lee
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View article: Cancer stem cells: landscape, challenges and emerging therapeutic innovations
Cancer stem cells: landscape, challenges and emerging therapeutic innovations Open
Cancer stem cells (CSCs) constitute a highly plastic and therapy-resistant cell subpopulation within tumors that drives tumor initiation, progression, metastasis, and relapse. Their ability to evade conventional treatments, adapt to metabo…
View article: Unraveling ER dimerization dynamics in endocrine disruption based on a BRET-focused approach
Unraveling ER dimerization dynamics in endocrine disruption based on a BRET-focused approach Open
Endocrine-disrupting chemicals (EDCs) are exogenous compounds that interact with the estrogen receptor (ER), thereby disrupting estrogen-mediated signaling. In a previous study, we employed a bioluminescence resonance energy transfer (BRET…
View article: TMET-08. RADIATION-INDUCED SLC25A22 CONTRIBUTES TO GLIOBLASTOMA RADIORESISTANCE ACQUISITION THROUGH REMODELING GLUTAMATE METABOLISM
TMET-08. RADIATION-INDUCED SLC25A22 CONTRIBUTES TO GLIOBLASTOMA RADIORESISTANCE ACQUISITION THROUGH REMODELING GLUTAMATE METABOLISM Open
Glioblastoma Multiforme (GBM), a malignant primary brain tumor, is treated by surgical resection followed by chemo- and radiotherapy. Nevertheless, most GBM patients show dismal prognosis due to the radioresistance acquisition of GBM cells…
View article: TMET-07. RADIORESISTANT GLIOBLASTOMA EVADES MITOCHONDRIAL LIPOTOXICITY THROUGH ALTERED DGKB AND DGAT1
TMET-07. RADIORESISTANT GLIOBLASTOMA EVADES MITOCHONDRIAL LIPOTOXICITY THROUGH ALTERED DGKB AND DGAT1 Open
Glioblastoma (GBM) is the most common and aggressive primary brain tumor, with a median survival of only 15 months despite multimodal therapy. Radiotherapy is a conventional therapy of GBM treatment, but the development of radioresistance …
View article: TMET-06. CLIP3 DOWNREGULATION LEADS TO RADIORESISTANCE IN GLIOBLASTOMA BY PROMOTING GLYCOLYTIC FLUX
TMET-06. CLIP3 DOWNREGULATION LEADS TO RADIORESISTANCE IN GLIOBLASTOMA BY PROMOTING GLYCOLYTIC FLUX Open
Glioblastoma Multiforme (GBM), a highly aggressive primary brain tumor, often develops resistance to standard treatments such as ionizing radiation (IR), which leads to a median survival of about 15 months. GBM contains glioblastoma stem c…
View article: Low-temperature pulverization-specific <i>Sargassum horneri</i> extract accelerates wound healing and attenuates inflammation in a mouse burn model
Low-temperature pulverization-specific <i>Sargassum horneri</i> extract accelerates wound healing and attenuates inflammation in a mouse burn model Open
Burn injuries, affecting local skin disruption as well as inducing systemic inflammatory responses, are presented as a global public health problem. To enhance the effects of burn wound healing, treatment must simultaneously regulate both …
View article: Novel Estrogen Receptor Dimerization BRET-Based Biosensors for Screening Estrogenic Endocrine-Disrupting Chemicals
Novel Estrogen Receptor Dimerization BRET-Based Biosensors for Screening Estrogenic Endocrine-Disrupting Chemicals Open
The increasing prevalence of endocrine-disrupting chemicals (EDCs) in our environment is a growing concern, with numerous studies highlighting their adverse effects on the human endocrine system. Among the EDCs, estrogenic endocrine-disrup…
View article: PAK3 downregulation induces cognitive impairment following cranial irradiation
PAK3 downregulation induces cognitive impairment following cranial irradiation Open
Cranial irradiation is used for prophylactic brain radiotherapy as well as the treatment of primary brain tumors. Despite its high efficiency, it often induces unexpected side effects, including cognitive dysfunction. Herein, we observed t…
View article: Author Response: PAK3 downregulation induces cognitive impairment following cranial irradiation
Author Response: PAK3 downregulation induces cognitive impairment following cranial irradiation Open
Cranial irradiation is used for prophylactic brain radiotherapy as well as treatment of primary brain tumors. Despite its high efficiency, it often induces unexpected side effects, including cognitive dysfunction. Herein, we observed that …
View article: Reviewer #1 (Public Review): PAK3 downregulation induces cognitive impairment following cranial irradiation
Reviewer #1 (Public Review): PAK3 downregulation induces cognitive impairment following cranial irradiation Open
Cranial irradiation is used for prophylactic brain radiotherapy as well as treatment of primary brain tumors. Despite its high efficiency, it often induces unexpected side effects, including cognitive dysfunction. Herein, we observed that …
View article: Reviewer #2 (Public Review): PAK3 downregulation induces cognitive impairment following cranial irradiation
Reviewer #2 (Public Review): PAK3 downregulation induces cognitive impairment following cranial irradiation Open
Cranial irradiation is used for prophylactic brain radiotherapy as well as treatment of primary brain tumors. Despite its high efficiency, it often induces unexpected side effects, including cognitive dysfunction. Herein, we observed that …
View article: PAK3 downregulation induces cognitive impairment following cranial irradiation
PAK3 downregulation induces cognitive impairment following cranial irradiation Open
Cranial irradiation is used for prophylactic brain radiotherapy as well as treatment of primary brain tumors. Despite its high efficiency, it often induces unexpected side effects, including cognitive dysfunction. Herein, we observed that …
View article: Mitochondrial glutamate transporter SLC25A22 uni-directionally export glutamate for metabolic rewiring in radioresistant glioblastoma
Mitochondrial glutamate transporter SLC25A22 uni-directionally export glutamate for metabolic rewiring in radioresistant glioblastoma Open
Glioblastoma Multiforme (GBM) is a malignant primary brain tumor. Radiotherapy, one of the standard treatments for GBM patients, could induce GBM radioresistance via rewiring cellular metabolism. However, the precise mechanism attributing …
View article: PAK3 downregulation induces cognitive impairment following cranial irradiation
PAK3 downregulation induces cognitive impairment following cranial irradiation Open
Cranial irradiation is used for prophylactic brain radiotherapy as well as treatment of primary brain tumors. Despite its high efficiency, it often induces unexpected side effects, including cognitive dysfunction. Herein, we observed that …
View article: PAK3 downregulation induces cognitive impairment following cranial irradiation
PAK3 downregulation induces cognitive impairment following cranial irradiation Open
Cranial irradiation is used for prophylactic brain radiotherapy as well as the treatment of primary brain tumors. Despite its high efficiency, it often induces unexpected side effects, including cognitive dysfunction. Herein, we observed t…
View article: Reviewer #2 (Public Review): PAK3 downregulation induces cognitive impairment following cranial irradiation
Reviewer #2 (Public Review): PAK3 downregulation induces cognitive impairment following cranial irradiation Open
Cranial irradiation is used for prophylactic brain radiotherapy as well as treatment of primary brain tumors. Despite its high efficiency, it often induces unexpected side effects, including cognitive dysfunction. Herein, we observed that …
View article: PAK3 downregulation induces cognitive impairment following cranial irradiation
PAK3 downregulation induces cognitive impairment following cranial irradiation Open
Cranial irradiation is used for prophylactic brain radiotherapy as well as treatment of primary brain tumors. Despite its high efficiency, it often induces unexpected side effects, including cognitive dysfunction. Herein, we observed that …
View article: DGKB mediates radioresistance by regulating DGAT1-dependent lipotoxicity in glioblastoma
DGKB mediates radioresistance by regulating DGAT1-dependent lipotoxicity in glioblastoma Open
Glioblastoma (GBM) currently has a dismal prognosis. GBM cells that survive radiotherapy contribute to tumor progression and recurrence with metabolic advantages. Here, we show that diacylglycerol kinase B (DGKB), a regulator of the intrac…
View article: Targeting Oncogenic Rewiring of Lipid Metabolism for Glioblastoma Treatment
Targeting Oncogenic Rewiring of Lipid Metabolism for Glioblastoma Treatment Open
Glioblastoma (GBM) is the most malignant primary brain tumor. Despite increasing research on GBM treatment, the overall survival rate has not significantly improved over the last two decades. Although recent studies have focused on aberran…
View article: Exosomal Plasminogen Activator Inhibitor-1 Induces Ionizing Radiation-Adaptive Glioblastoma Cachexia
Exosomal Plasminogen Activator Inhibitor-1 Induces Ionizing Radiation-Adaptive Glioblastoma Cachexia Open
Cancer cachexia is a muscle-wasting syndrome that leads to a severely compromised quality of life and increased mortality. A strong association between cachexia and poor prognosis has been demonstrated in intractable cancers, including gli…
View article: Targeting Glioblastoma Stem Cells to Overcome Chemoresistance: An Overview of Current Therapeutic Strategies
Targeting Glioblastoma Stem Cells to Overcome Chemoresistance: An Overview of Current Therapeutic Strategies Open
Glioblastoma (GBM) is the most malignant primary brain tumor. The current standard approach in GBM is surgery, followed by treatment with radiation and temozolomide (TMZ); however, GBM is highly resistant to current therapies, and the stan…
View article: Soybean-Derived Peptides Attenuate Hyperlipidemia by Regulating Trans-Intestinal Cholesterol Excretion and Bile Acid Synthesis
Soybean-Derived Peptides Attenuate Hyperlipidemia by Regulating Trans-Intestinal Cholesterol Excretion and Bile Acid Synthesis Open
Increased triglyceride, cholesterol, and low-density lipoprotein (LDL) levels cause hyperlipidemia. Despite the availability of statin-based drugs to reduce LDL levels, additional effective treatments for reducing blood lipid concentration…
View article: Removal of Various Hazardous Materials Using a Multifunctional Biomass-Derived Hydroxyapatite (HAP) Catalyst and Its Antibacterial Effects
Removal of Various Hazardous Materials Using a Multifunctional Biomass-Derived Hydroxyapatite (HAP) Catalyst and Its Antibacterial Effects Open
In the present study, oyster shells, a cause of environmental pollution, were employed effectively to synthesize hydroxyapatite (HAP) by facile oxidation and phosphorylation. The ability of HAP to adsorb various metal cations and inhibit b…
View article: Autophagic Organelles in DNA Damage Response
Autophagic Organelles in DNA Damage Response Open
Autophagy is an important subcellular event engaged in the maintenance of cellular homeostasis via the degradation of cargo proteins and malfunctioning organelles. In response to cellular stresses, like nutrient deprivation, infection, and…
View article: Potential of Waste Oyster Shells as a Novel Biofiller for Hot-Mix Asphalt
Potential of Waste Oyster Shells as a Novel Biofiller for Hot-Mix Asphalt Open
This paper reports the use of waste oyster shells as a novel biofiller for hot-mix asphalt (HMA) pavement applications. The effects of different fractions (e.g., 0, 5, 10, 15 wt %) of oyster shell powder (OSP) on the bitumen performance we…